상악 후방의 부분 무치악부에 Sintered porous surface implant의 적용에 관한 문헌고찰 및 증례보고

최희준,이광호,이영석,손경준 조선대학교 구강생물학연구소 2002 Oral Biology Research (Oral Biol Res) Vol.26 No.2

Implant therapy based on the principle of osseointegration has seen a remarkable expansion of its application in dentistry in recent years. This article is a consideration of an endosseous dental implant device(Endopcre, Innova) that uses a sintered porous surface geometry to achieve implant fixation by bone ingrowth. Its implant is documented excellent survival rate(97.2% after a mean functional time of 34.6 months) in Partially edentulous maxillae and insignificant crestal bone loss from baseline. The combination of an innovative, minimally invasive, indirect sinus elevation procedure with a porous-surfaced dental implant system may allow the routine treatment of posterior maxillary site in patients who would otherwise require much more sophisticated and expensive reconstructive surgery to receive longer dental implants .

Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.

섬진강 수계의 부착조류에 대한 생태학적 연구

최민규,김백호,최환석,이경보,이덕배,정연태 원광대학교 환경과학연구소 1997 環境科學硏究誌 Vol.6 No.1

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

포항 석병연안에서 삼중자망에 의해 채집된 어류의 종조성 및 양적변동

한경호,손종철,황동식,최수하 한국어류학회 2002 韓國魚類學會誌 Vol.14 No.2

경상북도 포항시 석병 연안에서 삼중자망 5폭을 사용, 1998년 1월부터 12월까지 총 12회에 걸쳐 어류를 포획하여, 어류의 종조성 및 양적변동을 조사하였다. 포획된 어류는 총 1網 7目 27科 58種, 607개체, 93,427g으로 쏨뱅이 目(Scorpaeniformes)과 쏨뱅이 目(Scorpaeniformes) 어류가 총 41種으로 전체 출현종 수의 70.7%를 차지하여 우점하는 분류군이었으며, 科별로는 양볼락 科(Scorpaenidae) 어류가 8種 출현하여, 가장 많은 種이 출현하였다. 개체수에서 우점종은 망상어, 노래미, 쥐노래미, 용치놀래기, 쥐치, 볼락, 개볼락, 멸치 및 임연수어로 이들 9種이 전개체수의 62.9%를 차지하였다. 생체량에서 우점종은 망상어, 쥐노래미, 임연수어, 노래미, 볼락 및 용치놀래기로 이들 6種이 전생체량의 58.4%를 차지하였다. 출현 개체수와 생체량은 수온이 상승하는 4월과, 고수온기인 7월 및 10월에 높게 나타났으며, 저수온기인 1월에는 낮게 나타나, 수온과 밀접한 관계가 있었다. 월별 출현종수는 수온이 낮은 1월에 10種이 출현하여 가장 적었고, 수온의 상승폭이 큰 5월에 24種으로 가장 많았다. 종 다양도지수는 1.640~2.594의 범위로 경월변화가 적고, 인근 해역에 비해서 높은 지수를 나타내고 있어, 다양한 어종과 안정된 군집구조를 형성하고 있는 것으로 나타났다. 본 조사해역에서 연 중 출현한 어종은 망상어, 노래미, 쥐노래미, 볼락 등이며, 체형이 크고 성장도가 양호할 뿐만 아니라 주거종으로서 경제성있는 어종으로 평가된다. Fishes were collected by trammel net to determine seasonal species composition and biomass in coastal waters of Seokbyeong, Pohang, Gyeongsangbuk-do from January to December, 1998. A total of 607 fishes(93,427g) was sampled and classified into 58 species belonging to 27 families and 7 orders. The most dominant orders were Scorpaeniformes and Perciformes, which together accounted for 70.7% of the total. The most dominant family Scorpaenidae was represented by eight species. The dominant species were Ditrema temmincki, Hexagrammos agrammus, H. otakii, Halichoeres poecilopterus, Stephanolepis cirrhifer, Sebastes inermis, Sebastes pachycephalus, Engraulis japonicus and Pleurogrammus azonus; they accounted for 62.9% of the total fishes collected. The dominant species in biomass were Ditrema temmincki, Hexagrammos agrammus, H. otakii, Halichoeres poecilopterus, Sebastes inermis and Pleurogrammus azonus. Those species accounted for 58.4% of the total biomass. The number of individuals and the biomass were much higher in summer and autumn than in winter and spring, and closely correlated with water temperature. Monthly number of species was highest in May, with 24 species and lowest in January, with 10 species. The highest diversity index was in June(H'=2.594), and lowest in January(H'=1.640). The diversity index was 1.640~2.594, with little monthly fluctuation. The diversity index in coastal waters of Seokbyeong was higher than that in other coastal waters. It suggest that the cluster structure may be stable.

IBM-PC/AT를 중앙처리장치로 이용한 영상처리시스템의 설계

유경걸,박상희,최윤호 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.2

In this paper, the 512×512×8 bit image processing system, which can acquire, process and display one frame image using IMB-PC/AT as a central processing controller, and implement high speed H/W logic, was designed, and its operation S/W of the total system was developed in the form of a menu for users' convenience.

選手들의 不安과 運動行動의 關聯性에 關한 硏究

김정완,최경호 慶尙大學校 1999 論文集 Vol.38 No.-

The purpose of this study was to explore the adaptability of the Spielberger's 'state-trait anxiety test' for measuring athlete's state and trait anxiety. Questionnaire in-cluding 40 items for anxiety, 5 items for motivation, 13 items for self-efficacy, 6 items for performance was administrated to subjects. The subjects of this survey were 277 male and 124 female athletes of middle school(n=24), high school(n=364), and college(n=13) in Kyeong Sang Nam Do. The results of this study were as follows: 1) Accord-ing the result of factor analysis for items to measure, 3 factors(psychological safety, trait anxiety, and state anxiety)were extracted. 2) The validity(Cronbach's alpha) of each factors was .829 for psychological safety, .773 for trait anxiety, and 776 for state anxiety. 3) By the results of Multiple regression, Forward step-wised multiple regression, and t-test be-tween high and low group of sports anxiety score, The common and differential mechan-isms between Trait Anxiety and State Anxiety were founded. Both Trait Anxiety and State Anxiety statistically significant predict Psychological Safety. While Trait anxiety influenced to self-efficacy, motivation, and performance, State Anxiety didn't. The major limit of this study was a restricted sample. Thus, a future cross-validation study using another nationalized sample should be followed.

금강에 서식하는 감돌고기 Pseudopungtungia nigra의 탁란

김익수,최승호,이흥헌,한경호 한국어류학회 2004 韓國魚類學會誌 Vol.16 No.1

2003년 5월부터 7월까지 전북 진안군 주천면의 금강상류의 지류인 주자천에서 감돌고기의 탁란에 관하여 조사하였다. 감돌고기는 꺽지의 수컷이 보호하는 산란장에 무리를 지어 침입하였고 탁란을 실시하였다. 감돌고기의 산란은 꺽지가 산란을 시작한 직후부터 시작되어 꺽지의 산란이 끝난 후에도 3∼5일 동안 더 진행되었다. 감돌고기 알의 부화는 대부분 숙주의 알보다 먼저 이루어졌고, 감돌고기의 자어는 부화 후 즉시 숙주의 산란장을 떠났다. 산란장을 지키는 부화 후 즉시 숙주의 산란장을 떠났다. 산란장을 지키는 꺽지 수컷이 사라졌을 때 산란장의 숙주의 알과 감돌고기 알은 즉시 다른 어류에 의해 모두 섭식되었다. 따라서, 감돌고기는 자신의 알이 부화할 때까지 숙주의 보호를 받는 커다란 이득을 획득한다. A field study of the brood parasitism by Korean shiner, Psudopungtungia nigra, on nests of the Korean aucha perch, Coreoperca herzi, was carried out from May 2003 to July 2003 at the Juja stream, Jinan-gun, Jeonlabuk-do, Korea. Observations in the wild showed that the Korean shiner concentrated on nests of Korean aucha perch in which the nest owners had just spawned. The Korean shiner always spawned in nests of Korean aucha perch. When the parasite shiner spawned in the perch nest, the parasite eggs hatched earlier than the host eggs. Parasite prelarvae shiner left the nest of the host immediately after hatching. Host and parasite eggs disappeared with no guarding by the host male. We suggest that the parasite eggs are protected from egg predators by the host male.

한국전통생활문화에 관한 고찰

이숙,홍윤호,신윤숙,신효식,한경미,최정미,김은정 全南大學校家政科學硏究所 2002 生活科學硏究 Vol.12 No.-

This study is objected on preliminary research for more scientific and wider studies on the Traditional Living Culture of Korea. For this purpose, studies about clothing, food, home management, Traditional Living Culture were reviewed and analysed. The results were as follows : First, Clothing culture studies concentrated on ritual clothings, Second, Food Culture studies included history of traditional food development and recipes. Third, in the field of home management value system, attitudes and parent-child relations were studied,

항 Vancomycin 내성균성 항생물질을 생산하는 Streptomyces sp.AMLK-335의 배양조건

이기형,임대석,최경희,이경호,김창한,김정환 건국대학교 동물자원연구센터 2000 動物資源硏究誌 Vol.21 No.-

본 연구는 새로운 항 vancomycin 내성균성 항생물질을 개발하기 위하여 실시되었으며, 전국 각지의 토양 시료로부터 분리한 방선균 중 vancomycin 내성균주인 K-98 Enterococcus faecium 642, K-98 Enterococcus faecium 637 균주에 대하여 항생물질을 생산하는 분리균주 AMLK-335를 선정하여 이 균주의 항생물질 생산에 대한 최적 발효 조건을 검토한 결과, 탄소원 첨가로는 glycerol(0.5%), 질소원 첨가로는 yeast extract(0.5%)가 가장 효과적으로 항생물질 생산에 이용되었고, 비타민을 첨가에 따른 항생물질 생산성의 차이는 크게 나타나지 않았으나, calcium pantothenate 첨가시 항균활성이 비교적 높아졌으며, 금속이온의 첨가는 K+, Pb+, Ba²+, NA²+ , Ca²+를 첨가하였을 때는 항생물질의 생산성이 비교적 높아졌으며, 그중 Ca²+ 첨가구가 가장 생산성이 높았으며, Fe²+ , Hg+의 금속이온을 첨가하였을 때는 항생물질 생산성이 감소하였으며, CaCO₃첨가는 비첨가구보다 높은 항생물질 생산성을 보였으나, 첨가량에 따른 영향은 대체적으로 없었다. pH의 변화에 따른 생산성은 전반적으로 pH가 항생 물질 생산에 영향을 미치지 못하였으나, pH 4.5∼6.0 부근에서는 비교적 높은 항생물질 생산성을보였으며, 통기량에 따른 항생물질 생산성은 통기량이 많을수록 항생물질 생산이 좋았다. 한편 배양기간에 따라 항생물질 생산성을 조사한 결과, 5일째에 가장 높은 항생물질 생산성을 나타내었으며, pH의 변화는 배양 초기에 하강하였다가 점차 상승하는 경향을 보였다. This study was carried out for examining antibiotic productivity of the strain Streptomyces sp. AMLK-335 producing anti-VRE antibiotic. According to different condition, the strain was cultured for 4 days at 27℃ and determined cell growth, pH value and antibiotic productivity using disk diffusion method. In the experiment, the strain Streptomyces sp. AMLK-335 was examined various culture conditions which was added 8 carbon sources, 12 nitrogen sources, 8 vitamins and 11 metal ions in each time and controlled concentration of CaCO₃, initial pH and aeration. From the studies of conditions for antibiotic production, antibiotic productivity was the best to use 0.5% glycerol as carbon source and 0.5% yeast extract as nitrogen source. When several vitamins were added to medium, there was little difference in antibiotic productivity. But the addition of calcium pantothenate slightly increased antimicrobial activity. The addition of metal ion, such as K+, Pb+, Ba²+, NA²+ and Ca²+ slightly increased antibiotic productivity except Fe²+ and Hg+. The addition of CaCo₃showed higher than non-addition experiment in antibiotic production, but there wasn't generally influenced at addition concentration. According to pH change, antibiotic productivity was increased at pH 4.5∼6.0, and when there was a lot of aeration, antibiotic productivity was increased.