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      • KCI등재

        백서의 후구절제 우울모델에서 Memantine 투여 후뇌구조와 해마 조직 소견 변화

        김소연,이영식,기백석,민경준,윤홍균,유현,남택균 대한정신약물학회 2006 대한정신약물학회지 Vol.17 No.5

        Objectives: The validity of olfactory bulbectomized rat as an animal depression model and the possibilities of the NMDA antagonist as an antidepressant would be evaluated by demonstrating structural alterations in their brain MRIs and histological findings of hippocampus. Methods: Those 8-week old male Sprague-Dawley rats received either an olfactory bulbectomy or sham operation and volume changes at ventricles and caudate nucleus in their brain MRI were acquired at preoperation and postoperation. Those olfactory bulbectomized rats received either memantine, an uncompetitive NMDA antagonist, or normal saline, a placebo, and their brain structural changes in MRI were acquired. At preoperation, postoperation, and postmedication each one of the rats with sham-operation, with memantine, and with placebo was sacrificed to acquire histological impressions. Results: (1) Comparison of the volume changes between preoperation and postoperation showed statistical significance; the volumes of the left and right lateral ventricles(p=0.007, p=0.008) and the third ventricle(p=0.003) increased significantly but the volumes of left and right caudate nucleus decreased(p=0.014,p=0.032), compared to that of the controls. (2) After 6-weeks of memantine administrations, the OB rats revealed more definite recovery in brain MRIs statistically than the controls: the volumes of left and right ventricles and left and right caudate nucleus(p=0.004, p=0.03 p=0.04, p=0.05).(3) The hippocampus histological findings of the olfactory bulbectomy showed frequently eosinophilic cytoplasm and hyperchromatic nucleus with shrinkage in CA3. After memantine intake, the hippocampus histological findings returned to nearly normal and showed mixtures of normal cell and abnormal neuron cell. 연구목적:뇌 구조 및 해마조직 변화 소견을 통해 백서의 후구절제 모델(olfactory bulbectomy, OB모델)이 우울증의 동물 모델로서 타당한가를 검증하고, NMDA 길항제인 memantine이 항우울제로서의 가능성이 있는지를 확인해 보고자 본 연구를 시행하였다. 방 법 :생후 8주된 수컷 Sprague-Dawley 백서를 MRI 기초 촬영 후 OB군(olfactory bulbectomized rats)과 sham 처치 군으로 나누었다. 수술 후 6주째에 뇌실과 미상핵의 구조 변화를 MRI로 확인하였다. 그 후 OB 군을 memantine과 위약 투여군으로 나누어 6주간 각각 구강 섭취하게 한 후 MRI 촬영을 실시하였다. 수술 전, 수술 후, 약물 투여 후에 각각의 그룹에서 한 마리씩 희생시켜 MRI로 측정하지 못한 해마부위의 조직 소김소연 등 483 견을 확인하였다. 결 과 :1) OB 수술군에서 sham 처치군에 비해 수술 후 좌측과 우측 측뇌실, 제 3 뇌실의 크기는 의미있게 증가하였고(p=0.07, p=0.08, p=0.03), 좌측과 우측 미상핵의 크기는 의미있게 감소하였다(p=0.014, p= 0.032). 2) Memantine 복용 군은 위약군에 비해 좌측과 우측 측뇌실과 좌측과 우측 미상핵의 크기가 의미있게 회복되는 소견을 보였다(p=0.04, p=0.03;p=0.04, p=0.05). 3) 수술후 해마 조직소견은 sham 처치군은 수술전과 차이가 없었으나 OB 군은 CA3 부위의 신경세포에서 세포질의 호산성 변화, 핵 위축, 과염색성등의 명확한 세포 손상 소견이 관찰되었다. 또한, memantine을 투여한 후 OB 군은 위약 투여한 군에 비해 손상된 세포수가 명백히 감소하고 다소간의 정상세포도 관찰할 수 있었다.

      • KCI등재

        A Case of Aspergillus Endocarditis Presenting as Endophthalmitis

        김소연,최지용,조창호 대한심장학회 2009 Korean Circulation Journal Vol.39 No.2

        Aspergillus endocarditis is an uncommon, but often fatal, disease that usually occurs in patients who have had prior cardiac surgery. Endophthalmitis is a very rare complication of infective endocarditis, especially at presentation. We report a case of Aspergillus endocarditis in a 68-year-old woman who presented with endophthalmitis. Aspergillus endocarditis is an uncommon, but often fatal, disease that usually occurs in patients who have had prior cardiac surgery. Endophthalmitis is a very rare complication of infective endocarditis, especially at presentation. We report a case of Aspergillus endocarditis in a 68-year-old woman who presented with endophthalmitis.

      • KCI등재

        Assessment of Non-Calcified Coronary Plaques Using 64-Slice Computed Tomography: Comparison With Intravascular Ultrasound

        김소연,김기식,이영수,이진배,류재근,최지용,장성국 대한심장학회 2009 Korean Circulation Journal Vol.39 No.3

        Background and Objectives: Non-invasive detection and characterization of plaque composition may constitute an important step in risk stratification and monitoring of the progression of coronary atherosclerosis. Multislice computed tomography (MSCT) allows for accurate, non-invasive detection and characterization of atherosclerotic plaques, as well as determination of coronary artery stenosis. The aim of this study was to determine the usefulness of MSCT for characterizing non-calcified coronary plaques previously classified by intravascular ultrasound (IVUS). Subjects and Methods: Seventy-one plaques were evaluated in 42 patients undergoing MSCT and IVUS. Coronary plaques were classified as hypoechoic or hyperechoic based on IVUS echogenicity. On MSCT, CT attenuation was measured using circular regions of interest (ROI) and represented as Hounsfield units (HU). Results: MSCT attenuation in hypoechoic plaques was significantly lower than it was in hyperechoic plaques (52.9±24.6 HU vs. 98.6±34.9 HU, respectively, p<0.001). When comparing CT attenuation between hypoechoic and hyperechoic plaques, 60.2 HU was the cut-off value for differentiating between the two, with a 90.7% sensitivity and a 78.6% specificity. Conclusion: MSCT might be a useful tool for non-invasively evaluating the characteristics of coronary artery plaques. Background and Objectives: Non-invasive detection and characterization of plaque composition may constitute an important step in risk stratification and monitoring of the progression of coronary atherosclerosis. Multislice computed tomography (MSCT) allows for accurate, non-invasive detection and characterization of atherosclerotic plaques, as well as determination of coronary artery stenosis. The aim of this study was to determine the usefulness of MSCT for characterizing non-calcified coronary plaques previously classified by intravascular ultrasound (IVUS). Subjects and Methods: Seventy-one plaques were evaluated in 42 patients undergoing MSCT and IVUS. Coronary plaques were classified as hypoechoic or hyperechoic based on IVUS echogenicity. On MSCT, CT attenuation was measured using circular regions of interest (ROI) and represented as Hounsfield units (HU). Results: MSCT attenuation in hypoechoic plaques was significantly lower than it was in hyperechoic plaques (52.9±24.6 HU vs. 98.6±34.9 HU, respectively, p<0.001). When comparing CT attenuation between hypoechoic and hyperechoic plaques, 60.2 HU was the cut-off value for differentiating between the two, with a 90.7% sensitivity and a 78.6% specificity. Conclusion: MSCT might be a useful tool for non-invasively evaluating the characteristics of coronary artery plaques.

      • KCI등재

        『朝鮮建築』에 나타난 해방직후 건축가의 혼종적 정체성

        김소연,이동언 대한건축학회 2006 대한건축학회논문집 Vol.22 No.4

        The main issue of this paper is to reinterpret the identity of Korean architects after Japanese colonial period in micro-historical way. The grand narrative of nationalism and modernization, in macro-historical perspective, concealed diverse and multiple identity of architects. The class identity of architects was modern intelligentsia educated and trained under Japanese Imperialism, which could not belong to imperial ruler, native hierarchy and subaltern in colony. The ideological identity, split by different experience and individual value inside class identity, made up dichotomous category such as the conservatives and the progressives, the left and the right wing, etc. The boundary between the categories, however, was blurred by ambivalent coexistence of modern idea and pre-modern lifestyle. The gender identity demonstrates architects were never free from traditional patriarchy however progressive they might be. In addition, the colonial identity reproduced orientalism, internalized through colonial experiences, after colonial period. It is the post-colonial identity that all above identities are complicatedly hybridized. Hybridized thus, the post-colonial identity of Korean architects constituted something new and different between indigenous traditional architecture and colonial modern architecture. This hybridizing process is the process of rehabilitating colonial otherness in the third way.

      • KCI등재

        혈액응고 V인자에 대한 후천적 억제인자 1예

        김소연,김선회,조한익,김현경 대한혈액학회 2008 Blood Research Vol.43 No.3

        Acquired inhibitor of coagulation factor V is a rare clinical condition and may cause significant morbidity and mortality. We report here the first Korean case of acquired isolated factor V inhibitor developed in a 73-year-old male patient after surgery for pancreatic head carcinoma. At post-operation day 2, intra-abdominal bleeding was recognized that was associated with a prolonged prothrombin time and activated partial thromboplastin time. The prolongation of both conditions was not corrected by a mixing test and factor V activity was reported to be 2%. Quantified titers of inhibitors were increased from 3.5 Bethesda unit to 8.4 Bethesda unit during follow-up analysis. In spite of the treatment with steroids and intravenous immunoglobulins, the case ended fatally. When acquired bleeding tendency with prolonged coagulation screening test is observed, evaluation of inhibitors of coagulation factors may be essential for the diagnosis and following appropriate management of the condition. (Korean J Hematol 2008; 43:190-193.)

      • KCI등재

        Molecular Cloning and Characterization of a Serine Protease-Like Protein from Silkworm (Bombyx Mori)

        김소연,정은정,송기준,박광숙 한국유전학회 2009 Genes & Genomics Vol.31 No.5

        The Bombyx mori ( B. mori) serine protease-like protein (BmSp) coding region (946 bp, GenBank accession number of mRNA, DQ118520; protein, AAZ40503) was generated from two separate and overlapping cDNA fragments using sequence homology with Trichoplusia ni azurocidin in a Bombyx EST database (Silkbase; http://www.ab.a.u-tokyo.ac.jp/silkbase/). The deduced amino acid sequence of BmSp, which encodes 303 amino acids, shows 44% amino acid identity to A. gambiae serine protease (CAA89967), 43% amino acid identity to Sarcophagi peregrina 26-kDa protease, an antibacterial protein and 31% identity to B. mori serine protease-2 (BmSP-2), a potential antiviral protein. Typical features of the BmSp included the serine protease active site triad His / Asp / Ser, three pairs of cysteine residues for disulfide bridges, and three residues, Asp / Gly / Gly, that help to confer trypsin-like specificity to the enzymes. Based on the result of sequence comparison and characterization, our results suggest that the BmSp probably the new subfamily of trypsin-like serine protease. Using RT-PCR and enzyme digestion, the full encoding sequence for BmSp was cloned into the E. coli expression vector pGEX-5X-1. The fusion protein GST-BmSp was effectively expressed in E. coli BL21(DE3) pLysS as inclusion bodies, and a denaturation and refolding procedure were performed to obtain soluble GST-BmSp. The purified protein was tested for antibacterial activity against Gram-positive and Gram-negative bacteria, but it did not show antibacterial activity in the agar well diffusion assay and liquid growth inhibition assay. The Bombyx mori ( B. mori) serine protease-like protein (BmSp) coding region (946 bp, GenBank accession number of mRNA, DQ118520; protein, AAZ40503) was generated from two separate and overlapping cDNA fragments using sequence homology with Trichoplusia ni azurocidin in a Bombyx EST database (Silkbase; http://www.ab.a.u-tokyo.ac.jp/silkbase/). The deduced amino acid sequence of BmSp, which encodes 303 amino acids, shows 44% amino acid identity to A. gambiae serine protease (CAA89967), 43% amino acid identity to Sarcophagi peregrina 26-kDa protease, an antibacterial protein and 31% identity to B. mori serine protease-2 (BmSP-2), a potential antiviral protein. Typical features of the BmSp included the serine protease active site triad His / Asp / Ser, three pairs of cysteine residues for disulfide bridges, and three residues, Asp / Gly / Gly, that help to confer trypsin-like specificity to the enzymes. Based on the result of sequence comparison and characterization, our results suggest that the BmSp probably the new subfamily of trypsin-like serine protease. Using RT-PCR and enzyme digestion, the full encoding sequence for BmSp was cloned into the E. coli expression vector pGEX-5X-1. The fusion protein GST-BmSp was effectively expressed in E. coli BL21(DE3) pLysS as inclusion bodies, and a denaturation and refolding procedure were performed to obtain soluble GST-BmSp. The purified protein was tested for antibacterial activity against Gram-positive and Gram-negative bacteria, but it did not show antibacterial activity in the agar well diffusion assay and liquid growth inhibition assay.

      • KCI등재후보

        Naringin Time-Dependently Lowers Hepatic Cholesterol Biosynthesis and Plasma Cholesterol in Rats Fed High-Fat and High-Cholesterol Diet

        김소연,최명숙,김혜진,이미경,전선민,도경민,권은영,조윤영,김동주,정규식,박용복,하태열 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4

        The flavonoid naringin was investigated for its differential effects on hepatic cholesterol regulation when sup-plemented for 3 weeks and 6 weeks. Sprague-Dawley rats were fed a high-fat and high-cholesterol diet with or without 0.02%naringin supplement for 3 or 6 weeks. Supplementation with naringin resulted in a significant decrease in the plasma choles-terol and triglyceride concentrations in the 6-week trial. Although high-density lipoprotein (HDL)-cholesterol was not alteredin either trial, the HDL-cholesterol/total cholesterol ratio (in percent) was significantly higher, and the atherogenic index wassignificantly lower in the naringin-supplemented groups in the 6-week trial. The hepatic cholesterol content was also loweredby naringin supplementation only in the 6-week trial. The hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activ-ity was lower in the rats supplemented with naringin for 6 weeks, while the hepatic acyl-coenzyme A:cholesterol acyltrans-ferase activity was lower in both the 3-week and 6-week trials. Results indicate that supplementation with naringin for 3 weeksdid not exhibit a hypolipidemic effect when given with a HFHC diet. Naringin can, however, be beneficial for lowering he-patic cholesterol biosynthesis and levels of plasma lipids when supplemented for 6 weeks in this animal model.

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