현역 군인 발생을 중심으로 본 2000년도 국내 삼일열 말라리아 발생 현황

박재원,김영아,염준섭,유정식,양병국,채종일 대한감염학회 2001 감염 Vol.33 No.4

Background : Since 1997, the annual case occurrence of vivax malaria in the Republic of Korea have exceeded 1,000 cases since 1997. The military is thought to be an important source of the current outbreak. We collected various informations about malaria cases (soldiers, veterans and civilians) which occurred in 2000, and analyzed the characteristics of the current outbreak. Methods : Informations about malaria cases of soldiers, veterans and civilians, including name, age, sex, day of onset, region, etc., were collected through the National Institute of Health. Results : Out of total 4,141 cases, 1,288 (31.1%) occurred in the military, 1,273 (30.7%) occurred among the veterans, and 1,580 (38.2%) occurred among civilians. The monthly case occurrence reached its peak in early August. Areas such as Cheolwon, Yeoncheon and Paju showed the highest prevalence. Conclusion : It is considered that the current malaria outbreak has escaped from the exponential growth phase, however, more attention should be paid to prevent further spreading of malaria infection. (Korean J Infect Dis 33:280∼284, 2001)

생쥐 소장의 interstitial cells of Cajal에서 ATP-민감성 K^(+)통로를 통한 향도잡이 전류의 조절

박찬국,김만우,김형석,최석,전제열 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Objectives: This study was performed to investigate whether ATP-sensitive K^(+) channels exist in interstitial cells of Cajal (ICC) of mouse small intestine and the physiological role of ATP-sensitive K^(+) channels in gastrointestinal motility. Methods: ICC were isolated from mouse small intestine and cultured for 2 days. Electrical activities of ICC were recorded using the whole-cell patch-clamp technique at 30°C. Results: ICC displayed rhythmic slow waves and spontaneous inward currents (pacemaker currents). Pinacidil, an ATP-sensitive K^(+) channel opener, induced membrane hyperpolarization and decreased amplitude of slow waves in current clamping mode. Also, pinacidil inhibited amplitude and frequency of pacemaker currents and activated outward currents at a holding potential of -70 mV. Pinacidil effects on slow waves and pacemaker currents were blocked by glibenclamide, a specific blocker of ATP-sensitive K^(+) channel. Forskolin, an activator of adenylate cyclase, induced membrane hyperpolarization and inhibited pacemaker currents like as pinacidil and blocked by glibenclamide. Conclusions: These results suggest that ATP-sensitive K^(+) channels exist in ICC and may be play an important role in regulating gastrointestinal motility through the modulation of pacemaker activities of ICC.

백서 삼차신경내 신경세포체의 치아이동에 따른 CGRP 면역염색성의 변화

박국필,성재현,박효상 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

이 연구의 목적은 중추신경계에서는 동통의 전달을 조절하며 말초조직에서는 혈관이완, 면역체계의 조절, 탐식기능 조절 등의 염증에 관여되며 골 생성세도 관여하여 치아이동시 중요한 기능을 할 것으로 추측되고 있는 CGRP의 생성장소인 삼차신경절내의 세포체의 크기에 따른 CGRP면역 반응성의 변화를 관찰하여 삼차 신경절내 CGRP면역양성을 띄는 각 크기의 세포들의 치아이동의시간 경과에 따른 반응을 밝혀보고자 하는 것이다. 생후 9주령의 Sprague-Dawley계 백서 30마리를 정상 대조군 6마리, 3시간 교정력 적용군 5마리, 12시간군 4마리, 1일군 5마리, 3일군 5마리, 7일군 5마리로 나누어 실험군은 각 해당 시간동안 상악 우측 제1대구치에 30gm내외의 교정력을 가한 후 희생시켰다. 희생시킨 백서의 삼차 신경절을 적출하여 냉동 절편을 형성한 후 토끼의 항체를 이용하여 면역화학 염색을 시행하였다. 삼차 신경절의 CGRP면역양성 신경세포체를 크기에 따라 소형 (20㎛ 미만), 중형(20-35㎛), 대형(35㎛초과)으로 나누어 교정력 적용시간에 따른 변화를 관찰하였다. 1. 삼차 신경절내 전 신경세포체중 CGRP면역양성 신경세포체가 차지하는 비율은 정상 대조군이 33.0%였으며, 교정력적용후 1일 후에는 24.5%로 감소하였으나 7일 후에는 41.8%로 증가하였다. 2. 정상대조군에서 CGRP면역양성 신경세포체중 소형, 중형, 대형은 각각 51.4%, 44.0%, 4.7%였다. 3. 소형의 CGRP면역양성 신경세포체는 3시간, 12시간 군에서 높게 나타났다. 4. 중형의 CGRP면역양성 신경세포체는 3일, 7일군에서 대형의 CGRP면역양성 신경세포체는 7일군에 높게 나타났다. 위를 종합하여 볼 때 치아이동 초기에는 CGRP면역양성 신경세포체중 소형의 세포가, 후기에는 중형, 대형의 세포가 반응한다는 것을 알 수 있었다. GRP was known as the modulator of pain transmission in central nervous system and local effector to peripheral tissue causing vasodilation, increased blood flow, modulation of immune sysem, stimulation of endothelial cell proliferation, and stimulation of bone formation. Numerous study, therefore, were done to elucidate involvement of CGRP to tooth movement. To investgate the response of CGRP immunoreactive nerve cells according to cell size in trigeminal ganglion during tooth movement, immunohistochemical study was performed using rat. Experimental rats(9 weeks old, 210gm) were divided as six groups(normal(n=6), 3 hour group(n=6), 3 hour group(n=5), 12 hour group(n=4), 1 day group(n=5), 3 day group(n=5), 7 day group(n=5), and were applied orthodontic force (apporximately 30 gm) to upper right maxillary molar. After frozen sections of trigeminal ganglions were immunostained using rabbit antisera, the change of CGRP immunoreactive cells in regard to cell size distribution(small cell(upto 20㎛), medium cell(20-35 ㎛), large cell(above 35㎛) were observed. The results were as follows 1. The percentage of CGRP immunoreactive cells to all nerve cells in trigeminal ganglion was 33.0% in normal control group, was decreased to 24.5% in 1 day group, and was increased to 41.8% in 7 day group. 2. The percentage of small, medium, and large cells expressing CGRP immunoreactivity in normal trigeminal ganglion to all CGRP immunoreactive cells were 51.3%, 44.0%, 4.7%, respectively. 3. The percentage of small cells with CGRP immunoreactivity to all CGRP immunoreactive cells was increased in 3 hour and 12 hour groups. 4. The percentage of medium cells with CGRP immunoreactivity was increased in 3 day and 7 day groups. 5. The percentage of large cells with CGRP immunoreactivity in 7 day group. Conclusively, the small cells with CGRP immunoreactivity in trigeminal ganglion respond to orthodontic force during initial phase of tooth movement, and later the medium and large cells with CGRP immunoreactivity respond.

악성 점막하 종양과의 구별이 어려웠던 Gastritis Cystica Profunda 1예

선제형,박진석,한민석,김수항,김우진,박인형,이숭,유종선,박찬국 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Gastritis cystica profunda (GCP) is a rare disease characterized by gastric foveolae elongation along with hyperplasia and cystic dilatation of the gastric glands extending into the tissue beneath the submucosa. GCP mainly develops at the gastroenterostomy stoma but can arise in a stomach that has not undergone surgery. The proposed pathogenesis is related to chronic inflammation, ischemia and the presence of a foreign body. GCP may present as a submucosal tumor, Polyp or a giant gastric mucosal fold. Endoscopic ultrasonography (EUS) is an effective diagnostic method for differentiating GCP from protruding and elevated gastric lesions. We report a case of GCP along with the endoscopic and EUS findings that were indistinguishable from a malignant submucosal tumor.

구조방정식모델을 통한 활동과 통행의 인과관계모델

김재국,이진우,박병선 東新大學校 工業技術硏究所 2002 工業技術硏究 Vol.8 No.-

Although, we could get more reasonable results from the transportation behavior study based on activity diary data, there were not make rapid progressing because of the absence of analytical methodology. Therefore, we set up causal structure model of activity participation, trip generation, and travel time by the structural equation modeling to conquer of the absence of analytical methodology. Results of our studies show that activity-diary can be analyzed by the structural equation modeling. It will be a good study momentum in the behavioral study based on activity diary which had not been generalized because of the absence of analytical methodology.

아메바성 대장염과 연관된 Henoch-Scho¨nlein Purpura 1예

장재현,원경준,이준,변유미,이재광,김영훈,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Henoch-SchonIein purpura is a common form of vasculitis primarily involving the skin, the gastrointestinal tract, the joints, the kidneys, and the nervous system. The etiological investigations are essential, because triggering factors are found in approximately half the patients such as viral, bacterial and parasitic infections, drugs, toxins, systemic diseases and cancer. But it's the correlation between Henoch-SchonIein purpura and Entamoeba histolytica has been rarely reported. We report a 29-years-old woman with Henoch-SchoIein purpura complicated by the lower gastrointestinal bleeding caused by the amoebic colitis. She complained of cramping abdominal pain, lower extremity purpura and hematochezia. Cysts and trophozoites of Entamoeba histolytica were detected in her stool. Skin biopsy demonstrated the leukocytoclastic vasculitis. She was administered metronidazole 1,500㎎ a day for the treatment of amebic colitis. Her hematochezia was improved, but the abdominal pain and purpura were not. The subsequent corticosteroid therapy improved her symptoms.

춘천호내 인공습지 조성에 따른 흐름특성 분석

최한규,박재국,백효선 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.B

Based on the data interpretation on an artificial marsh built in Chun-cheon Lake, the study analyzed flow characteristics and found that flow was unstable due to sediment of natural river but the effect of artificial marsh was similar with that of river improvement works. Flow velocity in the section of artificial marsh was found to be 1m/sec. Therefore flow velocity was stable, which could contribute to improving water quality. A flow velocity as well as stream vector was improved.

십이지장과 대장을 동시에 침범한 결핵 1예

이만재,박치영,곽재정,유보열,기장도,박찬국,김만우,김정용 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Tuberculosis of duodenum is so rare and is usually secondary to pulmonary or intestinal tuberculosis . It is difficult to diagnose duodenal tuberculosis in clinical and radiologic findings due to its non-specific symptoms and inconsistent lesion. The diagnosis was made on the basis of the histological study of the endoscopic biopsy and resected surgical specimen. so we report a case of tuberculosis of duodenal bulb and of ascending colon with, the brief review of the literatures.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

고관절 전치환술 후 합병된 비구 컵 해리와 동반된 활액낭종 : 증례보고 Case Report

성일보,정국진,박수철,김진호,정형진,황재광,염재광,정병현,안종국 대한고관절학회 2001 Hip and Pelvis Vol.13 No.1