올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.

진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

자폐스펙트럼 장애아동의 의사소통 기술 향상에 관한 단일대상연구의 문헌 분석

정유진,윤현숙 이화여자대학교 특수교육연구소 2014 특수교육 Vol.13 No.1

이 연구는 2007년부터 2013년까지 이루어진 자폐스펙트럼 장애아동의 의사소통 기술 향상을 위한 연구들을 조사하여, 일반적인 특징과 동향을 알아보고, 단일대상연구 증거기반 실제(evidence-based practices: EBP)의 기준이 되는 Horner 등(2005)이 제안한 질적 지표를 기초로 중재방법에 대한 문헌 분석을 실시하였다. 연구 결과, 첫째, 자폐스펙트럼 장애아동의 의사소통 기술 향상을 위한 단일대상연구들의 일반적인 특징을 분석한 결과, 연구대상 측면에서는 3명 이상으로 실시된 연구들이 절반 이상이었고, 연령은 주로 초등연령에서 이루어져 왔으며, 장애정도는 경증-중간 자폐에서부터 중도 자폐에 이르기까지 고르게 이루어져 왔다. 연구환경은 여러 기타 외부 환경에서 이루어진 연구들이 절반을 차지하였고, 실험설계는 주로 중다 기초선 설계와 중다 간헐 기초선 설계를 많이 사용했다. 독립변인으로는 다양한 중재방법들이 사용되었으며, 이 중 4편 이상의 논문에서 실시된 중재로는 상황이야기 중재, 보완대체 의사소통 중재가 있었다. 다음으로 종속변인으로는 의사소통 기능 증진의 효과를 본 연구들이 절반 이상을 차지하였다. 둘째, 자폐스펙트럼 장애아동의 의사소통 기술 향상을 위한 단일 대상연구들의 증거기반 실제의 기준이 되는 질적 지표 충족 정도를 살펴본 결과, 질적 지표의 영역별 평균 충족률은 종속변인 96%, 기초선 94%, 대상자 및 환경 91%, 실험통제 및 내적 타당도 91%, 독립변인 78%, 사회적 타당도 64%, 외적 타당도 62% 순으로 나타났다. 또한 각 논문별로 질적 지표의 충족여부를 살펴본 결과 21가지 질적 지표 중 90%에 해당되는 19가지의 질적 지표를 모두 충족시키는 경우는 6편(23%)인 것으로 나타났다. In this study, we investigated literatures done through 2007 to 2013 about the improvement of communication skill in children with autism spectrum disorder. We examined general feature and trends, and performed qualitative analysis based on quality indicator which can be a standard for evidence-based practice(EBP) in single subject research suggested by Horner et al.(2005). In the view of general feature and trends, we first found that more than half studies were performed with three or more children in terms of subject of study, and mainly carried out in the age before 13. Severity of disability was identified evenly from mild and moderate to severe autism. From the side of research environment, more than half studies were performed in many different environments, mostly using multiple baseline design and multiple probe design. Various interventions were conducted as independent variable. Social stories intervention and augmentative and alternative communication intervention(AAC) were employed in more than 4 literatures. In dependent variable, it was confirmed that more that half of studies showed the significant improvement in communication skill. In the analysis of satisfaction level in quality indicator, the average level of areal satisfaction in quality indicator was respectively 96% in dependent variable, 94% in baseline, 91% in subjects and environments, 91% in experimental control/internal validity, 78% in independent variable, 64% in social validity, and 62% in external validity. Besides, among all literatures examined by satisfaction level in quality indicator, 6 literatures (23%) fulfilled the requirements of 19 out of 21 quality indicators.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

공황 장애 환자에서 부모-자녀 결합 형태와 성격 요인에 관한 연구

윤혜진,이현수,정인과 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

In order to investigate the relationship between personality factors and parents-child bonding patterns influencing the development of panic disorder, we in Gu-Ro hospital studied 39 patients with panic disorder with 16 Personality Factor Questionnaire(16PF) and Parental Bonding Instrument. The results were as follows : 1) Higher overprotection scores and lower caring scores were noted in PBI. In 16PF higher desurgency, shyness, praxernia, guilt-proneness, liberalism and anxiety were observed. 2) Maternal overprotection was positively correlated with dominance, shyness, conservatism and maternal caring was positively correlated with dominance, high superego, suspiciousness, shrewdness. Paternal overprotection was positively correlated with self-control. Paternal caring was positively correlated with high intelligence, stableness and was negatively correlated with anxiety. Paternal overprotection and caring were negatively correlated with each other. Maternal overprotection was positively correlated with Paternal overprotection. 3) Groups classified by parental bonding pattern indicated that affectionless control(group Ⅳ) was correlated with more negative aspects of personality factors. These findings suggest than panic disorder patients have highly overprotection and low caring parents and that they have negative aspects of personality factors. Such negative aspects of personality factors seem to be related with their negative parent-child bonding patterns.

향신료의 젖산균에 대한 항균력 비교 연구

정현진,김미경,김미정,김순동 대구효성가톨릭대학교 식품과학연구소 1997 식품과학지 Vol.9 No.-

32종의 향신료를 물, 에탄올, 에틸에테르 및 에틸아세테이트로 추출하여 김치의 주발효균인 L. plantarum과 Leu. mesenteroides에 대한 항균력을 조사하였다. L. plantarum에 대한 항균력은 물 추출물에서는 caraway, cardamon, paprika, tarragon을 제외한 28종에서 항균력이 있었으며, 에틸에테르추출물에서는 arrowroot, paprika 및 tarragon을 제외한 29종이 항균력이 있었다. 에틸아세테이트추출물에서는 paprika 및 tarragon을 제외한 30종이 항균력이 있었으며, 에탄올추출물에서는 clove, paprika와 tarragon을 제외한 29종이 항균력을 나타내었다. Leu. mesenteroides에 대한 항균력은 물추출물에서는 caraway, cardamon, paprika 및 thyme을 제외한 28종에서 항균력을 나타내었으며, 에틸에테르추출물에서는 cardamon, cumin, paprika, tarragon 및 thyme을 제외한 27종이 항균력을 나타내었다. 에틸아세테이트추출물에서는 paprika 및 thyme을 제외한 30종이 항균력이 있었으며, 에탄올추출물에서는 cardamon, cumin, paprika 및 thyme을 제외한 28종이 항균력이 있었으며, 그 중 arrowroot, basil, garlic과 turmeric이 비교적 우수하였다. Leu. mesenteroides에는 항균력이 없으나 L. plantarum에는 높은 항균력을 가지는 것으로는 thyme 물추출물, cardamon, cumin 및 thyme의 에탄올추출물과 에틸에테르추출물, thyme의 에틸아세테이트추출물 등이었다. L. plantarum에 대하여 항균력을 나타내는 thyme 물추출물과 Leu. mesenteroides에 대하여 항균력을 나타내는 tarragon 물추출물을 첨가한 김치의 보존성을 조사한 결과 thyme 물추출물을 첨가한 경우에서 보존성과 품질면에서 양호하였다. 그 중 L. plantarum에 항균력이 있는 thyme 물추출물 첨가한 김치가 보존성 뿐만 아니라 맛에 있어서도 우수한 효과를 나타내었다. Antimirobial activities of 32 kinds of spices extracts on microorganisms related to kimchi fermentation were investigated. 32 kinds of spices such as allspice, arrowroot, basil, bay leaves, caraway, cardamon, celery, chilli powder, chives, cinnamon, clover, coriander, cumin, dill, fennel, garlic, horseradish, marjorarm, mugwort, mustard, nutmeg, onion, oregano, paprika, parsely, pepper, peppermint, rosemary, sage, tarragon, thyme and turmeric were extracted with water and serveral organic solvents such as ethylether, ethylacetate and ethylalcohol. Fractions were tested for antimicrobial activities against L. plantarum and Leu. mesenteroides. The extract of 28 kinds of spices except caraway, cardamon, paprika and tarragon by water extraction, those of 29 kinds except arrowroot, paprika and tarragon by ethylether extraction, those of 30 kinds except paprika and tarragon by ethylacetate extraction, and those of 29 kinds except clover, paprika and tarragon by ethylalcolhol extraction showed stong antimicrobial activities against L. plantarum. On the other hand, the extracts of 28 kinds of spices except caraway, cardamon, paprika and thyme by water extraction and those of 27 kinds except cardamon, cumin, paprika, tarragon and thyme by ethylether extraction, and those of 30 kinds except paprika and thyme by ethylacetate extraction, and those of 28 kinds except cardamon, cumin, paprika and thyme by ethylalcohol extraction showed strong antimicrobial activities against Leu. mesenteroides. Thyme extract by water extraction especially showed strong antimicrobial activities against kimchi microorganisms, finally prolonging shelf-life and enhancing quality of kimchi. The results suggest the possible use of the spices extract as natural preservatives for kimchi.

한국인 정상교합자의 3차원 디지털 모형을 이용한 순,협측 치면 곡률

채지현,송진욱,차정열,최정수,박영철 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.2

본 연구는 한국인의 치아형태에 적합한 브라켓 베이스를 만들기 위해 임상 치관의 순, 협측 곡률을 3차원적으로 계측하여 치관의 곡률 자료를 얻고자 하였다. 정상적인 해부학적 형태를 가지는 구강모형 30쌍을 3차원 디지털 모델로 제작한 후, FA점을 기준으로 수평 기준면과 수직 기준면을 설정하였다. 이 기준면에 대한 치면의 곡선을 형성한 후, 곡률을 이차방정식의 계수로 표현하였다. 수평면과 수직면의 곡률과 FA점을 기준으로 근심과 원심, 치은측과 교합면측의 곡률을 측정한 결과, 상악견치와 상악 제2소구치 외에는 남녀간 치면 곡률의 유의한 차이가 없었다. 하악 측절치, 상악 견치, 상하악 제1, 2소구치와 제1대구치에서 근원심 또는 치은교합면측 치면 곡률의 유의한 차이가 관찰되었다 (P < 0.05). 본 연구에서 얻어진 순, 협측 치면의 곡률 자료는 한국인의 치아 형태에 적합한 Straight Wire Appliance 개발의 기초 자료로 활용될 수 있다. Objective: This study was performed to investigate the labio/buccal clinical crown curvatures of Korean permanent teeth and to obtain the curve-ratio data in an attempt to fabricate bracket bases fit for each individual Korean permanent tooth. Methods: Three-dimensional digital models were made from 30 sets of dental casts with normal anatomic structures. According to the FA points, horizontal and vertical reference planes were established and lines were drawn on the tooth surfaces in reference to these planes. The curvature was expressed as the coefficient of a quadratic equation. Lines mesial, distal, gingival and occlusal to the horizontal, vertical reference planes and the FA point were drawn. Results: The curvature measured for each line revealed that there are no significant differences between male and female, except for maxillary canines and maxillary second bicuspids (P > 0.05). There were notable differences in the mesio-distal or gingivo-occlusal curvatures among the mandibular lateral incisors, maxillary canines, maxillary and mandibular first and second bicuspids and first molars (P < 0.05). Conclusions: The labial & buccal crown curvatures of teeth in Korean normal occlusion were measured on the mesial and distal, gingival and occlusal sides respectively in this study. Based on these data, a SWA can be developed to fit the individual features of Korean tooth crowns.

파노라마방사선사진 지수와 임플란트 실패와의 관계에 관한 연구

조현정,이원진,허민석,안창현,이진구,이삼선,최순철 大韓口腔顎顔面 放射線學會 2004 Imaging Science in Dentistry Vol.34 No.1

Purpose : Several panoramic indices have been suggested to assess bone quality from the morphology and width of mandibular cortex on panoramic radiography. The purpose of this study was to compare dental implant failure group with control group in panoramic mandibular index (PMI), mandibular cortical index (MCI), and gonion index (GI) and to determine the effect of these panoramic indices on dental implant failure. Materials and Methods : A case-control study was designed. Test group (n = 42) consisted of the patients who had their implants extracted because of peri-implantitis. Control group (n = 139) consisted of the patients who retained their implants over one year without any pathologic changes and had been followed up periodically. They had dental implants installed in their mandibles without bone augmentation surgery from 1991 to 2001. The following measures were collected for each patients: 1) PMI, MCI, and GI were measured twice at one-week interval on preoperative panoramic views; and 2) age, sex, implant length, implant type, installed location, occluding dentition state, and complication were investigated from the chart record. Results : The PMI showed moderate level of repeatability. The intra-observer agreement of MCI and GI were good. There was statistically significant difference in PMI between two groups. There were significant different patterns of distribution of MCI and GI between two groups. Among the panoramic indices, PMI and MCI showed significant correlation with dental implant failure. Conclusion : Panoramic indices can be used as reference data in estimating bone quality of edentulous patients who are to have implants installed in their mandibles.

폐결핵 환자 혈청에서 수용성 Interleukin 2 수용체 및 Adenosine Deaminase 활성도에 관한 연구

고정희,박성규,백상현,박찬권,박병수,안진영,최우석,박정규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Interleukin-2 (IL-2) induces T cell proliferation in an autocrine manner and provides a means by which antigen triggered T cells can be clonally expanded in vitro. During the following activation, the activity of IL-2 is mediated by specific high affinity IL-2 binding membrane receptors which are expressed shortly after activation. In this process, a 42 KD-fragment (soluble IL-2R) is continuously cleaved off and circulates as a soluble marker of T lymphocyte activation. Elevated level of soluble IL-2R has been identified in the serum of patients with malignant autoimmune and allergic disorders, systemic parasitic infection, undergoing graft versus host disease, acute or chronic lymphocytic leukemia and HIV-infection. ADA (adenosine deaminase) completes the process of differentiation of T cell and is essential for progression of T cell maturation. Therefore level of ADA is to correlated with magnitude of T cell immune response. The fact that expression of sIL-2R and ADA activity increases in peripheral blood T-lymphocytes of patients with active pulmonary tuberculosis suggests that T cell activation might have a major role in the pathogenesis of pulmonary tuberculosis. In order to evaluate the T cell immune response in pulmonary tuberculosis, we measured the serum concentration of sIL-2R and ADA activity in 17 patients with current pulmonary tuberculosis, 10 chronic inactive pulmonary tuberculosis, 10 as normal controls. (1) Current pulmonary tuberculosis had significantly higher levels of sIL-2R (237.24±95.47)when compared with those of inactive tuberculosis (78.6±11.06). and the control (68.17±15.4) group. (2) ADA activity in current pulmonary tuberculosis was significantly increased (34.41±20.63) when compared with those of inactive tuberculosis (24.7±14.36) and control (17.65± 5.94) group. (3) There was good correlation between sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group. (4) sIL-2R concentration and ADA activity was decreased significantly 6 months after anti-tuberculosis drug medication. In conclusion, sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group was increased when compared with those of inactive pulmonary tuberculosis and the control group. By the way, T cell mediated immune response was enhanced in current pulmonary tuberculosis, but in inactive chronic pulmonary tuberculosis who had treated by antituberculosis drug medication, the concentration of sIL-2R and ADA activity was nearly normal.

다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.