서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

타가메트정 400㎎에 대한 신일시메티딘정 400㎎의 생물학적동등성시험

윤미경,이병무,이성재,김선규,이재휘,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

Cimetidine is a histamine H₂-receptor antagonist, used for the treatment of endoscopically or radiographically comfirmed duodenal ulcer. pathologic GI hypersecretory conditions. and active, benign and gastric ulcer. Simple method for determining cimetidine in human plasma has been developed and validated. The analytical procedure for cimetidine showed a linear relationship in the concentration ranges from 0.05 to 5 pg/ml. Coefficient of variance (CV, ° o) for intraday and interdav validation and relative error (RE. ° o) were less than ±150 o. Based on this analytical method. the bioequivalence of two cimetidine 400 mg tablets, reference (Tagamet 400 mg) and test drug (Sinil CIMETIDINE 400 mg) was evaluated according to the guidelines set by the Korea Food and Drug Administration (KFDA). Release of cimetidine from the tablets in vitro was tested using KP VIII Apparatus II with various dissolution media (pH 1.2. 4.0. 6.8 butter solutions and water). Twenty-four healthy volunteers. 21.38±1.86 years in age and 68.71±8.68 kg in bode weight, were divided into two groups and a randomized 2x2 cross-over study was performed. After oral administration of a tablet containing 400 mg of cimetidine. blood samples were taken at predetermined time intervals and concentrations of cimetidine in plasma were determined using HPLC equipped with UV detector. The dissolution profiles of the two tablet formulations were very similar at all dissolution media. In addition. pharmacokinetic parameters such as AUC, and C_(max) were calculated and ANOVA was employed for the statistical analysis of parameters. The results were revealed that the diterences in AUCf and Cma, between the two tablets were 4.17% and 0.97% respectively. At 90% confidence intervals. the differences in these parameters were also within ± 20° o. All of the above mentioned parameters have met the criteria of KFDA guidelines for bioequivalence, indicating that the test drug tablet (Sinil CIMETIDINE tablet) is bioequivalent to Tagamet 400 mg tablet.

컴퓨터 면역시스템 개발을 위한 생체 면역시스템 모델링

선상준,심재윤,심귀보 중앙대학교 정보통신연구소 2000 정보통신연구소논문집 Vol.2 No.2

본 논문은 생체 면역시스템의 자기와 비자기를 구분하여 인식하는 세포독성 T세포의 특징을 이용하여 컴퓨터에서 자기 파일과 비자기 파일을 구분할 수 있는 T세포를 모델링하였다. 모델링한 T세포는 MHC 인식부와 향원 인식부로 구성되며 각각의 인식부를 이용하여 비자기 파일에 적용시켜 자기-비자기 구분이 가능함을 컴퓨터 시뮬레이션을 통하여 입증하였다. Biological immune system distinguishes nonself from self-body and protects self intrusion such as virus, pathogenic bacteria. In this paper, we make a model of the T-cell of immune system to apply to computer immune system. The modeled T-cell possesses the ability to be able to distinguishes self files from random files in computer. The T-cell consists of MHC perception and antigen perception, and distinguishes self from non-self through matching file which we must test. We verify the effectiveness of the proposed method by applying self-nonself discrimination in a computer virus.

지하공동구 화재 실험 및 시뮬레이션에 의한 화재 실험 예측 평가

윤명오,고재선,박형주,박성은 한국화재소방학회 2001 한국화재소방학회논문지 Vol.15 No.1

지하공동구는 최근 통신의 발달로 인해 국가 중추기능으로서의 주요 역할를 하는 시설로, 사고시 신속한 대처가 힘들고 케이블 연소시 발생하는 유독가스에 의한 검은 연기로 공동구 내에 진입하여 소화하기가 힘들다. 따라서 화재발생시 막대한 재산피해 및 통신의 두절 등 국가의 중추신경이 마비됨은 물론 시민 불편사항을 초래시켰다. 본 논문은 지금까지 발생되어온 공동구 화재를 바탕으로 실제 공동구 모형을 제작하여 화재를 재현함으로서, 과학적으로 화재의 성상을 분석하고 지하공동구 내에 소방설비를 갖춘 후에 일정온도에서 각각의 소방설비들이 제대로 작동하는지를 검증하는데 그 목적이 있다. 화재실험은 지하공동구 내에 정온식 감지선형 감지기, 방화문, 연결살수설비 및 환기설비를 설치하고 송 · 배전케이블은 일정구간 내화도료로 도장하며 난방관은 내화피복된 상태에서 실험하였다. 그 결과 최고 온도가 932℃로 측정되었고 일정온도에서 정온식 감지선형 감지기가 작동하여 화재위치를 정확히 수신반에 나타내었다. 그리고 송 · 배선케이블은 일정구간 내화도료로 도장한 것은 내화성능이 없는 것으로 나타났고, 내화피복된 난방관은 약 30분 정도의 내화 성능이 있는 것으로 나타났다. 컴퓨터 화재 시뮬레이션은 실제 화재 시험시의화재하중을 입력하여 실시한 결과 최고 온도가 943℃로 실제 화재시의 최고 온도인 932℃와 거의 일치하였다. 따라서 공동구 화재하중만으로 화재 시뮬레이션을 실시하여 화재의 성상에 대한 예측이 가능한 것으로 판단되며 시뮬레이션으로 얻는 열방출량, 연기층의 높이, 산소, 일산화탄소, 이산화탄소의 농도 등의 결과 값들을 실제 화재 실험시의 값으로 적용시킬 수 있는 것으로 판단된다. The utility tunnels are the important facility as a mainstay of country because of the latest communication developments. However, the utilities tunnel is difficult to deal with in case of a fire accident. When a cable burns, the black smoke containing poisonous gas will be produced. This black smoke goes into the tunnel, and makes it difficult to extinguish the fire, Therefore, when there was fire in the utility tunnel, the central nerves of the country had been paralyzed, such as property damage, communication interruption, in addition to inconvenience for people. This paper is based on the fire occurred in the utilities tunnel in the past, and reenacting the fire by making the real utilities tunnel model. The aim of this paper is the scientific analysis of the character image of the fire, and the verification of each fire protection system whether it works well after process of setting up a fire protection system in the utilities tunnel at a constant temperature. The fire experiment was equipped with the linear heat detector, the linear heat detector, the fire door, the connection water spray system and the ventilation system in the utilities tunnel. Fixed portion of an electric power supply cable was coated with a fire retardant coating, and a heating tube was covered with a fireproof. The result showed that the highest temperature was 932℃ and the liner heat detector was working at the constant temperature, and it pointed at the place of the fire on the receiving board, and Fixed portion of the electric power supply cable coated with the fire retardant coating did not work as the fireproof. The heating tube was covered with the fireproof had the function of the fireproof about 30 minutes.

Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells

( Jae-sung Ryu ),( Kyu-tae Chang ),( Ju-taek Lee ),( Malg-um Lim ),( Hyun-ki Min ),( Yoon-ju Na ),( Su-bin Lee ),( Gislain Moussavou ),( Sun-uk Kim ),( Ji-su Kim ),( Kinarm Ko ),( Kisung Ko ),( Kyung- 생화학분자생물학회 2017 BMB Reports Vol.50 No.6

The ACKNOWLEDGEMENTS should be corrected as follows, This research was supported by a grant (Code# PJ0074922012) from the Korean Rural Development Administration, and has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2010-0022316 and KCG5401011), and the KRIBB/KRCF Research Initiative Program (NAP), Korea. The published article in this journal was a part of the 2013 Doctoral thesis of Jae-Sung Ryu submitted to Wonkwang University, Korea. and not This research was supported by a grant (Code# PJ0074922012) from the Korean Rural Development Administration, and has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2010-0022316 and KCG5401011), and the KRIBB/KRCF Research Initiative Program (NAP), Korea.

정형외과 영역에서의 골 이식술의 유용성

윤택림,정재윤,문은선,송은규,서형연 全南大醫大 2000 전남의대학술지 Vol.36 No.2

지역발전을 위한 대학교 연구소 역할활성화에 관한 연구 : 아산·천안지역과 순천향대학교 사회과학연구소를 중심으로 focused on Asan and Chonan Area and the Research Institute of Social Science at Soonchunhyang University

윤주명,유형선,원재환,안동근 순천향대학교 사회과학연구소 2002 순천향 사회과학연구 Vol.8 No.1

The objective of this study is to survey the demand of profit and non-profit sectors to research institute of social sciences at soonchunhyang university(RISS of SCH) in Asan and Chonan city, to find the policy alternatives to develop RISS of SCH. Form the result of analysis, the degree of recognition to RISS of SCH of both profit and non-profit sectors is very low, but their willingness to cooperate with RISS of SCH is relatively high. Especially they want the partnership with RISS of SCH in reeducation of their staffs, exchange of information, and co-works in research and seminar so on. This study suggests as the developing ways of RISS of SCH, changing organizational structure, making eeducation programmes for staffs of profit and non-profit sector, creating new media to disseminate information, and publishing partnership research journal with neighborhood university so on.

고등학교 일반수학 교과서의 오류분석

유윤재,이순이 慶北大學校 師範大學 1992 敎育硏究誌 Vol.34 No.-

The purpose of the paper is to analyze the various fallacies of the current textbooks of high school mathematics. The scopes of the research consist of terminologies, editorial problems, and logical errors. By comparing with textbooks, it was found that mathematical teminologies are used differently. The reason why this problem happens is that the Ministry of Education has not unified the terminogies more concretely. Some textbooks do not explain some definitions clearly and the authors proposed some remedies to overcome these problems.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

이산월쉬함수를 이용한 디지털 PID 제어기의 대수적 파라미터 결정 방법에 관한 연구

金潤相,李明珪,沈在先,安斗守 성균관대학교 1998 학술회의지원논문목록집 Vol.1998 No.-

This paper presents an efficient algorithm which can determine the three types of PID parameter directly and sirnultaneously. The proposed algorithm is an algebraic method to obrain controller parameters using discrete Walsh functions, which makes controller design procedure systematic and straightforward. Also, by salving a set of linear equations derived for parameter determination, the proposed method does not involve any trial and error procedure, hence the difficulty of conventional approach can be avoided Simple examples are given to demonstrate the effectiveness with our proposed manner.