만성 두부외상 환자에서 99mTc - HMPAO Brain SPECT의 임상적 유용성

서정호(Jung Ho Suh),김동익(Dong Ik Kim),정태섭(Tae Sub Chung),이종두(Jong Doo Lee),박창윤(Chang Yoon Park),정진일(Jin Ill Chung),김영수(Young Soo Kim) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Minima1 deterioration of cerebral perfusion or microanatomical changes were undetectable on conventional Brain CT or MRI. So evaluation of focal functional changes of the brain parenchyme is essential in chronic head injury patients, who did not show focal anatomical changes on these radiological studies. However, the patients who had longstanding neurologic sequelae following head injury, there had been no available imaging modalities for evaluating these patients precisely. Therefore we tried to detect the focal functional changes on the brain parenchyme using Tc-99m-HMPAO Brain SPECT on the patients of chronic head injuries. Twenty three patients who had suffered from headache, memory dysfunction, personality change and insomnia lasting more than six months following head injury were included in our cases, which showed no anatomical abnormalities on Brain CT or MRI. At first they underwent psychological test whether the symptoms were organic or not. Also we were able to evaluate the cerebral perfusion changes with Tc-99m-HMPAO Brain SPECT in 22 patients among the 23, which five patients were focal and 17 patients were nonfocally diffuse perfusion changes. Thus we can predict the perfusion changes such as local vascular deterioration or functional defects using Tc-99m-HMPAO Brain SPECT in the patients who had suffered from post-traumatic sequelae, which changes were undetectable on Brain CT or MRI.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

COLOR STABILITY OF CURRENT PROSTHETIC COMPOSITES UNDER ACCELERATED AGING AND IMMERSION IN A COFFEE SOLUTION

Kim, Hyo-Jin,Heo, Seong-Joo,Koak, Jai-Young,Chang, Ik-Tae The Korean Academy of Prosthodonitics 2002 대한치과보철학회지 Vol.40 No.3

The color stability of current prosthetic composites is unknown, even though the quality of composite materials has been improving. This study examined the intrinsic color stability of various current prosthetic resins (ceramic-polymers) after an accelerated aging process and the extrinsic color stability after immersion in a coffee solution. By comparing the amount of discoloration after aging with that without aging, the effect of the accelerated aging process on external discoloration could be evaluated. Three current prosthetic composites (Artglass, Targis, Sculpture), one light polymerized direct composite (Z100) and one dental porcelain control (Ceramco) were assessed. The color changes (${\Delta}$E) of all the specimens were determined using the CIE $L^{*}a^{*}b^{*}$ color order system with a reflected spectrophotometer. The results were as follows: 1. The prosthetic composite materials subjected to the accelerated aging test showed no significant difference in color changes (p >.05). 2. In the coffee solution immersion test after the aging process, the color changes of the Targis and Artglass groups were not different from that of the Z100 group, which showed the highest color change. 3. In the immersion only test, a significantly high color change was observed in the sculpture glazing group. 4. The aging process influenced on the color changes more in the Targis, Artglass and Z100 groups than in the Sculpture and Ceramco groups.

십이지장 결핵 2예의 내시경적 고찰

장린,박충기,민영일,장영운,우정택,방익수,최학림,장주희 대한소화기내시경학회 1985 Clinical Endoscopy Vol.5 No.1

Today, the duodenal tuberculosis is a very rare disease. Final diagnosis of duodenal tuberculosis is difficult due to inconsistent symptoms and nonspecific duodenal lesions. We found 2 cases of duodenal tuberculosis by gastrascopy. In gastroscopic findings, there were undetermined ulcers and irregular nodular mucosal changes.

태권도 도장의 학원화 과정: 사회학적 제도주의의 동형화 개념을 중심으로

최영훈(Young Hoon Choi),박슬기(Seul Ki Park),장익영(Ik Young Chang) 한국스포츠사회학회 2024 한국스포츠사회학회지 Vol.37 No.2

열원에 따른 구리선의 미세조직 및 조성 변화

박성우,장익수,김윤희,김상현,이경화,김진표,한승희,김영만,김영도,오낭렴 내무부 국립과학수사연구소 2000 國立科學搜査硏究所年報 Vol.32 No.-

熱處理에 의한 양배추 시들음병 防除

張田益,秦石天,文英仁,姜榮吉 제주대학교 아열대농업연구소 2000 亞熱帶農業硏究 Vol.17 No.-

This study was conducted to evaluate the efficacy of soil heating treatment for the control of cabbage yellows. The results obtained are summarized as follows ; 1.The density of Fusarium oxysporum was not changed with time at room temperature while it was not isolated 25 and 5 days after the heating treatment of 35 and 40℃, respectively. However any of it was not detected above 45℃. 2.When cabbage was grown in the soil inoculated with the pathogen after the inoculated soil was incubated for 1, 3, 5 and 7 days at 45℃, Fusarium oxysporum wilt was not observed for cabbage grown in the soil incubated for more than 3 days. 3.Pseudomonas sp. and Bacilus sp. antagonists that show antifungal activity to were Fusarium oxysporum in petri dish assays were isolated. The growth temperature of Bacillus sp. was higher than that of Fusarium oxysporum.

太陽熱 消毒에 의한 양배추 시들음병 防除 效果

張田益,秦石天,文英仁,姜榮吉 제주대학교 아열대농업연구소 2000 亞熱帶農業硏究 Vol.17 No.-

This study was conducted to evaluate the efficacy of soil solarization, alone and combined with various treatments for the control of soil-borne diseases of cabbage at Cheju from 1988∼ 1999. The results obtained are summarized as follows ; 1.The average of maximum soil temperature at the l0cm depth under soil sruface from Aug. 4 to Sept. 3, 1998 were 6.5℃ higher under polyethylene(P.E.) film mulch compared with 35.4℃ of control. The maximum soil temperatures of above 40℃ at the 10cm depth were recorded for 23 days in the P.E. film mulch. 2.The infection rate of F. oxysporum wilt of cabbages grown after the treatment of disinfector dazomet+P.E. film mulch, was lowest, followed by manure+P.E. film mulch, and alone P.E. film mulch. 3.The leaf length of cabbages grown after P.E. film mulch were greater compared with untreated control but head weight showed no difference between P.E. film mulch and control.

危素의 神光 普光寺 碑文에 대한 檢討

張東翼,權寧培 慶北大學校 1991 論文集 Vol.51 No.-

Excavations and investigations into such materials as anthologies, ancient writings and epigraphs of the Koryo Dynasty have recently become mere active. The efforts have been rewarded with good results, thus complemenling the cursory annals of the period. Keeping in step with this tendency, we excavated and investigated materials which were related to the Koryo period that appeared in the Chinese anthologies. That materials are two works of Weisu, an intellectual of the Yuan Dynatsy in China. Tehy are records of historic facts that were found in Singwang Temple of Haeju and Bogwang Temple of Imju. They greatly help to understand some part of the history of Koryo Buddhism; that is, they help to make clear the foundation story and vicissitudes of the two temples and to reflect the fact that the monks of the temples went to Yuan and associated with intellectuals and high-ranking monks there. The monks from the two temples then introduced a new sect of Buddhism, Imje-jong into Koryo.

제주도 연안의 해황특성에 관한 연구 : 성산포를 중심으로

변창익,정용진,노홍길 제주대학교 해양연구소 1983 해양자원연구소연구보고 Vol.7 No.-

The paper describes the oceanographic condition characteristic of the coastal are a around Seongsan harbour and the Udo strait from June 1980 to June 1981. The region influenced by fresh water was limited within Seongsan harbour, indicating the tendancy of the effect by off shore water mass in the Udo strait. In spring and autumn salinity was much more than 34‰ and in sunmer lower than any other season. During the time of observation in Udo strait, water temperature ranged from 13℃ to 24.5℃, and salinity from 32.00‰. to 34.50‰. Maximun and minimum water temperature appears in August and April respectively. Salinity was, however, the opposite of the water temperature. The region from the central part so southern tip of the Udo strait was much influenced by off shore water. Surface and bottom waters were mixed well in this strait with each other. Results of surface water temperature during ten years (1970-1979) and in July 1981 indicated the appearance of cold water mass around Seongsan in summer.