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이소옥사졸과 그의 유도체들이 배위된 팔라듐(Ⅱ)과 백금(Ⅱ) 착물의 항암활성에 관한 이론적 연구
김정성,송영대,Kim, Jung-Sung,Song, Young-Dae 대한화학회 1998 대한화학회지 Vol.42 No.4
The palladium(II) and platinum(II) complexes(where, $([M(L)_2X_2]$, M=Pd(II), Pt(II); L=isoxazole(isox), 3,5-dimethylisoxazole(3,5-diMeisox), 3-methyl, 5-phenylisoxazole(3-Me, 5-Ph-isox), and 4-amino-3,5-dimethylisoxazole (4-ADI); X=Cl, Br) with isoxazole and its derivatives were investigated on antitumor activity by MM2 and EHMO calculation. Because for all the complexes the ${\sigma}MO$ energy level $(E_{{\sigma}(M-X)})$ between $d_x^{2-}_y^2$ orbital of central metal and px orbital of halogen atom is less than ${\sigma}MO$ energy level $(E_{{\sigma}(M-N)})$ between $d_x^{2-}_y^2$ orbital of central metal and px orbital of N atom, without exception. And judging, from the lower $(E_{\'{o}(m-x)})$ value in trans, the bonding strength was found to be weaker in trans isomer than in cis. For the Pd(II) and Pt(II) complexes which have planar ligands, it was shown that for all the complexes dissociation of X-atom in the Pd(II) complexes is easier than that of X-atom in the Pt(II) complexes in both cis- and trans-complexes. Therefore it suggests that the easier dissociation of $X^-$ ion has some relations with antitumor activity, and a linear equation with correlation coefficient of 0.96 was found between ${\Delta}E_{{\sigma}(N-X)}(E_{{\sigma}(M-N)}-E_{{\sigma}(M-X)})$ and inhibitory activity coefficient, logIA. 이소옥사졸과 그의 유도체가 배위된 팔라듐(II) 및 백금(II)착물$([M(L)_2X_2]$, M=Pd(II), Pt(II); L=isoxazole(isox), 3,5-dimethylisoxazole(3,5-diMeisox), 3-methyl, 5-phenylisoxazole(3-Me, 5-Phisox), and 4-am-ino 3,5-dimethylisoxazole(4-ADI); X=Cl, Br)의 항암활성을 분자역학(MM2)법으로 최소에너지를 갖는 구조를 구한 후 확장분자궤도함수(EHMO)법으로 조사하였다. 중심금속의 $d_x^{2-}_y^2$ 궤도함수와 할로겐 원자의 $p_x$ 궤도함수 사이의 ${\sigma}MO$ 에너지준위$(E_{{\sigma}(Pd,Pt-X)})$가 질소원자의 $p_x$ 궤도함수 사이의 ${\sigma}MO$ 에너지준위 $(E_{\sigma}(Pd,Pt-N))$보다 예외없이 더 높아서 결합이 약함을 알 수 있었다. 아울러 같은 착물에서 cis- 보다 trans-착물에서 $(E_{\sigma}(Pd,Pt-X))$ 값이 더 높아서 결합이 약함을 알았다. 또한 평면형 리간드가 배위될 경우 cis-, trans- 이성체 모두 백금착물에서보다 팔라듐착물에서 $X^-$ 이온의 이탈이 더 용이했다. 다라서 $X^-$ 이온으로 떨어져 나가는 용이성이 항암활성과 어떤 관계가 있을 것으로 생각하고 $E_{{\sigma}(Pd,Pt-N)}-E_{{\sigma}(Pd,Pt-X)}({\Delta}E_{{\sigma}(N-X)})$과 저해활성 계수인 logIA의 값를 도시하였던바 실험치와 상관 계수가 0.96인 좋은 직선성이 성립함을 알 수 있었다.
김정성,장희운,김진숙,김혁진,김주환 한국유전학회 2012 Genes & Genomics Vol.34 No.3
Schisandra chinensis (Turcz.) Baill. is a climbing woody vine found over a wide geographical range in northeast Asia. Its red five-flavored fruits have been used as drugs and food. In China and Korea, the dried fruit of S. chinensis has been used for a long time as a traditional medicine. Three species of the family Schisandraceae, S. chinensis, S. repanda, and Kadsura japonica, are distributed mainly in southern Korea. While S. chinensis is broadly distributed, S. repanda and K. japonica are restricted to the southern islands of Korea, especially Jeju. The amplification refractory mutation system (ARMS), one of molecular genotyping technique, is a simple and rapid method for detecting point mutations, restriction fragment length polymorphisms,and small deletions or insertions in a DNA sequence. This PCR-based technique utilizes a primer designed to react only when it anneals to specific target sequences in a DNA sample. In the present study, we analyzed rbcL of the chloroplast gene and ITS from S. chinensis and two related taxa, S. repanda and K. japonica, and developed a specific marker for distinguishing S. chinensis from the related taxa based on SNPs using multiplex PCR. Result showed that two species-specific fragments with 230 bp of rbcL and 278 bp of ITS region were additionally amplified only in all of individuals of S. chinenesis using multiplex PCR method. Here,we describe the details of the protocol for the molecular identification of S. chinensis and other related species. Our results cover five populations of S. chinensis in Korea.
Spiropyran과 그의 유도체들중 6-nitrospirobenzopyran의 Photomerocyanine에 관한 AM1연구
김정성,송영대,최진태 大邱大學校附設 基礎科學硏究所 1998 基礎科學硏究 Vol.15 No.1
Semiempirical AM1 quantum chemical calculation were carried out for the spiropyran and its derivatives and for the merocyanine-form four isomer of 6-nitrospirobenzopyran(2H-1-benzopyran-2-2'-indoline) to reveal the thermal back reaction of the photochromic spiropyran. The correlation was investigated between C and O of spiropyran and its derivatives by AM1(Austin Model 1) method. The bond length of C-O for spiropyran and its derivatives is decreased with substituting donating group for withdrawing group. It was found that a good relationship exists between the bond length of C-O for spiropyran and its derivatives and the calculated quantum chemical quantities, binding energy(E_(bind)), enthalpy of formation(Hr), dipole moment(μo ), and difference between HOMO and LUMO energy(ΔE) for spiropyran and its derivatives and for the merocyanine-form four isomer of 6-nitrospirobenzopyran.
제어법칙 고장탐구와 데이터 출력 및 비행 시뮬레이션 (Flight Replay, Plot, Simulation) 도구 개발
김정성,조성범,최기영 한국항공우주학회 2014 한국항공우주학회 학술발표회 논문집 Vol.2014 No.11
비행시험 자료 분석과 제어법칙의 고장탐구는 비행시험 이후 반드시 수반되어야 하는 과정이다. 본 논문에서는 비행시험 데이터를 이용하여 매트랩 시뮬링크 환경에서 설계된 제어법칙의 고장탐구와 비행시험 데이터를 출력하는 도구 개발의 내용을 담고 있다. Flight RPS의 개발로 비행 시험 이후에 제어법칙의 고장탐구와 비행 자료 분석에 소요되는 시간을 단축시켜 개발과정의 효율을 증가 시킬 수 있었다. 또한 비행 중 발생한 현상과 자료를 분석하는 과정에 비행 시뮬레이션 기능을 추가시켜 자료 분석의 이해도를 증가시켰다. The process that debugging of flight control law and analysis of flight data is always performed after all of flight tests. In this paper, we added a tool to debug control law based on MATLAB Simulink and flight simulation using flight data. By the development of Flight RPS, we could increase the efficiency of the development process. We could also increase the level of understanding of the analytical data by adding simulation in the process of analyzing the data and phenomena while the flight test.
트리아릴포스포늄 염과 카르보닐 화합물 사이의 위티그 반응의 입체선택성에 대한 고압 효과
김정성,최정훈,지진영,김창만,김용훈 대구대학교 기초과학연구소 1999 基礎科學硏究 Vol.15 No.3
The Wittig reactions of triarylphosphonium ylides with various carbonyl compounds under high pressure were carried out to investigate its effect on the cis-trans stereochemical outcome. Generally, the cis-stereoselectivities at atmospheric pressure are known to be resulted from smaller steric hindrance of α-carbon of carbonyl group with hydrogens of phenyl residue of triphenylphosphonium ylide and in oxaphosphetane intermediate stage. Thus, the steric interactions between triphenylphosphonium ylide and carbonyl compounds in the transition state can be maximized. And, the reactions of semistabilized ylide and stabilized ylide at atmospheric pressure generate mainly thermodynamically more stable trans-alkane after formation of betaine intermediate. The reactions at high pressure, however, can generate cis-alkene more exclusively through oxaphosphentane intermediate,directly without the formation of betaine intermediate by reducing distance between ylide and carbonyl compound. Reaction between benzyl triphenylphosphonium ylide, a semistabilized ylide, and butyraldehyde at atmospheric pressure gave cis-1-phenyl-1-pentene with 34/66 of Z/E stereoselectivity, but when pressurized at 10000 bar, cis-alkene with 69/31 the Z/E ratio was excellently yielded than trans-alkene. In the case of Wittig reaction of ethoxyacetyl triphenylphosphonium ylide, a stabilized ylide, with butyraldehyde, Z/E stereoselectivity at 10000 bar was inversed in contrast to atmospheric pressure.
Fe(II)착물의 금속-리간드 사이의 결합에너지와 실측 리간드화열과의 상관성에 관한 EHT-ZINDO/1 연구
김정성,송영대,최진태 大邱大學校附設 基礎科學硏究所 1997 基礎科學硏究 Vol.14 No.1
The correlation was investigated between the observed heat of ligation and calculated bond energy for octahedral Fe(II) complexes by EHMO(Extended Hückel Molecular Orbital) and ZINDO/1(Zerner's Intermediated Neglected of Differential Overlap) method. The net charge of Fe²+ ion of octahedral [Fe(H₂O)_(5)_(-)_(x)(NH₃]²+ complexes(x = 0, 1, …, 6) is decreased with substituting NH₃for H₂O molecule. It was found that a good relationship exists between the observed heat of ligation and the calculated quantum chemical quantity, net charge of central atom, enthalpy of formation, total dissociation energy. From this fact, we can obtain a linear equation △H_(obs) = -0.2858q_(Fc) + 0.8813, △H_(obs) = 0.0031H_(f) + 0.5725, △H_(obs) = 0.00476E_(diss) + 0.6434, respectively, theoretical equation.
국화속 구절초무리와 근연종인 산국 및 감국 에서 보이는 잎의 해부학적 특징
김정성,Hiroshi Tobe 한국식물분류학회 2009 식물 분류학회지 Vol.39 No.1
The Chrysanthemum zawadskii complex is demarcated from other species by having the white and pink ligulate flowers. Its morphological characters are greatly diversified, so that various classification systems have been suggested. The character of leaf thickness has been mentioned as the characteristic for recognizing some of infra-specific taxa within this complex. In this study, we used longitudinal leaf sections to investigate the leaf thickness and cell number of leaf blades of 13 populations including those of the members of the C. zawadskii complex, as well as 4 populations of the related species of C. boreale and C. indicum. From the result, it was clear that the leaves were thicker in populations of C. boreale, C. indicum and C. zawadskii complex (diminishing in that order), and that the leaves were composed of about 9 cell layers in all populations. Within the C. zawadskii complex, leaf shape and thickness varied among the populations. It was very interesting that the taxa with restricted distribution, like C. zawadskii var. tenuisectum, C. zawadskii var. alpinum, C. zawadskii var. lucidum, and C. zawadskii subsp. coreanum had a thicker leaves than found among widely occurring taxa. From this, leaf thickness is supposed to be an adaptation to the unique habitat of each population. 구절초 무리는 국내에 분포하는 국화속 중 흰색 또는 분홍색의 설상화를 가지는 특징으로 인해 다른 두 종과 구별되는데 외부형태학적 변이로 인하여 다양한 분류학적 견해가 제안되어 온 분류군이다. 본 연구에서는 지금까지 국화속의 종 및 종내 분류군을 인식하기 위해 이용되어 온 형태학적 형질 중 구절초 무리내의 종내 분류군을 인식하기 위한 특징의 일부로서 사용된 바 있는 잎의 두께에 주목하여 구절초 무리에 속하는 13개 집단과 근연종인 산국 및 감국의 4개 집단을 이용하여 잎의 구조적 특징을 확인하였다. 이를 위해 잎의 횡단절편을 제작하여 엽신의 두께와 세포층 수, 세포의 크기를 비교하였다. 잎의 두께를 확인해본 결과 산국, 감국, 구절초 무리 순으로 두꺼운 것으로 나타났으며 세 종 모두 9개 전후의 세포층으로 구성되어 있어 잎의 두께는 세포층 수가 아니라 세포 크기에 따라 달라지는 것으로 밝혀졌다. 구절초 무리 내에서는 집단 간에 잎의 형태 및 두께에서 다양한 변이를 보였는데 가는잎구절초, 바위구절초, 울릉구절초, 한라구절초 등 특히 제한적인 분포를 보이는 분류군들이 전국적인 분포를 보이는 분류군에 비해 상대적으로 두꺼운 잎을 가지는 것이 확인되었고, 이는 각 분류군이 고유의 서식환경에 적응한 결과로 생각된다.
김정성,박윤열,HIROSHI TOMIYASU 大邱大學校附設 基礎科學硏究所 1993 基礎科學硏究 Vol.10 No.-
Unusual kinetic behavior was observed in the substitutions of hemin with imidazole and cyanide ion under conditions of [L] S 2[hemin] (L=substituting ligand) in N,N--dimethylformamide. The rates of these reactions were much slower than those the formations of mono- and bis-coordinate complexes. Based on the kinetic results, these slow reactions were interpreted in terms of the dissociations of mono-coordinate complex to solvated hemin. The activation volume was determined to be 24.3 -- 0.4 cm3 mol'1 for the reaction with imidazole by the high pressure stopped flow method. The large positive value of the activation volume strongly supports a limiting dissociative mechanism.
시뮬레이션 궤적추적 기능을 가진 소형 무인항공기를 이용한 ACMI 시험 시스템
김정성,조성범,최기영 한국항공우주학회 2015 한국항공우주학회 학술발표회 논문집 Vol.2015 No.4
본 논문에서는 소형 무인항공기를 이용한 ACMI(Air Combat Maneuvering Instrumentation) 모의 기법에 대해 기술하고 궤적추종 시뮬레이션을 구성하였다. 실제 항공기와 소형 무인기의 비행 특성은 서로 다르다. 따라서 소형 무인기를 이용하여 ACMI시험을 수행하기 위해서는 소형 무인기의 비행데이터를 실기와 유사한 형태의 데이터로 변환해야 한다. 이를 위해 소형 무인기의 기동에 제한을 두고 실기와 소형 무인기의 비행속도의 비(Speed Scale Factor, SSF)를 이용하여 실제 항공기의 기동영역과 유사한 비행데이터를 생성한다. 또한 거리오차가 증가하는 오픈루프 형태의 시뮬레이션을 개선하기 위해 소형 무인항공기가 실기의 궤적을 추종하여 궤적 오차를 줄이는 방법을 제안하였다. In this paper address ACMI simulation system using Small UAV and perform trajectory Simulation. Flight characteristics of actual aircraft and small UAV are different from each other. Thus, small UAV flight data is to be modified for ACMI simulation system, similarly to the actual aircraft. Set maneuvering limit of small UAV and using ratio of flight speed, converts the data and generates data similarly to the flight data of actual aircraft maneuvering. Also, proposed that small UAV reduce the trajectory error to follow the actual aircraft trajectory for improve simulation of open-loop form of the trajectory error increases.