질소-산소계 시프염기 리간드의 합성과 전이금속(Ⅱ) 착물의 안정도상수결정

김선덕,송찬익,김준광,김정성 한국환경과학회 2004 한국환경과학회지 Vol.13 No.9

N,N-bis(2-salicylaldehyde)dipropylenetriamine(5-Hsaldipn), N,N-bis(5-bromosalicyl-aldehyde) dipropylenetriamine (5-Brsaldipn), N,N-bis(5-chlorosalicylaldehyde)dipropylene-triamine(5-Clsaldipn), N,N-bis(2-hydroxy-5-methoxybenzaldehyde)dipropylenetriamine(5-OCH₃saldipn) and N,N-bis (2-hydroxy-5-nitrobenzaldehyde)dipropylenetriamine (5-NO₂saldipn) were synthesized and characterized by elemental analysis, infrared spectrometry, NMR spectrometry and mass spectrometry. Their proton dissociation constants were determined in 70% dioxane/30% water solution by potentiometric. Stability constants of the complexes between these ligands and the metal ions such as Cu(Ⅱ), Ni(Ⅱ) and Zn(Ⅱ) were measured in dimethyl sulfoxide by a polarographic method. Stability constants for the ligands were in the order of 5-OCH₃> 5-H > 5-Br > 5-Cl > 5-NO₂saldipn. Enthalpy and entropy changes were obtained in negative values.

천측두 동맥의 외상성 가성동맥류 1례

최익수,김기준,전병훈 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Pseudoaneurysms form when a hemorrhage or hematoma from the injured arterial wall is replaced with an fibrous vessel wall, which is dilated by subsequent pulsating pressure. Recently, we experienced a patient with a pulsatile preauricular mass, measuring about 1.5× 1.5 cm, sustained from blunt trauma by the baseball. The presumptive diagnosis of pseudoaneurysm of the superficial temporal artery was made by Doppler sonography. Under local anesthesia, the aneurysm was excised en bloc following ligation. We report the rare case with a review of literatures.

마이크로머시닝을 이용한 Bump형 Probe Card의 제조

최원익,김용대,심준환,이종현 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

Probe card is the most important part of testing IC chips. This work was related to silicon vertical probe card which enabled to simultaneously test multiple semiconductor chips. We presented Bump-type vertical probe card. It was fabricated by dry etching using RIE technique, isotropic etching, and bulk-micromachining on SDB wafer. The process used in this work was very simple and reproducible, which had good controllability in the probe card dimension and spacing. It is expected that the fabricated probe card can reduce testing time, can promote productivity and enables bum-in test.

전처리 방법에 따른 하수슬러지 가용화 비교연구

권재현,김봉준,김민규,염익태,김형수 대한상하수도학회 2003 상하수도학회지 Vol.17 No.4

The pretreatment process was carried out to solubilize the sewage sludge for enhancing its biodegradability using alkaline treatment, ultrasonic treatment(l5kHz), ozone treatment and different combination of these three methods: alkaline followed by ultrasonic as well as ozone, and ultrasonic followed by alkaline. The solubilization efficiency was evaluated based on the SCOD/TCOD ratio and VSS/TS ratio. In results, the proper condition of alkaline treatment was shown as 30meq/l of NaOH, pH 12 and 3hours of reaction time. Solubilization efficiency increased to 17% from initial 2% based on SCOD/TCOD ratio under this condition. In ultrasonic treatment, the higher ultrasonic power, the longer treatment time and the lower sludge volume resulted in higher solubilization respectively. There was a rapid increase in solubilization efficiency after 20 minute, then it was measured as 32% of SCOD/TCOD ratio in 1 hour at a ultrasonic power of 1,300W with 1/sludge. Solubilization efficiencies in combined treatment using alkaline and ultrasonic were 47-53% higher than single treatment at a sonicated time of 1 hour. Ozone treatment followed by alkaline treatment also represented the enhanced solubilization compared to ozone treatment. Therefore, ultrasonic or ozone treatment assisted by alkaline could achieve the short treatment time as well as high solubilizetion efficiency.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

A Phase II Study of Gemcitabine Monotherapy in Breast Cancer Patients Refractory to Anthracycline and Taxane

Jun Yong Park,Chul Kim,Joo Hyuk Sohn,Yong Tae Kim,Sun Young Rha,Woo Ick Jang,Gwi Eon Kim,Hyun Cheol Chung 대한암학회 2002 Cancer Research and Treatment Vol.34 No.4

Purpose: We performed a phase II trial to evaluate theefficacy and the safety of gemcitabine monotherapy, apyrimidine antimetabolite, in patients, who had previouslyfailed anthracycline and taxane-based chemotherapyfor the treatment of metastatic breast cancer.Materials and Methods: Twenty-one patients withmetastatic breast cancer, which was unresponsive toprevious chemotherapy, were entered into this study.Gemcitabine was administered at 850 mg/m2, as a 60-minute intravenous infusion on days 1, 8 and 15. Thisregimen was repeated every 28 days with G-CSF support,but without dose reduction.Results: Objective responses were seen in 6 of the 20patients who were able to be evaluated (1 completeresponse and 5 partial responses), with an objectiveresponse rate of 30%. The median time to progressionwas 5 (1~20) months, and the median overall survivalduration was 11 (2~21) months. The actual dose intensitywas 566.7 mg/m2/wk (range; 340~637.5 mg/m2/wk)and the relative dose intensity was 0.89 (range; 0.40~1.00). Toxicity was mainly hematological. Toxicities included:grade 3 neutropenia in 20% and anemia in 5%.Grades 3 and 4 thrombocytopenia occurred in 15% of thepatients.Conclusion: Gemcitabine monotherapy is an effectiveand safe treatment for refractory breast cancer patientsheavily treated with the anthracycline and taxane- basedregimen. (Cancer Res Treat. 2002;34:274-279)

Peripheral Blood Inflammatory Cytokines in Idiopathic REM Sleep Behavior Disorder

Kim, Ryul,Jun, Jin‐,Sun,Kim, Han‐,Joon,Jung, Ki‐,Young,Shin, Yong‐,Won,Yang, Tae‐,Won,Kim, Keun Tae,Kim, Tae‐,Joon,Byun, Jung‐,Ick,Sunwoo, Jun‐,Sang,Jeo John WileySons, Inc. 2019 Movement disorders Vol.34 No.11

<P><B>Abstract</B></P><P><B>Background</B></P><P>Although previous research provides insight into the role of neuroinflammation in idiopathic REM sleep behavior disorder, the association of this disorder with peripheral blood inflammatory markers remains unclear.</P><P><B>Objective</B></P><P>To investigate inflammatory cytokines in plasma samples in patients with idiopathic rapid eye movement sleep behavior disorder and to explore whether these markers are associated with prodromal symptoms of α‐synucleinopathies.</P><P><B>Methods</B></P><P>We collected plasma from patients with polysomnographically confirmed idiopathic rapid eye movement sleep behavior disorder without parkinsonism or dementia (n = 54) and from healthy controls (n = 56). The following cytokines were measured: interleukin‐1β, interleukin‐2, interleukin‐6, interleukin‐10, and tumor necrosis factor‐α. The idiopathic REM sleep behavior disorder patients underwent sleep, motor, cognitive, olfactory, and autonomic testing.</P><P><B>Results</B></P><P>The anti‐inflammatory cytokine, interleukin‐10, levels in the idiopathic rapid eye movement sleep behavior disorder group were significantly upregulated compared to the control group (<I>P</I> = 0.022), but this difference did not withstand Bonferroni correction. The other proinflammatory cytokine levels did not differ between the groups. No correlation was found between the cytokine levels and any clinical variable.</P><P><B>Conclusions</B></P><P>Our data do not provide evidence supporting the role of peripheral inflammation in idiopathic rapid eye movement sleep behavior disorder. However, considering the limited statistical power because of the small sample size, further large‐scale longitudinal studies with a broader spectrum of cytokines are needed to clarify this issue. © 2019 International Parkinson and Movement Disorder Society</P>

Electrochemical characteristics of LiFePO4/LiCoO2 mixed electrode for Li secondary battery

Kim, Hyun-Soo,Kong, Mingzhe,Kim, Ketack,Kim, Ick-Jun,Gu, Hal-Bon Springer-Verlag 2009 JOURNAL OF ELECTROCERAMICS Vol.23 No.2

Combined effects of p73 and MDM2 polymorphisms on the risk of lung cancer

Jun, Hee Jung,Park, Sun Ha,Lee, Won Kee,Choi, Jin Eun,Jang, Jin Sung,Kim, Eun Jin,Cha, Sung Ick,Kim, Dong Sun,Kam, Sin,Kim, Chang Ho,Kang, Young Mo,Jung, Tae Hoon,Park, Jae Yong Alan R. Liss, Inc 2007 Molecular carcinogenesis Vol.46 No.2

<P>p73, a structural and functional homologue of p53, plays an important role in modulating cell-cycle control and apoptosis. MDM2 represses the transcriptional activity of p73 and thus attenuates its activity. Based on the interaction between p73 and MDM2 in cell-cycle control and apoptosis, we investigated the association between p73 G4C14-to-A4T14 and MDM2 309T > G polymorphisms, alone and in combination, on the risk of lung cancer in a Korean population. The p73 and MDM2 genotypes were determined in 582 lung cancer patients and in 582 healthy control subjects who were frequency-matched for age and gender. The p73 AT/AT and MDM2 309 GG genotypes were associated with a nonsignificant increased risk of lung cancer (adjusted odds ratio [OR] = 1.37, 95% confidence interval [CI] = 0.83–2.24; and adjusted OR = 1.29, 95% CI = 0.92–1.80, respectively), compared with their wild-type genotypes, respectively. When the p73 and MDM2 polymorphisms were combined, the risk of lung cancer increased in a dose-dependent manner as the number of variant alleles increased (P<SUB>trend</SUB> = 0.01). Subjects with three or four variant alleles were at a significantly increased risk of lung cancer (adjusted OR = 1.74, 95% CI = 1.11–2.74, P = 0.02) compared to subjects with zero variant allele. These results suggest an additive effect of the p73 and MDM2 variant alleles on an increased risk of lung cancer. © 2006 Wiley-Liss, Inc.</P>

Changes of depression and job stress in workers after merger without downsizing

Jun Ick Jung,Jun Seok Son,Young Ouk Kim,Chang Ho Chae,Chan Woo Kim,Hyoung Ouk Park,Jun Ho Lee,Young Hoo Shin,Jea Chul Ha 대한직업환경의학회 2018 대한직업환경의학회지 Vol.30 No.-

Background: Since the 1980s, restructuring, which includes downsizing, closures, mergers, and privatization, has expanded worldwide, and various studies have investigated its effect on health. However, previous studies have mainly focused on restructuring accompanied by massive lay-offs, and the effect of a merger on workers’ health is still controversial. This study aims to investigate changes in worker depression and job stress after a merger without downsizing, which is unusual in Korea. Methods: Repeated surveys were done in April 2014, April 2015, and April 2016 involving the participation of 209 subjects. Participants were divided into two groups, which were comprised of blue-collar workers (104) and whitecollar workers (105). Sociodemographic characteristics, including age, education level, job tenure, gender, marital status, smoking status, and alcohol consumption, were measured via a survey. To determine the level of depression, the Korean version of the Center for Epidemiologic Studies Depression Scale (CES-D) was employed, and to investigate job stress, the Korean Occupational Stress Scale-Short Form (KOSS-SF) was used. For statistical analyses, Pearson’s chi-square test, the Student’s t-test, and repeated measure analysis of variance (ANOVA) were performed. Results: The results showed that depression (CES-D, F[2, 400] = 0.466, p = 0.628) was changed but without significance and job stress (KOSS-SF, F[1.899, 379.831] = 3.192, p = 0.045) were significantly different. The betweengroup difference in the CES-D score between the blue- and white-collar workers by survey administration time was not statistically significant (F = 0.316, p = 0.574). The interaction between the survey time and occupational group was also not statistically significant (F = 0.967, p = 0.381). The between-group difference in the KOSS-SF total score was not statistically significant (F = 1.132, p = 0.289), and the interaction between the survey administration time and occupational group was also not significant (F = 0.817, p = 0.437). In the job stress subgroup analyses Job insecurity and Lack of reward showed a significant difference by survey administration time. Conclusion: This study showed that a merger without massive downsizing can cause negative health effects such as an changes in depression and increase in job stress. To improve the health of workers, both the immediate negative effects on health, and the long-term effects or their resolution over time should be considered prior to the merger.