정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

검사시간의 경과에 따른 컴퓨터 신경행동검사 수행기능의 변화양상

정성태,전만중,사공준 大韓産業醫學會 2007 대한직업환경의학회지 Vol.19 No.4

목적: 컴퓨터 신경행동검사에서 검사시간의 경과에 따른 측정치들의 타당도 변화양상과 타당도에 영향을 미치는 요인들을 평가하고 수용할 만한 타당도가 나타나는 최소한의 검사시간을 제시하여 컴퓨터 선경행동검사의 결과 해석의 정확성을 높이고 검사시간 설정의 기준으로 활용 하고자 수행되었다. 방법: 자동차공장 근로자 중 혼합 유기용제에 만성적으로 노출되는 도장공 118명과 연령을 짝지은 대조군 113명으로 총 231명을 대상으로 하였다. 대상자 전원은 고등학교졸업의 학력을 가진 남자 근로자였으며,연령,작업부서,근무년수,주야간 교대작업 여부,음주 및 흡연 습관을 자기기입식 설문지를 통하여 조사하고 SPES를 이용한 컴퓨터 신경행동검사를 시행하였다. 신경행동검사는 연습수행을 포함하여 단순반응시간 6분,부호숫자짝짓기 10회,손가락두드리기 5회를 수행하였다. 단순반응시간은 1분 단위로, 부호숫자짝짓기와 손가락두드리기는 수행단위(session)마다의 평균반응시간,표준편차 및 두드린 횟수에 대한 검사시간의 경과에 따른 변화양상을 관찰하고 t 통계량과 반복측정분산분석을 이용하여 타당도의 변화양상을 관찰하였다. 결과: 단순반응시간은 도장공과 대조군 모두에서 검사에 대한 미숙함은 적은 반면 시도가 반복됨에 따라 학습 효과에 비해 지루함 혹은 흥미의 감소 등의 영향이 더 큰 것으로 나타났다. 도장공과 대조군의 평균반응시간 차이의 타당도는 연습수행 후 1분의 검사시간에서 높았다. 부호숫자짝짓기의 초기에는 검사에 대한 미숙함 등이 많이 개입되며,시도의 횟수가 증가함에 따라 학습효과의 개입이 증가하였다. 5∼7번째 시도의 평균반응시간에 대한 t 동계량이 가장 컸다 손가락두드리기의 경우 우수는 학습 효과에 의해 시도가 반복될수록 두드린 횟수가 증가하는 경향이 있었고 열수는 피로에 의해 두드린 횟수가 점차 감소하는 경향이 있었다. 결론: 따라서 단순반응시간은 연습수행 1회 후 1분(1회째)의 검사를 분석에 이용하고,부호숫자짝짓기는 검사 시작 후 4번의 시도들을 연습수행으로 하며 ,이후 연속적인 3번의 시도에 대한 평균반응시간을 대표값으로 이용하고,손가락두드리기는 연습수행 1회 후 1,2번째 시도의 평균 두드린 횟수를 분석에 이용하면 타당도를 높이고 시간을 절약할 수 있을 것이다. Objective: A cross-sectional study was performed to assess changes in computerized neurobehavioral performance across multiple test sessions for developing a valid performance level and reducing test time. Methods: The study was conducted on 118 male car painters exposed to low-dose, mixed organic solvents. The study controls were 113 unexposed reference workers matched for age and educational year from different sections of the same factory. Each worker completed a medical and occupational exam and questionnaire. Three tests of the Swedish Performance Evaluation System (5 minutes of Simple Reaction Time, 9 sessions of Symbol Digit, and 4 sessions of Finger Tapping Speed) were administered to each group. Results: The mean age, mean duration of employment, and mean years of education were 33 years, 6.7 years, and 12 years in both groups, respectively. The mean reaction times of the Simple Reaction Time increased with the lapse of time. The known group difference between the exposed and control groups was larger for the first minute than for the successive 3 minutes. Both groups showed improved performance across the first to the seventh sessions on Symbol Digit. Following the seventh session, the performance levels of Symbol Digit had worsened. The t statistic of the two groups was the largest when the two mean reaction times were calculated from the sessions of the fifth to the seventh, In the dominant and non-dominant hands, the number of taps increased and decreased, respectively, across the sessions on Finger Tapping Speed. The known group difference was the largest when comparing the performances from the first to the second sessions. Conclusions: For valid interpretation and timesaving in computerized neurobehavioral tests, the following is recommended: one practice and one test session for Simple Reaction Time, four practice and three test sessions for Symbol Digit, and one practice and two test sessions for Finger Tapping Speed.

탈회동결건조골에 혼합한 형질 변형 성장인자(TGF-β1)가 골조직 재생에 미치는 효과

정성민,이만섭,박준봉 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.1

The purpose of ss this study was to observe the effect of TGF-Rl on the regeneration of bone in guided bore regeneration. Four adult dogs aged 12 to 24 months were used in this study. Experimental bone defects were created surgically with surgical bur and chisel on the 3th. premolars. In experimental group; bone defect were grafted with DFDB and TGF-R1. In control groups, bone defects were grafted with only Dl-.DB. At 1, 2, 3 and 4 weeks, dogs were serially sacrificed and specimens were prepared with Hematoxylin-Eosin stain and Goldner`s stain for light microscopic evaluation. The results of this study were as follows 1. The infiltration of inflammatory cells was prominent in control groups at 1, 2 and 3 weeks. 2. The lining of osteoblast was observed at 2 weeks in control group, but at 1 week in experimental group. 3. In both groups, osteoid was formed at 2 weeks. In control groups, osteoid was fromed on only bone surface. but in experimental groups, osteoid were formed on both bone & DFDB surfaces. 4. In only experimental groups, The fusion of new bone & DFDB was only observed at 3 weeks. and the fusion of new bone & DFDG was more prominent at 4 weeks. But in control groups, No fusion of new bone & DFDB was oberved at 3 and 4weeks From the above result, the TGF-01 was effective in bone formation and increased inductive effect of DFDB guided bone regeneration technique. Inductive effect of DFDB was increased with TGF-131.

국내 지역별 섬유산업의 디자인 현황 및 특화 상품 유통 개발 연구

정경연,박성준 홍익대학교 미술디자인 · 공학연구소 2005 미술디자인 논문집 Vol.- No.10

주파수 선택성 레일리 페이딩 환경에서 부호화 기법을 이용한 직교 멀티캐리어 시스템의 오율 해석

정재필,박기식,한성운,조성준 한국항공대학교 1997 論文集 Vol.35 No.-

본 논문에서는 주파수 선택성 레일리 페이딩 환경에서 RS부호화, 컨벌루션 부호화, 연접부화를 이용하는 직교 멀티캐리어 BDPSK시스템과 QDPSK시스템의 오율특성을 구하였다. 오율특성은 정규화된 지연시간(??), 비트에너지 대 잡음전력 스펙트럼 밀도비(??), 희망 신호전력 대 지연되 비희망 신호전력비(D/U)를 파라미터로 하여 나타내었다. 검토한 결과, BDPSK 신호인 경우 D/U가 20[dB]일 대 오율을 ??으로 유지하기 위해 필요한 Eb/No는 Rs부호화, 컨벌루션 부호화 및 연접부호화에서느 각각 대략 20.8[dB], 16.0[dB], 14.5 [dB]가 필요하며, QDPSK신호인 경우 Rs부호화, 컨벌루션 부호화 및 연접부호화에서 각각 대략 24.0[dB], 18.9[dB], 13.5[dB]가 필요함을 알 수 있었다. This paper has evaluated the error performance of orthogonal multicarrier BDPSK and QDPSK systems which use Reed Solomon coding, convolutional coding, and concatenated coding technique in a frequency selective Rayleigh fading environment. The results show that when D/U (desired wave's power to undesired delayed wave's power ratio)=20dB at error rate of ??, Reed Solomeon coded BDPSK signal, convolutional coded BDPSK signal, and concatenated coded BDPSK signal need about 20.8[dB], 16.0[dB], 14.5[dB] respectively in terms of Eb/No, and Reed Solomon coded QDPSK signal, convolutional coded QDPSK signal, and concatenated coded QDPSK signal need about 24.0[dB], 18.9[dB], 13.5[dB] respectively.

두경부 악성종양 절제술 후 유리피판을 이용한 재건술 40예의 고찰

백정환,손영익,김성민,추광철,하범준,심영목 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7

적층 코팅된 초경공구의 마모현상

정준기,조성산,박성호 弘益大學校 科學技術硏究所 1996 科學技術硏究論文集 Vol.7 No.1

On-line monitoring of cutting tool failure such as wear and fracture plays an important role in automation and optimization of machining processes, enhancement of part quality, and cost reduction. Considerable research has been conducted to apply acoustic emission (AE) to detection of tool failure and monitoring of machining processes of its fairly straightforward means of measurement and high sensitivity. In the present study, turning experiments were conducted with two-layer (WC/TiC/Al203) and three-layer (WC/TiC/Al203/TiN) coated tools that exhibit superior wear resistance and high-speed machining capability compared with uncoated tools in order to investigate characteristic variation of AE signals associated with wear of the coated tools and cutting speed. It is observed that the most severe wear of TiN outerlayer of three-layer coated tools occurs on the rake face, and that the wear resistance of the TiN outerlayer and the effect of outerlayer material on the magnitude of initial root mean square of AE decrease with the increase of cutting speed. Although characteristic variation of AE signal with the wear of tools exhibits slight dependence on the cutting speed, it is demonstrated that rapid increase of AE signals at the final stage of tool life can be utilized for on-line monitoring of tool failure in high speed machining.

프린트 기법을 이용한 문화상품 개발 및 연구

정경연,박성준 홍익대학교 산업디자인 연구소 2003 미술디자인 논문집 Vol.- No.8

So far, numerous attempts have been made to commercialize Korea's representative cultures in terms of contemporaneity, but only few of them have been upheld and developed with continuity. The purpose of this study is focused on making neckties, scarves, and purses with applications of weaving machine, our world-famous cultural inheritance, and developing them as general tourist goods. Now, there are many local communities who plan and hold cultural events and festivals featuring their native traditions. In addition, the development of a variety of cultural items is attempted in many-sided ways. Especially, cultural goods made using textile materials can provide more business opportunities for development and marketing, because they are more readily accessible to consumers in actual life. The recent development of digital technology has made it possible to produce various goods in small quantity by realizing the regular use of the digital textile print (DTP) system that allows fabrics to be printed on the spot. Such technological development provides great advantages of shortening the sampling and main processes, identifying consumers' preferences readily, and ultimately controlling the production volume. Therefore, these advantages can lead to higher strength in producing cultural goods that have been under a poor or no distribution system. Likewise, this study produced a small quantity of prototypes using the digital print in a way to examine consumers' preferences, which were difficult to predict through paper design or on the computer screen. As a result, the process of mass production could be handled more carefully after the processes of correcting and making up for the discovered facts. For some items, the weaving technique had to be applied due to those product features and design differences that could not be expressed by the print technique. However, the weaving method has a disadvantage of increasing the unit cost of production, because, although it may give a high-class image to products, it takes a long time to produce prototypes and work on corrections and it is impossible to produce in small quantities. In Korea, local communities (governments) offer various cultural events and functions in a way to promote national competitiveness, also expecting their incidental synergy effects. Those cultural events will serve to attract more tourists, and the development of cultural tourist goods will not only increase the income from tourism, but lead to the qualitative enhancement of cultural events. In conclusion, we will have to continue to concentrate on developing more advanced cultural goods as well as traditional cultural handicrafts.

파킨슨씨병 환자에 있어서 자가부신수질 이식술

정상섭,박상근,오성훈,김선호,윤도흠,박정수,양우익,최인준,안영수,김경환,박창일,김진수,이현철 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6

Recent experimental studies and clinical cases have suggested that grafting tissue from the adrenal medulla into the brain may alleviate the symptoms of Parkinson's disease. Autologous adrenal medullary grafts into the striatum was performed stereotactically in two patients with Parkinson's disease. Both patients were bedridden preoperatively, but 4 months after the surgery both became ambulatory and one was even capable of returning to his job. Even though the number of cases was small⑵ and the follow-up period was short, this study shows that adrenal medullary transplantation into the striatum may have some beneficial effects in patient with Parkinson's disease. Further experimental and clinical trials are necessary to see whether this procedure will be a recommendable surgical treatment for patients suffering from Parkinson's disease.

재중 조선족 문학비평 연구 : 1949년~1990년대 후반

정덕준,이상갑 한국현대문예비평학회 2003 한국문예비평연구 Vol.- No.13

After liberation the literary criticism of a Chinese-Korean people was begun with the basic enlightenment in a blank condition. The literary enlightenment had an extreme left-trend as a political instrument of propaganda. But in the first half of the 1957's the literary criticism of a Chinese-Korean people worked for the essential phase of literature. And yet the attempt died on its' feet by the struggle against the right faction. After the struggle the instrument of propaganda in literature was strengthened, and in the middle term of 1960's the tendency of a class struggle in literature was more deepened. Moreover after the great revolution of culture the three projection-principle required the class consciousness of literature more thoroughly. But after the middle term of 1980's the revaluation of realism and the controversy on the idea-renewal was attempted to overcome its' difficulty. Herewith the literary world was diversified. The open realism, that's it. Hereby the literary world of a Chinese-Korean people arrived at puberty.