Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

Repellent efficacy of essential oils and plant extracts against Tribolium castaneum and Plodia interpunctella

Lee Hwa‐Eun,Hong Su Jung,Hasan Najmul,Baek Eun Joo,Kim Jun Tae,Kim Young‐Duk,Park Mi‐Kyung 한국곤충학회 2020 Entomological Research Vol.50 No.9

This study was conducted to investigate the repellent efficacy of essential oils (Origanum vulgare, Pimpinella anisum, and Tanacetum cinerariifolium) and four plant extracts (Agastache rugosa, Capsicum annuum, Citrus reticulata, and Ginkgo biloba) against Tribolium castaneum (adults and larvae) and Plodia interpunctella (larvae). Gas chromatography/mass spectrometry analysis revealed the presence of carvacrol, anethole, and jasmolin I as the predominant constituent in O. vulgare, P. anisum, and T. cinerariifolium, respectively. Furthermore, ethyl hexopyranoside, 9,12‐octadecadienoic acid, cyclopentanol, and 2‐cresol were identified in A. rugosa, C. annuum, C. reticulata, and G. biloba, respectively. The repellent efficacy of each essential oil, plant extract, and the combination of oils was evaluated using a specially designed cylinder trap for 120 h. Among the three oils, O. vulgare and T. cinerariifolium had greatest repellent efficacy against P. interpunctella larvae. T. cinerariifolium exhibited effective repellence against the adults and larvae of T. castaneum. Therefore, O. vulgare (O) and T. cinerariifolium (T) were selected for further investigation of combined effects. Two essential oils were mixed in three different ratios of OT1 (1:3), OT2 (1:1), and OT3 (3:1). The repellent efficacies of OT1 and OT2 against the adults of T. castaneum were significantly greater than that of OT3. OT1 was effective against the larvae of T. castaneum, whereas OT2 was effective against the larvae of P. interpunctella. OT1 enhanced the repellent efficacy by approximately five times against larvae of T. castaneum, compared with that of T. cinerariifolium. Overall, OT1 was selected as the best repellent substance against all the tested insects.

급성심근경색증을 가진 한국인에 있어 Chlamydia Pneumoniae 감염의 영향에 대한 연구

이은미,오동주,황교승,안정천,송우혁,임도선,박창규,김영훈,서홍석,심완주,노영무,정희진,김우주,김종헌,송기준 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

암치료에 있어서 체질과 항암효과에 관한 한의학적 연구

성현제,신현규,박갑주,강봉주,은영아,김은해,정세영 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

As one of the chemical and experimental study on cancer treatment in Korea oriental medical hospital. Furthermore, we carried out the cytotoxicity test of extracts of herbal medicine. The results are as follows : About Clinical Aspects of the Oriental Medical Cancer Treatment - (1) Clinical experience is that 420 Oriental medical hospital were surveyed. Number of cancer patient treated by one oriental medical doctor was under 10(about 60%) or from 10 to 20(about 30%). (2) Diagnostic Procedure is that more than 80% of cancer patients were diagnosed by medical doctor of western hospital. (3) Therapeutic Method is that combination of oriental and western medical treatment was used in oriental medical hospital. (4) Relationship between cancer and constitutions is that to the relationship between cancer and constitutions, about 75% responded and most were considered to be Um. About Experimental Study - to evaluate the direct cytotoxicity of hot water and methanol extracts of 34 oriental medical presciptions on stomach cancer cell, SRB assay was carried out. (1) The IC50 value of water extract of Samsoum was 19㎍/㎖ and that of methanol extract was 15㎍/㎖, so that we confirmed Samsoum has a strong direct cytotoxicity. (2) The IC50 values of water extract of Coptidis Rhizoma, methanol extract of Caesalpiniae Lignum and Draba Semen were 10㎍/㎖, 19㎍/㎖ and 12.5㎍/㎖ respectively, so that we confirmed Coptidis Rhizoma, Caesalpiniae Lignum and Draba Semen have a strong direct cytototoxicity. (3) The IC50 value of combinatory prescription of Rhei Rhizoma, Forsythie Fructus and Caesalpiniae Lignum was about 40㎍/㎖.

한국 Drosophila아속 10종에 대한 유전적 유연관계

주은영,이양숙,김남우 경산대학교 기초과학연구소 2001 基礎科學 Vol.5 No.2

한국산 Drosophila아속 10종(D. virilis, D. tsigana, D. lacertosa, D. angularis, D. brachyephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai, D. unispina)의 계통관계를 알아보기 위하여 동위효소와 수용성 단백질 분석을 실시하였다. 15종류의 동위효소 분석에서 18개의 loci가 검출되었다. 18개 loci중 Mdh-2, Got, Me, Ao, G6pd, Adh, Fum은 종내 변이가 없었으며, 특히 Ao, Fum은 종간에서도 변이가 없이 monomorpic하였다. 이 동위효소 분석에서 D. lacertosa와 D. nigromaculata가 가장 낮은 유연관계를 보였다. 2DE에 의한 수용성단백질 분석에서는 D. nigromaculata와 D. brachynephros가 가장 낮은 유연관계를 보였으며, D. angularis와 D. brachynephros가 가장 높은 유연관계를 보였다. 이상의 결과를 종합하여 보면 한국산 Drosophila아속 10종은 D. virilis, D. tsigana, D. lacertosa의 group과 D. angularis, D. brachynephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai, D. unispina의 group으로 나눌 수 있으며, D. virilis가 속한 group이 더 primitive하다고 하겠다. 그러나 이 group이 다른 group에 직접적인 ancestor는 아니며 다른 ancestor가 있었을 것으로 생각된다. Phylogenetic relationships among the 10 species of the subgenus Drosophila in Korea, which is D. virilis, D. lacertosa, D. tsigana, D. angularis D. brachnephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai and D. unispina were investigated using 18 loci found from analysis of 15 allozymes and soluble proteins analysis. Mdh-2, Got, Me, Ao, G6pd, Adh and Fum showed monomorphic patterns in each species, and specially Ao and Fum are the same alleles. As for the genetic relationships based on the results from the allozymes analysis, D. curvispina and D. unisina were found to have the closest relationship (0.851), and D. lacertosa and D. kuntzei showed the reverse (0.198). the average genetic similarity of the 10 species by allozyme analysis was 0.458. Soluble proteins from the 10 species of subgenus Drosophila were analyzed by 2DE method. Genetic distance between D. angularis and D. brachynephros was closer (0.168) than any other species. D. curvispina and D. unispina, and D. kuntzei and D. takadai were grouped as related species. The allozyme and soluble protein analysis showed similar. The average genetic distance of the 10 species by 2DE analysis was 0.386, indicating that the subgenus Drosophila can be grouped into two classes; the one class in D. virilis, D. lacertosa, D. tsigana and the other D. angularis, D. brachynephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai and D. unispina.

e-Learning 내 지식창출(Knowledge Creation)을 위한 가상적인 바(Cyber-Ba)에 대한 고찰

주영주,조은아 이화여자대학교 사범대학 교과교육연구소 2006 교과교육학연구 Vol.10 No.1

지식관리시스템은 최근 e-Learning의 도입을 통해 조직 내 지식경영과 학습체계를 결합시키는 효율적이면서 효과적인 방향을 모색하고 있다. 특히 e-Learning은 다양한 정보기술 도구를 바탕으로 사이버 공간에서의 학습의 효과를 극대화시키는 것이 목표이며, 이를 지식경영의 측면에서 본다면 e-Learning은 조직이 사이버 공간 내에서 지식을 창출하게 하는 도구이자 시스템이 된다는 뜻이다. 그러므로 과연 정보기술을 통한 학습도구로서의 e-Learning이 조직의 지식 창출이라는 새로운 요구에 대해 어느 정도 도움을 줄 수 있는지를 알아보는 것은 앞으로 e-Learning과 지식경영을 통합시키고자 하는 노력에 있어 필수 과제라 생각된다. 이를 위해 우선 조직에서의 지식창출의 과정과 지식창출의 장으로서의 바와 관련된 노나카의 이론을 살펴보고, e-Learning에 있어 지식창출과 학습의 관계를 규명하고자 하였다. 또한 지식창출의 사회화, 외재화, 종합화, 내재화의 4가지 사이클 별로 어떠한 정보기술이 현재 상태에서 e-Learning상에서의 지식창출에 있어 지원 가능한지에 대해서 관련된 문헌을 고찰하였다. 조직 내에서의 지식창출 및 공유를 위해서는 가치있는 지식을 창조하는 활동을 학습이 지원하며, e-Learning은 그러한 의미의 진정한 학습이 이루어짐으로써 지식이 창출되는 환경이 되어야 한다. e-Learning 내에서 활용되는 정보기술은 지식창출의 과정별로 근본적인 바, 상호적인 바, 가상적인 바, 학습의 바 등 각각 가상적인 바를 형성함으로써 e-Learning을 통한 지식창출을 지원하게 되는 것이다. 즉 e-Learning 내에서 형성되는 가상적인 바가 지식창출의 네 가지 사이클을 모두 지원할 수 있다는 관점에서 e-Learning과 지식창출의 연계성이 의미를 가진다 하겠다. By introducing e-Learning, knowledge management system is seeking efficient and effective methods to combine knowledge and learning in organizations. Based on various informational technology, e-Learning aims at maximizing effect of learning in cyber space. In terms of informational technology, e-Learning is a tool and a system that enables organizations to create knowledge in cyber space. Therefore, it is essential to integrate e-Learning and knowledge management that how much e-Learning, as a learning method through informational technology, can help organizational knowledge creation. For this purpose, first, the article examined Nonaka's theory, the process of knowledge creation in organization, which is related to Cyber-Ba as a place of knowledge creation. The article also examined some related treatises on which informational technology is currently able to assist knowledge creation on e-Learning by four of each cycle; socialization, externalization, combination and internalization. For knowledge creation and sharing in organization, the activities to creating valuable knowledge should be assisted by learning, and e-Learning should be a knowledge-creating environment by achieving and authentic learning. Informational technology used in e-Learning, by forming each Cyber-Ba such as Originating Ba, Interacting Ba, Cyber Ba and Exercising Ba in the process of knowledge creation, will assist knowledge creation in e-Learning, In other words, from a viewpoint that Cyber-Ba which is formed in e-Learning can assist all the four cycle of knowledge creation.

기업 사이버교육 학습자들의 내적통제소재, 조직의 지원, 학습몰입, 학업지속의향 간의 구조적관계 규명

주영주,김수미,박수영,김은경 이화여자대학교 교육과학연구소 2009 교육과학연구 Vol.40 No.3

본 연구는 기업 사이버교육생을 대상으로 하여 내적통제소재, 조직의 지원, 학습몰입과 학업지속의향 간의 구조적 관계를 검증하는 것을 목적으로 하였다. 이를 위해 A기업의 2009년 1월 사이버강좌 수강생 447명을 대상으로 연구를 수행하였다. 그 결과 내적통제소재와 조직의 지원은 학습몰입에 직접적인 유의한 영향을 미쳤으며, 내적통제소재와 학습몰입은 학업지속의향에 직접적인 유의한 영향력을 가지는 것으로 나타났다. 또한 학습몰입은 내적통제소재와 학업지속의향, 조직의 지원과 학업지속의향을 매개하는 변수임을 확인하였다. 이와 같은 연구결과는 내적통제소재가 사이버교육 과정의 교수설계와 개발전략을 위해 고려되어야 하는 변수라는 것과, 조직의 지원이 기업 사이버교육의 효과성을 향상시키는데 있어서 중요한 변수라는 것을 시사한다. 이에 본 연구는 성공적인 사이버교육을 위한 학습전략을 제공하는데 있어서 기초적인 토대를 제공하는데 기여할 것으로 기대된다. The purpose of the present study is to verify the structural relationship among internal locus of control, organizational support, flow and learning persistence in Corporate Cyber Education. The subjects were 447 students who participated in A’s corporate cyber courses. A hypothetical model was proposed, which was composed of internal locus of control, organizational support, flow as an extraneous variable, and learning persistence as an endogenous variable. Flow has also been suggested as an intervening endogenous variable. The results of this study through structural equation modeling analysis indicated that both internal locus of control and organizational support significantly affect flow. Also, internal locus of control and flow affected learning persistence significantly. As a result of the Sobel test to examine the significance of the mediation effect, flow was a mediating variable between internal locus of control and learning persistence, organizational support and learning persistence. These results imply that internal locus of control should be considered for the design and development strategies of online courses. Also, organizational support is critical to enhance the effectiveness of corporate cyber education. This study proposes the first step of learning strategies for successful cyber education.

부의 양육참여와 아동의 사회적 능력과의 관계에 관한 고찰

은주영,류도희,이귀옥 경성대학교 2001 論文集 Vol.22 No.1

This paper reviewed the father's influence on his children's social ability. Traditional fathers were firm and demanding, authoritarian, and possessed the bulk of the power in their families. Recently, father's role on his family has been changed in that more fathers get involved in their children's bringing up. Fathers' instrumental role has negative effects on the emotional lives of fathers and their children, while when fathers show more affective and acceptive in fathering, their children develop highly in their social and intellectual ability. In order to increase paternal involvement, social supports is needed such as more flexible work schedule.

한국인에서 NOTCH4 유전자 내 두 개의 단일염기다형성과 정신분열병의 연합연구

주은정,정성훈,김미재,구영진,배승오,안용민,이규영,김용식 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : Previous studies on N0TCH4 gene and schizophrenia have not produced consistent results, and more studies with various ethnicities and populations were warranted. This study was performed with Korean population to find the role of the N0TCH4 gene in the development of schizophrenia. Methods : 235 schizophrenics and 236 normal controls participated in the study. Two SNPs (-1725 A/G and -25 T/C) on the N0TCH4 gene were investigated. Genotyping was done by Taqman assay, and statistical analysis was done by contingency chi-square test for the allele and genotype frequencies and PowerMarker V3.0 for the haplotype. Results : The two SNPs did not deviate from Hardy-Weinberg equilibrium in neither schizophrenics or normal controls. Two groups were not different in terms of allele and genotype distribution for both SNPs. Two SNPs were found to be in linkage disequilibrium. Haplotype analysis could not find an association between schizophrenia and these two SNPs. There was no association between the age at onset and the genotypes for both SNPs. Conclusion : We could not find any significant association between schizophrenia and the N0TCH4 gene in this Korean population. Although there are limitations in this study, this result supports the conclusion that the N0TCH4 gene is less likely to play a major role on the development of schizophrenia in the Asian population.