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정재윤,김혜영,서명환,이정구 대한평형의학회 2008 Research in Vestibular Science Vol.7 No.1
Background and Objectives: Many authors have suggested close relationship between benign paroxysmal vertigo of childhood (BPVC) and migraine. But the relationship between the two is not clearly determined. Therefore we investigate clinical features and the course in children with BPVC and the possibility of evolution of migraine in BPVC. Materials and Methods: We interviewed 30 subjects having enough medical records and fitted to BPVC category who visited otorhinolaryngology for vertigo from 1995 to 2006 year. Results: The BPVC was the most common diagnosis in our hospital and migraine associated vertigo was followed. The main features of the children with BPVC were in agreement with previous reports. The major differences were later age of onset, having trigger factor and non-spinning type of vertigo. During the follow up, 8 children developed migraine. Females were dominant duration of illness was longer in this group. Almost of them suffered from motion sickness and had more family history of migraine, which was maternal dominant. Conclusions: The long term close follow-up may be needed in BPVC having possibility of evolution to migraine. Background and Objectives: Many authors have suggested close relationship between benign paroxysmal vertigo of childhood (BPVC) and migraine. But the relationship between the two is not clearly determined. Therefore we investigate clinical features and the course in children with BPVC and the possibility of evolution of migraine in BPVC. Materials and Methods: We interviewed 30 subjects having enough medical records and fitted to BPVC category who visited otorhinolaryngology for vertigo from 1995 to 2006 year. Results: The BPVC was the most common diagnosis in our hospital and migraine associated vertigo was followed. The main features of the children with BPVC were in agreement with previous reports. The major differences were later age of onset, having trigger factor and non-spinning type of vertigo. During the follow up, 8 children developed migraine. Females were dominant duration of illness was longer in this group. Almost of them suffered from motion sickness and had more family history of migraine, which was maternal dominant. Conclusions: The long term close follow-up may be needed in BPVC having possibility of evolution to migraine.
Adjacent Segment Pathology after Anterior Cervical Fusion
정재윤,박종범,서형연,김성규 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.3
Anterior cervical fusion has become a standard of care for numerous pathologic conditions of the cervical spine. However, subsequent development of clinically significant disc disease at levels adjacent to fused discs is a serious long-term complication of this procedure. As more patients live longer after surgery, it is foreseeable that adjacent segment pathology (ASP) will develop in increasing numbers of patients. Also, ASP has been studied more intensively with the recent popularity of motion preservation technologies like total disc arthroplasty. The true nature and scope of ASP remains poorly understood. The etiology of ASP is most likely multifactorial. Various factors including altered biomechanical stresses, surgical disruption of soft tissue and the natural history of cervical disc disease contribute to the development of ASP. General factors associated with disc degeneration including gender, age, smoking and sports may play a role in the development of ASP. Postoperative sagittal alignment and type of surgery are also considered potential causes of ASP. Therefore, a spine surgeon must be particularly careful to avoid unnecessary disruption of the musculoligamentous structures, reduced risk of direct injury to the disc during dissection and maintain a safe margin between the plate edge and adjacent vertebrae during anterior cervical fusion.
정재윤,임상혁,손주현,이재곤,전대원,김용수 대한의학회 2018 Journal of Korean medical science Vol.33 No.50
Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis. Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements. Results: A total of 131 patients with liver cirrhosis were enrolled. The mean age of the patients was 53.7 years and alcoholic liver disease was the most common cause (61.8%). Sixty-four patients (48.9%) were diagnosed with sarcopenia. The median changes in skeletal muscle area per year (ΔSMA/y) were −0.89%. During a median follow-up period of 46.2 months (range, 3.4–87.6), 45 patients (34.4%) died. In multivariate analyses, age, Child- Pugh score, HVPG, presence of sarcopenia and ΔSMA/y were independently associated with mortality. Cumulative mortality was significantly higher in patients with ΔSMA/y < −2.4% than those with ΔSMA/y ≥ −2.4% (log-rank test, P < 0.001). Conclusion: Both the presence and rate of change of sarcopenia are independently associated with long-term mortality in patients with liver cirrhosis.
정재윤,국명근,김성철,강경선,소광섭 사단법인약침학회 2018 Journal of Acupuncture & Meridian Studies Vol.11 No.4
Homing of stem cells (SCs) to desired targets such as injured tissues remains a lingering problem in cell-based therapeutics. Studies on the biodistribution of intravenously administered SCs have shown the inefficacy of blood vessels as the homing path because most of the injected SCs are captured in the capillary beds of the lungs. We considered an alternative administration method using the acupuncture meridians or the primo vascular system. We injected SCs at the acupoint Zusanli (ST-36) below the knee of a nude mouse with a spinal cord injured at the thoracic T9-10 vertebrae. The SCs migrated from the ST-36, along the sciatic nerve, the lumbar 4-5, and then the spinal cord to the injury point T9-10. The SCs were not randomly scattered but were rather well aligned like marathon race runners, along the primo vascular system route toward the injury point. We observed