정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

마이크로파 여기 플라즈마광 생성을 위한 도파관 시스템 설계에 관한 연구

전상재,전후동,송창현,하석영,이승혁,이태호,박의준 금오공과대학교 2005 論文集 Vol.26 No.-

In this paper, the plasma lighting system(PLS) excited by the commercial high power magnetron is developed. The design concepts are based on maximizing the huninous efficacy in conjunction with the miniaturization of waveguide system Furthermore the fine tuning is simplified by using only one stub, and the impedance matching is maximized by introducing the tapering technique. The experimental results show that the luminous efficacy can be dramatically improved by the proposed design method.

이온화에너지 처리 아이스크림 및 우유의 단회투여 독성시험

이희준,최현종,한선경,구본철,신명수,함준상,조철훈,이완규 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

화학 용액 증착 공정으로 제조된 후막 Pb(Zr_(0.52), Ti_(0.48))O₃의 e_(31,f) 특성

박준식,양성준,강성군,나경환 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.9

Thick Pb(Zr_(0.52), Ti_(0.48))O₃(briefly, PZT) films are required for the cases of micro actuators and sensors with high driving force, high breakdown voltage and high sensitivity, and so on. In this work, thick PZT films were fabricated by chemical solution deposition process. Total 16 types of samples using thick PZT films with thicknesses, about 1 ㎛ and 2 ㎛, and Pt top electrodes shapes for measuring effective transverse piezoelectric coefficients (e_(31,f)) were prepared using MEMS processes. All samples were characterized by fabricated e_(31,f) measurement system before and after poling process at 125 kV/cm and 150℃ for 10 min. |e_(31,f)| values of samples after poling were higher than samples before poling. Those of 2 ㎛ thick PZT films were also higher than 1 ㎛ thick PZT films. We found that |e_(31,f)| was directly related with {111} to {h00} crystal structures of thick PZT films. And those with narrow electrodes (x₁- x_(0)) as top Pt electrodes were also higher than cases with wide top Pt electrodes in agreement with given equation.

소형 소각로에서 운전조건과 온도분포 사이의 관계 분석

김성준,박종환,전봉준 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.B

One aims to find out how the operation condition of secondary inlet angle effects the temperature distribution inside a small incinerator. A finite volume commercial code, PHONICS, is used to simulate the temperature field in an incinerator. The computational grid system is constructed by Multi-Block technique. The governing equations based on the curvilinear coordinates are used. Numerical experiments are done with the five variations of secondary air inlet. The temperature distribution is quantified by the statistical deviation of temperature in an incinerator. The computational analysis says that the certain angle of secondary air inlet could improve the uniformity of temperature distribution in an incinerator.

Pseudomonas sp . EL-091S 에 의한 4-Chlorophenol의 분해 Kinetics

손준석,이건,이상준 한국환경과학회 1993 한국환경과학회지 Vol.2 No.2

In order to find the most fitted biodegradation model, biodegradation models to the initial 4-chlorophenol concentrations were investigated and had been fitted by the linear regression. The degrading bacterium, EL-091S, was selected among phenol-degraders. The strain was identified with Pseudomonas sp. from the result of taxonomical studies. The optimal condition for the biodegradation was as fellows: secondary carbon source, concentration of ammonium nitrate, temperature and pH were 200㎎/l fructose, 600 ㎎/l, 30℃ and 7.0 respectively. The highest degradation rate of the 4-chlorophenol was about 58% for 24 hours incubation on the optimal condition. Biodegradation kinetics model of 5 ㎎/l 4-Chlorophenol, 10 ㎎/l 4-chlorophenol and 50 ㎎/l 4-chlorophenol were fitted the zero order kinetics model, respectively.

2차 공기 주입각도에 따른 소각로 내부의 재순환 영역 변화

김성준,박민주,정봉준 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.B

The purpose of this research is to find out how the inlet angle of secondary air affects the formation of recirculation zone inside a small incinerator. A commercial code, PHOENICS, is used to simulate the flow field of an incinerator. The computational grid system is constructed by Multi-Block technique. Numerical experiments are done with the five different angles of secondary air inlet. The formation of recirculation zone is evaluated by checking velocity fields. The computational results show that recirculation zone is clearly formed from 60 degree of inlet angle and the zone of recirculation is widen as angle of recirculation is increased to 75˚.

초등교과 관련 교수-학습 웹 자료 개발

김상준,신준식,박흥선 춘천교육대학교 초등교육연구소 2001 敎育硏究 Vol.18 No.-

응급실을 내원한 요로결석 환자

김성중,김준식,조준필 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

A clinical study was made on 139 cases of urolithiasis among the total number of 14798 who visited in the emergency center during 7 months from June 1994 to December 1994.The 186 patients was suspected the urolithiasis, then the 150 patients was followed through out-patient department of Urology and performed Intravenous pyelogram. Among the 150 cases, the urolithiasis was confirmed in 139 cases. The results are summarized as follows: 1. The ration of the male to female is approximately 2.97:1. 2. The age of the patients ranged from 20 to 50 in approximately 80.6%. 3. Among 52 patient who were not revealed stone in KUB, 45 patients were shown micro-scopic hematuria. The 22 patients were revealed urolithiasis in IVP.The 6 patients found the urolithiasis spontaneously delivered.The 17 patients were diagnosed through out-patient department of urology. 4. The 7 patients, who not hematuria and no stones in KUB, were revealed urolithiasis in IVP performed at other hospital. 5. The major clinical symptoms and signs were flank pain(117 cases),abdominal pain and suprapublic discomfort(35 cases),fever(7 cases),low back pain(7 cases),nausea and vomiting(6 cases),painful urination(1 case),and urinary frequency(1 case). 6. The specific location of the stones showed 98 cases in ureter, 7 cases in kidney,bilaterality(3 cases),and multiple stones(8 cases). The ureteral stones located most frequently in the lower 1/3 of the ureter with 55 cases.

국내 건설 환경 변화에 따른 여성 인력의 효율적인 활용 방안에 대한 연구

장상용,윤준선,백준홍 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The propose of this study is to present the possible solutions for the shortage of skilled labor in Korean construction industry that is currently encountered. This study examined employment trends in construction industry in Korea and U.S.A. The construction industry is highly influenced by economic cycle. The aging of the crafts and shortage of workers are pressing issue in this industry. In order to solve this problem, The construction industry must lead women labor to enter the their industry with appropriate education. This answer to the shortage is to retain those workers currently worked in other industry and to streamline construction practices to reduce labor strain.