관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

하경추부 손상환자에 대한 임상적 분석

박영록,홍순기,허철,김헌주,한용표 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.6

The authors analyzed 32 cases with lower cervical spine injuries according to their etiologies, the findings of cervical spine X-ray and computed tomography, initial neurological grading scales and time of operation. The results are summarized as follow : 1) Lower cervical spine injuries occurred in 32 of the 49 cervical spine injuried patients. 2) The important factors affecting on outcome were the initial neurological state(p=0.038) and the degree of spinal canal narrowing on cervical computed tomogram(p=0.046). 3) The degree of prevertebral soft tissue swelling and displacement of vertebral body on initial cervical spine X-ray did not significantly affect on outcome(p=0.052). 4) The most suitable operative time for lower cervical spine injuries was 10∼20 days after injuries and the mortality was 9.3%.

Interleukin-5 저해 활성 chalcone 화합물의 유효 입체 구조

이기철,김민석,P. Thanigaimalai,Vinay K. Sharma,박경래,김영수,정상헌 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-

Interleukin(IL)-5 appears to be one of the main proinflammatory mediators among the growing number of cytokines and chemokines that induce eosinophilic inflammation. Previously, our group synthesized a number of chalcone derivatives to determine their inhibitory activity against IL-5. However, the structure-activity relationship (SAR) of these chalcones was somewhat unclear, robably due to presence of three free rotatable bonds. To further, explore the SAR of these chalcones, we synthesized eight 2-(benzylidene)-2,3-dihydroinden-1-ones and 2- benzylidene)-3,4-dihydronaphthalen-1(2H)-ones 6 and evaluated for their inhibitory activity against IL-5. These rigidified chalcones 6 exhibited very weak inhibitory activity against IL-5 compared to chalcones 2. The structures of 6 closely resemble to the stretched conformations of chalcone 2, not effective conformation for the inhibition on IL-5 function.

이차원 LMS 알고리즘의 Systolic Array 구현

박완수,최훈,홍기섭,박봉수,배현덕 충북대학교 컴퓨터 정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.1

적응알고리듬의 VLSI 구현에 있어서 파이프라이닝이나 시스토릭과 같은 구조적 설계기법을 이용하여 알고리듬을 변환하는 것은 효과적이다. 알고리듬 변환은 z-변환 영역에서 연산의 규칙성과 반복성을 찾아 이루어 진다. 본 논문에서는 이차원 필터와 계수갱신 시스템을 시스토릭 구조로 설계하여 LMS의 확장 형태인 TDLMS을 STDLMS로 변환한다. 변화된 STDLMS를 이용 이차원 ALE를 Altera사의 Max-PlusII 상에서 구현하여 시뮬레이션을 통해 성능을 평가한다. 시뮬레이션 결과 salt-pepper 잡음과 가우시안 잡음에 오염된 화상을 ALE가 개선할 수 있음을 보였다. In VLSI realization of adaptive algorithm. it is necessary and efficient that the algorithm is transformed to structural one suitably using architectural design techniques such as pipelining or systolic array. These transform method use regular and recursive of operation of the algorithm on z-transform domain. In this paper, the TDLMS which is a extended version of LMS is transformed to STDLMS which has systolic array architecture in two dimensional filter and coefficients update system. The transformed STDLMS is applied for realization of two dimensional ALE. And the ALE performances are evaluated by Max-PlusII of Altera Co.. The simulation results show that the ALE enhances image data which were corrupted by salt-pepper noise and Gaussian noise.

지각된 사회적 지지와 대학생의 자기 효능감 간의 관계

박헌일,김기원 啓明專門大學 産業開發硏究所 2001 啓明硏究論叢 Vol.19 No.1

이 연구는 대학생을 대상으로 지각된 사회적 지지가 각 지지원 별로 그리고 각 지지원에서 지지 유형별로 자기 효능감과 관련성이 있는지를 알아보기 위한 두 가지 목적을 가지고 있다. 이 목적을 위하여 대학생 279명에게 자신이 지각하고 있는 사회적 지지를 응답하게 하고, 자기 효능감도 측정하였다. 연구의 결과 아버지의 지지와 친구/애인의 지지가 일반적 자기 효능감을 예측하는데 유용한 변인임이 밝혀졌으며. 사회적 자기 효능감을 예측하는데 유용한 변인은 친구/애인의 지지임이 확인되었다. 또한 각 지지원 별로 어떠한 지지 유형이 자기 효능감과 관련성이 있는지 역시 논의되었다. This study has two purposes. Firstly, we investigate the relationship between sources of social support and self-efficacy. Secondly we also investigate the relationship between types of social support and self-efficacy. the social support and general self-efficacy scale were put questionnaires to 297 college students. The social support scale consists of five, and self-efficacy scale consists of two sub-scales. Results indicated that college students' perceived social support (father's and friend/lover's support) has a statistical significance to predict general self-efficacy. But the social self-efficacy is related with friend/lover's and brother/sister's social support. Relationship with social support types and self-efficacy were also discussed.

대학생의 지각된 사회적 지지와 성격 특성과의 관계

박헌일,김기원 啓明專門大學 産業開發硏究所 2000 啓明硏究論叢 Vol.18 No.1

본 연구에서는 대학생들의 지각된 사회적 지지와 성격특성간의 관련성을 알아보았다. 이를 위하여 사회적 지지척도와 MMPI가 각각 지각된 사회적 지지와 성격특징을 측정하기 위하여 이용되었다. 785명의 남자와 816명의 피험자가 이 연구에 참여하였으며, 사회적 지지 척도의 신뢰도는 아주 뛰어났다. 남자와 여자간에 있어서 지각된 사회적 지지와 MMPI의 하위 척도가 차이가 있었다. 전체 집단에서 사회적 지지가 낮다고 지각하는 피험자들은 Ma척도가 낮았으며, Sc척도와 Pd척도가 높았다. 남자집단에서 사회적 지지가 낮다고 지각하는 피험자들은 F척도와 Hy척도가 높았으며, Ma척도가 낮았다. 여자집단에서 사회적 지지가 낮다고 지각하는 피험자들은 역시 Ma척도가 낮았고 Hy척도와 Mf척도가 높게 나타났다. We examined relationship between perceived social support of college students and their personality traits. For this purpose we used social support scale and MMPI to measure perceived social support and personality trait respectively. 785 male and 816 female subjects were participated in this study. Reliability of social support scale was excellent The results suggest that males and females differed in perceived social support and sub-scale of MMPI scores, In a total sample, canonical analysis result showed that subject who perceived lack of social support was lower in Ma scale and higher in Sc scale, Pd scale In male samples, the subject who perceived lack of social support was higher in F scale. Hy scale and lower in Ma scale, In female samples, the subject who perceived lack of social support was lower in Ma scale and higher in Hy scale, Mf scale.

3-아실-1.3-티아졸리딘-2-티온을 이용한 아미드 및 아미드유도체 합성

박기훈,정태명 慶尙大學校 1989 論文集 Vol.28 No.2

3-아실 티아졸리딘-2-티온(ATT)의 가아민 분해반응은 아미드 및 아미드 유도체 합성에 효과적으로 이용 되었다. ATT와 아미노 알콜이 반응할때 화학 선택적인 반응이 관찰되었다. ATT를 이용하여 몇종의 아미드 알카리오디 화합물과 Li에 민감한 ionophore를 합성 하였다. 아울러 ATT유도체가 페니실린에 민감한 Bacillus Substilus에 생물학적 활성을 나타내었었다.

고정식 교정 환자에서 전동치솔 효과에 관한 연구

박창헌,이기헌,황현식,홍석진 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.4

Patients with fixed orthodontic appliances frequently have increased levels of plaque accumulation leading to the possibility of gingivitis or enamel decalcification. Although many methods may be helpful in reducing dental plaque formation, optimal mechanical removal of plaque is tile most important factor during orthodontic treatment. The porpose of this study was to evaluate the efficacy of'an electric toothbrush, with a specially designed orthodontic brush head. compared with a manual toothbrush in controlling plaque and gingivitis for patients with fixed orthodontic appliances. Oral hygiene status was measured in thirty four patients, using a plaquc index, a gingival index and a bleeding index. before and four weeks after attachment of fixed orthodontic appliances. Patients were randomly divided into two groups, the electric and the manual toothbrush groups. Oral hygiene instruction was given according to the type of toothbrush used. The Braun Oral-B D9511 with Braun Oral-B Ortho OD 15-1 brush head was used as the electric toothbrush while the Butler G.U. M 124 was given as the manual toothbrush. After 4 weeks and 8 weeks, oral hygiene status was measured again. Through the comparison berween the electric and the manual toothbrush grpups. following results were obtained. 1. All oral hygiene indices showed increasing tendency after 4weeks of fixed orthodontic appliances. 2. All indices presented decreasing tendency four and eight weeks after oral hygiene instruction. 3. In case of gingival index and bleeding index. decreasing tendency did not show a statistically significant difference between the electric and the manual toothbrush groups. 4. The decreasing tendency of plaque index presented statistically significant difference between the two groups. showing that the electric toothbrush was more effective in terms of oral hygiene. These findings suggest that an electric toothbrush is useful to the orthodontic patients with fixed appliances.

성인형 당뇨병에서의 심혈관 합병증과 지질대사와의 관계

박헌진,안정기,이종선,김영건 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

Hypwelipiswmia is commonly observed in the diabetics, especially with cardiovascular complications. We studied lipid profiles and cardiovascular complication in the 191 adult onset DM patients. The results are as follows: 1. The age distribution was from 24 years old to 82 years old. Male patients were 99 persons, famale patients were 92 persons. The mean disease duration was less than 2 years in the 77 patients, more than 5 years in the 79 patients. 2. Upon the classification between sexes, the mean age was 55±1(SEM) years in the male group, 53±1(SEM) years in the female group. The mean disease durtion was 6.4±1(SEM) years in the female group, longer in the male group (P<0.05). The triglyceride level was 210±16(SEM)㎎% in the male group, 214±13(SEM)㎎% in the female group. The fasting blood sugar level was 147±6(SEM)㎎/dl in the male group, 158±8(SEM)㎎/dl n the female group. The cholesterol level was 229±5(SEM)㎎/dl in the male group, 248±5(SEM)㎎/dl in the female group, higher in the female group (P<0.05). 3. The cardiovascurlar complicatioin (Hypertension, Myocardial infarction, Myocardial ischemia, Angina, Gangrene, Proliferative retinopathy) were present in the 60 patients from 191 patients. Hypertension was present in the 48 patients, and the most prevalent. The mean age and carrdiovascular complication were higher in the more than 5 years of mean disease duration group(mean age 57.99±1.14(SEM)㎎ year) than less than 5 years group(mean age 52.12±0.10(SEM)㎎ year) (P<0.001, P<0.01). 4. The mean disease duration (7.40±1.01(SEM) years), mean triglyceride levels(271±1.01(SEM)㎎%), and mean cholestrerol levels( 257±8㎎.dl) in the cardiovascularly complicated group were higher than those of non-complicated group (P<0.01). 5. The triglycerdie level was high in the obese group (230±14SEM㎎%) than non-obese group (184±15SEM㎎%) (P<0.05). The obese patients were more prevalent in the female group than male group significantly. 6. Considering obesity and cardiovascular complications, the triglyceride value was higher in the obese complicated group(300±30SEM㎎%) than obese non-complicated (197±14SEM㎎ %) or non-obese non-complicated (168±13SEM㎎ %) group (P<0.001). The cholesterol level was higher in the obese complicated group (267±10SEM㎎/dl) than obese non-complicated (230±5SEM㎎/dl) or non-obese non-complicated group(229±7SEM㎎/dl) (P<0.05). 7. Classifying upon insulin response pattern, the obese patients were found in the response pattern, low response pattern, flat type pattern(no response pattern) in the decreasing number of order (P<0.01). The cardiovascular complications were found in the low response group, response group, and flat type pattern (no response) in the decreasing number of order ( P<0.05). The combined cases of obesity and cardiovascular complications were found in the low response group, response group and flat type group(no response) pattern in the decreasing number of order (P<0.01). The mean disease duration was longer in the flat type group (no response) (4.48±0.6SEM years) than the response group(2.43±0.90SEM years) (P<0.05). The mean triglyceride value was higher in the response group (267.38±154.75SEM㎎%) than the flat type(no response group) (198.35±154.05SD㎎%) (P<0.05). So, we conclude that in the NIDDM, obesity control(die control, ideal body weight mainterice, and hyperlipidemia control) is essential for better DM control and cardiovascular complication control.