자폐스펙트럼 장애아동의 의사소통 기술 향상에 관한 단일대상연구의 문헌 분석

정유진,윤현숙 이화여자대학교 특수교육연구소 2014 특수교육 Vol.13 No.1

이 연구는 2007년부터 2013년까지 이루어진 자폐스펙트럼 장애아동의 의사소통 기술 향상을 위한 연구들을 조사하여, 일반적인 특징과 동향을 알아보고, 단일대상연구 증거기반 실제(evidence-based practices: EBP)의 기준이 되는 Horner 등(2005)이 제안한 질적 지표를 기초로 중재방법에 대한 문헌 분석을 실시하였다. 연구 결과, 첫째, 자폐스펙트럼 장애아동의 의사소통 기술 향상을 위한 단일대상연구들의 일반적인 특징을 분석한 결과, 연구대상 측면에서는 3명 이상으로 실시된 연구들이 절반 이상이었고, 연령은 주로 초등연령에서 이루어져 왔으며, 장애정도는 경증-중간 자폐에서부터 중도 자폐에 이르기까지 고르게 이루어져 왔다. 연구환경은 여러 기타 외부 환경에서 이루어진 연구들이 절반을 차지하였고, 실험설계는 주로 중다 기초선 설계와 중다 간헐 기초선 설계를 많이 사용했다. 독립변인으로는 다양한 중재방법들이 사용되었으며, 이 중 4편 이상의 논문에서 실시된 중재로는 상황이야기 중재, 보완대체 의사소통 중재가 있었다. 다음으로 종속변인으로는 의사소통 기능 증진의 효과를 본 연구들이 절반 이상을 차지하였다. 둘째, 자폐스펙트럼 장애아동의 의사소통 기술 향상을 위한 단일 대상연구들의 증거기반 실제의 기준이 되는 질적 지표 충족 정도를 살펴본 결과, 질적 지표의 영역별 평균 충족률은 종속변인 96%, 기초선 94%, 대상자 및 환경 91%, 실험통제 및 내적 타당도 91%, 독립변인 78%, 사회적 타당도 64%, 외적 타당도 62% 순으로 나타났다. 또한 각 논문별로 질적 지표의 충족여부를 살펴본 결과 21가지 질적 지표 중 90%에 해당되는 19가지의 질적 지표를 모두 충족시키는 경우는 6편(23%)인 것으로 나타났다. In this study, we investigated literatures done through 2007 to 2013 about the improvement of communication skill in children with autism spectrum disorder. We examined general feature and trends, and performed qualitative analysis based on quality indicator which can be a standard for evidence-based practice(EBP) in single subject research suggested by Horner et al.(2005). In the view of general feature and trends, we first found that more than half studies were performed with three or more children in terms of subject of study, and mainly carried out in the age before 13. Severity of disability was identified evenly from mild and moderate to severe autism. From the side of research environment, more than half studies were performed in many different environments, mostly using multiple baseline design and multiple probe design. Various interventions were conducted as independent variable. Social stories intervention and augmentative and alternative communication intervention(AAC) were employed in more than 4 literatures. In dependent variable, it was confirmed that more that half of studies showed the significant improvement in communication skill. In the analysis of satisfaction level in quality indicator, the average level of areal satisfaction in quality indicator was respectively 96% in dependent variable, 94% in baseline, 91% in subjects and environments, 91% in experimental control/internal validity, 78% in independent variable, 64% in social validity, and 62% in external validity. Besides, among all literatures examined by satisfaction level in quality indicator, 6 literatures (23%) fulfilled the requirements of 19 out of 21 quality indicators.

酸棗仁이 CT105에 의한 신경세포 상해 및 白鼠의 기억에 미치는 영향

정정욱,박창국,박치상,이소연,윤현덕,신오철 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objective: This study was designed to research whether demonstrate neuroprotective and memory enhancing effects of Z1BU, suggesting its beneficial actions for the treatment of AD. Methods: The present study investigated effects of the dichloromethane extract of Semen Zizyphi Spinosae(ZIBU) on neurotoxicity and reactive oxygen species(ROS) and nitric oxide(NO) formation in PC 12 cell line overexpressed with carboxyl-terminal 105 amino acid peptide fragment of amyloid precursor protein(CT105). In addition, the present study evaluated its radical scavenging activity and effects on acetylcholinesterase(AChE) activity. Furthermore, effects on neuronal loss in CAl area and cognitive deficits induced by scopolamine treatment were also evaluated in rats. Result: we found in this study that ZIBU significantly inhibited apoptotic neuronal death induced by CT105 overexpression in PC12 cells, with the IC_(50) value of 23 ㎍/ml. Based on phase-contrast and fluorescence microscopic examinations, ZIBU reversed morphological changes of CT105-expressed PC-12 cells. It was also found that Z1BU significantly induced neurite outgrowth and inhibited formation of ROS and NO.Z1BU scavenged DPPH radicals and inhibited AChE activity. Furthermore, it attenuated memory impairment induced by the injection of scopolamine in rats, based on passive avoidance test. Crystal violet staining of rat brain slices exhibited increase in the viability of pyramidal neurons in hippocampal CAI area. Conclusion: these results demonstrate neuroprotective and memory enhancing effects of ZIBU, suggesting its beneficial actions for the treatment of AD.

올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.

공황 장애 환자에서 부모-자녀 결합 형태와 성격 요인에 관한 연구

윤혜진,이현수,정인과 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

In order to investigate the relationship between personality factors and parents-child bonding patterns influencing the development of panic disorder, we in Gu-Ro hospital studied 39 patients with panic disorder with 16 Personality Factor Questionnaire(16PF) and Parental Bonding Instrument. The results were as follows : 1) Higher overprotection scores and lower caring scores were noted in PBI. In 16PF higher desurgency, shyness, praxernia, guilt-proneness, liberalism and anxiety were observed. 2) Maternal overprotection was positively correlated with dominance, shyness, conservatism and maternal caring was positively correlated with dominance, high superego, suspiciousness, shrewdness. Paternal overprotection was positively correlated with self-control. Paternal caring was positively correlated with high intelligence, stableness and was negatively correlated with anxiety. Paternal overprotection and caring were negatively correlated with each other. Maternal overprotection was positively correlated with Paternal overprotection. 3) Groups classified by parental bonding pattern indicated that affectionless control(group Ⅳ) was correlated with more negative aspects of personality factors. These findings suggest than panic disorder patients have highly overprotection and low caring parents and that they have negative aspects of personality factors. Such negative aspects of personality factors seem to be related with their negative parent-child bonding patterns.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

항진균물질을 생산하는 Streptomyces fimbriatus AF21-3의 분리 및 동정

장주현,김정완,이우윤,윤영준,이경림,김승곤,이태수 인천대학교 2000 基礎科學論文集 Vol.11 No.1

Actinomycetes were isolated from soil to find new antibiotics. An active antimicrobial compound was isolated from the culture filtrate of Actinomycetes AF 21-3. The Actinomycetes strain which showed strong antifungal activity against Candida tropicalis and Microsporum gypseum was identified as Streptomyces fimbriatus and named as Streptomyces fimbriatus AF 21-3.

포터의 이론 : “다이아 몬드” 원리 이해 Understanding the “Diamond” Principles

박용성,윤중현 群山大學校基礎科學硏究所 1994 基礎科學硏究 Vol.9 No.-

다국적 기업의 글로발 경영에서 가장 중요한 각 나라의 정부의 역할, 경영문화 등이 어떠한 영향을 주었는지 마이클 포터는 그 새로운 다이아몬드 이론(여건 상태로 수요상태, 관련 및 보강 산업체, 그리고 회사 경영 전략 및 구조) 을 통해서 새로이 경쟁우위 원칙을 수정했다. 현재 새로운 경영전략 추세는 자가 경영팀, 밴치마크, 시간경쟁, 그리고 전략동맹 등이 있으나 이러한 경영 전략 방법은, 어느 정도 국제경쟁에 있어 기본적인 교훈을 주었지만 포터의 이론을 완전히 전략적인 경영에 반영하지는 못했다. 이 논문은 포터 다이아몬드 이론에서 습득한 전략 경영 5가지 이행원칙이 왜 그리고 어떻게 경쟁우위를 갖게 되었는지 기업 경영의 실제적인 보기를 들어 설명 분석하였다.

Clostridium difficile 장염에 의한 속발성 유전분증에서 발현된 독성 장염

조형원,정혜경,강현주,이윤표,강혜원,심기남,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Amyloidosis is characterized by extracellular deposition of protein fibrils in one or multiple organs. AA amyloidosis is secondarily occurred to be related with chronic infections or inflammatory diseases. We report a 67-year-old man suffered from secondary AA amyloidosis related with chronic Clostridium difficile colitis after repeated total hip replacement surgery. Infection control is the most important treatment of AA amyloidosis secondary to chronic infection. However, the patient’s C. difficile colitis was not controlled well, eventually toxic megacolon with sepsis was developed. Consequently, he had to take total colectomy, but he expired with multi-organ failures. We suggested that early surgical procedure might be one option for intractable C. difficile colitis complicated with secondary amyloidosis.

식품영양학 전공자를 위한 인턴십 교육 프로그램 개선방안

주나미,윤지영,김옥선,정현아,박상현,고영주,조기원 한국식생활문화학회 2005 韓國食生活文化學會誌 Vol.20 No.1

This study was conducted to evaluate the effect of current dietetic internship program. The survey sample was dietetic practitioners who were charged with a training for dietetic students. The questionnaire requested information about demographic information, experience of guidance for the dietetic student, self evaluation as trainer, fortification items in university education, and difficulties of the internship program. Data was analyzed using SAS for windows(version 6.12), Descriptive statistics were used such as means. standard deviations. frequency distribution and percentages. Comparison of mean differences was analyzed using t-test and ANOVA. Participants identified how effective the current internship program was. Result indicated that the effectiveness was not high(2.81), and under 29 years old age group, under 6 years work experience group. and contracted foodservice group had positive opinion of the program significantly. Under 29 years old age group, evaluated themselves as a good trainer. The results revealed that respondents wanted to be fortified the practical training courses in school curriculum.

난소 및 난소 종양 염전의 초음파 소견

오연희,이현경,이원재,이성우,박수성,윤혜원,임문환,심재철,김용탁,김성숙,김정란 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

Acute torsion of the ovary and ovarian mass is a recognized surgical emergency, but rarely has the diagnosis been made preoperatively on the basis of imaging studies. The sonographic findings in 14 cases of surgically proven torsion of the ovary and ovarian mass are described. Mostly cystic ovarian mass, engorged vessel, dilated uterine tube, beak-like echo(torsion site), smooth mass wall thickening an free-fluid collection in cul-de-sac are described. More significant in terms of specificity were the demonstration in 6 cases(42.9%) of the smooth mass wall thickening and in 8 cases(57.1%) of a free fluid in the cul-de-sac. We report the sonographic findings of ovary and ovarian mass torsion that may suggest the preoperative diagnosis of this condition.