Solar urticaria in Korean patients

( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.

자료포락분석(DEA)를 이용한 보건의료의 효율성 측정

김남송,박홍섭,김은진,김설화,김정숙,김현아,김경숙,신지혜,최은정,양은진,유선미,유수진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 이트라코나졸 액과 플루코나졸 시럽의 예방 효과 : 전향적, 무작위, 비교 임상시험

최수미,이동건,최정현,박선희,엄기성,김유진,김희제,민창기,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

목적 : 조혈모세포이식 환자에서 호중구 감소 기간 동안 이트라코나졸 액(ITZS)과 플루코나졸 시럽(FCZS)의 진균 감염에 대한 예방 효과를 전향적으로 비교해 보고자 하였다. 재료 및 방법 : 2001년 8월부터 2002년 6월까지 가톨릭 조혈모세포이식센터에 입원하여 동종 조혈모세포이식을 받은 만 18세 이상의 환자들을 각각 ITZS와 FCZS군으로 무작위 배정하여 침습성 진균 감염 발생과 약제 관련 부작용을 전향적으로 조사하였다. 결과 : ITZS군에 40명, FCZS군에 38명이 배정되었고, FCZS군 환자의 평균 나이가 더 많았다. 시험 약제 평균투여기간은 ITZS군 16.4일, FCZS군 21.9일로 ITZS군이 더 짧았다. 이는 ITZS군에서 소화기 부작용으로 인한 약제 중단이 더 많았기 때문으로 보인다. 시험 약제 투여 후 총 빌리루빈 수치의 유의한 증가가 관찰되었으나, 약제 관련 부작용은 모든 환자에서 가역적이었다. 호중구감소 기간동안 표재성 진균 감염은 두 군에서 모두 발생하지 않았고, 침습성 진균 감염은 ITZS군 5명(12.5%), FCZS군 8명(21.1%)으로 FCZS군에서 많았으나, 통계학적으로 유의하지 않았고, 사망률에도 유의한 차이는 없었다. 결론 : 침습성 진균 감염에 대한 이트라코나졸 액과플루코라졸 시럽의 예방 효과에 유의한 차이는 없었으나, 앞으로 더 많은 환자를 대상으로 잘 짝지어진 대조군 연구가 필요할 것으로 보인다. 부작용 중 간독성과 관련하여 이식시 투여되는 여러 약제들과의 상호작용에 대한 연구도 필요할 것이다. Background : Though fluconazole is widely used for antifungal prophylaxis, it is ineffective against mould infections including Aspergillus species. Itraconazole has a broader spectrum than fluconazole but the capsule form shows erratic bioavailability in neutropenic patients. In this study, we compared itraconazole oral solution (ITZS) with fluconazole syrup (FCZS) for the prevention of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant recipients. Materials and Methods : Adults receiving allogeneic hematopoietic stem cell transplantation (HSCT) from september 2001 to June 2002, were randomly allocated to either the ITZS group or the FCZS group. We prospectively evaluated the safety and efficacy of each drug. Results : Out of 78 patients (40 patients in the ITZS group and 38 patients in the FCZS group) who were eligible for this study, 37 patients completed the course of prophylaxis without any evidence of IFI. The mean duration of prophylaxis was 16.4 days for the ITZS group and 21.9 days for the FCZS group (P<0.006). Drug-related adverse events occurred in 28 patients (70.0%) and 19 patients (50.0%) in the ITZS group and the FCZS group, respectively. Common adverse events of ITZS were nausea, vomiting, and diarrhea. Drug-related reversible hepatotoxicity occurred in 4 patients in the ITZS group. There was a significant elevation of total bilirubin level in the ITZS group. The incidence of suspected IFI occurred in 5 patients (12.5%) who received ITZS, compared with 8 (21.1%) who received FCZS (P=0.372). There were no proven IFIs or superficial (oral/vaginal) fungal infections in both groups. Overall mortality was not different between the two groups (2.5% in the ITZS group versus 5.3% in the FCZS group, P=0.610). Conclusion : ITZS and FCZS showed similar protection against IFI during pre-engraftment period. Poor tolerability due to gastrointestinal troubles of ITZS might limit its success as prophylactic therapy. Well matched controlled study with large number of patients will be required in the future.

SUS 304 마이크로 와이어 직선화 처리에 관한 연구

신홍규,김남수,김웅겸,홍남표,김병희,김헌영 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

In the study, we have developed a straightening system for the SUS 304 micro wires that are normally used in the medical and semi-conductor fields. To apply heat to the micro wires, we introduced the direct wire heating method which generates the thermal energy by the electrical resistance of the wire itself. To avoid the deterioration of the wire surface by the environment, such as the oxidation or the hydration, the N_(2) gas was filled in the glass pipe in which the straightening process was being performed. A precision tension meter was also attached to control the tension of the wire during the heating and straightening process. In order to control the straightening process, several experimental investigations with varying the tension, the feeding velocity and the temperature (current) was carried out. As a result of experiments, we obtained the optimal processing conditions satisfying the straightness requirement of the micro wires.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

다발성 결절양상의 피부전이로 발견된 췌장암 1예

김희수,이상표,박성우,류성태,오웅식,이정환,김홍자 대한내과학회 2004 대한내과학회지 Vol.66 No.4

췌장암은 악성종양의 5% 이하를 차지하며, 피부전이는 매우 드물다. 저자들은 결정성 전신피부병변으로 내원한 환자에서 초음파와 컴퓨터단층 촬영상 췌장종괴가 발견되고 CA 19-9이 매우 높았으며 피부조직 검사를 시행한 결과 전이성 선암으로 판정되어 췌장암에서 유래된 피부전이암으로 진단되어진 증례를 접하고 문헌고찰과 함께 보고한다. Carcinoma of the pancreas represents less than 5% human malignant neoplasm. It's skin involvement is rare. A 73 year-old man presented with multiple skin lesions located on the face, neck and body. The histopathologic study of the skin lesion was confirmed to be an metastatic adeno-carcinoma. The primary tumor was regarded as the mass at the head of the pancreas observed on the CT scan, but was not confirmed by biopsy. We report a case of multiple cutaneous metastasis from pancreatic carcinoma with brief review of related literature.

고구마의 Callus와 Plant Regeneration에 미치는 培地의 添加物, 特히 Ethylmethanesulphonate(EMS)의 影響

金烘受 東亞大學校生命資源科學大學附設 農業資源硏究所 1993 農業生命資援硏究 Vol.2 No.1

1.고구마(cv. 千美) 葉柄(petiole) callus로 부터의 植物體(callus 고구마)가 再生되었다. 再生培地의 알맞은 Hormone添加는 0.1㎎/ℓNAA, 1㎎/ℓ BA의 組合이었다. 2. Petiole callus와 EMS 0.1% 4h處理는 callus는 peroxidase isozyme band pattern에 있어서 共有 band 外에 A1∼4, B1∼3의 새로운 2個의 zone이 生成되었다. plant regeneration petiole은 처음 callus와 같았으나 outer pot에서 生長된 고구마 petiole가 됨에 따라 Initiate petiole로 復元되었다. 3.Esterase isozyme band 數는 4個로(Est1∼4) peroxidase보다 적었다. Callus 고구마의 petiole esterase isozyme은 成長함에 따라 Initial petiole으로 復元되었으며 EMS處理 callus는 Est4의 活性度가 强한 isozyme variation을 出現시켰다. 4.Protein band는 各 column이 14.2Kd以下의 3個의 共有 band를 가졌으나 모두 다른 band variation을 보였다. 따라서 callus 고구마의 mutation이나 EMS를 直接 處理한 callus의 mutation 效果가 期待된다. Callus derived sweet potato (cv. Chunmi) was developed with some different variation. Subculture calli in vitro and plant regenerated from petiole callus has various new band pattern and intensity of peroxidase, esterase and protein by the means of polyacrylamide gel electrophoresis. According to development of regenerated plant peroxidase isozyme were restored to the control plant isozyme patterns, but new bands of esterase and protein were preserved as it is generally. Effects of ethylmethanesulphonate(EMS) 0.1% 4h to the callus formed from petiole were taken place as new deep band patterns of peroxidase and esterase. The other hand protein band of EMS treated or nontreated control callus has three low molecular weight under ca. 14.2Kd common bands respectively, more over EMS nontreated callus has ca. 24, 44Kd and treated callus after 28days has ca. 24Kd new band except above three common bands.

웹 온톨로지를 이용한 공급자와 판매자의 데이터 통합 모델

김영근,김수경,안기홍 한밭대학교 정보통신전문대학원 2005 정보통신전문대학원 논문집 Vol.3 No.1

정보통신의 발전은 경제 구조에 많은 변화를 가져왔으며, 향후에도 많은 변화를 예고하고 있다. 가장 대표적인 것은 경제 흐름의 근간이라 할 수 있는 유통의 변화이다. 이것은 통신망 위에 구축되는 가상의 공간에서 이루어지는 유통을 지칭하는 것으로, 빠른 속도로 발전하고 있다. 이러한 빠른 발전에도 상품데이터베이스를 구성하는 것에는 매우 불합리한 비효율성이 존재한다. 상품데이터베이스 구성의 가장 큰 비효율은 싸이트들이 개별의 데이터베이스를 구성한다는 것이다. 이런 문제를 해결하기 위해 시멘틱웹의 RDF(Resource Description Framework)언어를 이용하여 웹 온톨로지를 구성하여 공급자와 판매자간 상품 데이터를 공유하게 된다면, 전자상거래에서 상품데이터베이스 구성의 비효율성을 제거 할 수 있다. 따라서 본 논문에서는 RDF의 소개와 RDF 웹 온톨로지 편집기를 제작하고, 구성된 RDF를 참조하여 간단한 쇼핑몰을 구성하여 온톨로지를 통한 데이터의 효율적 상호운영성(Interoperability)을 증명하여, 현재 제안되고 있는 상품 카탈로그 분야의 발전에 기여하고자 한다. IT development has brought about many changes in an economic structure, and will bring about many changes in the future. The most representative thing is the change of distribution which is a basis of the economic flow. It means a distribution an a virtual space built through communication network. It has rapidly developed. However, building the product database by each site for numberless products is very unreasonable simple repeating process. To solve this problem, if the product data is shared between a supplier and seller through the web ontology by using the Semantic Web RDF (Resource Description Framework) language, an efficiency of e-commerce will be created. Accordingly, the study is intended to prove an efficient interoperability of data through ontology by introducing the RDF, fabricating the RDF web ontology editor, and building a simple shopping mall through organized RDF, and to contribute to a development of currently-proposed product catalog field.