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        • KCI등재

          성인여성의 인유두종바이러스와 자궁경부암 예방백신에 대한 지식, 암예방 수행 및 자궁경부암 예방백신 수용도 분석

          송갑선,전은미,김주연 대한암예방학회 2013 Journal of cancer prevention Vol.18 No.1

          This study was conducted to identify the knowledge of HPV and HPV vaccines and the acceptance of cancer preventive vaccine targeting adult women. The convenience sampling was conducted on subjects of 271 adult women who have visited Gynecologic Clinics residing in the B-city. For data analysis, it conducted the analysis of mean and standard deviation, t-test, ANOVA, and Pearson's Correlation Coefficient. The research results demonstrate that the knowledge about HPV vaccine was higher in less than 40's in their age, subjects over college-graduates, single status in marriage condition, and subjects who have jobs, but the knowledge appeared to be very low with mean score, 5.34 (range 0∼22). In terms of the performance of cancer prevention, subjects of college graduates, those who have religion and were in higher economic level, those who are married, have no job, have a sex-partner and sexually transmitted diseases experience specially made an effort to prevent cancer. Of the subjects, 66.7% responded that they had a will to receive HPV vaccination and 86% subjects wanted to make their children vaccinate. In addition, there was no correlation found between the knowledge of HPV vaccine and the cancer- preventive performance.

        • KCI등재

          Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma

          임선민,조상희,황인규,최재우,장현,안명주,박건욱,김지원,고윤호,안희경,조병철,남병호,전상훈,홍지형,권정혜,최종권,강은주,윤탁,이근욱,김주항,김진수,이현우,김민경,정동민,김지은,김범석,윤환중,김상우,김혜련 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1

          Purpose Head and neck squamous cell carcinoma (HNSCC) is a deadly disease in which precision medicine needs to be incorporated. We aimed to implement next-generation sequencing (NGS) in determining actionable targets to guide appropriate molecular targeted therapy in HNSCC patients. Materials and Methods Ninety-three tumors and matched blood samples underwent targeted sequencing of 244 genes using the Illumina HiSeq 2500 platform with an average depth of coverage of greater than 1,000. Clinicopathological data from patients were obtained from 17 centers in Korea, and were analyzed in correlation with NGS data. Results Ninety-two of the 93 tumors were amenable to data analysis. TP53 was the most common mutation, occurring in 47 (51%) patients, followed by CDKN2A (n=23, 25%), CCND1 (n=22, 24%), and PIK3CA (n=19, 21%). The total mutational burden was similar between human papillomavirus (HPV)–negative vs. positive tumors, although TP53, CDKN2A and CCND1 gene alterations occurred more frequently in HPV-negative tumors. HPV-positive tumors were significantly associated with immune signature-related genes compared to HPV-negative tumors. Mutations of NOTCH1 (p=0.027), CDKN2A (p < 0.001), and TP53 (p=0.038) were significantly associated with poorer overall survival. FAT1 mutations were highly enriched in cisplatin responders, and potentially targetable alterations such as PIK3CA E545K and CDKN2A R58X were noted in 14 patients (15%). Conclusion We found several targetable genetic alterations, and our findings suggest that implementation of precision medicine in HNSCC is feasible. The predictive value of each targetable alteration should be assessed in a future umbrella trial using matched molecular targeted agents.

        • KCI등재

          Time Trends for Prostate Cancer Incidence from 2003 to 2013 in South Korea: An Age-Period-Cohort Analysis

          이현영,김도경,두승환,양원재,송윤섭,이보라,김재헌 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1

          Purpose Prostate cancer (PCa) incidence is affected by aging phenomenon and performance of screening test. In United States, PCa incidence is affected by period effect of U.S. Preventive Services Task Force (USPSTF) recommendation. However, no study has reported the effect of USPSTF recommendation or aging phenomenon on PCa incidence in South Korea. Thus, the objective of this study was to investigate effects of age, period, and birth cohort on PCa incidence using age-period-cohort analysis. Materials and Methods Annual report of cancer statistics between 2003 and 2013 from National Health Insurance Service (NHIS) in South Korea for the number of PCa patients and Korean Statistical Information Service (KOSIS) data between 2003 and 2013 from national statistics in South Korea for the number of Korean male population were used. Age-period-cohort models were used to investigate effects of age, period, and birth cohort on PCa incidence. Results Overall PCa incidence in South Korea was increased 8.8% in annual percentage (95% confidential interval, 6.5 to 11.2; p < 0.001). It showed an increasing pattern from 2003 to 2011 but a decreasing pattern from 2011 to 2013. Age increased the risk of PCa incidence. However, the speed of increase was slower with increasing age. PCa incidence was increased 1.4 times in 2008 compared to that in 2003 or 2013. Regarding cohort effect, the risk of PCa incidence started to increase from 1958 cohort. Conclusion PCa incidence was affected by period of specific year. There was a positive cohort effect on PCa incidence associated with age structural change.

        • KCI등재

          Apatinib Combined with Local Irradiation Leads to Systemic Tumor Control via Reversal of Immunosuppressive Tumor Microenvironment in Lung Cancer

          Li-jun Liang,Chen-xi Hu,Yi-xuan Wen,Xiao-wei Geng,Ting Chen,Guo-qing Gu,Lei Wang,You-you Xia,Yong Liu,Jia-yan Fei,Jie Dong,Feng-hua Zhao,Yiliyar Ahongjiang,Kai-yuan Hui,Xiao-dong Jiang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

          Purpose This study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma. Materials and Methods Lewis lung cancer cells were injected into C57BL/6 mice in the left hindlimb (primary tumor; irradiated) and in the right flank (secondary tumor; nonirradiated). When both tumors grew to the touchable size, mice were randomly divided into eight treatment groups. These groups received normal saline or three distinct doses of apatinib (50 mg/kg, 150 mg/kg, and 200 mg/kg) daily for 7 days, in combination with a single dose of 15 Gy radiotherapy or not to the primary tumor. The further tumor growth/regression of mice were followed and observed. Results For the single 15 Gy modality, tumor growth delay could only be observed at the primary tumor. When combining SABR and apatinib 200 mg/kg, significant retardation of both primary and secondary tumor growth could be observed, indicated an abscopal effect was induced. Mechanism analysis suggested that programmed death-ligand 1 expression increased with SABR was counteract by additional apatinib therapy. Furthermore, when apatinib was combined with SABR, the composition of immune cells could be changed. More importantly, this two-pronged approach evoked tumor antigen–specific immune responses and the mice were resistant to another tumor rechallenge, finally, long-term survival was improved. Conclusion Our results suggested that the tumor microenvironment could be managed with apatinib, which was effective in eliciting an abscopal effect induced by SABR.

        • KCI등재

          Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN

          Tonglei Liu,Shuang Liu,Yu Xu,Ruo Shu,Feng Wang,Cheng Chen,Yujian Zeng,Huayou Luo 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

          Purpose This study aimed to probe into the associations among circular RNA ZFR (circ-ZFR), miR- 130a/miR-107, and PTEN, and to investigate the regulatory mechanism of circ-ZFRmiR- 130a/miR-107PTEN axis in gastric cancer (GC). Materials and Methods GSE89143 microarray data used in the study were acquired from publicly available Gene Expression Omnibus database to identify differentially expressed circular RNAs in GC tissues. The expressions of circ-ZFR, miR-130a, miR-107, and PTEN were examined by real-time reverse transcription polymerase chain reaction, while PTEN protein expression was measured by western blot. The variation of GC cell proliferation and apoptosis was confirmed by cell counting kit-8 assay and flow cytometry analysis. The targeted relationships among circ- ZFR, miR-130a/miR-107, and PTEN were predicted via bioinformatics analysis and demonstrated by dual-luciferase reporter assay and RNA immunoprecipitation assay. The impact of ZFR on gastric tumor was further verified in xenograft mice model experiment. Results Circ-ZFR and PTEN were low-expressed whereas miR-107 and miR-130a were highexpressed in GC tissues and cells. There existed targeted relationships and interactions between miR-130a/miR-107 and ZFR/PTEN. Circ-ZFR inhibited GC cell propagation, cell cycle and promoted apoptosis by sponging miR-107/miR-130a, while miR-107/miR-130a promoted GC cell propagation and impeded apoptosis through targeting PTEN. Circ-ZFR inhibited cell proliferation and facilitated apoptosis in GC by sponging miR-130a/miR-107 and modulating PTEN. Circ-ZFR curbed GC tumor growth and affected p53 protein expression in vivo. Conclusion Circ-ZFR restrained GC cell proliferation, induced cell cycle arrest and promoted apoptosis by sponging miR-130a/miR-107 and regulating PTEN.

        • KCI등재

          Involvement of Up-regulation of Death Receptors and Bim in Hispolon-mediated TNF-related Apoptosis-inducing Ligand Sensitization in Human Renal Carcinoma

          Jung Mi Yun,Kyoung-jin Min,Taeg Kyu Kwon 대한암예방학회 2019 Journal of cancer prevention Vol.24 No.3

          Background: Hispolon has been shown to possess antitumor effects in various cancer cells. However, the underlying mechanisms are not fully understood. In this study, we evaluated the sensitizing effect of hispolon on TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human renal carcinoma cells. Methods: Apoptosis was analyzed by using cell-based cytometer. The mRNA levels were assessed by reverse transcription-PCR. Bax activation was determined by oligomerization and fluorescence-activated cell sorting with Bax-NT monoclonal antibody. The protein expression was measured by Western blotting. Results: Hispolon induced up-regulation of Bim and death receptors expression at the post-translational level. Conclusions: Hispolon enhanced TRAIL-mediated apoptosis in renal carcinoma cells, but not in normal cells. (J Cancer Prev 2019;24:155-162)

        • KCI등재

          Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis

          Nan Li,Junjie Piao,Xinyue Wang,김기열,배정윤,Xiangshan Ren,Zhenhua Lin 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4

          Purpose This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. Materials and Methods The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. Results Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth. Conclusion Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.

        • KCI등재

          Hesperidin과 Hesperetin의 in vitro에서의 항산화 효과

          김현영,이여,조은주 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.4

          In this study, we investigated the antioxidant activity of hesperidin and hesperetin, which are the active compounds from Citrus junos, under in vitro. We measured the scavenging activities of hesperidin and hesperetin on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical (․OH), nitric oxide (NO) and the inhibition activities on oxidation of protein and lipid under in vitro. Hesperidin and hesperetin dose-dependently scavenged DPPH, ․OH and nitric oxide (NO). In addition, hesperidin and hesperetin significantly reduced oxidation of protein and lipid induced by 2,2'-azobis(2-aminopropane) dihydrochloride. Hesperidin had stronger activity in protein oxidation, on the other hand hesperetin had stronger activity in lipid oxidation. The present study indicates that hesperidin and hesperetin would have antioxidant activities by protecting against oxidative damage induced by free radicals. (Cancer Prev Res 15, 333-339, 2010)

        • KCI등재

          Tumor-Associated Macrophages Derived TGF-β-Induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells through Smad2,3-4/Snail Signaling Pathway

          Jianhui Cai,Limin Xia,Jinlei Li,Shichang Ni,Huayu Song,Xiangbin Wu 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1

          Purpose We investigated the role of tumor-associated macrophages (TAMs) on the epithelial to mesenchymal transition (EMT) of colorectal cancer cells and determined the potential mechanism involved in the metastatic process. Materials and Methods In this study, flow cytometry was used to detect the expression of target proteins. We used transwell assay to evaluate the migration of cancer cells under specific conditions. Using real-time polymerase chain reaction, we examined the expressions of cytokines and EMTrelated markers in mRNA level. Animal assay was performed for analysis in vivo and hematoxylin and eosin was used to visualize the effect of TAMs on tumor metastasis. We also used immunohistochemistry and Western blotting to detect the expression of target proteins. Results Here, we observed enrichment of TAMs in colorectal tumor tissues, resulting in high metastasis in clinical therapy. Moreover, those TAMs could facilitate the EMT progression of colorectal cancer cells, which is induced by the transforming growth factor-β (TGF-β) derived from TAMs, leading to the invasion and migration of cancer cells. Conclusion Our results demonstrated that TAMs contributed the EMT progression through a TGF-β/ Smad2,3-4/Snail signaling pathway, and disrupting this pathway with TGF-β receptor inhibitor could suppress metastasis, readjusting our focus to the connection of TAMs and cancer metastasis.

        • KCI등재후보

          Cytogenetic Study in Suspicious Cases of Malignant Pleural Effusion

          Seung-Bum Han,Dae-Kwang Kim 대한암학회 2002 Cancer Research and Treatment Vol.34 No.3

          Purpose: This study was performed to detect malignantcells in suspicious cases of malignant pleural effusionby cytogenetic analysis.Materials and Methods: Eleven cases with pleural effusionwere included in this study. Cells in pleural effusionwere treated by direct, or short term, culture to preparechromosomes. To analyze chromosomes, the G-bandingmethod was used.Results: Chromosome preparations succeeded in 10cases. 5 cases had normal karyotypes, but in 2 of thesecases malignant cells were detected on cytologicalexamination. The other 5 cases had abnormal chromosomes,but on cytological examination showed normalcell appearances.Conclusion: Cytogenetic analysis of pleural effusions isnot used routinely, but is more sensitive than the cytologicalexamination of malignant pleural effusions. So, chromosomeanalysis is a good diagnostic tool, when chromosomalabnormalities are detected in an effusion. If acombination of cytology and cytogenetic study are used,the chance of detecting malignant cells in pleural effusionwill be higher, and then more invasive diagnostic procedures,such as thoracoscopy or thoracotomy, could beavoided. (Cancer Res Treat. 2002;34:234-238)

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