정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

일차 양측성 구순열의 일단계 재건에 대한 증례보고

임석균,이기혁,김영균,김수관,이병준,여환호,서재훈 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Bilateral cleft lip reconstruction can be performed in one-or two-stages. The choice depends on the surgeon's proficiency and experience. However the type and severity of the cleft must be considered. Complete or incomplete symmetric, bilateral clefts in which the premaxilla is within the alveolar arch or slightly protruded can be successfully treated with simultaneous lip reconstruction on both sides. There are some advantages that one-stage lip reconstruction facilitates creation of a symmetric and balanced lip, retraction of protruding premaxilla and the parent's psychologic satisfaction. However, there are some disadvantages such as micrognathia of the upper jaw by severe scar formation and poor adaptation of flap margins by severe tension. The surgeon must be able to judge and exploit the advantages offered by one-stage approach. We present the case report of one-stage reconstruction of primary bilateral cleft lip with literature reviews.

건축복합방수 신공법의 특성에 관한 연구 : 신공법 사례를 중심으로 Focused on Advanced Hybrid Waterproofing Technologies

임병훈 우송대학교 2003 우송대학교 논문집 Vol.8 No.-

Recently hybrid waterproofing technology is developed little by little in construction sites. But there is not any other criteria of performance chracteristics of this technology. This study is the basic research about selecting optimum performance chracteristics of hybrid waterproofing technology which is including material and construction method. The result of this study showed that (1) Safety performance consists of fatigue resistance, crack contorl, deterioration processing of tensile (2) Comfortability performance consists of watertightness, bond performance (3) Persistency performance consists of abrasion resistance, tensile performance, flexural strength, chemical resistance

VOCs의 光觸媒處理에 관한 硏究

임경택,김춘희,고경숙,배병훈,문종익 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.2

This study has been carried out to observe photodegradation efficieny of TCE with the variation of IN irradiation strength, liquid thickness and immobilized TiO₂. The results are summarized as fallows; 1. Without photocatalyst, the TCE removal efficiency was observed to be about 15% with UV irradiation. 2. Above 93% of TCE were mineralized by immobilized TiO₂on glass panel(5g, 500℃) and UV irradiation. The photodegradation efficiency increased with increasing UV lamp numbers and reaction rate increased with increasing TCE initial concentration. 3. The photodegradation efficiency decreased with increasing the liquid thickness and above 96% of TCE were removed with using 3 UV lamps and liquid thickness less than 6cm.

輕量氣泡콘크리트의 塗膜防水 適合性에 관한 實驗硏究

임병훈 우송대학교 2000 우송대학교 논문집 Vol.5 No.-

The purpose of this study is to verify the waterproofing properties of membrane coating to the Autoclaved Lightweight Concrete (ALC). ALC have basically high water absorbtion and low strength in its physical properties. These properties incite several types of troubles. In these study three kinds of experiment, those are watertight test, adhesion test and application test, are executed. It can be concluded as follows (1) Water content rate of ALC is not related to the performance of membrane coatings. (2) Membrane coatings, which is composed of epoxy resin, is inferior to another resin coating. And so it is necessary that epoxy resin coating is attend to use on the ALC material. (3) It is clear that synthetic resin except epoxy is superior to waterproofing properties such as flow and hardness of coating material.

액체크로마토그래피/질량분석법을 이용한 랫트 혈장내의 Surfactin C의 정량법에 관한 연구

임종환,김명석,이동연,이상훈,백경진,김태원,정두순,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Surfactin isolated from Bacillus subtilis has a strong surface tension-lowering activity, together with antiviral, antitumor, fibrinolytic and hypocholesterolemic activities. LC/MS is a simple, rapid and effective technique for the determination of surfactin C in rat serum. The separation of surfactin was achieved on reverse phase column. The mobile phase consisted of 0.1% trifluoracetic acid in water (A) and acetonitrile (B). As a result of analysis of blank rat serum samples, matrix interference was not shown. The values of precision and accuracy were satisfied w the guideline. A newly developed LC/MS method for the determination of surfactin C was successfully applied in its pharmacokinetic analysis.

공동주택의 바닥소음실태 및 개선방안 연구

임병훈 우송대학교 부설 산업연구원 2003 산업연구 Vol.5 No.1

The impact noise insulation performance of a apartment floor depends on the various factors such as stiffness and thickness of the concrete slab, finishing materials and the construction method. An approach from these point of view it is important to improve impact noise insulation performance and to develop several method. In this study suggest that it will be settled urgently which is to reduce stiffness of the concrete slab, to substitute the lightweight concrete, finishing material and various constuction method such as floating floor system.

共同住宅 바닥騷音(衝擊音)低減用 시스템개발에 관한 基礎硏究

임병훈 우송대학교 부설 산업연구원 1999 산업연구 Vol.1 No.1

The impact noise insulation performance of a floor depends on the various factors such as stiffness and thickness of the concrete slab, finishing materials and the composition method. An approach from these point of view is important in order to impreve impact noise insulation performance. There have been limits in attempts to solve the impact noise problems through traditional method which applied the mat style damping material into the floor due to the limited conditions. It can be concluded as follows (1) It is important to improve impact noise that have a cavity space between slab and wall of Apartment house (2) To develop for reducing floor impact noise it must be required such as structural stability including creep deformation, construction skill considering clearance, and cost (3) The cost of new system have to decide between existing mat system and lightweilght core mortar system

건축설계과정에서 나타나는 협업프로세스에 관한 연구 : 파빌리온 설계사례를 중심으로

김정훈,김소희,임병민,김진아,송정화,오건수 남서울대학교 2007 남서울대학교 논문집 Vol.13 No.4

This study aims to deduce the effective collaborative process of architectural design process based on the specific pavilion design case. The study schematizes the collaborative procedure which is generated at the early stage of design process, analyzes the decision support system and suggests the method for reaching a compromise.Finally, this study suggested collaborative process method of architectural design and provided the basic concept that can be used for the similar projects. Keywords : Collaborative Design, Design Process

Stretch-Shorening Cycle이 ArmCurl 동작에 미치는 영향

우병훈,김석희,임용규 漢陽大學校 體育科學硏究所 2003 體育科學 Vol.23 No.23

In this research, We were selected 10 students from Physical Education at the H University in Seoul through random sampling and by group they had no physical defects. We were compared them mutually through mechanical analysis according to muscular contraction type in the stretch-shortening cycle and shortening-stretch cycle in concentric and eccentric contractions. To investigate their differences, We were performed armcurl motion analysis. As a result, We were derived conclusions as follows. As for the maximum momentum of total segments that is a kinetic variable, that of SSC was higher by DM 0.06kg · m/sec. and by DM 0.97J in the mechanical energy of the total segments; and by DM 22.20N at the maximum power than that of CC. In the analysis of integral electromyography that is avariable of analysis of electromyography, the integral electromyography of biceps brachii muscle increased by DM 0.0240mv · s in the case of the SSC motion than when in the CC motion. There was no difference in the triceps brachii muscle. On the basis of this conclusion, We consider that the stretch-shortening cycle can affect many parts in the movement of the body. Through the results of the analysis of the armcurl motion, we can see that the stretch-shortening cycle is able to put out its strength by using elastic energy accumulated at the time of concentric contractions after accumulating elastic energy through pre-stretching before concentric contractions. Furthermore, since it puts out much more power 'in utilizing muscles compared to simple concentric contractions, We think the training method such as plyometric training can develop more power than previous training methods.