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후두 미세수술 중 병변 내 스테로이드 주입이 음성에 미치는 효과 분석
박재선,강현석,이인범,진성민,이상혁 대한후두음성언어의학회 2022 대한후두음성언어의학회지 Vol.33 No.3
Background and Objectives Vocal fold (VF) scar is known to be the most common cause of dysphonia after laryngeal microsurgery (LMS). Steroids reduce postoperative scar formation by inhibiting inflammation and collagen deposition. However, the clinical evidence of whether steroids are helpful in reducing VF scar formation after LMS is still lacking. The purpose of this study is to determine whether intralesional VF steroid injection after LMS helps to reduce postoperative scar formation and voice quality.Materials and Method This study was conducted on 80 patients who underwent LMS for VF polyp, Reinke’s edema, and leukoplakia. Among them, 40 patients who underwent VF steroid injection after LMS were set as the injection group, and patients who had similar sex, age, and lesion size and who underwent LMS alone were set as the control group. In each group, stroboscopy, multi-dimensional voice program, Aerophone II, and voice handicap index (VHI) were performed before and 1 month after surgery, and the results were statistically analyzed.Results There were no statistically significant differences in the distribution of sex, age, symptom duration, occupation and smoking status between each group. Both groups consisted of VF polyp (n=21), Reinke’s edema (n=11), and leukoplakia (n=9). On stroboscopy, the lesion disappeared after surgery, and the amplitude and mucosal wave were symmetrical on both sides of the VFs in all patients. Acoustic parameters and VHI significantly improved after surgery in all patients. However, there was no significant difference between the injection and control group in most of the results.Conclusion There was no significant difference in the results of stroboscopy, acoustic, aerodynamic, and subjective evaluation before and after surgery in the injection group and the control group.
박재선 고신대학교 의학부 1993 高神大學校 醫學部 論文集 Vol.9 No.1
During the past two decades, a dramatic progress has been made in the treatment of childhood acute lymphoblastic leukemia(ALL). The long-term survival of childhood ALL has been improved from around 20% in the beginning of 1970' to as high as 60-70% currently. It is largely due to the improved combination chemotherapy, preclinical treatment of the most sanctuary area, the central nervous system, improved survival of poor-prognosis subgroup by intensive chemotherapy and salvage of relapsed patients with better chemotherapy regimens and with bone marrow transplantation. To date, the use of other therapeutic approach than multiple combination chemotherapy has been unconceivable. Consequently, review of important outocmes of the recent chemotherapeutic regimens will give us a future direction and help to refine present treatment protocol.
유지 혈액 투석환자의 혈중 포도당 농도 변화에 관한 연구
박재선,선휘경,박봉건,이상준,김은순,김희숙,정우경,권인순,고행일,정귀원 인제대학교 2000 仁濟醫學 Vol.21 No.2
Objectives: The study was done to investigate the changes of serum glucose concentrantion and glucose loss during hemodialysis with and without glucose in the dialysate. Method and Materials: Authors studied 23 patients(11 non-diabetes and 12 diabetes) with end-stage renal disease undergoing long-term maintainence hemodialysis. Hemodialysis was performed with glucose free and glucose containing dialysate. Each blood and dialysate outlet fluid sample was drawn for glucose concentration every hour. Results: 1) In non-diabetes and diabetes, serum glucose concentration was decreased during hemodialysis with glucose free dialysate. 2) Net glucose loss during the four hours of hemodialysis was 50-7lg. 3) There was no change in serum glucose concentration during hemodialysis with glucose containing dialysate in non-diabetic endstage renal disease. But, in diabetes, the serum glucose concentration was decreased during hemodialysis with glucose containing hemodialysate. Conclusion: This study suggested that blood glucose concentration was decreased during hemodialysis because of glucose loss in dialysate outlet fluid. Therefore, the addition of glucose to dialysis fluid may help the prevention of hypoglycemia and energy balance. But, in diabetes, further study is needed.
사염화규소 누출사고지점 주변 식물에 대한 노출지표 평가
박재선,김지영,김명옥,박현우,정현미,최종우 한국환경농학회 2017 한국환경농학회지 Vol.36 No.4
BACKGROUND:Silicon tetrachloride reactswithmoisture in the atmosphere to generate hydrogen chloride, which affects the environment. Since silicon tetrachloride and its by-products are dispersed in the atmosphere in a short time after the silicon tetrachloride release into the atmosphere, it is difficult to directly assess the extent of environmental impact. In the present study, the exposure test of silicon tetrachloride or hydrogen chloridewas examined in order to establish the criterion of the range affected by the silicon tetrachloride release, and the actual crops in the area exposed to silicon tetrachloride leakage were analyzed. METHODSANDRESULTS:For the experiment of exposure to silicon tetrachloride or hydrogen chloride, the leaves of red-pepper and cornwere used in glass sealed containers. In the actual accident area, 59 samples from10 different kinds of cropswere collected. The pretreatment of the samplewas performed by freezing and grinding, and then extracted using distilledwater. The pHand concentration of chloride (Cl-) ion of the extracted solution weremeasured using pH meter and ion chromatograph, respectively. CONCLUSION: Exposure to silicon tetrachloride caused visible damage, increasing the concentration of chloride ion, and decreasing the pH as well as hydrochloric acid. In the actual crops of the affected area, the tendency was the same as the result of the laboratory test, and the range of influence could be estimated through the concentration of Cl- ion over 2,000 mg/kg, and the correlation evaluation between the concentration of Cl- and pH. Therefore, the concentration of Cl- ion and the correlation betweenCl- and pH would be considered as the factors to estimate the influence range of silicon tetrachloride release. .
박재선 고신대학교(의대) 고신대학교 의과대학 학술지 1993 고신대학교 의과대학 학술지 Vol.9 No.1
-Abstract- During the past two decades, a dramatic progress has been made in the treatment of childhood acute lymphoblastic leukemia(ALL). The long-term survival of childhood acute ALL has been improved from around 20% in the beginning of 1970' to as high as 60-70% currently. It is largely due to the improved combination chemotherapy, preclinical treatment of the most sanctuary area, the central nervous system, improved survival of poor-prognosis subgroup by intensive chemotherapy and salvage of relapsed patients with better chemotherapy regimens and with bone marrow transplantation. To date, the use of other therapeutic approach than multiple combination chemotherapy has been unconceivable. Consequently, review of important outcomes of recent chemotherapeutic regimens will give us a future direction and help to refine present treatment protocol.