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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
홍경한,전상신,이승재,박찬수,권일욱,김재열,김병철,하옥남 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.4
Fin-tube type(Fin-type) heat exchanger has been tested in order to replace the heat exchanger of parallel flow type(P.F-type) which is now widly used in automobile air conditioning system. The following conclusions are drawn by the comparison of the characteristics of the heat exchangers. Evaporator and condenser capacities and COP(Coefficience of performance) were varied as with the compressor speed, outdoor air temperature and air flow rate changed, which much influenced on the characteristics of the air conditioning system. Evaporator and condenser capacities were increased with increasing compressor speed and outdoor air temperature. Evaporator and condenser pressures of Fin- type were decreased by 7% and 5% respectively compared with those of P.F-type. The COP of Fin-type was decreased with increasing outdoor air temperature and compressor speed. The COP of P.F-type was decreased by 14% compared with that of Fin-type.
논문 : 수위-유량 관계곡선을 이용한 수막재배용 지하수 사용량 추정
이봉주 ( Bong Joo Lee ),김용철 ( Yong Cheol Kim ),조병욱 ( Byung Wook Cho ),윤욱 ( Uk Yoon ),하규철 ( Kyool Chul Ha ),이병대 ( Byeong Dae Lee ),문상호 ( Sang Ho Moon ),윤필선 ( Phil Sun Yoon ),김성윤 ( Sung Yun Kim ) 대한지질공학회 2015 지질공학 Vol.25 No.1
수위-유량 관계곡선을 이용한 동절기 수막재배기간의 지하수 사용량 추정 방법을 제시하고, 이를 논산 왕전리 수막재배 지역에 현장 적용하였다. 연구지역의 동절기 수막재배 기간의 농수로수의 구성성분은 주로 지하수와 강우의 직접 유출 성분으로 구성된다. 농수로 수위를 관측하고, 강우에 의한 농수로 수위 상승분을 수위 관측 자료로 부터 제거시키기 위해 기저유출분리법을 적용하였다. 강우에 의한 수위 상승분이 제거된 농수로 수위자료에 수위-유랑 관계를 적용하여 연구지역의 수막재배용 지하수 배출량을 산출하였다. 왕전리 지역의 수막재배용 지하수 사용량은 평균 10,900 m3/d, 420m3/d/ha인 것으로 추정되었다. 추정 지하수 사용량(420 m3/d/ha)과 전국의 수막재배면적(10,746 ha), 그리고 연간 수막재배일수(120 days/year)을 기준한 전국 규모의 수막재배용 지하수 사용량은 5억 4천만 m3에 이른다. 이는 농업용 지하수연간 사용량(약 17 억 m3)의 약 32%에 달한다. A method is proposed to estimate groundwater usage for water curtain cultivation (WCC) using a rating curve, and it is applied to field measurements of groundwater discharge used for WCC in Wangjeon-ri, Nonsan. During the winter season, the hydraulic components of irrigation ditches in the study area consist mainly of direct run-off and groundwater discharged from nearby pumping wells. Changes in stage of the ditches were monitored, and a baseflow separation method was applied to remove increments in stage due to direct run-off. The resulting records of stage were translated to groundwater discharge by applying the-stage-discharge relation. The estimated average groundwater discharge for the WCC in Wangjeon-ri was 10,900 m3/d or 420 m3/d/ha when the estimation is normalized by the total area for WCC facilities of this region. Applying this estimation (420 m3/d/ha) to the entire area of the WCC in Korea (10,746 ha),and considering the number of pumping days for the WCC (120 days/year), the total ground water usage for the WCC nation-wide is estimated to be 0.54 billion m3. This is equivalent to 32% of the total groundwater discharge for agricultural use in Korea (1.7 billon m3).
하철종(Chul-Jong Ha),양병모(Byeong-Mo Yang),이현철(Hyun-Chul Lee),이근준(Geun-Joon Lee),백영식(Young-Sik Baek) 대한전기학회 2010 전기학회논문지 Vol.59 No.7
A high temperature superconducting power cable (HTS power cable) was applied large current capacity by no resistance in normal state. Fault state was risen out of over-current but, it was limited to resistance. this study was modeling equivalence, and unbalanced state analyzed operating charateristics of HTS power cable. The equivalence model was composed superconductor, shield, and former part. This model simulation was appeared conductor and shield current in normal state, but fault state was appeared former current as rise current by resistance. so it need to sufficiently influenced the quench characteristic when the former design.
EMTP-RV를 이용한 초전도 케이블 모델링 및 계통 적용 시 보호협조 분석
하철종(Chul-Jong Ha),백영식(Young-Sik Baek),이근준(Geun-Joon Lee),이현철(Hyun-Chul Lee),양병모(Byeong-Mo Yang) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7
본 논문에서는 EMTP-RV를 이용하여 초전도 케이블과 보호기기를 모델링 하였고, 고장 발생 시 케이블에 발생하는 ?치 현상을 분석하였다. 그리고 계통 적용 시 초전도 케이블을 모선으로 사용하고 보호협조를 분석하였다.
Steroid Responsive Tremor Syndrome in a Maltese Dog
Byeong-Teck Kang,Dong-In Jung,Chul Park,김주원,Ha-Jung Kim,Chae-Young Lim,Ki-Jin Ko,Sue-Kyung Cho,So-Young Lee,박희명 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.3
A 4-year-old, spayed female Maltese dog was presented for evaluation of acute onset of generalized tremor,right-sided head tilt, horizontal nystagmus, and mild ataxia with 4-day duration. However, the dog was bright, alert,and responsive. The neurological examinations revealed that bilateral horizontal-, positional nystagmus, and mild ataxia.Menace responses were also absent in both eyes. Typically, moderate generalized intension tremors were noted in fourlimbs and the head. No abnormalities were found in hemogram, radiography, and magnetic resonance imaging (MRI).ealed a mild nonsuppurative inflammation. Thus, steroidresponsive tremor syndrome (SRTS) was strongly suspected because of its inflammatory and idiopathic features. Thedog excellently responded to immunosuppressive doses of corticosteroid. Therefore, we definitively diagnosed the dogas SRTS based on the exclusion of other causes of the tremor, clinical signs, and response to treatment. This is afirst case report of SRTS in our country and we here describe clinical and neurological features in SRTS.
Post-resection prognosis of patients with hepatic epithelioid hemangioendothelioma
Byeong-Gon Na,Shin Hwang,Chul-Soo Ahn,Ki-Hun Kim,Deok-Bog Moon,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Seung-Mo Hong,Sung-Gyu Lee 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.3
Purpose: Epithelioid hemangioendothelioma (EHE) is a rare borderline vascular tumor. This retrospective, single-center study evaluated the outcomes of hepatic resection (HR) in patients with hepatic EHE. Methods: Over the 10-year period from 2009 to 2018, 11 patients with hepatic EHE underwent HR, accounting for 0.1% of the 11,979 adults who underwent HR at our center. Diagnosis of hepatic EHE was confirmed by immunohistochemical staining for CD34, CD31, and factor VIII-related antigen. Results: The 11 patients included 9 females (81.8%) and 2 males (18.2%) with mean age of 43.5 ± 13.6 years. Preoperative imaging resulted in a preliminary diagnosis of suspected liver metastasis or EHE, with 9 patients (81.8%) undergoing liver biopsy. No patient presented with abnormally elevated concentrations of liver tumor markers. The extents of HR were determined by tumor size and location from trisectionectomy to partial hepatectomy. All patients recovered uneventfully from HR. Five patients showed tumor recurrence, with 4 receiving locoregional treatments for recurrent lesions. The 1-, 3- and 5-year disease-free survival rates were 90.9%, 54.5%, and 54.5%, respectively. Currently, all patients remain alive and are doing well. Univariate analysis on tumor recurrence showed that tumor size ≥ 4 cm was significantly associated with tumor recurrence (P = 0.032), but tumor number ≥ 4 was not related to (P = 0.24). Conclusion: Hepatic EHE is a rare form of primary liver tumor often misdiagnosed as a metastatic tumor. Because of its malignant potential, HR is indicated if possible. HR plus, when necessary, treatment of recurrence yields favorable overall survival rates in patients with hepatic EHE.