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서성화,오창욱,조환성,정혜미,박일형 대한골다공증학회 2011 Osteoporosis and Sarcopenia Vol.9 No.1
Objectives: We performed research and analysis to determine the risk factors of osteoporosis for women after menopause by conducting a survey and measuring the bone density through a free program to diagnose osteoporosis. Subjects and Methods: Kyungpook National University organized and then started the free osteoporosis diagnosis program on May 11 in 2005. One hundred forty six women whose age was between the early forties and late eighties took the survey. The risk factors for osteoporosis were analyzed according to the data which was obtained from the survey. The measurements of the bone mineral density (BMD) of right calcaneus area were recorded by the use of ultrasound equipment. Results: Within the results, between the advancing age (P=0.000) of subjects, the lower BMI (P=0.002), the more children (P=0.004), the breast fed longer (P=0.047), the individuals who had a lower age when menopause began (P=0.037) and their BMD showed significant correlation. Conclusions: The results express that the osteoporosis risk-factors for Korean women, despite the advancing age and the lower BMI as absolute factors, that the more children, the longer breast feeding and the lower the age that menopause began, would result in a lower density of bone.
서성화,원종일,우흥식,Seo, Seong-Hwa,Weon, Jong-Il,Woo, Heung-Sik 대한안전경영과학회 2011 대한안전경영과학회지 Vol.13 No.4
The hazard conditions on plant works of the steel industry have been investigated to efficiently prevent from industrial accidents. The plant works are eventually carried out by workers of smaller service companies where the safety management systems are not well established, on behalf of the main steel company. Based on the preliminary risk assessment on the plant working and open literature reviews, the safety management systems, which can be applied to the plant workplace of each process, are studied and then the step-by-step 4M check-list method is established. Accordingly, the risk assessment technique using 4M checklist for the plant workplace is proposed. In addition, a standardized flow-chart for safety management of plant work is introduced. These risk assessment technique and flow-chart can definitely contribute to the reduction of industrial accidents, considering the risk characterization and the unsafe conditions in small and medium-sized plant workplace, as effective safety management tools and safety guide line.
서성화,박일형,이주미 대한골대사학회 2014 대한골대사학회지 Vol.21 No.3
Introduction: Bone mineral density (BMD) is an important index in diagnosis of osteo-porosis and other metabolic bone diseases, prediction of fractures, and monitoringtreatment. This study was to find a more feasible technique for prediction of osteoporot-ic fracture between dual energy X-ray absorptiometry (DXA) and quantitative computedtomography (QCT) and to reveal the actual change of bone strength when BMD waschanged. Methods: Ten of these 20 specimens were used as the demineralized groupand the other 10 as the control. Each specimen was immersed in HCl solution at for aperiod of at least 10 minutes, up to 100 minutes, at an interval of 10 minutes for differ-ent levels of demineralization. BMD was measured using DXA and QCT. Uniaxial com-pression tests were conducted to mea sure biomechanical parameters. Pearson correla-tion analysis was used respectively be tween BMD and biomechanical parameters andbetween DXA and QCT. Results: Elastic modulus (r=0.87) and yield stress (r=0.84)showed a statistically significant correlation with DXA BMD. Through correlation analysiswith QCT BMD and elastic modulus, correlation coef ficient showed hemi-vertebra(r=0.80) and trabecular (r=0.68). In yield stress, there was a statistically significant cor-relation in hemi-vertebra (r=0.87) and trabecular bone (r=0.84). Conclusion: DXA is acurrent standard technique not only for diagnosis of osteoporosis but also for predictionof fracture risk compared to QCT. Actual decrease of bone strength was much greaterthan that of BMD by both DXA and QCT.
전자석을 이용한 권선형 유도발전기 에너지 효율 향상 연구
서성화,김재용,권진홍,김태영,문기학,조영태 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
환경파괴를 대처할 신재생에너지는 꾸준히 개발 되어왔지만, 오히려 건설하는 과정에서 미래자원을 공급 하는 가치보다 환경 경관지역수용성을 제대로 고려하지 못해 건설 사업에 차질이 생기고 있다. 이로 인해 신재생에너지의 최대가동률을 높이는 기술을 유연하게 적용할 필요가 있다. 본 연구에서는 일반적으로 많이 사용되어온 영구자석 발전기가 아닌 전자석을 이용한 유도발전기를 응용하였고, 실험 해당 지역의 풍황 분석, 발전기 설치 및 효율측정에 대해 연구하였다.
4M 위험성평가 기법을 이용한 앗차사고의 효과적인 발굴기법
서성화 ( Seong Hwa Seo ),원종일 ( Jong Ii Weon ),우홍식 ( Heung Sik Woo ) 한국안전학회(구 한국산업안전학회) 2012 한국안전학회지 Vol.27 No.5
In this study, a new technique for detecting near miss using 4M risk assessment method is suggested. Until now, the safety education with instances of near miss has just been progressed in most industrial settings, without any systematic guideline. By menas of appling 4M risk assessment method, the organized technique, which could effectively manage the fundamental prevention of industrial accident in advance, is developed. The organized technique of near miss-management suggested in this study will take an effective role in basically expanding the application of risk assessment method, as well as in contributing the activity of zero-accident as a safety guideline in hazardous workshops.
서성화 ( Seong Hwa Seo ),김민 ( Min Kim ),원종일 ( Jong Il Weon ),우흥식 ( Heung Sik Woo ) 한국안전학회(구 한국산업안전학회) 2011 한국안전학회지 Vol.26 No.3
Access-control of hazard zone in a steel manufacturing industry is studied in terms of safety management. Based on the results of risk evaluation for hazard zone, three risk zones with low, middle and high level are categorized. These zones have different color door and locking shape depending on their risk levels. At the high level, red door and key-based locking system are employed to accessed-controled path. Furthermore, tagout, lockout, interlock system for emergency stop, warning and flashing are also introduced. New standardized procedure of access-control for various hazard zones, which could help to greatly contribute to the prevention of accidents in advance, is proposed considering the risk level and the condition of given hazard zones. The standardized procedure of access- management suggested in this study will take an effective role as one of safety guide lines for hazardous workshop of manufacturing industries.
오미자 박, schizandrin 및 gomisin A에 의한 RAW264.7 세포주에서 lipopolysaccharide로 유도된 염증 반응의 억제
서유미(Yu-Mi Seo),김현지(Hyun-Ji Kim),이은주(Eun-Joo Lee),정정욱(Chungwook Chung),성화정(Hwa-Jung Sung),손호용(Ho-Yong Sohn),박종이(Jong-Yi Park),김종식(Jong-Sik Kim) 한국생명과학회 2018 생명과학회지 Vol.28 No.3
오미자는 전통적인 한약재로서 schizandrin과 gomisin A와 같은 다양한 생리활성물질을 함유하고 있는 것으로 알려져 있다. 본 연구에서는 오미자 박의 에탄올 추출물(PSC)과 schizandrin (SZ) 및 gomisin A (GA)에 의한 항염증 활성 및 그들의 작용기전 연구를 수행하였다. 먼저, PSC는 LPS에 의해 염증이 유도된 RAW264.7 세포에서 세포생존율에는 영향을 미치지 않고 농도의존적으로 nitric oxide (NO) 생성을 감소시켰다. PSC는 염증유발유전자인 iNOS와 COX-2의 발현을 감소시켰으나, TNF-α의 발현에는 영향을 주지 않았다. 또한 오미자 박의 에탄올 추출물은 p38, ERK1/2 및 JNK의 총 단백질의 발현에는 영향을 주지 않으면서, 그들의 인산화를 감소시켰다. 이러한 결과는 PSC가 MAPK 신호를 저해함으로써 염증 반응을 조절할 수 있음을 시사한다. 또한 SZ와 GA도 LPS에 의해 염증이 유도된 RAW264.7 세포에서 세포 생존율에 영향을 미치지 않으면서 NO 생성을 감소시켰다. SZ은 iNOS 유전자의 발현만을 감소시킨 반면, GA는 iNOS와 COX-2 두 유전자의 발현을 모두 감소시켰다. 종합적으로 이러한 연구결과는 오미자 박 추출물, schizandrin 및 gomisin A에 의해 중재되는 항염증 활성 및 작용기전을 이해하는데 도움을 줄 것이다. Schizandra chinensis has been used as a traditional Chinese medicine and is known to have various bioactive components, including schizandrin and gomisin A. In the current study, we investigated the anti-inflammatory activities and their working mechanisms of ethanol extracts of pomace of Schizandra chinensis (PSC), schizandrin (SZ), and gomisin A (GA). First, we analyzed the effects of PSC on nitric oxide (NO) production and cell viabilities in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The results indicated that PSC dramatically reduced NO production in LPS-activated RAW264.7 cells in a dose-dependent manner without affecting cell viabilities. PSC also decreased the expression of pro-inflammatory genes iNOS and COX-2, whereas the expression of TNF-α was not affected by PSC. In addition, PSC inhibited phosphorylation of p38, ERK1/2, and JNK but did not change the expression of their total protein. The results indicate that PSC can regulate LPS-induced inflammatory responses by suppressing MAPK (mitogen-activated protein kinase) signaling. We also analyzed the effects of SZ and GA on NO production and cell viabilities in RAW264.7 cells. The results showed that SZ and GA also decreased NO production in a dose-dependent manner in LPS-activated RAW 264.7 cells without affecting cell viabilities. SZ reduced the expression of iNOS, whereas GA downregulated iNOS and COX-2. Overall, these findings clarify the molecular mechanisms of the anti-inflammatory effects mediated by SC, SZ, and GA.