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        • 1LN-11: Development of stretchable electrode based on polymeric nanofiber and nanoparticle composites

          임정균 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0

          Conductive electrodes and electric circuits that can remain active and electrically stable under large mechanical deformations are highly desirable for applications such as flexible displays, field-effect transistors, energy-related devices, smart clothing, and actuators. However, high-conductivity and stretchability seems to be mutually exclusive parameters. Here we introduce a conductive composite mat of silver nanoparticles and rubber fibers that allows the formation of highly stretchable circuits through a fabrication process that is compatible to any substrate and scalable for large-areas applications. Silver nanoparticle precursor is absorbed in electrospun poly(styrene-block-butadiene-block-styrene) (SBS) rubber fibers and then converted into silver nanoparticles directly in the fibers mat. Percolation of the Ag nanoparticles inside the fibers leads to a high bulk conductivity which is preserved at large deformation.

        • KCI등재

          소염약침 복합치료가 교통사고로 인한 초기 경추 편타 손상에 미치는 영향

          임정균,이진복,이형걸,육태한,김종욱 대한침구의학회 2011 대한침구의학회지 Vol.28 No.4

          Objectives : This study was performed to evaluate the effects of the acupuncture therapy in combination with Soyeom pharmacopuncture therapy on acute whiplash injury by traffic accident. And thermal change of posterior neck and shoulder was observed. Methods : The clinical study was conducted to 20 cases of acute whiplash injury patients who had been admitted in Dept. of Acupuncture and Moxibusion, Woosuk University Hospital from December 1, 2010 to May 31, 2011. The patients were randomly divided into two groups. In one group(test group), patients were treated with the acupuncture therapy in combination with Soyeom pharmacopuncture therapy. And in the other group(control group), patients were treated with acupuncture therapy only. To estimate the efficacy of treatments, visual analog scale(VAS), neck disability index(NDI) of posterior neck pain were checked. And also thermal change of posterior neck and shoulder was observed by digital infrared thermographic imaging(DITI). Results : Both group represented effective improvement in VAS and NDI of posterior neck pain. Especially, test group is more effective than control group in VAS comparison, statistically. In test group, temperature of posterior neck and shoulder was decreased after treatments. But there was no significant difference between two groups on thermographic change. Conclusions : Through this study, Soyeom pharmacopuncture therapy is considered to be effective for reducing pain in acute whiplash injury patients. And after Soyeom pharmacopuncture therapy, temperature of posterior neck and shoulder show a tendency to decrease.

        • KCI등재

          A Blood-brain Barrier Permeable Derivative of 5-Fluorouracil: Preparation, Intracellular Localization, and Mouse Tissue Distribution

          임정균,Goutam,Biswas,김완일,김경태,정성기 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.3

          5-Fluorouracil (5-FU), an anticancer agent was covalently attached to the recently developed sorbitol-based G8transporter, and the conjugate (7) with FITC was found to have an affinity toward mitochondria and to readily cross BBB to gain an entry into mouse brain. Measured by IC_50, the conjugate (9) without the fluorophore showed enhanced cytotoxic activity toward two types of multidrug-resistant cell lines. These results strongly suggest that the sorbitol-based G8 transporter can be utilized as a good CNS delivery vector.

        • KCI등재

          足三里(ST36)穴 刺鍼 후 시행한 燒山火法과 透天凉法이 체표온도 변화에 미치는 영향 비교

          임정균,이형걸,정다정,육태한,김종욱 대한침구의학회 2012 대한침구의학회지 Vol.29 No.2

          Objectives : This study was performed to compare the effects between Mountain-burning fire method and Heaven-penetrating cooling method on thermographic change. Materials and Methods : The experiment was conducted to 20 students of College of Oriental Medicine, Woosuk University from July 12, 2011 to July 26, 2011. Acupuncture stimulation was applied at left Zusanli(ST36) with Mountain-burning fire method in A group(n=10) and Heaven-penetrating cooling method in B group (n=10). To estimate thermographic change, temperature of left Zusanli(ST36), Shuigou(GV26), Zhongwan(CV12) were measured by DITI(digital infrared thermographic image) before acupuncture stimulation and 30sec, 10min after needle removal. Results : In A group, the temperature of left Zusanli(ST36), Shuigou(GV26), Zhongwan(CV12) were decreased at 30sec after needle removal, statistically. And the temperature of Zusanli(ST36), Zhongwan(CV12) were decreased at 10min after needle removal, statistically. In B group, the temperature of Zusanli(ST36), Zhongwan(CV12) were decreased at 10min after needle removal, statistically. But, there was no significant difference between two groups on thermographic change, statistically Conclusions : Acupuncture stimulation applied at left Zusanli(ST36) with Mountain-burning fire method has more widespread effects than Heaven-penetrating cooling method. But further studies will be needed such as thermographic change with no stimulation and with more subjects.

        • KCI등재

          정신지체에 대한 한의학 치료와 연구 동향;2003-2007년 중국 임상 논문에서

          임정균,김락형,Im,,Jeong-Gyun,Kim,,Lak-Hyung 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.1

          Objectives This study was designed to analyze the clinical studies on Mental retardation(MR) in traditional Chinese medicine(TCM). Methods For this study, we searched the clinical studies on MR, which had been published from 2003 to 2007, through web site CNKI(中國知識基礎設施工 http://www.cnki.net). There were 17 clinical studies and we focused on those studies. Results 1. In those Chinese studies, they used following words to describe Mental retardation; 小人弱智($xi\check{a}o\acute{e}rru\grave{o}zh\grave{i}$), 智能發育不全($zh\grave{i}n\acute{e}ngf\bar{a}y\grave{u}buqu\acute{a}n$), 智力低下($zh\grave{i}l\grave{i}d\bar{i}xi\grave{a}$), 精神發育遲滯($j\bar{i}ngsh\acute{e}f\bar{a}y\grave{u}ch\acute{i}zh\grave{i}$), 智能落后($zh\grave{i}n\acute{e}nglu\grave{o}h\grave{o}u$), 智能落后($zh\grave{i}n\acute{e}ngch\acute{i}hu\check{a}n$), 失天愚型患人($xi\bar{a}nti\bar{a}ny\acute{u}x\acute{i}nghu\grave{a}n'\acute{e}r$). 2. There were many kinds of TCM treatment methods for MR, such as herbal medicine, acupuncture, electroacupunture, acupoint injection, Chuna therapy, and special education. And those TCM treatments methods showed higher efficacies in the treatment of MR compared with Western medicine. 3. Mental retardation was related with the deficiency of heart, kidney, liver, spleen(心虛, 腎虛, 肝虛, 脾虛) and the pathological mechanism of Phlegm(絹) and Blood stasis(慫沂)in the studies about the Bian Zheng-the types of differential diagnosis- of MR. 4. Most of studies used Intelligence Quotient(IQ) to assess the efficacy of TCM treatment of MR. And the duration of treatment, the degree of illness, the age of patient, and the cause of illness affected the prognosis of MR. Conclusions These results suggest that traditional medicine could be one of the useful treatments on MR. And these results could be used in the clinical practices and studies on MR in Korea.

        • KCI등재

          Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporter

          임정균,Kaustabh,K.,Maiti,김완일,김경태,정성기 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.4

          The biotin-attached G8 molecular transporter (5) was synthesized and used together with quantum dots in preparing the complexes (QD-MT). The QD-MT complexes were studied in terms of the cellular uptake and the internalization mechanism in live HeLa cells with the aid of various known endocytosis inhibitors. It has been concluded that the QD-MT complex is internalized largely by macropinocytosis. The mouse tissue distribution of the QD-MT complex by i.p. and i.v. routes showed some organ selectivity and a good ability to cross the BBB.

        • AZT 또는 5-Fu이 결합된 분자 수송체들의 고유 특성 분석과 세포 내 위치 연구

          임정균 순천향대학교 부설 산업기술연구소 2015 순천향 산업기술연구소논문집 Vol.20 No.1

          대표적인 에이즈 치료제인 AZT와 종양치료에 널리 쓰이는 5-Fu 모두 혈뇌장벽을 통과하지 못하고 뇌로 전달되지 못하는 결 점을 갖고 있다. 최근에 소르비톨을 근간으로 하는 분자수송체와 AZT 또는 5-fluorouridine이 결합된 새로운 결합체가 합성되 었고 형광체를 포함하고 있다. 두 가지 결합체의 UV-Vis 및 HPLC를 통한 고유특성 데이터를 얻어 분석하였고 결합체들의 Hela세포 내에서의 위치를 live와 fixation 처리 후 비교 실험하여 상이한 결과를 얻었다.

        • 합성 트레할로스 유도체의 세포독성 실험

          임정균 순천향대학교 부설 산업기술연구소 2016 순천향 산업기술연구소논문집 Vol.22 No.1

          트레할로스는 포도당 두 개로 이루어진 이당류의 탄수화물인데 최근에 퇴행성신경질환의 치료에 도움이 된다 고 보고되고 있다. 최근에 우리그룹에서는 트레할로스 유도체들을 4가지 종류로 합성하였으며 세포막 투과를 잘하고 쥐의 뇌에 잘 도달하여 혈뇌장벽을 투과함을 보고하였다. 이러한 트레할로스 유도체들의 세포독성을 측정하기 위하여 MTS와 MTT 실험방법을 이용하였다. TD-G8 보다 TD-G6가 세포독성이 적었으며 TD-G6의 IC50 값은 100 μM가 넘어 독성이 매우 적다는 것을 알 수 있었다.

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