제 3형 Gaucher세병으로 인한 진행성 근간대성 간질 2예

허경,예종수,김상진,김성은,김응규,조효근,김찬환,김현주 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

Die-upset Nd_(15)Fe_(77)B_8 자석의 자기적 특성에 미치는 제조조건 및 Ga 첨가의 영향

이경섭,김용성,박현순,서수정 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

The effects of process parameters and Ga addition on the magnetic properties of die-upset Nd_15Fe_77B_6 magnets were studied. The intrinsic coercivity (_iH_C) was decreased because of grain coarsening by die-upset process. The Remanence (4πM_r) was varied by the extend of crystalline anisotropy. The alignment of c axis depend on the temperature and speed of die-upset process. The coercivity loss by die upsetting was reduced with Ga addition.

평양 남정리 53호분 출토 토제칠기의 보존 및 제작기법 연구 : 토제칠이배, 토제칠반, 토제칠안

황현성,임수경,김희진,이태진,고민정,윤은영 국립중앙박물관 2013 고고학지 Vol.19 No.-

본고는 일제 강점기 조사 미등록 유물 정리사업의 일환으로 수행한 평양 남정리 53호분 출토 토제칠이배, 토제칠반, 토제칠안에 관한 연구이다. 남정리 출토 유물은 소지가 목심이 아닌 토제라는 것과 칠이배와 칠반을 얹은 칠안이 함께 출토되었다는 점에서 주목할 만하다. 토제칠이배 및 칠반 그리고 칠안의 보존처리를 통해 이들의 형태와 문양 등에 대해 알 수 있었다. 또한 칠기에 사용된 붉은색 안료의 성분을 분석하여 안료의 주성분이 진사(HgS)였음을 확인하였다. 이번 연구에서 기존에 잘 알려지지 않았던 한반도 내 위치한 낙랑의 토제칠기에 관해 살펴볼 수 있었으며 이러한 제작방법이 한나라 고유의 문화인지 아니면 재지세력이 한나라의 영향을 받아 현지화한 문화의 산물인지에 대해 생각해 볼 수 있는 기회라 생각된다. This research paper examines the lacquered pottery cup, plate and table unearthed from Tomb No. 53 at Namjeong-ri in Pyongyang, which were under conservation treatment as a part of the Project of Unregistered Artefacts Uncovered in the Japanese Colonial Era. It is very rare to have a lacquered pottery cup and plate, lying on a lacquered pottery table, as a set of grave goods. In particular, they are not wooden but pottery items. Through conservation treatment for lacquered pottery cup, plate and table, it was possible to find out their shapes and decoration patterns. The resulting analysis of the red pigment used indicates that cinnabar (HgS) is the main element. This research is significant because it examines lacquered pottery wares produced in Lelang, which has rarely been conducted. Further research will need to prove whether their production techniques were in the unique Chinese Han style or were produced by indigenous craftsmen who adopted the Chinese Han technique.

NITINOL을 이용한 차동식 액츄에이터의 설계에 관한 연구

정상화,김현욱,신현성,차경래,신병수 한국공작기계학회 2002 한국공작기계학회 춘계학술대회논문집 Vol.2002 No.-

In the recent years, as the research and the development of micro and precision machinery become active, the interest of micro actuators using SMA (Shape Memory Alloy) has been increased. The dynamic characteristic analysis of SMA is necessary for actuator application and many common researches report the material characteristics of SMA sufficiently. However, the research on dynamic characteristics is very deficient. In this paper, the helical spring are fabricated with NiTi SMA wire of high resistivity. The force, response speed, temperature, and displacement are measured by digital force gauge, infrared thermometer, and laser displacement sensor so that the dynamic characteristics of this SMA is analyzed. Also, bidirectional actuator was fabricated and experimented for its performance.

철골 구조설계 공정 표준화를 위한 CIS/2 AAM 모델 연구

한경민,조수제,박성수 釜山大學校 都市問題硏究所 1999 都市硏究報 Vol.8 No.-

The aim of this research is analysing CIS/2 AAM model fot investigating the Steel Framework Process Data Modeling Standards. This paper introduces CIS/2 AAM model and LPM/5 which is produced by CIMSteel project. and produces it's STEP Part 21 File Translator for exchanging building data, The overall objective of this paper is to analysis LPM/5 Logical Product Model and to evaluate File Read/write Translater. The results of this paper are as follow; 1) The study on CIS/2 is helpful to developing dominant Steel Framework Process Model 2) It may be basis of developing analysis application, which is based on STEP modelling technique.

국내 다기관에서 조사한 지역사회획득 메티실린내성 황색포도알균의 빈도와 임상적 특성

송진수,최평균,송경호,조재현,김성한,방지환,이창섭,박경화,박경운,신수,최희정,김의석,김동민,이미숙,박완범,김남중,오명돈,김의종,김홍빈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 최근 전세계적으로 지역사회획득 메티실린내성 황색포도알균(community-associated methicillin-resistant Staphylococcus aureus, CA-MRSA)의 보고가 증가하고 있다. 하지만, 우리나라에서는 CA-MRSA 감염증에 대한 증례보고만 있을 뿐 아직까지 체계적인 연구결과가 없는 실정이다. 저자들은 국내에서 CA-MRSA의 빈도, 감염증의 임상적 양상, 분리된 균주의 항균제내성 양상을 조사하였다. 재료 및 방법 : 2005년 1월부터 2005년 6월까지 7개 병원에서 MRSA가 분리된 환자의 명단을 파악한 후 의무기록지와 건강보험심사평가원의 자료를 검토하였다. 외래나 응급실에서 혹은 입원 후 72시간 이내에 균주가 분리되고 MRSA 획득과 관련된 위험인자가 없는 경우 CA-MRSA로 정의하였으며, 분리된 균주의 임상적 의미에 따라 원인병원체(pathogen), 집락화(colonizer), 미결정(undetermined)으로 분류하였다. Penicillin과 oxacillin을 제외하고 3개 이상의 다른 계열 항균제에 내성이면 다제내성으로 정의하였다. 결과 : 연구기간동안 총 3,251주의 황색포도알균이 분리되었으며, 이 중 MRSA는 1,900주(58.4%)였다. MRSA 가운데 CA-MRSA는 114주(6.0%) 였으며, 이들이 분리된 부위는 귀(62주), 비뇨기계(14주), 피부 및 연부조직(11주), 호흡기계(10주), 혈액(3주) 등이었다. CA-MRSA 균주 가운데 집락균은 22주, 원인병원체는 22주였으며, 나머지 균주에 대해서는 그 임상적 의미를 결정할 수 없었다. 항균제 감수성 검사를 시행한 73균주 중 47주(64.4%)는 다제내성이었다. CA-MRSA 감염증 22예 중 피부 및 연부조직 감염(9예)과 중이염/외이도염(9예)이 가장 흔하였다. 침습적 감염증(invasive infection)은 4명(원발성 균혈증 3예, 감염성 관절염 1예)에서 확인되었지만, CA-MRSA 감염증으로 사망한 환자는 없었다. 결론 : 병원내 감염증에서는 MRSA가 심각한 문제이지만, 아직까지 지역사회 감염증에서 CA-MRSA는 흔하지 않았다. Background : Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. In Korea, little is known about the epidemiology and clinical features of community-associated MRSA (CA-MRSA). Material and Methods : Clinical microbiology laboratory databases of 7 hospitals were reviewed to identify the patients from whom MRSA was isolated during the period of January to July 2005. Only one isolate per patient was enrolled. In order to identify the risk factors of MRSA acquisition, the medical records and the Health Insurance Review Agency databases were reviewed. CA-MRSA was defined as MRSA isolated from patient without established risk factors. We analyzed patient demographics, underlying medical conditions, characteristics of infection, and antimicrobial susceptibility profiles. Results : Of total 3,251 S. aureus isolates, 1900 (58.4%) were MRSAs. Of the MRSA isolates, 114 (6.0%) were CA-MRSA. Of 114 CA-MRSA isolates, 22 (19.3%) were colonizers, 22 (19.3%) were pathogens, and the clinical significance of remaining 70 (61.4%) could not be determined. Median age of the 22 patients with CA-MRSA disease was 47 years. Nine patients had skin and soft tissue infections, 9 ear infections, 3 bacteremia, 1 septic arthritis. Seven patients had underlying medical disease. None died of the CA-MRSA infections. Of the 73 isolates of CA-MRSA, 47 (64.4%) were resistant to more than 3 classes of antibiotics besides β-lactams. Conclusion : Although MRSA is highly prevalent among hospital-associated S. aureus infection, CA-MRSA infections are not common.

Benzoyl peroxide의 환경에서의 초기 위해성 평가

김미경,배희경,김수현,송상환,구현주,박광식,이문순,전성환,나진균 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.1

Benzoyl peroxide is a High Production Volume Chemical, which is produced about 1,375 tons/year in Korea as of 2001 survey. The substance is mainly used as initiators in polymerization, catalysts in hte plastics industry, bleaching agents for flour nad medication for acne vulgaris. In this study, quantitative Structure-Activity Relationships(QSAR) are used for getting adequate information on the physical-chemical properties of this chemical. And hydrolysis in water, acute toxicity to aquatic and terrestrial organisms for benzoyl peroxide were studied. The physical-chemical properties of benzoyl peroxide were estimated as followed; vapor pressure=0.00929 pa, Log K_(ow)=3.43, Henry's Law constant=3.54×10^(-6) atm-m³/mole at 25℃, the half-life of photodegradation=3days and bioconcentration factor(BCF)=92. Hydrolysis half-life of benzoyl peroxide in water was 5.2hr at pH 7 at 25℃ and according to the structure of this substance hydrolysis product was expected to benzoic acid. Benzoyl peroxide has toxic effects on the aquatic organisms. 72 hr-ErC_(50)(growth rate) for algae was 0.44mg/L, 48hr-EC_(50) for daphnia was 0.07mg/L and the 96hr-LC_(50) of acute toxicity to fish was 0.24mg/L. Acute toxicity to terrestrial organisms(earth worm) of benzoyl peroxide was low(14 day-LC_(50)=>1,000mg/kg). Although benzoyl peroxide is high toxic to aquatic organisms, the substance is not bioaccumulated because of the rapid removal by hydrolysis (half life=5.2hr at pH 7 at 25℃) and biodegradation(8.% by BOD after 21days). The toxicity observed is assumed to be due to benzoyl peroxide rather than benzoic acid, which shows much lower toxicity to aquatic organisms. One can assume that effects occur before hydrolysis takes place. From the acute toxicity value of algae, daphnia and fish, an assessment factor of 100 was used to determine the predicted no effect concentration(PNEC). The PNEC was calculated to be 0.7㎍/L based on the 48hr-EC_(50) daphnia(0.07mg/L). The substance shows high acute toxicity to aquatic organisms and some information indicates wide-dispersive use of this substance. So this substance is a candidate for further work, even if it hydrolysis rapidly and has a low bioaccumulation potential. This could lead to local concern for the aquatic environment and therefore environmental exposure assessment is recommended.

남자 대학생의 음주 형태 변화에 영향을 미치는 유전적, 심리사회적 요인

김시경,이수경,김민경,이상익 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.4

Objectives : This study aimed to determine the general predictive factors of change in drinking behavior and to provide materials for preventing drinking problems during early adulthood through examining genetic and psychosocial factors affecting the change of drinldng behavior in college students. Methods : The subjects were 101 male college students, apart of 534 students who had completed the previous study in 2000. In the present study as a 6-years follow up, we reassessed the drinking pattem and psychosocial variables and compared the results with previous data of the same subjects. To identify factors affecting the current drinking pattem, we used stepwise multiple regession and logistic regression analysis. Results : D allele (ALDH2) was found to reduce the degree of drinking and suppress problematic drinking, and C allele (TPH) had a suppression effect on problematic drinking. Drinking motive had a direct effect on the degree of drinking and Pro-blematic drinking. Negative cognitive expectancy had a direct effect on problematic drinking. Conelusion : Authors found some factors affecting the change of alcohol drinking behavior in college students and confirmed that there were hierarchies of significance among these factors. These may be applicable as variables for predicting drinking behavior in early adulthood.

3D Dental-CT를 이용한 상악 매복 과잉치의 진단 : 증례보고

김재곤,김수경,양연미,백병주,김성희 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

과잉치는 법랑기(enamel organ)가 치배형성을 지속하거나 과도한 세포증식을 함으로써 발생한다. 과잉치는 상악 전방부에서 종종 발견되며, 유치열기와 혼합치열기에서 다양한 문제를 야기한다. 과잉치는 형태에 따라서 보충치(supplemental tooth)와 흔적치(rudimental tooth)로 나눌 수 있다. 보충치는 정상 절치와 크기 및 형태가 유사하나, 흔적치는 비정삭적인 형태와 작은 크기를 갖고 있다. 보충치는 영구 측절치 부위에서 호발하며 정상 전치와 유사한 형태와 크기를 갖고 있으므로, 발치시 주의를 기울여야 한다. 본 3증례는 상악 전방부에 정상 전치 형태의 과잉치를 갖는 증례들이다. 모든 증례에서, 치근단, 교합, 파노라마 방사선 사진 등의 기존 방사선 사진 촬영 외에 3Dimensional Dental-Computed Tomography(3D Dental-CT)를 촬영하여 진단하였다. 기존 일반 방사선 사진들(conventional radiographs)과 3D Dental-CT를 비교시, 일반 방사선 사진들은 2차원적인 영상만을 제공하여 상의 해석에 있어서 술자의 주관이 개입되는 한계가 있다. 반면 3D Dental-CT는 과잉치의 정확한 위치와 형태에 대한 객관적인 정보를 제공하며, 좀 더 보존적인 수술을 시행하고, 수술 시간과 스트레스를 줄이는데 유용하다. 그러므로 일반 방사선 사진 촬영 후 과잉치의 위치가 불분명하고 인접 영구치의 손상이 의심되는 경우 3D Dental-CT를 이용한 진단이 고려된다. Supernumerary teeth are teeth which result from the continued budding of the enamel organ of the preceding tooth or from excessive proliferation of cells. They are most often found in the maxillary anterior region. And they can be responsible for a variey of irregularities in the primary and transitional dentition. There are two morphological types of supernumerary teeth: supplemental and rudimentary. Supplemental teeth have normal shape and size. In contrast, rudimental teeth have abnormal shape and smaller size. Supplemental supernumerary teeth are most common in permanent lateral incisor area. Its extration must be decided more carefully with differential diagnosis between normal teeth, because it has nomal shape and size. We reports 3 cases of the normal incisor shaped teeth in the maxillary anterior region. In all cases, we used the 3D Dental-CT as well as the conventionl plain film such as periapical, occlusal, and panoramic ridiograph. Consequently, 3D Dental-CT was valualble to figure out the exact position and morphology of supernumerary teeth, to do more conservative surgery, and to reduce surgery stress and time.

베체트병에서 만성 기침으로 발현한 폐동맥류 1예

정승현,송주경,정성수,강성욱 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

저자들은 만성 기침이 있었으나 정확한 원인을 찾지 못한 채 보존적 치료만 받던 베체트병이 있는 37세 여자환자를 경험하였고 흉부 방사선사진과 흉부 전산화 단층 촬영으로 폐동맥류로 진단하고 고용량의 스테로이드로 치료하였고 이 과정에서 대량 객혈이 있었으나 보존적 치료로 호전된 베체트병 1 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Pulmonary Artery Aneurysm Manifesting as Chronic cough in Behcet's disease Behcet's disease is a relapsing chronic inflammation disorder of unknown etiology. Although Behcet's disease has originally been described as a triad of recurrent oral aphthous ulceration, genital ulceration and uveitis, it is now recognized as a multisystem disease with vasculitis as the main pathological finding. Clinical manifestations additional to this triad include involvement of the skin, joints, large vessels, lung, gastrointestinal and genitourinary tracts, brain. We report a case of pulmonary artery aneurysm manifesting as chronic cough in Behcet's disease. She was a 47 year-old woman with Bechet's disease treated with prednisolone and colchicine. She had suffered from chronic cough for several years, but been treated only with antitussive agents. Chest CT revealed multifocal patchy consolidation in lung parenchym and aneurysmal dialatation of pulmonary artery. We diagnosed pulmonary aneurysm with CT finding as the cause of chronic cough.