정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

경식도 심초음파도의 Direct Planimetry를 이용하여 측정한 대동맥판 면적의 심박출량 및 좌심실 구출율의 변화에 따른 정확도

진승원,김종진,김희열,박지원,전두수,윤호중,박준철,노태호,채장성,김재형,홍순조,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

심실 조기 수축의 발생 부위 및 연결 간격의 차이에 따른 혈역학적 변화

진승원,김재형,노태호,조은주,김희열,이만영,김종진,박준철,채장성,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

공개키 보안 시스템에서 계층 및 동등 레벨 링크만을 이용한 PKI(Public Key Infrastructure)연구

조인준,정희경,김진수 培材大學校 1997 培材論叢 Vol.2 No.-

공개 키 방식의 보안 시스템에서 키 관리는 PKI(Publie Key Infrastructure)를 기반으로 이루어진다. 디렉토리 인증 프레임워크(directory Authentication Framework) 표준으로 X.509가 제시된 후 이를 구현하기 위한 여러 방법들이 제안 되었다. 본 논문에서는 X.509 PKI 표준을 기반으로 동종조직들간의 효율적 보안 서비스제공이 가능한 동등 레벨 링크 PKI(PLL-PKI : Peer Level Link-PKI)를 새롭게 제안 하였다. A asymmetric form of key management is based the PKI(Public Key Infrastructure). After the directory authentication framework published to X. 509, the several methods for this implementation were proposed. In this paper, the PLL-PKI(Peer Level Links-PKI) is newly proposed for efficient security services on the same level of organizations.

임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.

유한요소법을 이용한 수종 심미수복물의 응력 분석

조진희,방몽숙 전남대학교 치과대학 1990 전남치대논문집 Vol.2 No.1

The purpose of this study was to analyze the stresses and displacements of various esthetic restorations and abutment teeth. The finite element models of central incisor were divided into four groups according to the types of restoration. Three load cases were applied ; 1) 45 degrees on the incisal edge, 2) horizontal force on the labial surface, and 3) 26 degrees diagonally on the lingual surface. Material property, geometry, and load conditions of each model were inputed to the two dimensional finite element program and stresses and displacements were analyzed. Results were as follows ; 1. In the cases of porcelain fused gold crown and porcelain laminate veneer, stresses were equally distributed in supporting abutment tooth. The metal coping of porcelain fused gold crown and collarless porcelain fused gold crown functioned as a good stress distributor. 3. When the horizontal load applied, the highest tensile and compressive stresses were seen in the cervical margin of restoration and the dentin of the abutment tooth. 4. The highest displacement of restoration was seen when load was applied at an angle of 26 degrees diagonally in lingual surface of tooth in centric occlusion. 5. The influence of loading direction on the stresses and displacements in the restoration was greater than that of various design. 6. The possibility of fracture was highest in porcelain jacket crown.

중국의 정보통신기술 표준 전략 : 한국의 정보통신산업에 주는 함의

이희진,오상조 한국정보사회진흥원 2008 정보화정책 Vol.15 No.4

Since China's accession to WTO in 2001, standards have emerged as an effective means to protect and promote domestic industries, especially in the ICT sector. China develops its own standards in many areas of the ICT sector, and intends to establish each of them as an international standard. Despite the significance of understanding the impacts of these standard setting attempts on the ICT industry in Korea, there is little research in this area. This paper investigates China's attempts to set up ICT standards. Three standards (WAPI, TD-SCDMA and AVS) are examined to find similarities and differences in the processes of their development and standardization. Techno-nationalism and techno-globalism are used to identify the patterns of China's ICT standards strategy. In contrast with a previous study which concludes China's standards policy as 'neo-techno-nationalism', this paper reveals that each case has a distinguished orientation in terms of techno-nationalism and techno-gloabalism: WAPI is aligned with techno-nationalism, TD-SCDMA with techno-globalism, and AVS with techno-hybrids or neo-techno-nationalism. Implications for the Korean ICT industry are discussed in the context of Korean ICT firms' entrance to the Chinese market, ICT standards in coming FTAs, and standards wars where Korean ICT firms are increasingly involved. 중국은 정보통신 여러 분야에서 자국의 표준을 제정하고 이를 세계표준으로 발전시키려는 노력을 하고 있다. 본 논문에서는 국가 기술 혁신 시스템에 대한 연구들에 바탕을 두고 중국의 정보통신 표준 제정 시도를 분석한다. 중국의 정보통신분야 표준 제정 노력 중, 대표적인 세 가지 표준(WAPI, TD-SCDMA와 AVS)의 개발 및 표준화 전개 과정을 비교 분석하였다. 이들 표준들은 그 제정 과정의 유사성에도 불구하고, 표준 제정의 시작 시점, 수립하고자 했던 표준의 종류, 표준화 작업그룹 내의 외국 기업 참여, 동기 등의 측면에서 상이한 점을 발견할 수 있다. 중국의 표준 제정 정책은 포괄적인 국가의 관여, 국가와 민간부문의 적극적인 연계 등의 특징을 갖는 신기술국가주의라는 하나의 틀로 범주화하기는 어렵고, 기술국가주의(WAPI), 기술세계주의(TD-SCDMA), 그리고 혼합(AVS)의 형태를 띠면서 진화하고 있다. 결론에서는 한국 정보통신 기업의 중국 시장 진출, 정보통신 기술을 둘러싼 세계 표준 전쟁, 미국 및 유럽과의 FTA 등의 맥락에서 중국의 표준 정책을 이해하는 것이 한국의 정보통신 산업에 갖는 중요성을 검토하고 향후 연구 과제를 제시한다.

개에서 심실 조율부위 및 조율주기에 따른 혈역학적 변화

김희열,김재형,노태호,김종진,진승원,유기동,이만영,채장성,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

健康한 韓國人의 動脈血液 가스 및 酸一鹽基 平衡値에 對한 觀察

崔震守,曺方煥,朴喜淑,金顯承,金瑛,白正敏,徐錫助 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.3

The purpose of this paper is to make an attempt in this investigation to determine normal adult values of arterial blood gas and acid-base balance in 53 healthy Korean male and female subjects of varying age and then compare with the data obtained by others. Determinations of the acid-base status of the arterial blood were performed at 37℃ by the Astrup method using a radiometer instruments, consisted of BGA2A/3-MK 2 system. The mean and standard errors of each component were as follows: pH 7.42±0.043, oxygen saturation 96.96±0.089%, pO?? 97.66±0.91mmHg, pCO?? 37.08±0.68mmHg, CO?? content 24.29±0.43mM/L, bicarbonate 23.26±0.68mM/L, buffer base 46.56±0.66mEg/L, and base excess -0.024±0.001mEg/S. Compared with normal adult values in literatures, all the components of the data appear to be in the same range without any significant difference.

계측 장비를 위한 무선 RF모듈의 개발

전희종,서영조,오정언,김병진 崇實大學校 1999 論文集 Vol.29 No.1

The existing equipment with wire communication can expect the stability of data transmission. However, according to increasing a number of Measuring Instruments, wiring work becomes a heavy burden. Restriction to application about portable Measuring Instruments and the lack of flexibility are another drawback of wire communication. This paper presents the scheme of the design and implementation of a RF(Radio Frequency) based module. The RF based module is designed to the multi communication between Measuring Instruments. The RF based module consists of RF circuit and microprocessor. The main properties of RF circuit are maximum 5[Kbps] transmission rate, maximum 90m transmission distance and 433[MHz] frequency band. The microprocessor rearrange the data into AHDLC(Advanced High level Data Link Control) format and then instructs RF circuits to transmit/receive the data. The RF module is expacted to have a wide application field such as fire/security alarm, remote control/measurement etc..