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Background:fatty liver disease (NAFLD) is liver disease characterized by diffuse fatty infilteration and inflammation. NAFLD is closelyrelated with metabolic syndrome such as diabetes, obesity, hyperlipidemia, and hypertension. Definitive diagnosis of NAFLDstill requires a liver biopsy. So, it is difficult to diagnosis of NAFLD in the health screen examinees. The aim of thiswas to assess the association fatty liver diagnosed by ultrasonography and components and parameters of metabolic syndromein the non-alcoholic health screen examinees. Methods:health screen examinees (1,985 men, 1,844 women) who participated in health screening at health promotion center in KosinMedical Center from March, 1997 to December, 2003 were enrolled in this study. All participants was no evidence of viralhepatitis and alcohol abuse. The examinees were divided two group, fatty liver and nonfatty liver group and the clinical,biochemical and metabolic parameters analyzed by multiple regression and logistic methods. Results:variables (age,然index (BMI),(WC),,density lipoprotein (HDL) cholesterol were significantly high in the fatty liver group than nonfatty liver group (p,乂There was a significant positivecorrelation between WC and weight, blood pressure,,odds ratio between WC and fatty liver was 1.614 in men and 2.906 in women (p<0乂1 乂As subjects were grouped accordingto their number of components metabolic syndrome, the development of fatty liver was increased according to the numbersof components of metabolic syndrome (p<0.05), zGTP was a significant positive correlation with WC, weight, blood pressure,BMI, total cholesterol, triglyceride (p<0.01 乂When subjects were grouped accordingto the /GTP level, group I (<20 UZL) and group II (20 U/L〜40 U/L) and group III (>40 U/L),Significant differences was notice in almost of all variables (weight, blood pressure, BMI, WC, total cholesterol, triglyceride,fasting blood glucose) among each group (p<0,000乂 Conclusion: These results suggestedthat fatty liver in non alcoholic health examinees is closely associated with metabolic syndrome and number of componentsof metabolic syndrome. Among the metabolic parameters, the author noticed that zGTP is not a marker of alcohol induced liverdisease but may also a independent and reliable marker of metabolic syndrome.
Background : Multidrug-resistant tuberculosis (MDRTB) is defined as the reduction in susceptibility of Mycobacterium tuberculosis to Isoniazid and Rifampin with or without resistance to additional drugs. The development of MDRTB is a big problem not only to the patients but also to the society given with its lower cure rate. The purpose of this study is to investigate the prevalence and the clinical features of MDRTB at a university hospital and to establish the proper therapeutic plan. Method : The incidence of MDRTB among 161 patients diagnosed as pulmonary tuberculosis by the AFB culture between January 1997 and June 2000, and the relationship of MDRTB with the history of previous therapy, associated diseases, bronchial involvement, and the consequence of treatment were studied retrospectively. Results : Forty eight (29.8%) patients were resistant to at least one drug and 27 (16.8%) patients suffered from MDRTB. Among the MDRTB patients, 22 had the previous history of therapy. More than 30 percent of all the patients had associated diseases, such as diabetes mellitus, malignancy, chronic liver disease, systemic erythematous lupus or psychosis. Endobronchial lesions suggesting bronchial involvement of tuberculosis were found in 37 (35%) patients. Out of the 16 patients eligible for the efficacy of treatment among 27 MDRTB patients, nine (56.3%) patients were treated successfully but seven (43.8%) were failed. Conclusion : Prevalence of MDRTB was high especially in patients with previous therapy history and the result of treatment was modest in this study. It is imperative to prevent the emergence of drug resistance by the proper delivery of chemotherapy and the development of new drugs.