정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

iPhone을 이용한 실시간 부산 버스도착 안내시스템 설계 및 구현

이학수,최희종,김진일 東義大學校産業技術開發硏究所 2011 産業技術硏究誌 Vol.25 No.-

일상생활에서 가장 밀접하게 이용하는 버스 승차에 대한 불편함을 줄이고자 최근 주목 받고 있는 iPhone을 기반으로 부산 버스도착 안내시스템 설계하고 구현하였다. 본 시스템은 인터넷에 접속하여 검색할 필요 없이 응용프로그램에서 사용자가 원하는 정보를 제공하고, 사용자 편의 기능을 구현한 활용 가능한 실시간 부산 버스도착 안내시스템이다. 개발결과는 iPhone에 장착하여 사용할 수 있도록 앱스토어에 업로드하였다.

하악 피질골과 연조직의 해부학적 두께를 위한 정량적 평가

이수경,임원희,전윤식 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.3

한국에서의 간질의 사회적 낙인

이상암,유희정,허경,박형국,신동진,송홍기,정원영,권오영,이성수,김요식,김성은,이병인 대한간질학회 2002 대한간질학회지 Vol.6 No.2

이슬람敎의 中國傳入과 回族共同體의 胎動

李熙秀 漢陽大學校 民族學硏究所 1997 民族과文化 Vol.5 No.-

市乳의 貯藏期間에 따른 耐冷性 微生物 및 化學的 特性의 變化에 關한 硏究

이수원,강일수,양희진,백승천 성균관대학교 생명과학자원연구소 1997 生命資源科學硏究 Vol.4 No.1

The present study was conducted to predict shelf life of pasteurized milk with analysis of volatile compounds and sensory evaluation of milk to growth of psychrotrophic bacteria. Pseudomonas fluorescens KFRI 00194 inoculated concentration of 10^4 cfu/㎖ to observe of changes on sensory evaluation and volatile compounds of pasteurized milk. The results obtained in these experiments were summarized as follows; The psychrotrophic bacteria number at 4℃ were increased 6.39×10 exp(4)cfu/㎖ until first day and 2.20×10 exp(6)cfu/㎖, 1.17×10 exp(7)cfu/㎖ after 5 and 10days, respectively. The volatile compounds were shown the decreasing tendancies in acetaldehyde, ethanol depending on storage days, especially ethanol contents were significantly decreased between 5 and 10days storage(P<0.05). Diacetyl, 2-heptanone, 2-butanone and 3-methyl-1-butanol were shown the increasing tendencies of contents. Diacetyl, 2-heptanone and 2-butanone were significantly increased between 5 and 10days, 1 and 5days, 5 and 10days and 1 and 5days, respectively(P<0.05). However, 3-methyl-1-butanol was shown a increasing tendancy depending on storage days but the significantly different was not recognized. The changes of sensory evaluation were rapidly decrease from 6.8point first day to 4.2point after 10days and the decrease of organoleptic acceptability was significantly different recognized(P<0.05), excepted of 1 and 2days. The organoleptic acceptability according to increasing of psychrotrophic bacteria numbers were decreased. The organoleptic acceptability depending on changes of volatile compounds were shown to a conversed correlation coefficient with the exception of acetaldehyde and acetone. Especially, 2-heptanone, 2butanone and 3-methyl-1-butanol were gradually decreased of acceptability by the contents.

신주위 공간 및 요근을 침범한 췌장성 가성낭포 1례 : 진단및 경피적 배액술 Diagnosis and Percutaneous Drainage

이현경,오연희,이원재,한동선,오민구,이성우,박수성 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

Pancretic pseudocyst is a well-known complication of pancreatitis and may occur in unusual locations. Involvement of the left perirenal space and psoas muscle is rare. Radiologic findings and management of a surgically proven case of pancreatic pseudocyst extending to left perirenal space and psoas muscle is described.

쿠르드인의 종교생활 : -이슬람 이전 전통신앙과 통과의례를 중심으로-

이희수 漢陽大學校 民族學硏究所 1997 民族과文化 Vol.6 No.-

Tryptophan Hydrxylase 유전자 다형성과 정신분열병 및 임상변인과의 관련연구

이성필,백인호,조희수,도규영 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 세로토닌의 속도조절효소인 tryptophan hydroxylase(TPH) 유전자의 다형성은 여러 정신질환의 발병과 임상양상과의 관련성이 연구되었으나 정신분열병 환자를 대상으로 한 연구는 없었다. 본 연구에서는 정신분열병의 발병 및 임상변인과 TPH유전자 다형성과의 관련성을 알아보기 위하여 정신분열병 환자와 정상인을 대상으로 TPH 대립유전자 및 유전자형의 빈도를 조사하였고 정신분열병 환자군에서는 임상아형, 자살사고 및 자살행동, 발병연령, 가족력여부 등의 임상적 변인과의 관련성을 알아보았다. 방 법 : 217명의 정신분열병 환자와 236명의 정상대조군을 대상으로 DNA를 분리하여 TPH 유전자를 증폭하고 제한효소 (Nhel)를 이용하여 유전자형을 구분하였다. 결 과 : 환자군과 정상대조군 사이에는 TPH 유전자형 및 대립유전자의 빈도에서 유의한 차이는 없었으나 자살행동을 보인 빈도는 각각의 유전자형에 따라 유의한 차이를 보였다(χ²=6.504 p=0.039). 그 외 임상아형, 발병연령, 가족력, 자살사고 등의 변인에 따른 유전자형의 빈도 차이는 없었다. 결 론 : TPH 유전자의 다형성은 정신분열병의 발병이나 임상양상, 자살사고, 가족력 및 발병연령과는 유의한 상관관계가 없으나 자살행동과는 관련이 있는 것으로 생각된다. Objectives : The genetic polymorphism of tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, has been to be related with various psychiatric disorders such as bipolar disorders. However, the role of TPH gene polymorphism in schizophrenia is totally unknown. Author examined the association of the TPH gene polymorphism with the development and the clinical variables of schizophrenia. Methods : Genomic DNAs from 217 schizophrenic patients and 236 healthy controls were isolated, and TPH gene was amplified using PCR. Amplified TPH DNA was digested with NheI and the polymorphism was examined by electrophoresis on agarose gel. Results : The allele frequencies and the genotypes of TPH gene were not significantly different between the schizophrenics and the control groups. They were also not associated with most of the clinical variables of schizophrenia such as subtypes, suicidal ideation, age at onset, and family histories. Among the clinical variables, only suicidal rate was highly correlated with genotype 218C/C. Conclusion : We found possible association of the suicical behavior with 218C/C polymorphism. However, it seems that A218C polymorphism of TPH gene does not associated with the development and other clinical variables of schizophrenia.

Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.