Treatment Effects of Maxillary Molar Distalization with Palatal Plate: CBCT Synthesized Cephalometric Analysis

국윤아,김혜진,Mohamed Bayome,Park,Vu Thi Thu Trang 대한통합치과학회 2014 대한통합치과학회지 Vol.3 No.1

The purpose of this study was to evaluate the clinical treatment effects of molar distalization with palatal plate using 2 dimensional (2D) cephalograms converted from CBCT. This retrospective clinical study included 20 consecutively treated patients (11 male, 9 female), with an average age of 15±3 years. Cephalometric analysis was made on 2D cephalogram images derived from 3D CBCT. Skeletal, dental, and soft tissue measurements were evaluated. Through the use of palatal plate, clinically successful distalization of maxillary molars was achieved. Statistically significant changes in molars positions were observed between T1 and T2 (before and after the distal movement). The first molar and second premolar distalization were 3.98±1.23 mm and 1.17±3.54 mm with distal tipping of 3.17±4.97°and 3.21±2.86°, respectively. Moreover, the incisors were retracted 3.12±3.24 mm, with 10.31±4.98°of tipping and 1.75±1.54 mm of extrusion. All skeletal changes during treatment were not significant. The upper and lower lips were retracted 1.57 and 1.49 mm respectively. The palatal plate could be a valid clinical option for efficient distalization of the maxillary first molars in Class II patients.

ABN각의 변화요인에 관한 연구

국윤아,김상철 원광대학교 치의학연구소 1993 圓光齒醫學 Vol.3 No.2

The purpose of this study was to investigate the factors which cause the variation of ANB angle. The cephalograms, taken from 150 subjects, 77 in Class Ⅰ malocclusions and 43 in Class Ⅱ malocclusions. 30 in Class Ⅲ malocclusions, were studied and analyzed statistically. The obtained results were as follows 1. The classification by the ANB angle agreed with the clinical classification by Angle's in 55.8% of Class I , 79.1% of Class Ⅱ, 100% of Class Ⅲ. 2. Multiple regression analysis showed that ANB angle was much influenced by SNA. SN-GoGn. in Class 1 (57.1%), SNA, SN-occlusal plane, SN-palatal plane in Class Ⅱ (56.3%), SNA, SN-GoGn, in Class Ⅲ (54.8%), SNA. SNGoGn, NSAr in total(51.9%). 3. Regression equation in Class Ⅰ was that ANB angle=0.417×(SNA angle)+0.270× (SN-GoGn)-40.608. In clinical orthodontics, the anteroposterior relationship of apical bases can be evaluated by comparing ANB angle calculated from regression equation with that angle directly measured from cephalogram.

익산지역 초등학생의 앵글씨 제3급 부정교합 유병률과 유전적인 소인에 관한 연구

국윤아 원광대학교 치의학연구소 1996 圓光齒醫學 Vol.6 No.1

The purpose of this study was to investigate the prevalence and genetic tendency of Class Ⅲ malocclusion among 400 primary school students. Cephalometric head films and impressions for models were taken to evaluate the malocclusion and the results were statistically analyzed. 1. There was no significant differences between the sexes for the occurrence of Class Ⅲ malocclusion. The prevalence of Class Ⅲ malocclusion was a 5 % among the students. 2. Among the students with Class Ⅲ malocclusion, there was a 10% genetic tendency for mandibular prognathism in the parents and a 5% in the grandparents including three generations. The results suggest a 20% genetic relationship between Class Ⅲ malocclusion and genetic tendency.

안면비대칭의 교정적 치료

국윤아 대한치과의사협회 1997 대한치과의사협회지 Vol.35 No.5

배자와 태아에서 하악골의 형태발생 및 교원질 발현에 관한 면역조직화학적 연구

국윤아,김상철,김은철,김오환,김정기 대한치과교정학회 1996 대한치과교정학회지 Vol.26 No.2

치아 위치에 영향을 미치는 악안면의 성장 발육에서 Meckel 연골발생전 후의 하악골 형성과정과 교원 단백질 분포 및 발현정도를 알아보고자 좌고를 측정하여 태령을 결정한 후 4주부터 38주까지 50례의 배자와 태아를 대상으로 통법에 따른 조직절편을 제작하였으며 Hematoxylin과 Eosin, Alcian blue-pas와 Goldner의 Masson Trichrome 염색, 그리고 제1형과 제2형 교원 단백질에 대한 면역조직화학 염색을 시행하였다. 좌고 20.5 MM 배자에서 Meckel 연골이 출현하였으며, 좌고 22mm에서 38mm까지 하악골 외방에 신생골을 형성하고, 좌고 60mm태아에서 Meckel 연골이 점유하던 공간이 신생골로 채워져 연골내골화가 뚜렸하게 관찰되었으나, 좌고 240mm에서 Meckel 연골이 거의 소실되었다. 교원질에 대한 면역 염색결과에서 Mackel 연골 출현전 제1형 교원질 발현은 주로 상, 하악돌기의 구강상피에 국한되어 관찰되었고 제2형교원질 발현은 상대적으로 약간 적었다. Meckel 연골 출현 및 신생골 형성시기는 제1형교원질이 주로 치제상피와 신생골에서 약양성의 발현을 보였으며, Meckel 연골 및 신생골에서는 제1형보다 제2형의 교원질이 많이 발현되었다. 막내골화시기에는 제1형 교원질이 골아세포 및 골기질에서 중등도로 발현되었으나, 제2형에서는 경미하게 나타나 Meckel 연골형성전 후 제2형에서 제1형으로 발현전환이 있었다. Underlying malocclusions and dentofacial deformities are often related to variations in the craniofacial development. Type I and type Ⅱcollagens are considered the major collagens of bone and cartilage respectively. Monitoring the patterns of those protein expressions during development will provide a basis for the understanding of normal and abnormal growths. This study was undertaken to investigate the morphogenetic changes and the expression patterns of type I and Ⅱcollagen proteins involved in the developing mandible of human embryos and fetuses. 50 embryos and fetuses were studied with Hematoxylin and Eosin, Alcian blue-PAS, Masson Trichrome, and Immunohistochemical stains. The results were as follows: 1. A 13.5mm embryo showed the stomatodeum with dental lamina, maxillary and mandibular processes. Meckel's cartilage appeared in the mandibular arch of a 20.5mm embryo. New bone formation was bilaterally initiated at the outer side of middle portion of Meckel's cartilage of 22-38 mm embryos. 2. Meckel' cartilage was resorbed at the 15th week fetus. The endochondral ossification was observed where there was direct replacement of cartilage by bone. Meckel' cartilage disappeared and membraneous ossification were observed at the 25th week. 3. Before the appearance of Meckel's cartilage, the expression of type I collagen was moderate at the odontogenic epithelium of maxillary & mandibular process, but mild for the expression of type Ⅱ collagen. 4. During the appearance of Meckel's cartilage and new bone formation, the immunoactivity of type Ⅱ collagen was more expressed than type I collagen at the Meckel's cartilage and new bone. 5. During intramembranous bone formation, the expression of type Ⅱcollagen was rare in the bony trabeculae. There was a switch for the expression of collagens from type Ⅱto type I during the appearance of Meckel's cartilage.

치주인대세포의 증식 및 세포활성에 미치는 1,25-(OH)₂D₃의 영향에 관한 연구

국윤아(Yoon-Ah Kook),김상철(Sang-Cheol Kim),김형룡(Hyung-Ryong Kim) 대한치과교정학회 1995 대한치과교정학회지 Vol.25 No.3

1,25-(OH)_²D_³가 치주인대세포의 증식에 미치는 영향과 조골세포 기능을 나타내는 지표이며 골의 석회화 과정에 관여하는 alkaline phosphatase의 활성도에 미치는 영향을 관찰하여 아직 확실히 밝혀져 있지 않은 치주인대조직에 대한 1,25-(OH)_²D_³의 생물학적 기능을 알아보고자 교정 치료 목적으로 발거된 치아로부터 치주인대세포를 배양하였다. 1,25-(OH)_²D_³를 첨가하여 24시간 후 [^³H]thymidine으로 DNA를 표지하여 세포의 증식을 관찰하였으며 1,25-(OH)_²D_³가 치주인대세포에서 조골세포의 표지효소인 alkaline phosphatase의 활성도에 미치는 영향을 24시간 또는 6일간 1,25-(OH)_²D_³ 처리 후 측정한 결과 100nM농도의 1,25-(OH)_²D_³은 치주인대세포의 증식을 유의하게 증가시켰으며 10nM에서는 차이를 보이지 않았다. 1,25-(OH)_²D_³을 24시간 첨가시 10nM에서는 ALP활성도는 80.8±31.4nmol로서 대조군 38.5±5.3nmol에 비해 유의하게 증가하였으며 또한 1,25-(OH)_²D_³을 6일동안 첨가하였을때에도 10nM에서 106.7±23.0nmol로 대조군 29.3±1.0nmol에 비해 유의하게 증가되었다. 이상의 결과를 종합하면 1,25-(OH)_²D_³이 치주인 대세포의 증식 및 세포기능을 시사하는 결과를 사료된다. The hormonally active vitamin D metabolite, 1,25-dihydroxy vitamin D_³ [1.25-(OH)_²D_³] is one of the several humoral factors that may regulate osteoblast differentiation. The purpose of this study was to evaluate the effects of 1,25-(OH)_²D_³ on the PDL cells. Human PDL cells were prepared from the first premolar tooth extracted for the orthodontic treatment and they were incubated in the environment of 37°C, 5% CO_² and 95% humidity. [^³H]-thymidine incorporation as a measure of proliferation potential and alkaline phosphatase activity were evaluated at 10nM, l00nM 1,25-(OH)_²D_³. The observed results were as follows. 1. 1,25-(OH)_²D_³ was significantly enhanced [^³H]-thymidine incorporation at l00nM, But did not affect by 10nM. 2. 1,25-(OH)_²D_³ was significantly increased alkaline phosphatase activity at 1 day and 6 days in a dose-dependent manner.

보철치료를 위한 치아 이동

국윤아(Yoon-Ah Kook) 대한치과의사협회 2010 대한치과의사협회지 Vol.48 No.12

Adjunctive orthodontic therapy may be required to create appropriate space, to address misalignment and tooth size discrepancy for better function and esthetics. The desired interproximal alveolar contour and gingival embrasure form can be developed during treatment. Various applications of temporary anchorage devices for pre-prosthetic tooth movement allowed clinicians to achieve high efficiency, shorter treatment time, and less discomfort of patient. Biomechanical considerations for the periodontal status of the affected teeth are required to successfully control the vertical and horizontal space. Hence, the interdisciplinary approaches have an essential role in maximizing the favorable treatment outcome. In particular, pivotal clinical decisions such as whether to open or close the space should be made by consensus of the involved dentists. This article presents the orthodontic treatment approaches for prosthodontic works including mesiodistal and vertical space regaining specially for cases of unrestored teeth over an extended period of time.

철 킬레이터에 의한 골모세포 분화유도에서 Heme Oxygenase-1의 관여

함선도,이선경,국윤아,김용일,신경섭,이소윤,배원정,이상임,이영만,강순일,박재국,류원국,채종문,이승훈,김은철 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.2

The present study aimed to verify the effects of DFO on PDL cells, with particular emphasis on focusing on osteoblastic differentiation. Its mechanisms related to heme oxygenase-1 (HO-1) pathway were also analyzed. DFO increased the expression of HO-1 and early osteoblastic differentiation markers, such as alkaline phosphatase (ALP) and bone sialoprotein (BSP). DFO upregulated heme oxygenase-1. Treatment with HO-1 siRNA blocked the DFO-stimulated osteoblastic differentiation and HO-1 expression. The NF-kB inhibitor pyrrolidine dithiocarbamate, phosphatidylinositol 3-kinase inhibitor Wortmannin, and p38 MAPK inhibitor U0126 blocked the effects of DFO on HO-1 expression and osteoblastic differentiation in PDL cells. Collectively, these data suggest that DFO promotes osteoblastic differentiation and induces the expression of defense protein HO-1 probably via PI3K, p38 MAPK, and NF-kB signalling pathways in PDL cells.

Crowding with no posterior crossbite treatment by rapid patatal expansion

Kook, Yoon Ah,Mojdah Akhavan,Zernik, Joseph H 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.6

중증도 내지는 심한 총생과 회전이 있는 12.5세 여자 환자의 증례에 대한 보고이다. 발치를 하지 않고, 상하악 치열궁의 확장에 의해 치료하였다. 구치부의 반대교합이 없었지만, 상악의 경우 급속구개확장을 시행하였다. 양악의 총생과 치아 회전이 해소되었으며, 교합기능과 안모 심미의 개선을 이루었으며, 적절한 수평 및 수직 피개교합을 이룩하였다. 최근에 많이 사용되는 구치부 반대교합이 없는 경우에서의 급속구개확장은, 진단학적 기반 및 적응증에 관한 재평가가 필요하다고 생각된다. This is a case report of a 12.5-year-old girl who presented with moderate to severe anterior dental crowding and rotations. Treatment involved no extraction, but expansion of both the maxillary and the mandibular arches. Maxillary expansion was assisted by rapid palatal expansion despite the fact that this patient did not present with posterior crossbite Crowding and rotations in both arches were corrected and good occlusal function and improved facial esthetic were achieved, with acceptable overbite and overjet. The application of rapid maxillary expansion in cases with no posterior crossbite, which has increased in recent years, calls for re-evaluation of the diagnostic basis and indications for the use of this technique.

A STUDY ON THE EXPRESSION OF TYPE Ⅰ AND TYPE Ⅱ COLLAGEN GENES AND PROTEINS IN THE DEVELOPING HUMAN MANDIBLE

Kook, Yoon-Ah,Kim, Sang-Cheol,Kim, Eun-Cheol 대한치과교정학회 1995 대한치과교정학회지 Vol.25 No.6

Type Ⅰ and type Ⅱ collagens are considered the major collagens of bone and cartilage respectively. Monitoring the patters of those gene and protein expressions during development will provide a basis for the understanding of the normal and abnormal growths. This study was undertaken to investigate the expression of collagen genes and proteins involved in the developing human mandible. Fifty embryos and fetuses were studied with Alcian blue-OAS, Masson's Trichrome, reverse transcription polymerase chain reaction (RT-PCR), Western blot analysis, and Southern blot analysis. Our results showed that pro-α1(Ⅱ) collagen gene expression begins in the 5th week. Type Ⅱ collagen is synthesized in mesenchymal cells in advance of overt chondrogenesis. The gene expression for type Ⅱ collagen was highest during the appearance of Meckel's cartilage. There was a switch in collagen protein expression from type Ⅰ to type Ⅱ during the appearance stage of Meckel's cartilage. The distribution of the mRNA for type Ⅱ collagen corresponded well with the pattern of type Ⅱ collagen protein. The endochondral ossification was observed where there was direct replacement of cartilage by bone.