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In vivo metabolism of Talosin A, new isoflavonol glycoside from Kitasatospora kifunensis, in rats
임종환,In-Bae Song,Youn-Hwan Hwang,Myoung-Seok Kim,Jong-Woo Kim,Jin-Yong Kim,서주원,윤효인 대한수의학회 2011 Journal of Veterinary Science Vol.12 No.2
The isoflavonol glycoside Talosin A, genistein (GT)-7-α-L-6-deoxy talopyranose (GT-Tal), was first isolated from the culture broth of Kitasatospora kifunensis MJM341. The aim of the present study was to evaluate the oral absorption and metabolism of the newly isolated isoflavonol glycoside, GT-Tal compared to genistin (GT-7-O-β-D-glucopyranoside; GT-Glu). Free GT-Glu and GT-Tal could not be detected prior to enzymatic hydrolysis of the corresponding conjugates in rat plasma. Following oral administration of GT-Tal (15 min), GT-Tal was rapidly absorbed through the gastrointestinal tract and metabolized into GT-Tal conjugates with a mean C_(max) of 2.74 μg/mL. GT-Tal was further metabolized to its aglycone, free GT and conjugated GT. After oral administration, GT-Glu was absorbed after being convereted to its aglycone and then further metabolized into its conjugate metabolites (free GT with a mean C_(max) of 0.24 mg/mL at 1.25 h; conjugated GT with a mean C_(max) of 1.31 mg/mL at 2.00 h). Significant differences in absorption and metabolism of GT-Tal and GT-Glu were observed. GT-Tal was metabolized into its corresponding conjugates or underwent deglycosylation to form GT, whereas GT-Glu was metabolized into its aglycone, GT.
임종환,김명석,박병권,황윤환,황미현,박승춘,윤효인 한국독성학회 2005 Toxicological Research Vol.21 No.4
The aim of the present study was to evaluate systemic bioavailability of surfactin and to determine its pharmacokinetic profiles. The stability of surfactin to pH, temperature and protease was evaluated. Surfactin was resistant to high temperature, a wide range of pH and the action of hydrolytic enzymes. The pharmacokinetic natures of surfactin which were shown the short half-life, rapid clearance and poor bioavailability. The results of study should provide preliminary data of surfactin for further dose-finding studies and for the design of application forms. It is also be important to a context of the safety of surfactin.
임종환 제주대학교 산업기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.1
This paper presents a technique for localization of a mobile robot using sonar sensor. Localization is the continual provision of a knowledge of position which is deduced from its a priori position estimation. The environment of a robot is modeled into a two dimensional grid map. We define a physically-based sonar sensor model and employ an extended Kalman filter to estimate position of the robot. The performance and simplicity of the approach is demonstrated with the results produced by sets of experiments using a mobile robot.