정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

세계 정상 마라토너들의 구간별 경기 내용 분석

윤양진 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

This study was designed to analyze a total of 9 laps time of 75 leading marathoners who ran the whole distance at the various international marathon races within 2 hours and 9 minutes in 2000 to 2003. The subjects included 3 Korean marathoners(A group), 20 Japanese marathoners(B group) and 52 Multination marathoners(C group). The results of the study were as the follows: 1. In the first half(1~4 laps) of the whole race domestic marathoners set faster records than other nations marathoners and in the latter half(5~8 laps) of race domestic marathoners set slower records than multination marathoners with no significant.......

태권도 품새 수련의 전통적 이론 분석

양진방,노윤기 龍仁大學校 武道硏究所 2004 武道硏究所誌 Vol.15 No.1

The Purpose of this study was to analyze various philosophical theories based on the traditionaltheories of Taekwondo Pumsae training, divided them into contemporary and traditional meanings and technical and moral meanings focused on changes in the objectives, methods and values of training. In addition, it analyzed theories resulting from changes in emphatic points and key parts of the training. Moreover as a research on the philosophical possibility and theories of Pumsae training, this study attempted approaches through established Tae-geuk philosophy, Yigi-ron of Sung Confucianism and metaphysical and physical concepts. This study sought for Taegeuk philosophy in the principles of the composition of motions, Yi(理) as an idea or philosophy in the moral aspect, and moral and traditional meanings as the concept of moral training.Gi(氣) was divided into the form of motions in the aspect of motion, the concept of physical training in the technical aspect, and physical concept as contemporary meanings. This Yigi idea was divided into Yigiyiwon-ron(二氣二元論) and Yigiilwon-ron(二氣一元論). It was divided the idea into mind-body dualism and mind-body monism of Pumsae training through a philosophical approach to Pumsae and furthermore discussed the possibility of a philosophical approach to a new concept mind-body dualistic monism. This is ideal Pumsae training philosophy in search of new possibility how Pumsae should be trained in the middle of changes in the objectives, methods and values of Pumsae training. In particular, the contemporary concept of Pumsae is a sports concept coming from judgment or Taekwondo matches, which is an important part in the process of training that may indicate a new direction. Directions for philosophical research on the theories of Pumsae training were as follows: the first philosophical views about the questions of what the ontological meaning of Pumsae as an essential philosophical idea is, namely, what Pumsae is, and why it is necessary and why it should be trained; the second theories appearing in the processof associating the idea and philosophy of Pumsae with traditional ideas; and the third, philosophy appearing in theprocess of establishing the principle of the composition of Pumsae motions. Traditional philosophical ideas of Pumsae training include Tae-geuk philosophy, Yuga philosophy, Yigi philosophy, the spirit of Hwarangdo, the spirit of loyalty and filial piety and moral and philosophical ideals such as Confucianism, Buddhism and Zen. These ideas have been settled, typified or frequently discussed in relation to Pumsae. However, it is not clear how these ideas and traditions have been adopted in Pumsae and how external factors, such as Chinese ideas and Japanese, and furthermore Oriental culture should be understood and applied in the principle of the composition of Pumsae motions. In order for Pumsae training to be born againas a traditional theory or idea, it is necessary to pay attention to objective evaluation of and realistic approaches to researches on Eastern and Western philosophical and their approachability to each other. In particular, the traditional concept of training is evolving to a contemporary concept in response to various situations and demands, and such a transition will be an important element in establishing sound Pumsae training philosophy and finding tasks for development.

효과적인 다차원 분석을 지원하는 스프레드시트 방식의 OLAP 인터페이스 설계 및 구현

윤민희,김진호,문양세 강원대학교 정보통신연구소 2006 정보통신논문지 Vol.10 No.-

OLAP systems support effectively data analysis over a large volume of business data to make decisions for an enterprise. In order to process data analysis efficiently, OLAP systems pre-compute the summary of business data over various dimensions and store them into data warehouses. Several specialized tools have been developed to display and to browse the results of complex analytical queries on data warehouses. In this paper, we developed a spreadsheet-like tool to support OLAP operations and to browse the results of analytical queries. Spreadsheet is one of the most popular and user-friendly data analysis tool. It also has lots of advantages, which is interactive, easy to learn, etc. Thus this paper implemented an OLAP tool using spreadsheet-style interface to analyze large OLAP data on World-Wide Web. Through this tool, users can process OLAP activities easily and effectively by using the same ways as well-known shreadsheet tools like Microsoft Excel.

成人男子의 體格, 身體構成 및 上腕의 方向別 筋力에 관한 硏究

梁點紅,尹良津,徐國段 부산대학교 사범대학 1991 교사교육연구 Vol.22 No.-

벼 생육중기 및 출수기 태풍 "올가" 건풍에 의한 엽신 피해의 품종간 차이와 수량 및 품질 변화

윤영환,김정곤,정남진,곽강수,강양순 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.4

1999년 8월3일~8월4일간 태풍 올가 도래시 건풍에 의한 생육중기 엽신 피해의 품종간 차이와 출수기 이삭 갈변에 따른 수량 및 품질에 미치는 영향을 조사하여 다음과 같은 결과를 얻었다. 1. 잎의 증산량 및 수분저하속도가 클수록, 잎이 길이가 길고 폭이 넓을수록 엽신의 피해정도가 컸다. 2. 이삭의 피해 정도가 증가될수록 임실 및 등숙비율은 현저히 낮아지는 경향이며, 쌀 수량은 무피해 대비 피해 3~5는 14~16%, 피해 7은 28%, 피해 9는 48% 감수하였다. 3. 이삭의 피해 정도별 백미 완전미 비율은 피해 정도가 클수록 감소를 보였으며 피해 0~3에서 63~65%, 피해 5~9에서 42~58%의 분포를 보였다. 4. 이삭의 피해정도가 증가할수록 백도 및 색도치가 낮아지며, 단백질 함량은 증가하고 식미치는 저하하는 경향을 보였다. This study was carried out to characterize the influence of dry wind by typhoon "Olga" during Aug. 3~Aug. 4, 1999 on the rice plant(Oryza sativa L.). For the purpose, the affection of the dry wind during the mid-growing stage and heading stage on the leaf damage, yield and rice quality were investigated. The extent of the leaf damage increased with the increase of leaf size and transpiration rate, and also with the decrease of moisture content in the leaves. The percentage of fertile grain decreased in proportion to the increase of the extent of the panicle damage. Compared with none-damaged rice plants in the panicle, the milled rice yield decreased by 14~16% in the degree 3~5 of the panicle damage, and 28~48% in the degree 7~9. The percentage of head rice was the same in the both milled and brown rice in the degree 0~3 of the panicle damage. Above the degree 5, however, it decreased with the increase of the panicle damage. The whiteness and lightness decreased in proportion to the increase of the degree in the unhulled, brown and milled rice. And, there was a tendency that the protein content in the milled rice increased but eating quality decreased with the increase of the panicle damage.

남중 육상경기 선수의 Foot Ratio와 체력과의 상관

윤길환,서국웅,이훈식,정미라,윤양진,박승범 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

Foot ratio and physical fitness were measured and multiple-compared in the level of P<.05 on the subject of 28 prize winners from Men's part of middle school in the field and track events of the "P" youth athletic tournament in 1998 and 7 general students adopted by random sampling. These are conclusions from the result of relative analysis of foot length measured by X-ray, Medial longitudinal arch's height, foot ratio and physical fitness in the level of P<.05. 1. No significance was discovered in FR but throwing group is better than medium and long distance group. 2. Flexibility and endurance have meaning in physical fitness. The short distance group has better flexibility than the medium and long, throwing and general one. And medium and long distance/ throwing group have better endurance than general one. 3. FR and physical fitness show a negative correlation in the muscular strength of throwing group.

골아세포 MC₃T₃-E₁의 증식과 기능에 Insulin Like Growth Factor Ⅰ, Ⅱ 및 부갑상선 호르몬이 미치는 영향

윤현구,정호연,양인명,김성운,김진우,김광원,김영설,최영길,서광식 대한내과학회 1992 대한내과학회지 Vol.42 No.1

MC₃T₃-E₁골아세포군을 이용하여 IGF-Ⅰ과 Ⅱ를 투여하고 DNA합성과 골아세포기능을 측정하기 위해 PTH에 대한 C-AMP반응정도, alkaline phosphatase 활성도를 측정하여 다음과 같은 결과를 얻었다. 1) IGF-Ⅰ과 Ⅱ는 모두 DNA합성이 어느 농도까지는 증식효과를 나타내지만 그 이후에는 억제되는 양상을 보였다. 2) PTH에 대한 골아세포의 C-AMP반응으로 증가되었지만 IGF-Ⅰ과 Ⅱ의 투여시 농도변화에 따른 의미있는 변화는 없었다. 3) 본 실험의 조건에서 alkaline phosphatase 활성도는 증가되지 않았다. 이상의 결과로 MC₃T₃-E₁ 골아세포에 IGF-Ⅰ과 Ⅱ는 세포의 증식을 자극하여 PTH는 C-AMP생성을 촉진하는 효과가 있었다. The effect of insulin-like growth factor (IGF) Ⅰ and Ⅱ on cloned MC₃T₃-E₁ cells that had osteoblastic activity was examined by [³H] thymidine incorporation into DNA, cyclic AMP responsiveness to parathyroid hormone (PTH), and alkaline phosphatase activity. IGF Ⅰ and Ⅱ stimulated the growth and proliferation of osteoblastic cells at 20ng/㎖ and 50ng/㎖, respectively. We next examined the effect of IGF-Ⅰ and Ⅱ on the expression of osteoblastic activity. Adenylate cyclase response of PTH to IGF-Ⅰ and Ⅱ-treated cells showed maximal stimulation at 10 and 50㎚PTH, respectively, but IGF Ⅰ and Ⅱ induced limited activity of osteoblastic function. In conclusion, IGF-Ⅰ and Ⅱ were potent stimulators to the growth of osteoblastic cells but did not have an immediate effect on expression of osteoblastic function in this experiment.

大學校 敎職員의 健康實態에 관한 基礎的 調査硏究

양점홍,황철문,남태호,백영호,윤양진,황영성 부산대학교 사범대학 1993 교사교육연구 Vol.26 No.-

The purpose of this study was to analyze the staffs' health of P. University through survey research. Also, the staffs's health problem was analyzed by the regular health test's result and their lifestyle. The results were as following: 1. The analysis of lifestyle (1) A habit of smoking 1. It was presented the male smokers(55.9%) and females smokers(0.6%) of P. university staffs were found in this study. 2. It was presented the male smokers smoked average 18.2 pieces a day. Also, they began to smoke cigarette 21.5 years old. 3. The persistent smokers were 24.6% and 52.2% of smokers be going to quit smoking cigarette someday in the future. (2) A habit of drinking 1. It was presented 85.7% of males and 59.1% of females subject drinking normally. 2. It was presented 3.7% of male subjects were drinking alcohol almost everyday in a week. 3. The most frequent kind of alcohol is as following order a beer(males 67.6% & females 79.6%) and a soju(males 28.3% & females 4.3%). Males drunken average amount of beer was 2 bottles(640ml) and females drunken average amount of beer was 0.8 bottles in a week. (3) A habit of exercise 1. It was presented males (29.0%) and females (15.1%) were exercising regularly, but males (23.3%) and females (38.6%) of staffs were not exercise at all. 2. It was found males' regular kind of exercise was as following order mountain-climbing, tennis, and jogging and females' regular kind of exercise was as order swimming, free handing exercise, and mountain-climbing. 3. It was presented 25.1% of staffs exercised 6 times a week regularly. And each times of exercise, 37.3% of staffs spent less than 30 minutes. 4. It was presented staffs exercised for health (72.4%) and 48.4% of staffs could not exercise as following reasons of not enough times, home work, research.... 5. Male staffs prefer as following order kind of sport tennis, swimming, and golf and female staffs prefer as following order kind of sport swimming, tennis, and bowling in the future. (4) A habit of eating 1. It was presented 5.5% of males and 16.6% of females did not have a breakfast regularly. 2. Concerning balance of food content: do not concerning food (males 34.7% & females 23.8%) and subjects like vegetables 9males 25.7% & females 32.7%) were found. 3. It was presented 8.5% of males and 5.4% of females took the vitamin regularly. (5) Health condition 1. In present evaluation for subject's health condition, very healthy (males 7.5% & females 6.0%) and poor health (males 2.0% & females 1.8%) were found in this study. 2. In present evaluation criterion for subject's health condition, the ability of adaptation on fatigue was appeared the most (males 35.9% & females 40.7%). 3. It was presented subjects have a digestive trouble (males 23.5% & females 33.1%) which were the best health problem in subjects. 2. A analysis of result of regular health test (1) Physique test 1. It was presented height (males 169.5cm & females 158.6cm) and body weight (males 65.9kg & females 53.1kg) were found in this study. 2. According to this study, obesity (males 11.2% & females 5.6%) and low body weight (males 8.8% & females 14.8%) were found in this study. 3. A high blood pressure subject (males 8.7% & females 2.5%) over than a contraction blood pressure 140mmHg and A high blood pressure subject (males 8.5% & females 1.9%) over than a expansion blood pressure 90mmHg were found in this study. (2) A blood test 1. Normal hemoglobin of subject (males 99.8% & females 62.3%) and 37.7% of females less than normal hemoglobin were found in this study. 2. 5.3% of males and 2.5% of females have greater than a concentration of glucose 140mg/dl, but there was anyone less than a concentration of glucose 50mg/dl. 3. The greater than 251mg/dl staff''s T.C.(males 7.1% & females 4.9%) and the less than 130mg/dl staffs' T.C.(males 2.0% & females 3.7%) were found in this study. 4. It was found males 5.3%, 11.6% & females 1.9%, 4.3% were presented greater than GOT and GPT 341U/L. (3) Hepatitis, Urinary Sugar, and Urinary Protein test 1. According to this study result, positive hepatitis was presented males (6.5%) and female(4.3%). 2. Urinary sugar is greater than +- males (1.8%) and females (2.4%) were found in this study. 3. Urinary protein is greater than +- males (1.6%) and females (1.8%) were found in this study. (4) Chest X-ray test 1. It was found male (1.6%) suffered from tuberculosis of the lungs. (5) Dental test 1. It was presented 77.3% of males and 88.9% of females was not existed the upper caries. Also, 75.7% of males and 90.7% of females was not existed the bottom caries. 2. It was presented 96.8% of males and 99.4% of females had the non-deficit of teeth in the upper part of teeth. Also, 93.9% of males and 98.1% of females had the non-deficit of teeth in the bottom part of teeth. 3. It was presented 19% of males and 3.7% of females have the periodontal disease. (6) General report and judgment 1. In general report, it was found 75.3% of males and 91.4% of females were the normal health condition. It was presented 9.1% of males and 4.9% of females were the liver disease, 4.9% of males and 1.2% of females were the sugar diabetes, 4.9% of males and 0.6% of females were the high blood pressure, and 1.4% of males and 1.9% of females were high arrest of bleeding. 2. In general judgment, it was presented 75.5% of males and 91.4% of females were the normal health condition. However, it was presented 17.8% of males and 7.4% of females were required high observation, 6.7% of males and 1.2% of females were required simple observation. As presented P. University staffs' lifestyle, it was found still many staffs have not right living habit. It is necessary to be wellness of lifestyle and satisfaction of life through correction of self responsibility and management in their life. Therefore, it is possible to live with healthy in better quality of life which is high quality of life and new concept of health were offered. Also, researcher expected the regular health examination be more practical contents than informal contents. Researcher recommended that it is necessary to support the university administration to be more flexibility of the regular health examination day than set the certain day of regular health examination and it required to create a way of using the P. university hospital.

효과적인 다차원 분석을 지원하는 스트레드시트 방식의 OLAP 인터페이스 설계 및 구현

윤민희,김진호,문양세 강원대학교 정보통신연구소 2006 정보통신논문지 Vol.10 No.-

OLAP systems support effectively data analysis over a large volume of business data to make decisions for an enterprise. In order to process data analysis efficiently, OLAP systems pre-compute the summary of business data over various dimensions and store them into data warehouses. Several specialized tools have been developed to display and to browse the results of complex analytical queries on data warehouses. In this paper, we developed a spreadsheet-like tool to support OLAP operations and to browse the results of analytical queries. Spreadsheet is one of the most popular and user-friendly data analysis tool. It also has lots of advantages, which is interactive, easy to learn, etc. Thus this paper implemented an OLAP tool using spreadsheet-style interface to analyze large OLAP data on World-Wide Web. Through this tool, users can process OLAP activities easily and effectively by using the same ways as well-known shreadsheet tools like Microsoft Excel.