정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

미세 골절 진달을 위한 초음파 C-scan의 활용 가능성

박원근,최민주,이원흠,이윤준,이헌주,강창익,박전홍 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The study examines the medical potential of an ultrasonic C-scanning technique and for diagnosis of the fatigue induced micro-fractures of the bone. In general, it is not easy to detect the micro­fracture by a simple radiological technique. In the study, the micro­fractures were made on the tibia taken from pigs using a three point bending. Comparison was made between the ultrasonic C-scan images (25 MHz) and X-ray images of the bones with the micro-fractures, It was found that the micro-fractures invisible on the X-ray images were observed on the ultrasonic images. It is proposed further in-vitro and in-vivo studies making the ultrasonic C-scan technique clinically useful for the diagnosis of the fatigued induced micro-fractures of the bone which are not possible to detect by the conventional radiological method.

Evans 증후군 1례

장성익,이의재,황성수,이경일,이원익,이준성 최신의학사 1990 最新醫學 Vol.33 No.1

Poly (1-(2-Carbomethoxyacryloyl)-5-Fluorouracil)의 Drosophila 대사과정에 미치는 생리유전학적 영향에 관한 연구

李元鎬,金益成,趙元濟 부산대학교 환경문제 연구소 1985 環境硏究報 Vol.3 No.-

Genetic study on 5-fluorouracil(5-FU), 1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMA-FU) and poly(CMAFU) treated in Drosophila melanogaster was undertaken by the adult feeding method of Lewis and Bacher. Toxic capacity, sex ratio, egg to adult viability, required developmental period, fecundity, and productivity induced by 5-FU, CMAFU, and poly(CMAU) had been analyzed. The results obtained were as follows: 1) The order of toxicity was decreased by 5-FU, CMAU, poly(CMAU) and control group. But there was no change by varying concentration. 2) The effects on the sex-chromosome were regarded by the sex ratio:In the control, sex ratio was 0.5349, in experimental groupⅠ treated with 5-FU 0.5862, in the groupⅡtreated with CMAFU 0.5747, and in the groupⅢ treated with poly (CMAFU) 0.5758, respectively. The differences between control and experimental groups were not significant. 3) The egg to adult viability of OR females was 86 percent in the control group, 0 in the experimental groupⅠ, 60 percent in the experimental groupⅡ, and 65 percent in the experimental groupⅢ. 4) The reguired developmental periods were calculated to be 9.43 days in the control group, 0 in the experimental groupⅠ,13.29 days in the group Ⅱ, and 13.23 days in the group Ⅲ. 5) The fecundities appeared from the first to the fifth culture were 16 eggs in the control group,12 in the experimental group Ⅰ,Ⅱ, and 13 in the groupⅢ, respecively. 6) The productivities were calculated to be 178 in the control, 0 in the experimental groupⅠ, 152 in the groupⅡ, and 186 in the groupⅢ. 7) It is found that a physiological genetic effect on the Drosophila melanogaster is much weaker for CMAFU and poly (CMAFU) than for 5 FU.

완전 고환성 여성화 증후군 1례

이원주,김택훈,권경익,김종인,조남규,박세출 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2

저자들은 외형상 여성으로써 원발성 무월경과 양측 외음부 종양 촉지를 주소로 입원한 complete testicular feminization syncrome 1례를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다 The 46, XY individual with complete testicular feminization syndrome is a phenotypic female who is usually somewhat tall, has excellent breast development and presents to the gynecologist because of primary amenorrhea and an inguinal mass. In complete testicular feminization syndrome, axillary and pubic hair are sparse or absent and some degree of virilization such as clitorial hypertrophy, partial labioscrotal fusion and hirsutism doesn't occur at puberty. We report a case of complete testicular feminization syndrome with the brief review of literatures.

달리기 운동 프로그램이 시각장애인의 건강관련 체력에 미치는 영향

이명수,양점홍,홍순미,최재현,박원익,이창준 釜山大學校 附設 體育科學硏究所 2004 體育科學硏究所 論文集 Vol.20 No.-

The purpose of this study was to find out the effect of jogging(LSD ; Long Slow Distance) and walking training on health-related fitness of the blind.....

天安 및 忠淸地域의 産婦人科 應急患者에 관한 臨床的 硏究

李元起,朴忠學,朴鎭完,許義宗,李昌益 단국대학교 1995 論文集 Vol.29 No.-

The objective of this study is to analyze clinical evaluation of 313 patients in Obstetrics and Gynecology who visited Emergency Room in Dankook University Hospital from June, 1994 to December, 1994 for the purpose of successful and perfect emergency care of the patients in Obtetrics and Gynecology in Cheonan-Chungcheong District in the futrure. Today, the goal of modern obstetrics is the well-being of both mother and fetus. And there are many gynecologic diseases which lead the female patient to emergency room with the chief complaint of severe abdominal pain or vaginal bleeding, etc. We have of emergency patients, clinical characteristics of the patients, the time of patient's entrance in emergency room, the monthly distribution of visit, the crowding day of visit, the distribution of the patients according to living area, the admission rate, and the management of the patients, etc. Followings are the results summarized : 1. The mean age was 29.8 years(range form 10 to 85). The mean number of gravidity and parity were 2.0 and 1.1 respectively. The mean number of abortion and living child were 1.0 and 1.0 respectively. 2. The most predominant monthly distribution of visit were August and December. 3. The admission rate was 48.2% and the discharge rate was 49.5%. 4. Distribution of department was Internal Medicine, Pediatrics, Orthopedics, and Obstetrics & Gynecology, in order. 5. The most crowding day of visit was Sunday(22.0%). The peak time of patint's entrance in emergency room was between 20:00 PM and 24:00 PM(24.3%), and the second peak time was between 16:00 PM and 20:00 PM(21.4). 6. Of 313 patients, 53% were known to live in Cheonan city and Cheonan county. 82.7% were known to live in Chungcheong District. 7. In 151 patients who admitted the ward, 53% were obstetric patients and 47% were gynecologic patients. 8. In 80 obstetric patients of admission, the most common chief complaint was labor pain(76.3%). In 71 gynecologic patients of admission, the incidence of disease was abortion(32.3%), ectopic pregnancy(25.4%), and pelvic inflammatory disease(11.3%), in order. 9. Major operations were performed in 40 patients of 151 admitted patients(26.5%). Minor operations including Dilatation and Curettage were performed in 12 patients(7.6%). 10 In 155 patients of discharge, the incidence of disese was abortion(36 patients), pelvic inflammatory disease(20 patients), false labor(15 patients), and uterine bleeding(11 patients), in order.

지방 국립대학의 우수학생 유치방안에 관한 연구 : 부산대학교를 중심으로

이원호,안창규,정영홍,황해익,주철안 釜山大學校 敎育硏究所 1992 敎育硏究 Vol.2 No.1

Korean universities have developed rapidly since its liberation from hapanese rule in 1945. Korean higher education system has contributed to the socio-economic development of the country. However, Korean higher educational system has some problems. One of the problems is its unbalanced development of higher educational institutions between the capital city and other cities. Koreans traditionally regarded highly colleges and universities in the capital city. The government including private foundations have invested large resources in building colleges and universities in cities and providences had been neglected. However, colleges and universities play crucial role in the local, regional development of the country. It is important to raise academic quality of the colleges and universities in non-capital cities. The quality of colleges and universities depended primarily on faculty, finance, etc. Therefore, it is an imperative condition to recruit academically excellent students for the development of colleges and universities in non-capital cities. Three research questions have guided the research. 1) How the college entrants' academic performance has changed. 2) What colleges and universities have utilized admission policy to recruit excellent students. The research has found out the following results. 1) The academic performances of college entrants in non-capital city were lowered in the 1980s. 2) Colleges and universities have emphasized the academic excellence, which is primarily related to research and academic activities of the faculty. 3) High school students and teachers in Pusan city give local university lower rate than what it is The findings suggest that local college and university make sustained, ststematic efforts in order to develop its status among the institutions. The efforts should include short-term and long-term policies : 1) Marketing activities about scholarship programs, graduates' career prospects, facilities, and the faculty etc. 2) Hiring excellent faculty members 3) Strengthening graduates' gaining job 4) furnishing required facilities and making attractive campus 5) Upgrading the quality of academic and research activities

STI571 (Glivec^(�))에 의하여 빠른 치료 반응을 보인 불응성 Gastrointestinal stromal tumor

윤경원,이제중,김여경,황호인,이병환,조상희,정익주,김형준 全南大醫大 2001 전남의대학술지 Vol.37 No.4

열대 지역에서 통일형 초다수성 벼 품종의 생육 및 수량성 비교

이지윤,준현,성환,손영보,송유천,한상익,박동수,권영업,이철원,이종희 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2