논문 : 강원도 양양지역 소나무림의 지상부 바이오매스와 수관층 연료특성에 관한 연구

김성용 ( Sung Yong Kim ),이영진 ( Young Jin Lee ),장미나 ( Mi Na Jang ),서연옥 ( Yeon Ok Seo ),구교상 ( Kyo Sang Koo ),정성철 ( Sung Cheol Jung ),김경하 ( Kyung Ha Kim ) 한국임학회 2012 한국산림과학회지 Vol.101 No.2

본 연구의 목적은 강원도 양양지역에 분포하는 소나무림을 대상으로 지상부 바이오매스와 수관층 연료특성에 대하여 분석하고자 하였다. 연구대상지는 강원도 양양군 현남면 하월천리 일대 소나무림으로 선정하였으며, 총 13본의 표본목을 벌채하여 분석하였다. 본 연구 결과에 의하면, 양양지역 소나무림의 줄기밀도(g·cm-3)는 0.347~0.409, 지상부 바이오매스 확장계수는 1.251~1.419의 범위로 나타났다. 지상부 연료량은 총 161.6 Mg·ha-1로 나타났으며, 줄기 126.4 Mg·ha-1, 가지 29.3 Mg·ha-1, 잎 5.9 Mg·ha-1로 나타났다. 수관층 연료특성 인자에 관한 연구에서는 수관화 확산 시 연소될 수 있는 연소가능 연료(잎~1 cm이하 가지)의 비율은 45.2%로 나타났고, 연료량을 수관체적으로 나눈 연소가능 연료밀도(kg·m-3)는 평균 0.178로 나타났다. 본 연구의 결과는 소나무림의 바이오매스 및 탄소 흡수량 추정과 수관화 위험성을 연료적 관점에서 평가하는데 있어 유용한 기초자료가 될 것으로 사료된다. The objective of this study was to analyze the above-ground biomass and crown fuel characteristics of Pinus densiflora stands in Yangyang, Gangwon province. A total of thirteen representative trees were destructively sampled in Yangyang region. The results showed that the stem density (g·cm-3) was 0.347~0.409, whereas the above-ground biomass expansion factors ranged from 1.251~1.419. In terms of crown fuel biomass, the above-ground biomass was 161.6 Mg·ha-1 while the stem biomass, branch biomass and needle biomass were 126.4 Mg·ha-1, 29.3 Mg·ha-1 and 5.9 Mg·ha-1, respectively. Needles and twigs with less than 1 cm diameter accounted 45.2% of the total crown fuel load. The available crown bulk density, which was calculated by dividing the crown fuel load to the crown volume, was 0.178 kg·m-3. The results of this study on the biomass and carbon stocks estimation of the Pinus densiflora together with the crown fire hazard assessment based on crown fuel loads are very significant information for the forest managers.

P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

( Jie Hyun Jeon ),( Joo Ha Kim ),( Jung Woo Lee ),( Kui Young Park ),( Seong Jun Seo ),( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

갈대 생육지에서 질소 시비가 사초의 생육과 수량 및 사료가치에 미치는 영향

서성,박진길,김원호,김맹중,이상학,정종성,박형수,성하균,이종경,Seo, Sung,Park, Jin Gil,Kim, Won Ho,Kim, Meing Jooung,Lee, Sang Hak,Jung, Jong Sung,Park, Hyung Soo,Sung, Ha Guyn,Lee, Joung Kyong 한국초지조사료학회 2013 한국초지조사료학회지 Vol.33 No.2

본 연구는 질소(N) 시비가 부존 조사료자원인 갈대(Phragmites communis)의 생육과 수량 및 사료가치에 미치는 영향을 구명하고자 2012년에 충남 천안과 경기 안산지역에서 실시되었다. 천안 국립축산과학원 갈대 재배지에서는 N 무시비구, N 50 kg/ha구, N 100 kg구 등 3처리를 두고 4월 30일 시비, 6월 21일 수확하였으며, 안산 시화간척지 갈대 자생지에서는 N 무시비구, N 60 kg/ha구 등 2처리를 두고 5월 1일 시비, 8월 1일 수확하였다. 갈대의 초장과 엽색은 N 시비구에서, 그리고 N 시비수준이 높을 때 양호하였다. 건물률은 N 시비구에서 약간 낮아지는 경향으로 천안지역은 무시비구 39.8%, N 시비구 37.6%, 36.7%, 안산지역은 무시비구 39.4%, N 시비구 37.6%였다. 천안지역의 건물수량, 조단백질 수량 및 가소화 건물수량은 무시비구에서 ha당 각각 4,026 kg, 235 kg, 1,850 kg, N 50 kg 시비구는 각각 4,658 kg, 306 kg, 2,388 kg, N 100 kg 시비구는 각각 5,622 kg, 446 kg, 3,143 kg으로 유의적으로 증가하였으며 (p<0.05), 안산지역은 무시비구에서 각각 2,802 kg, 177 kg, 1,288 kg, N 60 kg 시비구는 각각 3,876 kg, 294 kg, 1,853 kg으로 유의적으로 증가하였다 (p<0.05). 천안지역의 조단백질 함량, 건물 소화율 및 상대사료가치 (RFV)는 무시비구에서 각각 5.85%, 45.96%, 64.0 (품질 5등급), N 50 kg 시비구는 각각 6.58%, 51.27%, 72.3 (5등급), N 100 kg 시비구는 각각 7.94%, 55.91%, 72.7 (5등급)로 높아졌으며, 안산지역도 무시비구에서 각각 6.30%, 45.98%, 70.2 (5등급), N 60 kg 시비구는 각각 7.59%, 47.80%, 78.3 (4등급)으로 높아지는 경향이었다. 이상의 결과를 종합하여 볼 때, 갈대 생육지는 시비가 가능한 조건이라면(하천변이나 강변 등 수질오염이 우려되는 지역이 아닌), ha당 N 60~100 kg을 생육기에 시용해 주는 것이 생산량과 사료가치를 크게 개선시켜줄 수 있어 바람직하였다. This study was carried out to investigate the effect of nitrogen (N) fertilization on the forage growth, production and quality of native reed (Phragmites communis) grasses. Field experiments were conducted in Cheonan and in Ansan, 2012. Treatments were control (no N fertilization), 50 kg/ha and 100 kg/ha in Cheonan plots (fertilization on April $30^{th}$, and harvest on June $21^{st}$). Treatments in Ansan plots were control (no N fertilization) and 60 kg/ha (fertilization on May first, and harvest on August first). Forage growth and leaf colors were improved in N fertilized plots. However, the drymatter (DM) percentage was slightly decreased with N fertilization. Forage yields, in terms of DM, crude protein (CP) and digestible DM (DDM), were significantly increased with N fertilization in both sites. In Cheonan, DM, CP and DDM yields per ha were 4,026 kg, 235 kg and 1,850 kg, respectively, in the control plot, and were 4,658 kg, 306 kg and 2,388 kg, respectively, in the N 50 kg plot, and 5,622 kg, 446 kg and 3,143 kg, respectively, in the N 100 kg plot. In Ansan, DM, CP and DDM yields per ha were 2,802 kg, 177 kg and 1,288 kg, respectively, in the control plot, and were 3,876 kg, 294 kg and 1,853 kg, respectively, in the N 60 kg plot. Forage quality in terms of CP content, in vitro DM digestibility (IVDMD) and relative feed value (RFV) were also increased with N fertilization in both sites. In Cheonan, the CP content, IVDMD and RFV were 5.85%, 45.96% and 64.5 (grade 5), respectively, in the control plot, 6.58%, 51.27% and 72.3 (grade 5), respectively, in the N 50 kg plot, and 7.94%, 55.91% and 72.7 (grade 5), respectively, in the N 100 kg plot. In Ansan, the CP content, IVDMD and RFV were 6.30%, 45.98% and 70.2 (grade 5), respectively, in the control plot, and 7.59%, 47.80% and 78.3 (grade 4), respectively, in the N 60 kg plot. In conclusion, N fertilization of 60~100 kg/ha was desirable for greater forage production, with a higher quality of native Phragmites communis achievable. This should only be applied if the fertilization area is not located at a riverside/streamside or in riparian land where there is a high risk of water pollution by fertilization.

Valuation of ecosystem services in the organic carbon of the Pinus densiflora forest at Mt. Namsan, Seoul Metropolitan City

Lee, Eung-Pill,Lee, Soo-In,Jeong, Heon-Mo,Han, Young-Sub,Lee, Seung-Yeon,Park, Jae-Hoon,Jang, Rae-Ha,Hong, Youg-Sik,Jung, Young-Ho,Kim, Eui-Joo,Lee, Sang-Hun,You, Young-Han The Ecological Society of Korea 2019 Journal of Ecology and Environment Vol.43 No.4

Background: Standing biomass, litter production, rate of litter decomposition, amount of litter on forest floor, and amount of soil organic carbon distribution were investigated from March 2016 to November 2018 in order to evaluate the ecosystem value through organic carbon distribution in the Pinus densiflora forest at Namsan, Seoul Metropolitan City. Results: The amount of organic carbon in the Pinus densiflora forest was 261.09 ton C ha^-1 during the research period, and fixed organic carbon in plant through net photosynthesis was 3.2 ton C ha^-1 year^-1. The organic carbon in plant was 62.77 ton C ha^-1 (24.04%), in litter on the forest floor was 3.65 ton C ha^-1 (1.40%), and in soil was 194.67 ton C ha^-1 (74.56%). The value of plant, litter on forest floor, and soil organic carbon distribution were each 6,277,000 won ha^-1, 365, 000 won ha^-1, and 19,467,000 won ha^-1. The value per ton of fixed organic carbon in plant through net photosynthesis was 320,000 won ha^-1 year^-1 and the value of ecosystem services stored in carbon in the Namsan forest ecosystem was about 26.1 million won ha^-1 for 3 years. Conclusions: The results of this study suggest that the pine forests of Namsan rapidly decompose leaves due to the high atmospheric temperature and accumulate a large amount of organic carbon in the soil to provide climate control regulatory service function.

Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance

Kim, Seog Ju,Cho, Seong-Jin,Jang, Ha Min,Shin, Jonghan,Park, Pil-Whan,Lee, Yu Jin,Cho, In Hee,Choi, Jung-Eun,Lee, Heon-Jeong S. Karger AG 2009 Neuropsychobiology Vol.61 No.1

<P>There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between <I>BDNF</I> Val66Met polymorphism and negative life stressors in HA. <I>BDNF</I> Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 ± 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the <I>BDNF</I> genotype and negative life stressors in HA (p = 0.02). Only subjects with the Val/Val genotype showed higher HA with recent negative stressors. Our finding suggests that <I>BDNF</I> Val66Met polymorphism might influence HA by interacting with recent negative stress experience.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

Streptozotocin-당뇨병 백서에서 당뇨병 이환기간에 따른 대동맥의 이완능 저하 및 Oxygen-Free Radical에 의한 이완능의 손상정도

김정국,김신우,김수동,서예경,하승우,김보완,백운이,권삼,강승완 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

목적: 당뇨병의 이환기간이 혈관의 내피세포 의존성 및 비의존성 이완능의 저하에 미치는 영향과 이환기간에 따라 oxygen-free radical(OFR)에 의한 동맥이완능의 손상정도에 차이가 있는지를 알아보고자 하였다. 방법: Streptozotocin(STZ)으로 당뇨병이 유도된 3 주 및 10주째의 백서군과 연령이 비슷한 정상 대조백서군의 적출 대동맥환을 norepinephrine으로 수축시킨 상태에서 내피세포 의존성 이완제인 acetylcholine(ACh) 및 비의존성 이완제인 nitroglycerine(NTG)에 대한 이완능을 즉정하여 비교 관찬하였다. 또한 xanthine과 xanthine oxidase의 혼합으로 생성된 H₂O₂에 대동맥환을 노출시킨뒤 역시 ACh과 NTG에 대한 이완능의 손상정도를 비교하였다. 결과: 3주및 10주째 당뇨병 백서의 대동맥환은 모두 대조군 백서의 대동맥환에 비해 ACh에 대한 이완능이 유의하게 감소하였으며 10주째 당뇨병 백서군에서의 ACh에대한 이완능의 저하는 3 주째 당뇨병 백서군에 비해 유의하게 심하였다.H₂O₂에 노출시킨 뒤 ACh에대한 이완능은 3주 및 10주 째 당뇨병 백서군에서 모두 대조군에 비해 유의하게 심한 손상을 보였으나 3주와 10주째 당뇨병 백서군 사이의 손상정도의 차이가 통계학적으로 유의하지는 않았다. 한편 3주 및 10주째 당뇨병 백서군 모두 NTH에 대한 대동맥환의 이완능은 대조 백서군과 별다른 차이가 없었으며 또 H₂O₂에 노출시킨 뒤에도 NTG에 대한 이완능의 손상은 관찰되지 않았다. 결론: STZ-당뇨병백서에서 대동맥의 이완능은 당뇨병에 이환된지 3 주째에 이미 ACh에 대한 내피세포 의존성 이완능이 선택적으로 저하되며 당뇨병의 이환기간이 길수록 이완능의 저하가 심하였고, OFR에 의한 동맥 이완능의 손상도 내피세포 의존성 이완능에만 선택적으로 나타나나 이환기간에 따라 OFR에 의한 이완능 손상정도에는 뚜렷한 차이가 없음을 시사하고 있다. Objectives: Diabetes mellitus produces histological evidence of endothelial as well as changes in vascular function in experimental animal. Oxygen free radicals interfere with of destroy endothelium-dependent relaxation in normal and diabetic blood vessels. The present study was investigated whether the duration of diabetic state can affect the severity of impairment in endothelium-dependent and/or independent relaxation and the sensitivity to oxygen free fadical (OFR)-induced damage in diabetic rat vasculature. Methods: The relaxative responses of aortic ring precontracted with norepinephrine in vitro to cumulative concentrations of acetylcholine (ACh) and nitroglycerine (NTG) were conducted in 3- and 10- week streptozotocin (STZ)-diabetic rats and agematched controls. After exposure to H₂O₂generated by mixing xanthine and xanthine oxidase, the degree of impairment in relaxative responses to ACh and NTG were also compared between 3- and 10-week diabetic rats. Results: The relaxative responses of aortic rings produced by cumulative concentrations of ACh were significantly lower in both 3- and 10-week diabetic rats than in the age-matched controls. The impairments of relaxative responses to ACh in 10-week diabetic rats were significantly greater than those in 3-week ones. After H₂O₂ exposure, the impairments of relaxative responses to ACh in 3- and 10-week diabetic aortas was also significantly greater than those in the control in the control ones. However, the severity of H₂O₂-induced damage in 10-week diabetic aortas was not significantly different than that in 3-week ones. In contrast, aortic rings of 3- and 10-week diabetic rats could still be fully relaxed by NTG, even after exposure to H₂O₂. Conclusion: These findings suggest that in SRZ-diabetic rat aortas selective impairment of endothelium-dependent relaxation to Ach can be found early even over a 3-week period after the induction of diabetes and the impairment may be greater in those with the longer duration of the diabetic state and that the impairment of the vascular relaxation by OFR is also selective to endothelium-dependent response but the sensitivity of OFR-induced damage may not be related to the duration of the diabetic state.

구미지역 직업성질환 감시체계

김성아,김진석,전혜리,정상재,김상우,이채용,함정오,유재영,최태성,하봉구,조민환,우극현 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.1

목적: 구미지역 내 대학병원이자 특수건강진단·보건관리대행기관의 산업의학전문의, 보건관리대행 간호사, 사업장 간호사를 중심으로 직업성질환감시체계를 구축하여 주요 직업성질환들의 발생현황과 규모를 파악하고자 하였다. 또한 연차적으로 산업, 직업, 업무내용 등에 따른 분포나 원인을 기존 자료원(특수건강진단의 직업병 유소견자와 산재요양승인 되는 직업병자)과 비교하여 분석·기술하고 예방 및 관리를 포함한 보건의료기술개발까지을 포함하는 종합적인 감시체계를 구축하고 운용하고자 하였다. 방법: 구미지역의 산업적 특성에 맞는 직업성질환감시체계를 구축하고 지역 감시체계의 모델을 제시하였다. 6대 감시대상 직업성질환(독성 간염, 직업성천식, 직업성 근골격계질환, 직업성 피부질환, 직업성 암, 수지진동증후군)의 실행적 환례정의, 보고양식 및 보고체계 개발, 분석양식 및 결과 배포 형식을 개발하였으며, 그 유병규모를 파악하고, 감시질환의 분포 및 특성, 관련인자 등을 분석·기술하고자 하였다. 이때, 1년간의 환례분석시 직업병 유소견자 및 직업병 요양자에 대한 자료와 함께 비교 분석하였으며, 노동통계자료를 이용하여 년간 발생률을 추정하였다. 결과: 2001. 1. 1일부터 2002.4.30일까지 총 287건이 보고되었으며, 직업성 근골격계질환 132건(46.0%), 직업성 피부질환 100건(34.8%), 독성간염 34건 (11.8%), 직업성천식 16건 (5.6%), 수지진동증후군 5건 (1.7%) 이었으며 직업성 암은 한건도 보고되지 않았다. 보고경로별로는 보건관리대행에서 33건 (11.5%), 해당 유해인자별로 실시되는 특수검진 외의 각종 건강진단업무 수행 중 발견된 환례에 대한 보고가 206건(71.7%)이었다. 직종별 분류의 결과는 섬유업종사자, 단순노무종사자, 음식업종사자 등이 다수를 차지하였다. 근골격계질환의 경우, 수근관증후군이 42건(33%), 외상과염/내상과염이 39건(30%)로 가장 많았다. 직업성 피부질환은 97건이 접촉성 피부염으로 유기용제류가 59건(59%)으로 가장 많고, 니켈 및 에폭시수지에 의한 알레르기성 접촉성 피부염이 각각 6건과 5건이었다. 독성 간염은 모두 DMF 나 DMAc에 의한 것으로, 근무시작 후부터 간기능이상이 발견되기까지의 근무기간은 대부분이 3개월 이하이며, 1개월 이하인 경우도 10건이나 되었다. 동 기간 중 감시환례에 대해 산재요양 자료와 중복여부를 확인한 결과, 중복되는 것은 하나도 없었다. 특수건강진단에서 직업병유소견자로 판정된 경우는 독성간염에서 3건이 있었으며, 나머지 질환은 중복되는 것은 없었다. 2001도 구미지역의 근로자수와 보고환례건수를 이용하여 연간 발생률을 추정하였다. 근로자 10만 명당 연간 발생률은 상지 근골격계질환은 63.6명, 피부질환 48.2명, 독성 간염 17.9명, 천식 7.7명, 수진진동증후군 2.4명이었다. 참여예상인원은 총 46명이었으며, 실제 참여자수는 21명, 평균참여율은 46%, 실제 참여 1이당 평균 보고건수는 산업의학전문의가 28건으로 가장 많았고, 대행간호사는 45,건, 사업장 간호사는 3.3건이었다. 결론: 지역 감시체계는 기존 통계자료들에서 발견되지 않았던 직업성질환의 발견에 유용한 통계원이며, 특히 지역의 특성과 여건을 고려하여 체계화된 시스템을 구축하여 운용한다면 더 성과가 클 것이다. Objectives: Area-based occupational disease surveillance in Kumi (KODS) was used to collect data on occupational diseases. The data was used to estimate the magnitude of the diseases, to analyze for their characteristics and to find links for their intervention and prevention. Methods: Since January 2001, occupational physicians and nurses in Occupational Health Service (OHS) have reported six major occupational diseases; occuaptional musculoskeletal disorders of the upper extremities (MSDUE), occupational dermatoses, toxic hepatitis, occupational asthma (OA), hand-arm vibration syndrome (HAVS), and occupational cancer. For the respective diseases, a reporting sheet and operational diagnostic criteria were developed by the KODS. An analysis of the KODS data, collected over a certain period, was compared with data from the Korea Labor Workers Corporation (KLWC) and the Specific Health Examination (SHE), and the incidence rates of the diseases estimated. Results: Between Jan 2001 and Apr 2002, 287 cases of the six major occupational disease were reported. Of these, there were 132 (46.0%), 100 (34.8%), 34 (11.8%), 16 (5.6%), and 5 (1.7%), cases of MSDUE, occupational dermatoses, toxic hepatitis, OA, and HAVS, repectively. But, there were no cases of occupational cancer. 33 (11.5%) of the incidence were reported via the OHS, 206 (71.7%) from health checkups, and the other 48(16.8%) from other routes. The synthetic fibers and electronic components manufacturing industries accounted for the greatest number of reported cases. With resport to occupation, the greatest numbers of incidence were reported from the elementary occupations, textile workers, assemblers, and cooks and food services worker, in that order. Of the MSDUE cases, carpal tunnel syndrome and epicondylitis were the two most common diseases. Most of the occupational dermatoses were due to contact dermatitis, with organic solvents (59%), nickel (6%), and epoxy resin (5%) accounting for the majority of these cases. All cases of toxic hepatitis were induced by dimethylformamide or dimethylacetamide, which were reported by a unique monitoring system. During same period, there were no cases claimed by workers to the KLWC, and only three cases from SHE, were identified. Using data from workers' number and surveillance, the annual incidence of MSDUE, dermatoses, hepatitis, OA, and HAVS, per 100,000 workers were 63.6, 48.2, 17.9, 7.7, and 2.4, respectively. Conclusions: These results show that an area-based surveillance system can be very effective for the collection of data on work-related diseases, at least in Kumi.

시상하부-뇌하수체 질환에서 종합적 뇌하수체전엽 기능검사의 진단적 의의

김수동,김신우,김정국,하승우,김보완 慶北大學校 醫科大學 1993 慶北醫大誌 Vol.34 No.4

시상하부-뇌하수체질환의 기저질환에 따른 종합적 뇌하수체전엽 자극검사의 진단적 가치를 알아보고자 81례의 뇌하수체 기능부전증환자를 대상으로 시상하부질환군과 Sheehan증후군, 말단비대증과 프로랙틴종, 그리고 뇌하수체선종에서 시야장애가 동반된 군과 장애가 없는 군으로 나누고 기능검사의 결과를 비교하였다. 1. Sheehan증후군 15례 가운데 GH 및 cortisol결핍이 전례(각각 100%)에서 FSH, LH 및 TSH결핍이 11∼12례(73∼80%)에서 관찰되었고 13례(86%)에서는 TRH에 대한 PRL분비증가가 저하 또는 소실되었다. 두개인두종 10례를 포함한 시상하부질환 14례 가운데 12례(86%)는 PRL의 기저지가 비정상직으로 증가되어 있었으며 TRH자극에 대해 PRL분비 증가가 11례(79%)에서 둔화되어 있었다. GH분비능도 11례(79%)에서 저하되었으며 그 밖의 cortisol, LH, TSH, FSH의 순으로 분비능이 저하되어 있었으나 그 빈도는 Sheehan증후군에 비해 전반적으로 낮았다. 2. 말단비대증 18례 가운데 14례(78%)에서 GH기저치가 비정상적으로 증가되어 있었고 13례(72%)는 저혈당자극에 대해 정상적인 GH의 증가를 보였으며 8례(44%)에서 고프로랙틴 혈증이 동반되었다. 프로랙틴종 18례 가운데 전례(100%)에서 PRL기저치가 증가되었고 13례(72%)에서 TRH에 대한 PRL의 증가반응이 둔화되었다. LH, FSH, cortisol 및 TSH분비능의 장애는 말단비대증군에서 프로랙틴종에 비해 다소 높은 빈도를 보이는 경향이었다. 3. 뇌하수체선종 가운데 시야장애가 동반된 21례에서 시야장애가 없는 23례에 비해 GH, cortisol및 LH의 분비반응이 저하된 빈도가 다소 높은 경향이었다. 이상의 결과로 보아 종합적 뇌하수체전엽 기능검사는 시상하부-뇌하수체질환의 기저질환을 진단하는데 중요한 정보를 제공할 수 있다고 생각한다. The combined stimulation test using TRH, LHRH and insulin has allowed investigation of the reserve of all pituitary tropic hormones under physiological and pathological conditions. To evaluate the diagnostic efficacy of this test for differentiating the underlying causes of hypopituitarism, we analyzed retrospectively the results of these tests done in 81 patients with proven hypothalamo-pituitary disorders. 1. In 15 patients with Sheehan's syndrome as a typical type of primary hypopituitarism, responses of both GH and cortisol to insulin-induced hypoglycemia were decreased in 15 cases all (100% in both) and of FSH, LH and TSH in 11 to 12 cases(73-80%). Incremental response of prolactin(PRL) to TRH was diminished or absent in 13 cases(86%). In 14 patients with hypothalamic diseases, including 10 cases of craniopharyn-gioma, as a representative secondary hypopituitarism, the basal PRL levels were abnormally elevated in 12 cases (86%) and both responses of PRL to TRH and of GH to hypoglycemia were blunted in 11 cases (79% in both). The frequency of impaired cortisol secretion was 50%, followed by LH, TSH and FSH secretion : overall frequency much lower than in Sheehan's syndrome. 2. In 18 acromegalics with pituitary adenoma, basal GH levels were abnormally elevated in 14 cases(78%) and incremental responses of GH to hypoglycemia were found in 13(72%). Hyperprolactinemia was accompanied in 8 (44%). In 18 patients with prolactinoma, basal PRL levels were moderately to markedly elevated in all of them(100%) and responses of PRL to TRH were blunted in 13(72%). The frequency of impaired secretion of LH, FSH, cortisol and TSH was slightly higher in acromegalics than in patients with prolactinoma. 3. The frequency of impaired secretion of GH, cortisol and LH tended to be slightly higher in patients with pituitary adenoma associated with visual field defect than those without visual field defect. These results suggest that the combined pituitary stimulation test will give us some of reliable information for evaluating the underlying causes of hypopituitarism.

Suppression of lung inflammation by the methanol extract of <i>Spilanthes acmella</i> Murray is related to differential regulation of NF-κB and Nrf2

Kim, Kyun Ha,Kim, Eun Jung,Kwun, Min Jung,Lee, Ji Yeon,Bach, Tran The,Eum, Sang Mi,Choi, Jun Yong,Cho, Sayeon,Kim, Sang-Jun,Jeong, Seung-Il,Joo, Myungsoo Elsevier 2018 Journal of Ethnopharmacology Vol.217 No.-

<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>Although <I>Spilanthes acmella</I> has been used to relieve inflammation, fever, pain, or infection in traditional Asian medicine, experimental evidence supporting these functions is scarce. Here, we examined an anti-inflammatory function and a possible underlying mechanism of <I>S. acmella</I> Murray (SAM).</P> <P><B>Materials and method</B></P> <P>The methanol extract of SAM was fingerprinted by HPLC. C57BL/6 mice were administered with a single intratracheal (i.t.) LPS and 2 h later with a single i.t. SAM. The effect of SAM on lung inflammation was assessed by histology, semi-quantitative RT-PCR, and MPO assay of lung tissue. The effects of SAM on a pro-inflammatory factor NF-κB and an anti-inflammatory factor Nrf2 were analyzed by immunoblotting of nuclear proteins and by semi-quantitative RT-PCR analysis of mRNA of the genes governed by these transcription factors. V5-Nrf2 was precipitated by an anti-V5 antibody and the ubiquitinated V5-Nrf2 was revealed by immunoblotting of HA-tagged ubiquitin.</P> <P><B>Results</B></P> <P>The i.t. SAM robustly diminished a neutrophilic lung inflammation induced by i.t. LPS treatment of mice. In RAW 264.7 cells, SAM suppressed the nuclear localization of NF-κB and the expression of NF-κB-dependent cytokine genes. SAM increased the level of Nrf2 in the nucleus and the expression of Nrf2-dependent genes while suppressing ubiquitination of Nrf2.</P> <P><B>Conclusion</B></P> <P>Our results suggest that SAM can suppress a neutrophilic inflammation in mouse lungs, which is associated with suppressed NF-κB and activated Nrf2. Our results provide experimental evidence supporting the anti-inflammatory function of <I>S. acmella</I>.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>