정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

CT법을 이용한 진직도 및 직각도 측정에 관한 연구

이승수,김민주,박정보,전언찬 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.1

As high-precision parts are needed with manufacturing techniques improved, the demand of high-precision machine tools has been increasing. They are made to developed the precision measuring skill to maintenance the accuracy of themselves as a matte of course. We on the paper measured straightness and orthogonality of the square to verify that is possible for CT(circular test) method by 2-dimensional probe and the square to measure orthogonality. Furthermore, we compared the result of the study with the computer simulation's to prove its possibility, and made an improvement of measuring method.

원호검사법을 이용한 진원도 측정 방법의 개선에 관한 연구

이승수,김민주,전언찬 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.2

A study for the circularity of machine tool is classified into two ways. One is to measure the circularity of machine tool by a existing measuring device. The other is to measure the circularity by remodeling the existing measuring device. We will improve on measurement of circularity using circular test method by a two-dimensional probe and a master ring for machining tools and investigate influence of trigger method, acceleration, data sampling.

환경 및 시간경과에 따른 건축용 단열재의 열전도율 변화에 관한 실험적 연구

이승언,강재식,정영선,최현중 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

The objective of this research is to provide the basic experimental data for thermal insulation design standard of buildings and for test criterion. We tested the thermal conductivity of insulation materials which was the insulation materials in domestic buildings with environmental condition change and long-time elapse. In research, we measured change of thermal conductivity with change of contained water rate by weight, test temperature change and the passage of time. the specimens of insulation materials were kept in test condition, which was influenced by the outside environment during long-time elapse test. The result of the research shows 1)the contained water rate of artificial mineral fiber insulations is higher than others, 2)thermal conductivity rises as test temperature goes up, 3)the thermal conductivity of the extruding insulations and hardened Urethane foam changes with environmental condition and time elapse. As a result, the test methods and standards for thermal conductivity properties have much room for consideration.

瀉白散의 肥滿細胞 嫫介性 炎症性 細胞活性物質 分泌 抑制 效果

이병주,신조영,이시형,홍재의,박병민,이승언 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

Ocjective : Sabaeksan has been used for the purpose of prevention and treatment of bronchial asthma and allergic asthma in korea. Methods : To investigate the biological effect of Sabaeksan, the author examined cytotoxicity and inflammatory cytokines secretion with human leukemic mast cell line, HMC-1. HMC-1 was stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. Sabaeksan by itself had no effect on viability of HMC-1. Result : The effects of Sabaeksan on the secretion of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 from HMC-1 were evaluated with enzyme-linked immunosorbent assay. Sabaeksan (1 mg/㎖) inhibited PMA plus A23187-stimulated TNF-α and IL-6 secretion, by 43.86 ± 5.26%, 56.39 ± 3.65%, respectively. Sabaeksan also inhibited the NF-κB (p50/p65) expression. Conclusion : Taken together, these results suggest that Sabaeksan inhibit the production of inflammatory cytokines in HMC-1 cells through blockade of NF-κB activation.

RC 프레임면내 조적채움벽의 내진성능 평가에 관한 실험적 연구

이정한,차승렬,강대언,오상훈,이용재,이원호,김상대 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The objectives of this study are 1) to find out the shear behavior and shear capacity of RC bare frames, brick-infilled RC frames, 2) to evaluate the equation of the shear capacity of two types of RC frames by comparison the Japanese Standard and modified equation adopting the test results. The main variable is the absence of brick infill wall. The test results show that the shear capacity of specimen IF-4.2 is 2.3 times as high as that of the specimen IF-4.2.The shear behavior of RC bare frame which is governed by predominant flexural yielding is changed to predominant shear yielding by affection of the brick infill wall. A comparison of the results obtained by the Japanese Standard equation and the modified equation to the test data indicates that the proposed equation is compatible with the test results.

건축에서 지역성의 탈은폐 : 하이데거의 “열린 터”(the Open)와 “틈새내기”(Rift-design) 사유를 바탕으로 Based on the Thought of Heidegger's “the Open” & “Rift-design”

이승헌,이동언 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

In contemporary architecture, the expression of regionality has been continuously interested and experimented. But there were few theoretical approaches on the meaning of regionality and few authentic explorations for the expression of it. Thus this paper draws out a theoretical frame for regionality from Heidegger's two main thoughts , "the Open" and "Rift-design" and suggests ‘disclosure montage’ as a technique of the practical expression of them in architecture. The ‘creative opening’ of regionality is possible through "Rift-design." And "Gestalt", in other words, disclosure montage, can be created in the "rift" by "the conflict between lighting and concealing in the opposition of the world and earth". An architecturally reactivated images of a region are revealed through the technique of ‘disclosure montage’ as a useful expression strategy of "the Open" and "Rift-design." Finally, in order to verify the above mentioned theory, Steven Hall's works are made into a scrutiny.

국내외 ‘영아’ 관련 연구물의 최근 동향 분석 : 2000년~2013년 발간 논문을 대상으로

이승연,권수현,권연정,김언경,나영이,유주연,최정아 이화여자대학교 교육과학연구소 2015 교육과학연구 Vol.46 No.3

The purpose of this study was to examine research trends in infant research published from 2000 to 2013, in order to understand overall aspects in research topics, methods, and subjects in infant research and to suggest directions for future infant research. A total of 2916 journal articles and theses/dissertations, both domestic and foreign, were selected for the analysis. The findings of this study were as follows: First, for the 14 year period, 737 domestic articles, 634 domestic theses/ dissertations, 1242 foreign articles, and 303 foreign dissertations on infant research were published, and there was a steady increase in the number of articles and theses/dissertations over the years. Second, in terms of research topics, different patterns were found between the domestic ones and the foreign ones; the topic of “education and teachers” in the domestic ones and “development” in the foreign ones occurred most frequently. Third, in terms of research methods, the domestic ones employed “survey” the most, and the foreign ones employed “experiment” the most among quantitative research methods; when analyzing the relation between methods and topics, the foreign ones showed clear matches between topics and research methods, while the domestic ones preferred “survey” regardless of the topics. Fourth, in terms of subjects/participants, “infants” were the most researched in both the domestic ones and the foreign ones, followed by “parent” and “teachers.” Among the infants, the domestic ones focused on 25~36-month olds the most, while the foreign ones focused most on 0~12-month olds. In addition, in all types of infant research, there were more single subject studies than multiple subject ones.

그라프트 중합에 의한 클로로프렌 고무의 물성에 관한 연구

황승순,이상호,손진언,박동원 동아대학교 생산기술연구소 2002 生産技術硏究所硏究論文集 Vol.7 No.1

Graft-copolymerization were performed with poly(chloroprene) and methyl methacrylate (MMA) in order to determined the effects of initiator concentration, reaction time, and nitrogen purging on the kinetics of the copolymerization and physical properties of the copolymer. At high concentrations of initiator poly(chloroprene-graft-methyl methacrylate) is more viscous in case that nitrogen is purged during the copolymerization, compare to the copolymerization under air environment. The conversion of MMA increases with the concentration of initiator while the elongation of the copolymer maintains relatively steady. After the copolymerization elapses around 3 hours with nitrogen purging, the viscosity of the copolymer increases rapidly. However, the viscosity is almost steady regardless of time under air environment. Whereas the conversion of MMA increases with reaction time, the efficiency of grafting decreases. The graft copolymer prepared in air has relativity constant tensile strengths of 200 Kgf/cm2. The copolymer prepared with nitrogen purging has tensile strengths grater than 250 Kgf/cm2 and shows a maximum value, 275 Kgf/cm2, at the reaction time of 2.5 hours. Drying the solvents used to make chloroprene adhesive is faster in order of methyl alcohol, methyl cyclopentane, o-xylene, and cyclohexane.

21C 신지식인 양성을 위한 EQM 시스템 구축

최병태,이형민,전상봉,서승교,이우언,백종현 대구산업정보대학 2001 논문집 Vol.15 No.-

The aim of this paper is to form and to operate EQM, to say education quality management. In order to achieve the above stated purpose, the paper hypothesizes that there are similarities between enterprises and colleges in quality management. The basic method of the paper is systematic approach, modifies TQM, which is total quality management. The result is that EQM program must form and operate the feedback system for teaching and learning effect, the PSMT(project, self-study, media, team unit style teaching and learning) as a new teaching and learning method, and the digital system as an advanced mechanism, in education quality management.