정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

두피에 발생한 유상피 혈관육종 1예

노진혁,이병진,조옥자,박시룡 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7

Angiosarcoma is a rare malignant tumor of endothelial cell origin. Histopathologically, varied differentiation may be observed even within the same tumor. Epithelioid angiosarcoma is one subset of poorly differentiated angiosarcoma which is a rare variant. We report a case of epithelioid angiosarcoma of the scalp in a 59-year-old man. The patient had a painful solitary, 2×3 cm sized, dome-shaped, firm, erythematous to purplish nodule with crust on the vertex of the scalp. Histopathologically, the tumor was chiefly composed of solid sheets of atypical epithelioid cells with prominent eosinophilic cytoplasm, a large vesicular nuclei, and occasional intracytoplasmic vacuoles. Well to moderately differentiated areas with irregular vascular channel-like structures lined by atypical hyperchromatic endothelial cells were also seen in the peripheral areas of the tumor. Immunohistochemically, the tumor cells were positive with CD31 which is sensitive marker of endothelial cell. (Korean J Dermatol 2003;41(7) : 971~973)

요관추벽

이종태,안병수,노준,박도영,장대수 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

The ureteral folds are full-thickness inward projections of the ureteral wall. They are believed to represent persistence of normal fetal tortuosities of the ureter. The frequency of a "corkscrew" ureter was highest in the new born(75%) and decreased in frequency to an 11% incidence at 2 years of age. They have no postnatal clinical significance until 2 years of age. We have experienced one case of ureteral fold. The patient was a 4-year-old boy and his chief complaints were fever and scrotal pain. To determine the proper diagnosis, we carried out intravenous pyelography. We have noted multiple, thin, well defined, transverse radioluciencies project into the lumen of the ureter. We report this case with the review of literatures.

多目的 實驗을 爲한 亞音速 Wind Tunnel의 Modification 과 그의 實驗的 性能 考察

李鍾純,盧秉俊,吳永澤 全北大學校 1981 論文集 Vol.23 No.-

This stuudy is aimed at the modification of the wind tunnel for its multi-purpose experimental Use. The theoretical design and modified sections of the wind tunnel; the diffuser, the tranquility chamber, the convergent would be experimentally examined. The diffusion angle was calculated 7˚ to prevent the kinetic energy of the air flow fromthe friction loss, for the uniform flow, a tranquility chamber with a honey-comb plate and six grids plates and to accelerate the velocity, a convergent with the curvature calculated by the equation derived from the Bernoulli's one were modified. For their performance test, a nozzle and a vane were equipped respectively at the outlet of the wind tunnel, where one has measured the velocities and analysed them theoretically and graphically.

마케팅 커뮤니케이션 도구로서의 스포츠 스폰서십에 관한 연구

노영태,이영덕,이상봉,박병주,전동호 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

The objective of this paper is to build sports sponsorship strategic through studying the state of sports sponsorship and the case study in foreign country. I propose the sports sponsorship strategic in new approach to build the structure of more positive sports sponsorship and the understanding of sports player management in korea that greets 2002 World Cup. For that, To build newly sports sponsorship strategic must have the following requires; 1. The transition of think ; from cost concept to investment concept It is necessary the transition of think from cost concept which is a short startegic to investment concept. That is, it hope to the possibility of player lastingly than to immediately short effect which is used by activating player popular in advertisements. 2. More intensive services for customs It is necessary to show the goal accomplished possible for sports fans, ad maintain sponsorship in long run. In same time, we must aware the publics to be understood of a better cooperate image. 3. To secure a specialty It is necessary to bring up the linkage industry and the manpower of specialist for activating sports as a business dimension, not as a hobby and a nation representative. It must expand specialist to the scout management, the advertisement and the event opening.

우리 나라 공업교육의 현황과 과제

노태천,이병욱 충남대학교 공업교육연구소 2000 論文集 Vol.23 No.1

This study purposes to provide prospects to renew industrial education with focus on recent policies. For the purpose, we have reviewed the current state of industrial education in Korea and pointed out its problems. We can point out solutions of industrial education in Korea based on this study; structural reform in technical high school, management of various, specialized and self-controlled curriculums, improve teaching-learning methods corresponded to learner's level, cultivating teacher training programs and retraining system, including the test of industrial education domain for college entrance examination, establishing the public place for teaching practice. But, what the most importance things need to improve are as follows; social structure of academical cliquism, irrational a wage system, and personnel management, contemp of the technology and skill, and so on.

결합조직형성 모종 1예

이병진,노진혁,조옥자,박시룡 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.1

Desmoplastic trichilemmoma is a rare variant of trichilemmoma characterized by typical features of trichilemmoma with abundant desmoplastic stroma. We report herein a 54-year-old man presented with 2-year history of a solitary bean sized verrucous nodule on the occipital scalp. Histologically, the tumor showed a well-defined lobular growth extending from the epidermis into the dermis with abundant central desmoplastic stroma. Epithelial lobules at the margins of the neoplasm showed the typical features of trichilemmoma composed of glycogen-rich clear cells and peripheral palisading columnar cells. In contrast, at the center the cells assume a more random pattern of cords and strands traversed by the hyaline stroma, mimicking invasive carcinoma. It was diagnosed desmoplastic trichilemmoma by the distinctive histologic appearance and totally excised. (Korean J Dermatol 2003;41(1) : 120∼122)

Isolation and Transcriptional Expression of CuZn Superoxide Dismutase from Codonopsis lanceolata

Lee,Kang,In,Jun-Gyo,Yu,Chang-Yeon,Yun,Song-Joong,Min,Byung-Hoon,Rho,Yeong-Deok,Kim,Moo-Sung,Yang,Deok-Chun 한국자원식물학회 2004 Plant Resources Vol.7 No.3

To investigate the defense mechanism against the abiotic stress, a cDNA clone encoding a CuZn superoxide dismutase (CuZnSOD) protein was isolated from a cDNA library prepared from tabroot mRNAs of Codonopsis lanceolata. The eDNA, designated ClSODCc, is 799 nucleotides long and has an open reading frame of 459 bp with a deduced amino acid sequence of 152 residues. The deduced amino acid sequence of ClSODCc matched to the previously reported CuZnSODs. Consensus amino acid residues (His-45, -47, -62, -70, -79, -119 and Asp-82) were involved in Cu-, Cu/Zn-, and Zn- binding ligands. The deduced amino acid sequence of ClSODCc showed high homologies (82%-86%) regardless of species. Expression of ClSODCc by oxidative stress was increased up to 1 h after treatment and declined gradually. Much earlier and stronger expression of ClSODCc was observed in the cold stress treatment.

꼬리줄나비고기, Chaetodon wiebeli의 초기발생

이치훈,김병호,노섬,이영돈 제주대학교 해양과환경연구소 2004 해양과환경연구소 연구논문집 Vol.28 No.2

The development of eggs and larvae of the butterflyfish. Chaetodon wiebili were observed. Fertilized eggs were spherical. colorless. and driven into gelatinous masses. They measured 0.75±0.18 in diameter and not contain an oil globule. Hatching taken place 61.0 hours after two celled stage at water temperature 25.6-27.7℃. Newly hatched larvae measured 0.91 nm in total length and had an ovoid yolk of 0.65 nm in longest diameter. In 72 hours after hatching. the larvae grew 1.72 nm in total length. The mouth and anus were open and the melanophore pigments appeared above the eyes. The pectoral fins are formed and the larvae began to swim actively.

악교정 수술후 발생한 감염 4증례

진병로,김종섭,박진호,이창곤,박희대,이희경 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.1

Postoperative infection following orthognatic surgery is rare. When postoperative infections occur, the initial treatment consists of incision and drainage of the affected area, culturing to identify bacterial stains and verify antibiotic sensitivity, and the institution of the appropriate antibiotic regimen. Some plates and screws may eventually require removal, the initial therapy should be attempted to retain the plates and screws until adequete healing has taken place. In orthoganthic surgery, intra-operative complications as a lesion of inferior alveolar nerve, fracture of osteomised segments, incomplete sectioning, malposittion of segments, haemirrhage may occur. The surgeon should be familiar with possible complications to be caused and how to manage them. Prevention of postoperative infection following the orthognathic surgery consists of minimal periosteal reflection, aseptic management of operation field, proper surgical technique, rigid fixation, prophylactic antibiotics.