암민코발트(Ⅲ) 착이온의 수소이온해리반응에 미치는 온도의 영향

오상오,박유철,이동철 慶北大學校 物理化學硏究所 1984 硏究論文集 Vol.5 No.-

The acid ionization constants of cis-aquo-bis(ethylenediamine)cobalt(Ⅲ) complexes have been spectrophotometrically (at 500 nm) measured in aqueous solution. According to curve fitting method, the equilibrium constants of reaction(1) and (2), K_1 and K_2 were measured at a various tempratures from analyzing the extinction coefficients of Co(Ⅲ) complex ions in a wide range of pH. 〔Co(en)_2(H_2O)_2〕^3+ ⇔ 〔Co(en)_2(OH)(H_2O)〕^2+ + H^+ (1) 〔Co(en)_2(OH)(H_2O)〕^2+ ⇔ 〔Co(en)_2(OH)_2〕^+ + H^+ (2) K_1 and K_2 values increased with increasing the temperature, were 1.5×10 exp(-6) and 1.5×10 exp(-10) respectively at 30℃ in 1M sodium nitrate solution :ΔH_1=7.5㎉/mole, ΔH_2=6.5㎉/mole and, ΔS_1=-2e.u., ΔS_2=-23.6 e.u. The enthalphy and entropy changes indicate that the acid-base equilibria of Co(Ⅲ) ions are endothermic process and the effect of solvation is controlled over the reactions.

암민코발트(Ⅲ) 착이온의 수소이온해리반응에 미치는 온도의 영향

오상오,박유철,이동철 慶北大學校 1982 論文集 Vol.33 No.-

The acid ionization constants of cis-aquo-bis(ethylenediamine)cobalt(Ⅲ) complexes have been spectrophotometerically (at 500 nm) measured in aqueous solution. According to curve fitting method, the equilibrium constants of reaction(1) and (2), K_1 and K_2 were measured at a various tempratures from analyzing the extinction coefficients of Co(Ⅲ) complex ions in a wide range of pH. 〔Co(en)_2(H_2O)_2〕^3+??〔Co(en)_2(OH)(H_2O)〕^2++H^+ (1) 〔Co(en)_2(OH)(H_2O)〕^2+??〔Co(en)_2(OH)_2〕^++H^+ (2) K_1 and K_2 values increased with increasing the temprature, were 1.5×10 exp (-6) and 1.5×10 exp (-10) respectively at 30℃ in 1M sodium nitrate solution : ΔH_1=7.5Kcal/mole, ΔH_2=6.5Kcal/mole and, ΔS_1=-2e.u., ΔS_2=23.6 e.u. The enthalphy and entropy changes indicate that the acid-base equilibria of Co(Ⅲ) ions are endothermic process and the effect of solvation is controlled over the reactions.

분사법에 의한 탄산칼슘 제조

신보철,한상오,김주호,송지훈,송근호,이광래 강원대학교 석재복합신소재제품연구센터 2001 석재연 논문집 Vol.6 No.-

본 연구는 탄산가스화법에 의한 탄산칼슘 입자 제조 공정에 있어서, 탄산가스로 채워진 반응기에 수산화칼슘 슬러리를 분사하는 방법으로 탄산칼슘 입자를 제조하였다. 수산화 칼슘의 농도(0.25~1.0wt%), 분사압력(0.5kgf /㎠~1.5kgf /㎠) 및 반응기 온도(20℃, 28℃)의 변화에 따른 생성된 탄산칼슘을 관찰하였다. 수산화 칼슘의 농도가 비교적 높으면(0.75wt%, 1.0wt%), 생성물의 pH와 전도도는 높게 나타났다. 분사압력에 의한 탄산칼슘 제조의 변화는 분사압력이 높아질수록(1.5kgf /㎠), pH와 전도도는 높게 측정되었다. 그러나, 수산화 칼슘의 농도와 분사압력의 변화가 탄산칼슘의 입자크기, 형태, 결정구조에 영향을 미치지는 않았다. 반응기의 온도가 28℃에서 생성된 탄산칼슘은 1.0㎛이하의 칼사이트 상 입자가 제조되었으며, 20℃에서 생성된 탄산칼슘은 0.5㎛이하의 칼사이트 상 입자가 제조되었다. 반응기의 온도가 낮아질수록 탄산칼슘 입자의 크기가 작아짐을 알 수 있었다. For the preparation of calcium carbonate particles from aqueous Ca(OH)2 slurry, carbonation reaction of aqueous Ca(OH)2 slurry was carried out by spouting the aqueous slurry of Ca(OH)2 into reactor filled with CO2 gas. The concentration of Ca(OH)2 varies from 0.25wt% to 1.0wt%, nozzle pressure from 0.5kgf /㎠ to 1.5kgf /㎠, and reactor temperature were set at 20℃ and 28℃. With relatively high concentration of 0.75wt% and 1.0wt% of Ca(OH)2, pH and conductivity of product-stream were observed high value. High pH and conductivity were observed at high nozzle pressure of 1.5kgf /㎠. The concentration of Ca(OH)2 and nozzle pressure, however, did not change the particle size and shape of calcium carbonate synthesized by carbonation reaction. The reaction temperature affected particle size. At reactor temperatures of 28℃ and 20℃, the particle sizes were about 1.0㎛ and 0.5㎛, respectively. Crystal structure of calcium calcium carbonate was of calcite. When reactor temperature was lower, the size of calcium carbonate particle was smaller.

회분식 반응기에서의 공정변수 변화에 의한 침강성 탄산칼슘 제조

신보철,한상오,김주호,송지훈,송근호,이광래 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

For the preparation of calcium carbonate particles from aqueous Ca(OH)2 slurry, carbonation reaction of aqueous Ca(OH)2 slurry was carried out by batch method the CO2 into reactor filled with aqueous slurry of Ca(OH)2. The concentration of Ca(OH)2 varies from 1.00 to 7.00wt%, reactor temperature at 20 and 40℃, and reactor pressure from atmospheric pressure to 6.0kgf/cm2. Crystal structure of calcium carbonate was of calcite, the particle size were about 0.05 ∼2.0㎛, and the particle shape was cubic and spindle. When reactor temperature was higher, particle size of calcium carbonate was bigger and particle share was varied, but reaction rate was increased. When reactor pressure was higher, particle size of calcium carbonate was smaller, particle shape was cubic, and reaction ramie was increased.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

猪島의 집게類

吳相哲 제주교육대학교 2001 論文集 Vol.30 No.-

이족로봇의 경사면 균형 유지와 보행에 관한 연구

오성남,윤동우,손영익,김갑일,임승철,강환일 명지대학교 산업기술연구소 2007 産業技術硏究所論文集 Vol.26 No.-

This paper aims to provide a way to improve dynamic stability of biped robots against undesirable disturbances and in a slope. By using an angular velocity sensor and an acceleration sensor on its waist, we can make a medium-sized biped robot walk stably in a slope against impulsive disturbances. In addition, it is possible for the robot to walk stably in an unknown slope. The measured signals from the sensor are used for compensating the reference angles of ankle, knee, and pelvis joints. Some experiments show that the stability of the robot is much enhanced by using cheap sensors and a simple algorithm. This work helps biped robots walk more stably in real environments.

두경부자세 및 혀, 설골의 위치가 두개안면형태에 미치는 영향에 관한 연구

오진섭,태기출,국윤아,김상철 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.4

두경부 자세 및 혀, 설골의 위치와 두개안면골격간의 연관성을 알아보기 위해, 원광대학교 치과대학 재학생 중 선천적 두경부 이상이나 결손치가 없고 과거 교정 치료나 보철치료의 경험이 없는 남자 50명과 여자 40명을 대상으로 natural head position(NHP)상태에서 두부방사선 사진을 채득하여 전통적인 두개내 참고선과 두개의 진성 참고선을 이용하여 계속한 결과 다음과 같은 결론을 얻었다. 1. 두경부 자세변수들에서는 남녀간 차이가 없었으나, 설골의 위치는 남자가 여자에 비해 더 전하방에 위치하였으며, 더 큰 전하방 경사도를 보였다. 2. 경추의 경사도가 클수록 NHP에서 안면돌출도는 작게 나타났으며, 경추의 전방만곡이 증가할수록 수직적인 안모형태를 보였다. 3. 두경부각이 작을수록 두개저에 대하여 설골이 전방에 위치하였으며, 두경부각과 설골의 수직적인 위치는 연관성을 보이지 않았다. 4. 하악골이 전돌될수록 설골은 전방에 위치하였으며, 두개안면형태와 설골의 수직적인 위치는 미약한 연관성을 나타냈다. The purpose of this study was to examine the associations of head posture, the position of the tongue or the hyoid bone to craniofacial structure. Cephalograms taken in Natural head position(NHP) of 90 dental students (50 in male, 40 in female, 20 to 30 years in age) were traced and measured using the extracranial true horizontal and vertical lines. The obtained results were as follows; 1. There was no sex difference in head posture, but the hyoid bone was placed anteroinferiorly in male more than in female and anteroinferior inclination of the hyoid bone showed greatly in male. 2. The more inclined was the cervical column, the less prognathic was the face in natural head posture, and the larger cervical curvature, the more vertical pattern of the face. 3. The less small showed craniocervical angulation, the more anteriorly placed was the hyoid bone to the cranial base, and there was no significantly association between craniocervical angulation and the vertical position of the hyoid bone. 4. The more prognathic was the mandible, the more anteriorly placed was the hyoid bone, and there was slightly association between the craniofacial morphology and the vertical position of the hyoid bone.

Iminodiacetatonickelate(Ⅱ)와 Copper(Ⅱ)간의 금속치환반응의 속도론적 연구

오상오,박유철,도길명 慶北大學校 文理科大學 1978 文理學叢 Vol.5 No.-

The substitution reaction between copper(Ⅱ) and iminodiacetationickelate(Ⅱ) has been investigated spectrophotometrically at an ionic strength, μ=2.o and temperature, 25℃ with a various pH (3.0-5.0). From the observed rate constants the over-all rate of the substitution reaction us expressed as follows; Rate=(k_0″+k_H+[H^+]+k_Cu^2+[Cu^2+])[Ni(Ⅱ)-L] Where[Ni(Ⅱ)-L] is the concentration of the iminodiacetationickelate(Ⅱ). The values of k_0″, k_H+ and k_Cu^2+ were 2.1×10 exp(-4) sec^-1, 1.2 M^-1 sec^-1 and 1.8×10 exp(-2) M^-1, respectively. In addition to that, the path rate-deter mining step of the metal exchange reaction are discussed.

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1