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Polytetrafluoroethylene의 길이에 따른 신생내피의 조직학적 변화에 대한 실험적 연구
강기훈,이광석 고려대학교 의과대학 1998 고려대 의대 잡지 Vol.35 No.2
One of the most widely used synthetic grafts in vascular surgery is polytetrafluoroethylene(PTFE). PTFE offers major advantages compared with the other synthetic materials because of its highly electronegative and hydrophobic surface. Neoendothelialization of PTFE is still the most controversial issue and seems to prevent its reliable clinical use in microvascular grafting procedures. It is difficult to compare different studies because of variations in the physical characteristics of synthetic grafts and the investigation periods. The purpose of this study was to investigate the patency rates and the histologic findings of neoendothelialization according to the length of implanted PTFE in rabbit. Thirty New Zealand White rabbits, weighing 3.0 to 3.5kg, were used for this study. Under the operating microscope, all grafts were implanted in the right carotid arteries of rabbits by interrupted end-to-end microanastomosis. They were divided into two groups according to the length of implanted PTFE with an internal diameter of 3mm. Each group comprised fifteen rabbits. All implanted grafts were 25㎛ in fibril length and 0.39mm in wall thickness. The length of graft in group Ⅰ was 8mm and that of graft in group Ⅱ was 24mm. Three grafts per group were harvested at 1, 2, 4, 8, and 12 weeks after implantation respectively. All PTFE grafts were observed for patency rates and the histologic findings with light microscope and scanning electron microscope. The results obtained were as follows : 1. The patency rate was 96.7%(29/30) on the average: 93.3%(14/15) in group Ⅰ and 100%(15/15) in group Ⅱ. There was no difference in patency rates according to the length of implanted PTFE. 2. Light microscopically, the beginning of neointimal lining was noted in both groups at 1 week after implantation. At 8 weeks after implantation, the entire inner surface of implanted PTFE was lined completely by neointima in both groups. At 12 weeks after implantation, neointima and subintimal tissue were noted at the midportion of implanted PTFE in group Ⅰ. However, neointima of group Ⅱ in the midportion of implanted PTFE was composed of single layered neoendothelial cells without subintimal tissue. 3. Scanning electron microscopically. the inner surface of implanted PTFE was lined by amorphous fibrin layer at anastomosis site in both groups at 1 week after implantation. At 2 weeks after implantation, flat irregular layer like normal endothelium was noted at anastomosis site in both groups. At 8 weeks after implantation, the entire inner surface of implanted PTFE was lined by neointima in both groups. At 12 weeks after implantation, closely apposed endothelial-like cells were noted in the mid-portion of implanted PTFE in group Ⅰ, the long axis of neoendothelial cells was parallel to the direction of the blood flow, but the inner surface of implanted PTFE was still noted in group Ⅱ. In conclusion, there was no difference in patency rates according to the length of implanted PTFE, and at 1 week after implantation neoendothelium started to grow from both anastomosis sites toward the center of implanted PTFE in both groups; however, the formation of neointima and subintimal tissue was delayed and incomplete in longer implanted PTFE. In the future, further study must be performed to accelerate the neoendothelialization after implantation of PTFE for the clinical use in microvascular surgery.
강기훈,안홍세,Kang, Kee-Hoon,Ahn, Hong-Se 한국통계학회 2006 응용통계연구 Vol.19 No.3
본 연구는 함수적 데이터 분석의 몇 가지 이론에 대해 소개하고 분석 기법을 실제 자료에 적용하는 내용을 다루었다. 함수적 데이터 분석의 이론적 내용으로 기저를 이용해 자료를 함수적 데이터로 표현하는 방법, 그리고 함수적 데이터의 변동성을 조사하는 주성분분석, 선형모형 등에 대해 살펴보았다. 그리고 우리나라 기온 데이터와 강수량 데이터를 대상으로 각각 함수적 데이터 분석 기법을 적용해 보았다. 또한, 기온과 강수량 데이터에 대해 함수적 회귀모형을 적합시켜 두 변수간의 함수관계를 살펴보았다. In this paper we review some methods for analyzing functional data and illustrate real application of functional data analysis. Representing methods for functional data by using basis function, analyzing functional variation by functional principal component analysis and functional linear models are reviewed. For a real application, we use temperature and precipitation data measured in Korea from the January of 1970 to the May of 2004. We apply functional principal component analysis for each data and test the significance of regional division done by using shining hours. We also estimate functional regression model for temperature and precipitation.
마을만들기사업 주민참여 프로그램이 노인들의 공동체의식과 삶의 만족도에 미치는 영향 - 부여군 부여읍 구교1·3리의 새뜰마을사업을 중심으로 -
강기훈,김성길 대한국토·도시계획학회 2019 國土計劃 Vol.54 No.1
마을만들기사업에서 지역의 공동체의식과 주민의 삶의만족도를 제고하기 위해 다양한 주민참여 프로그램들을 운영하고 있다. 그러나 해당 프로그램들에 대한 이론적 기반은 이를 충분히 뒷받침하지 못하고 있다. 현재 관련 연구의 대부분이 물리적 환경 개선과 공동체의식 간의 관계를 다루는 데 중점을 두고있어 주민참여 프로그램과 공동체의식 간의 관계에 대한 연구는미흡한 실정이다. 더욱이 마을만들기사업의 주민참여 프로그램과 고령화를 연계하여 분석한 연구는 거의 없는 상황으로 이에 대한 연구가 필요하다. 본 연구의 목적은 마을만들기사업에서 주민참여 프로그램이노인의 공동체의식과 삶의 만족도에 미치는 영향을 알아보는데있다. 이를 위해 다음과 같은 연구내용을 설정하였다. 첫째, 주민참여 프로그램이 노인의 공동체의식에 영향을 미치는지 파악한다. 둘째, 주민참여 프로그램이 노인의 삶의 만족도에 영향을 미치는지 파악한다. 셋째, 삶의 만족도와 공동체의식 간의 영향관계를 파악한다. 넷째, 위의 연구를 바탕으로 공동체의식과 삶의만족도를 제고하기 위한 주민참여 프로그램의 함의를 이끌어내고 정책적 시사점을 도출하고자 한다.