당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

艾葉粉末의 添加給與가 肉鷄에 미치는 影響

文勝式,朴玉潤,宋瑛敏 진주산업대학교 1985 論文集 Vol.23 No.-

本 試驗은 1985년 9월 20일 孵化된 肉鷄用(Hubbard) 병아리 120首를 各區當 30首씩 4개區로 나누어 晋州農林 專門大學 養鷄場에서 3주간(1985.10.19~11.8)에 걸쳐 艾葉을 C(0%), T_1(1%), T_2(2%), T_3(3%)水準으로 飼料에 添加하여 給與試驗을 하였던 바 다음과 같은 성적을 얻었기에 報告하는 바이다. 1. 增體量은 T_1區(1296.32g), C區(1274.70g), T_3區(1264.32g) 및 T_2區(1259.64g)의 순으로 나타났다(p>0.05). 2. 飼料攝取量은 C區(2715. 13g), T_1區(2738.60g), T_2區(2754.16g) 및 T_3區(2811.46g)의 순으로 나타났고 飼料要求率은 T_1區(2.113), C區(2.130), T_2區(2.178) 및 T_3區(2.232)의 순으로 나타났다(p>0.05). 3. 産肉指數는 T_1區(306.48), C區(303.01), T_2區(293.38) 및 T_3區(284.86)의 순으로 나타났다. 4. 屠體率은 ♀는 T_1區(69.45), T_2區(69.30), T_3區(67.58) 및 C區(66.45)의 순이였고 ♂은 T_3(70.03), T_2區(69.13), T_1區(67.85) 및 C區(66.58)의 순이였다. 5. 臟器重量은 대조구와 처리구간에 차이를 볼 수 없었다. 6. 經濟性을 분석한 結果 各 區別 수당수익은 T_1區(613원), C區(590원), T_2區(583원) 및 T_3區(572원)의 순으로 나타났다. This experiment was all located to 4 plots by 30 chickens per each plot with 120 chickens of broiler-Hubbard hatched at the 20th of September, 1985 and the formula feed added in the levels of 0(C plot), 1(T_1 plot), 2(T_2 plot) and 3%(T_3 plot) of Artemisia was supplied for these of each plot during 3 weeks from October, 19 to November, 8, 1985 at the poultry house, Chinju Agricultral & Forestry Technical College. The results found out the effect of Artemisia meal addition on the growth of broiler-Hubbard were as follows: 1. The weight gain(g) was heavy in the order of T_1(1296.32), C(1274.70), T_2(1264.32) and T_3(1259.64) and non significant (p>0.05) between plots. 2. Feed consumption(g) was heavy in the order of C(2715. 13), T_1(2738.6), T_2(2754.16) and T_3(2811.46) and feed conversion, T_1(2.113), C(2.130), T_2(2.178) and T_3(2.232) (p>0.05). 3. Point spread was high in the order of T_1(306.48), C(303.01), T_2(292.38) and T_3(284.86). 4. Dressing percent of female ws high in the order of T_1(69.45), T_2(69.30), T_3(67.58) and C(66.45), and of male, T_3(70.03), T_2(69.13), T_1(67.85) and C(66.58). It was generally higher in the Artemisia meal addition plot than in the control. 5. Internal organies weight was non significant differences(p>0.05) between treatment plots and control. 6. In economical analysis, net income(won) per bird of each plot was 613(T_1), 590(C), 583(T_2) and 572(T_3).

통상정보학의 실용성 제고를 위한 연구방향

박승락,박문서 한국통상정보학회 1999 통상정보연구 Vol.1 No.2

연구방법론의 관점에서 통상정보학은 매우 다양한 방법으로 접근이 가능하며, 특히 정보통신기술을 적극적으로 활용할 수 있기 때문에 항상 새로운 접근 방법이 출현할 수 있다. 또한, 정보기술의 급격한 발전으로 국제전자상거래가 급격히 확산되고 있는 현 시점에서 수출기업의 단순한 무역자동화 수준을 벗어난 국제간 B to B 전자상거래의 전략적 활용방안에 대한 연구가 필요한 때이다. 이에 본 연구에서는 통상정보학의 실용성 제고를 위한 구체적인 연구방향으로써 전략 정보시스템과 조직이론을 가미한 조직간 정보시스템 이론을 제시함으로써, 조직간의 전략적 연계를 통한 전략적 통합정보시스템 구축전략을 제시하고자 하였다. 이를 통하여 정보화의 이점을 통상학 분야에 도입하고, 전략적으로 활용 가치가 있는 정보를 생산, 저장, 유통 및 활용함으로써 학술적 비용발생을 최소화하며, 기업의 이윤발생을 촉진함으로써 국가경쟁력의 확보에 기여할 수 있도록 하는 것이 통상정보학의 궁극적인 지향 목표이다.

닭의 乾燥 筋胃粘膜 粉末 投與가 Egg Type Fowl에 미치는 效果에 對한 硏究 : 第Ⅲ報 初産日令 및 質에 미치는 影響에 對하여 Ⅲ. The effect of First laying age in a day egg quility

文勝式,朴玉潤,宋瑛敏 진주산업대학교 1982 論文集 Vol.20 No.-

This experiment was conducted to investigate the effects of the additions at the level of 0(C), 1(T_1), 2(T_2) and 3%(T_3) of Fowl Gizzard Mucouse Membrane Powder in the formula feed on the average day at first laying and egg quality with a total of 40 pieces laying hens for 4 treatments during the experimental period of 84 days from Feb.1, 1982 to April 25, the same year at the brooding laboratory, Dept. of Animal Science, Jin Ju Agricultural and Forestry Junior Technical College. The average obtained are summarized as follows: 1. The average day at first laying day was long in the order of T_1(158.8±8.30), T_2(159.9±10.13), T_3(162.6±3.53) and C(164.3±7.04) and the average weight at first laying(kg), heavy in the order of T_1(2.10±0.16), T_2(2.11±0.19), T_2(2.13±0.08) and C(2.27±2.25)(P>0.05). The egg weight at first laying(g) was heavy in the order of T_2(47.5±5.09), T_3(48.15±4.13), T_1(48.9±4.93) and C(51.99±2.13)(P>0.05) 2. The average egg weight(g) was heavy in the order of C(59.66±2.06), T_1(59.74±2.56), T_2(60.70±5.23) and T_3(62.64±3.67) and the egg shell, thickness in the order of T_3(0.362±0.036), C(0.370±0.038), T_1(0.378±0.022) and T_2(0.382±0.034)(P>0.05). The yolk and albumen weight(g) was heavy in T_2(18.20±1.57), C(18.35±.95), T_3(18.60±0.97) and T_2(18.92±1.05), T_1(33.61±1.94), C(34.32±1.65), T_2(35.37±3.77) and T_3(36.64±2.62) in those order(P>0.05).

마약길항제의 방출 제어형 제제 (제2보) : 나록손 이식제제의 생체적합성 및 약물속도론적 평가 Biocompatibility and Pharmacokinetics of Naloxone Implant

문미란,박주애,이승진,김형국,김길수 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

For the effective administration of narcotic antagonist, the application of sustained release implantable systems with biodegradable polyphosphazene was examined. Using poly[(diethyl glutamate)-co-(ethyl glycinate) phosphazene]. the implantable devices containing naloxone hydrochloride were prepared and in vivo implantation studies were carried out subcutaneously in rat and rabbit with this preparation for the biocompatibility and pharmacokinetics. The histological finding in rats at initial time period was the inflammation that occurred focally around the implants, but they were showed subsequent mild and limited chronic inflammations and the irreversible changes such as necrosis and degeneration of the muscle or connective tissues were not observed. Therefore the placebo and naloxone implants are considered to be biocompatible formulations histologically. In pharmacokinetic studies, the release of naloxone from the naloxone implants into blood plasma was maintained in 192 hours, but the initial burst effect was observed. If this problem was solved, the application for the narcotic antagonist sustained release systems can be expected.

전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

하지의 동맥부전증 환자에서 동반된 복부 대동맥류

문인성,박장상,고용복,김용귀,홍성곤,김승남 대한혈관외과학회 1999 Vascular Specialist International Vol.15 No.1

The early diagnosis of abdominal aortic aneurysms are difficult, especially when they are not clinically evident. Because of the generalized nature of atherosclerosis, there is reason to believe that there is a high incidence of aneurysms of the abdominal aorta in patients with peripheral vascular disease. But the screening test for hidden abdominal aortic aneurysms in patients with peripheral arterial disease has not been used for routine manner. So we retrospectively reviewed the 9 patients who had asymptomatic abdominal aortic aneurysms with symptomatic peripheral arterial disease during the last four and half-year period: among them three aneurysms were screened preoperatively by physical examination with their diameter more than 5 cm and 6 aneurysms were found intraoperatively with their mean diameter of 3.8cm. The ages ranged from 66 through 84 years with the mean age 73 years. There were 7 men and 2 women. The sites of the peripheral occlusive disease is as follows: femoral artery only in 1, iliac artery only in 2, both iliac and femoral arteries in 5, and from iliac artery through tibial artery with thrombus formation in 1. We suggest that ultrasonographic screening for the presence of hidden abdominal aortic aneurysm preoperatively in patients with lower extremity occlusive arterial disease is needed, especially when the ages of patients is older than 65 years and the site of arterial disease include iliac segment.

産卵鷄에 대한 練炭灰添加給與 效果에 關한 硏究

朴成振,文勝式,鄭場龍 진주산업대학교 1982 論文集 Vol.20 No.-

This experiment was conducted to investigate the effect of Briquette ash treatment on egg production rate, egg weight, feed conversion and egg quality with date obtained from 100 pieces egg type fowls Babcock (B 380, 230days-age) fed and allotted 5 treatments at the rate of 0%(C), 0.5%(T_1) 1.0%(T_2), 1.5%(T_3)AND 2.0%(T_4) during the experiment period of 119 days from May 21, 1982 to September 20, the same year ar Department of Animal science, Jin Ju Agricultural and Forestry Junior Technical College. The results obtained are summarized as follows; 1. Average egg weight at each experiment plot was 62.21g(T_2) 61.62g(T_3), 60.88g(T_4), 60.42(T_1) and 60.04g(C), but the difference was not significant. Feed conversion at each experiment plot was 2.52(T_2) 2.60(T_3), 2.65(C) and 2.67(T_4). 2. Average egg production rate at each experiment plot was 82.02%(T_2) 81.85%(C) 81.43%(C), 79.41%(T_3) and 78.23(T_4), but the difference was not significant. 3. Weight of egg yolk and albumen were higher at fed with the treated Briquette ash plot than that without Briquette ash plot, and weight of egg shell and thickness were not significant.