Alcohol extract of Geum Chung Cho alleviates alcohol-induced short-term memory impairment in gerbils

Han-Sam Cho,Tae-Woon Kim,Sang-Seo Park,Mal-Soon Shin,Jae-Min Lee,Eun-Sang Ji,Chang-Ju Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.10

Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.

일반아동, 정신지체아동과 학습장애아동의 사회적 기술 발달 경향

조용태,김순자 대진대학교 1999 大眞論叢 Vol.7 No.-

The purpose of this study was to explore the developmental trends in social skills of the normal, mental retardation, and learning disabilities children at primary schools. A total of 314 children(100 normal children, 100 mental retardation children, and 114 learning disabilities children) participated in this study. Social skills(Cooperation, Assertion, and Self-control skill) of children measured by Gresham and Elliott's Social Skills Rating System(SSRS). The results of the study were as followings: First, social skill of the normal children was found to be linear trend. However, social skill of the mental retardation and learning disabilities children were not found consistent trend. Second, cooperative skill within social skills of the normal, mental retardation, and learning disabilities children were found to be linear trend. Third, assertive skill within social skills of the normal children was found to be linear trend. However, assertive skill of the mental retardation and learning disabilities children were not found to be consistent trend. Forth, self-control skill within social skill of the normal and mental retardation children were found to be linear trend. However, self-control skill of the learning disabilities children was not found to be consistent trend.

매복된 하악 제1대구치의 외과적 노출술을 이용한 치험례

조윤정,박영옥,김태완,김현정,김영진,남순현 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2

제1대구치는 저작과 혼합치열기 이후의 수직적 교합관계형성에 핵심적인 역할을 하고 악골의 성장발육에 관여한다. 제1대구치의 매복은 하안면 고경의 감소, 낭의 형성, 치관 주위염, 인접치의 치근 흡수, 부정 교합 등의 문제점을 야기할 수 있다. 치료방법으로는 주기적 관찰, 외과적 노출술, 교정적 견인, 외과적 재위치술, 발치 등이 있으며 이중 외과적 노출술이 가장 기본이 되는 술식이다. 외과적 노출술시에는 맹출로의 개방성을 유지하는 것이 중요하며 개방성을 유지시키기 위한 방법으로는 레진관의 접착, 산화 아연 유지놀 시멘트, 치주포대 등을 노출된 부위에 충전시키는 방법 등이 있다. 본 증례에서는 매복된 하악 제1대구치에서 장애물의 제거와 외과적 노출술을 시행한 결과 자발적인 맹출을 관찰할 수 있었다. 또한 surgical pack과 투명상유지장치를 사용하여 간편하고 효과적으로 맹출로의 개방성을 유지할 수 있었다.

골반 내 농양 1예

조인숙,이해혁,김태희,이권해,남계현,이임순,김정식,박성진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Pelvic inflammatory disease (PID) is a disease that affects young, sexually active, reproductive age women. Most pathogens are Chlamydia trachomatis and Neisseria Gonorrheae transmitted sexually. One of serious acute complication of PID is tubo-ovarian abscess (TOA) that involves the fallopian tube, ovary and adjacent structures (eg, bowel, pelvic peritoneum). The microbiology of TOAs is polymicrobial with anaerobic organisms and causal organisms of PID. Common anaerobic organisms are Peptostretococcus spp, Bacteriodes spp, Prevotella spp, Escherichia coli and aerobic streptococci. Treatment is necessary to admission for intravenous broad-spectrum antibiotics and surgery is often reserved for patients with suspected rupture or patients who fail to respond to antibiotics. So, we reported this case found pelvic abscess due to ruptured tube-ovarian abscess.

경기종목의 특성에 따른 유·무산소성 대사능력 및 무산소성 파워에 관한 실험적 연구

조현철,송순천,김학렬,손태열 成均館大學校 科學技術硏究所 1989 論文集 Vol.40 No.2

This experimental study was designed, 1) to observe maximal oxygen uptake and anaerobic threshold during incremental loading treadmill exercise by 2-min interval. 2) to determine the anaerobic power in the wingate test during bicycle ergometer work with toe-stirrups. The subject were 16 college elite boxing player, 10 college elite soccer player The results were as -follows: 1. The means±SD of maximal oxygen uptake and maximal oxygen uptake per kg body weight were 4.06±0.66l/min, 4.27±0.46l/min, and 60.58±7.61ml/kg/min 63.05±3.41ml/kg/min, respectively. also maximal heart rate were 187.88±9.44 beats/min, 185.40±6.57 beats/min. respectively. 2. The means±SD of maximal oxygen uptake and maximal oxygen uptake per kg body weight at anaerobic threshold was 2.93±0.5l/min, 3.23±0.47l/min (AT-VO2. l/min), and 43.70±6.97ml/kg/min, 47.71±4.99ml/kg/min (AT-VO2. ml/kg/min), respectively. also Anaerobic Treshold level (AT-% VO2max) was about 72.49±4.37% VO2max, 75.37±8.8% VO2max, and AT-% HRmax was about 86.07±5.97% HRmax, 87.84±6.25% HRmax, respectively. 3. The means ±SD of Anaerobic Power in the wingate test was 592.50±65.42 Wattes, 588.00±46.30 Wattes, respectively. The results of this study indicated that boxing players are incresed training program and exercise prescription for anaerobic metabolic process, soccer players are done training program for aerobic metabolic process, because of decresed maximal oxygen uptake and anaerobic threshold level.

전자의무기록의 충실성 검토를 통한 미비기록 개선 활동

조윤정,김경숙,이향숙,이진영,김태민,김민순 한국의료QA학회 2008 한국의료질향상학회지 Vol.14 No.1

문제: 전자의무기록(EMR) 시행 후 의무기록 정리율의 저하와 질적인 측면에서의 충실성과 정확성에 대한 문제점이제기되었다. 목적: 전자의무기록의 정리율과 충실성 검토를 통하여 문제점을 파악하고개선점 찾아 의무기록 정리율을 향상시키고 충실성을 높이고자 하였다. 의료기관: 서울시에 소재한대학병원 의무기록과 질 향상 활동: 전자의무기록의 문제점을 개선히키 위하여 사용자 편의를 위한 EMR프로그램 수정 및 보완, 진단·수술 관련 작업, 업무개선, 교육, 홍보 등의 활동을실시하였다. 개선효과: 의무기록 정리율, 전자인증미비, 경과기록 기재일수, 퇴원요약주진단적합률, 기록지별 필수항목기 재율, 충실성에서 향상이 이루어졌다.

측두골 골절 : 임상적 및 방사선학적 분석 Clinical and Radiological Analysis

조성원,최순관,조성진,김범태,신원한,윤일규,변박장 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

The objective of this study is to review of the incidence of temporal bone fractures and complications resulting from temporal bone fractures and to analyze the correlation between clinical and radiological findings. A series of 49 patients who were diagnosed temporal bone fracture with rhinorrhea, bloody otorrhea, admitted to Soonchunhyang University Chon-an Hospital from January 1997 to September 1999, were studied retrospectively. Clinical analyses were focused on age, sex, type of accident, external wound site, CSF leakage, hearing loss and facial nerve palsy. The high resolution CT scan consisted of a series of 3-mm thick sections through the temporal bone using the GE CT scanner (General Electric Inc.). In radiologic analyses, fracture types of temporal bone were divided into longtudinal fracture(LF), transverse fracture(TF) and mixed fracture(MF) respectively. The CT scans were examined for mastoid antral haziness(MH), middle ear cavity haziness(MeH), ossicular chain disruption(OD), otic capsule fracture(OF), pneumocephalus(Pn). The type of facial canal fracture was classified as fracture of internal auditory canal portion(FIAC), fracture of perigeniculate portion(FPG), fracture of tympanic portion(FT), fracture of mastoid portion(FM). The correlation between clinical and radiological findings was analysed. A total of 49 fractured temporal bones resulted in 9 CSF fistula, 23 hearing loss( 13 conductive type, 7 sensorineural type), 17 facial nerve injuries ranging from mild paresis to complete paralysis. The mose common etiology of the injury was from a motor vehicle accident(28%). The type of fracture observed on high resolution CT scanning was a LF in 39(78%) patients, a TF in 7(14%) patients and a MF in 3(6%) patients. The majority of fractures terminate in the floor of the middle cranial fossa in LF and passed lateral to the otic capsule in TF. Average time of onset of delayed facial palsy was 3.5 days. No patient developed prolonged otorrhea or meningitis during hospitalization and there was no requirement of surgical management. Hearing loss was the most common complication of temporal bone fracture(48%). Conductive hearing loss was associated with middle ear cavity haziness and ossiclular chain disruption. in temporal bone CT. A total of 29 cases facial canal fracture in temporal bone CT resulted in 14 perigeniculate portion(FPG), 12 tympanic portion(FT), 3 mastoid portion(FM). There was no correlation between radiological facial canal fracture and clinical facial nerve palsy. Four of 17 patients with facial nerve injury required facial nerve exploration under general anesthesia. We thought that prognosis and therapeutic planning in patients with temporal bone fractures were based on the clinical and radiological findings.

만성 화농성 중이염의 세균학적 고찰

조남순,이영훈,강기훈,최제환,송태현,이병돈,장혁순,강주원,김연준 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background and Objectives : Chronic suppurative otitis media is one of the frequent diseases in otolaryngologic field. It is important to choose of antibiotics in the management of infectious disease. But the organisms in infections have been changed and resistance to antibiotics has been grown as the development of antibiotics has been achieved. And so it has been necessary to recognize the changes of organisms and resistance in antibiotics. Our study was performed to identify the pathogens isolated from discharges in chronic otitis media and evaluate the antibiotic agents, to recognize the change of to resistance to·antibiotic agents and to use the appropriate anitiotics. Materials and Methods : Retrospectively, authors reviewed the backeriologic study of 114 cases of chronic suppurative otitis media who visited the Department of Otolaryngology, Soonchunhyang University in Seoul from Nov. 1996 to Oct. 1999 and analyzed 101 strains and its sensitivity test to various antibiotics. Result : In 93 cases in which pathogenic organism was isolated, single infection was 85 cases(91.4%) and mixed infection was 8 cases(8.6%). The most frequent pathogenic organism was Staphylococcus aureus(59.4%), Pseudomonas aeruginosa(13.9%), Providencia(4.8%), Alcaligenes(3.0%) and Streptococcus pneumoniae(2.9%) were the next. Methicilline-Resistance Staphylococcus aureus was 34 cases(57.6%) of Staphylococcus aureus. Staphylococcus aureus was sensitive to Vancomycin(96.7%), Trimethoprim-Sulfamethoxazole (57.6%), Cefuroxime(42.4%) and Ciprofloxacin(40.7%) but resistant to Penicillin(94.9%). Pseudomonas aeruginosa was sentitive Amikacin(100%), Ciprofloxacin(100%) and Gentamicin(67%). Conclusion : As MRSA recently was wide spread in community accquired infection as well as nosocomial infection, we must consider strict control of MRSA.

구치부 인접면 와동에서 유동성 복합레진 이장재의 두께가 치은 변연부 미세누출에 미치는 영향

조윤정,김태완,김현정,김영진,남순현 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

This in vitro study aimed to investigate the influence of flowable composite lining with different thicknesses on the marginal quality. One hundred twenty cavities, each preparated with proximal box-type(3mm of bucco-lingual width, 2mm of mesio-distal depth and gingival margin of 1mm supra-CEJ) were randomly dived into four groups. group I : Tetric ceram filling alone (control group) group II: 0.5mm thickness Tetric flow + Tetric ceram filling group III: 1.5mm thickness Tetric flow + Tetric ceram filling group IV: 2.5mm thickness Tetric flow + Tetric ceram filling The followings are the results: 1. Group II showed significantly less microleakage compared to group I(control group)(p<0.05). 2. There was no statistically significant difference between group III, IV and group I(p>0.05). 3. Group II showed significantly less microleakage compared to group III. IV(p<0.05). 4. There was microleakage more or less in all group. It was concluded that 0.5mm flowable composite lining improved cavity adaptation and marginal sealing. 구치부 인접면 와동에서 유동성 복합레진 이장재의 두께가 치은측 변연의 미세누출에 미치는 영향을 평가하기 위하여 발거된 소구치 및 대구치의 근, 원심면에 box 형태의 와동(협설폭경 3mm, 근원심폭경 2mm, 상아법랑경계 상방 1mm에 치은 변연) 120개를 형성한 뒤, 무작위로 30개씩 선정하여 다음과 같은 4개의 군으로 분류하였다. group I- Tetric ceram 충전군(대조군) group II- 0.5mm두께의 Tethc flow + Tetric ceram group III- 1.5mm두께의 Tetric flow + Tetric ceram group IV- 2.5mm두께의 Tetric flow + Tethc ceram 색소침투법으로 치은측 변연부 미세누출을 측정하여 다음과 같은 결론을 얻었다. l. group II는 groupI에 비해 낮은 미세누출을 보였다(p<0.05). 2. group III,IV과 group I 사이에는 통계적으로 유의한 미세누출의 차이가 없었다(p>0.05). 3. group II는 group III, IV에 비해 낮은 미세누출을 보였다(p<0.05). 4. 모든 group에서 정도의 차이는 있으나 치경부에서 미세누출을 보였다. 이상의 결과로, 혼합형 복합레진으로의 구치부 인접면 와동 수복시 0.5mm 두께의 유동성 레진으로의 와동저 이장은 치은측 변연의 봉쇄능을 향상시켜 변연부 미세누출을 감소시킬 수 있는 방법으로 사료된다.

심실중격결손증-치험 1예-

조광현,우종수,황윤호,이양행,박철호,김종성,김철호,이경순,조영일,박태인 인제대학교 1985 仁濟醫學 Vol.6 No.4

A successful treatment of infants and children with congenital heart defects depends upon several factors: diagnosis must be accurate, the operative technique, including techniques of perfusion and myocardial preservation, must be suited to the needs of patients and intensive cares, including accurate anesthesia, must be applied through all stages of investigation and treatment, i.e. before, during and after the operation. Recently we performed a open heart surgery successfully for a six-years old girl who had suffered from frequent upper respiratory tract infection and mild to moderate exertional dyspnea with congenital heart defects (ventricular septal defect, Kirklin type II, with patent foramen ovale). The operation and postoperative course were very smooth. And now we report this with review of literatures.