정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

외이경혈 미세전류신경근 자극과 체성경혈 미세전류신경근 자극이 압통역치에 미치는 효과

한승수,고현철,조원호 한국전문물리치료학회 1997 한국전문물리치료학회지 Vol.4 No.2

용인대학교 체육관 트레이닝장 이용 현황에 관한 분석

한성철,이한경,안병훈 용인대학교 학생생활연구소 1997 학생생활연구 Vol.5 No.-

After the research on the using realities of the gym training center in Yong-in university, the following results were gained. 1. The research showed that the using status of the training center of the students in a college of martial arts was 76.06% and that for the frequency of use in proportion to the number of students by each department, the department of Judo averaged 4.2 times a semester, the department of Combative arts, 2.9 times, the department of Taekwondo, 3.1 times and the department of guard 8.3 times. 2. The using status of the training center of the students in a college of arthletic science turned out to be 16.74%, and in the frequency of using training center during one semester of the students in each department, the department of social sports was 3.2 times, the department of special physical training, 1.1 times and the department of physical training, 5.3 times. 3. The using status of the training center of a college of arts turned out to be 1.81%, and in the frequency of use by each department, the department of dancing studies used 0.03 times, the department of industrial design, 0.7 time, the department of paintings, 0.06 times, the department of national clssical music, 0.007 times, and the department of drama and cinema, 0.05 times, and then the department of cultural properties protection and the department of multimedia never used. 4. The using status of the training center of a college of business administration turned out to be 2.11%, and in the frequency of use by each department, the department of business administration was 0.6 times, the department of tourist management, 0.27 time, the department of management information, 0.04 times, the department of police administration, 2.3 times and the department of Chinese studies, 0.1 times. 5. The using status of the training center of a college of natural science turned out to be 2.08%, and in the frequency of use by each department, the department of environmental health used 0.33 times, the department of food nutrition, 0.2 times, the department of computing statistics, 0.07 times, the department of physical therapeutics, 0.43 times and the department of life science, 0.3 times. 6. The rest users turned out to be 1.19%, and thesc were mainly graduate school students, social education center members and school staffs.

음향방출 센서를 이용한 세라믹 가공 상태 감시

한명철,김정관,허승현,김성렬,김찬봉 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

The acoustic emission (AE) sensor has been widely used for monitoring the machining states or tool abrasion, etc. This paper presents the relation between machining time and states such as tool abrasion for ceramic machining processes, which can be applicable to develop the dentistry machining center. A commercial PZT-type of AE sensor was used for experiments, and the aquisition data was analyzed in the AE signal strength versus machining time. The results show that it is possible to estimate the tool life and the ceramic machining state. In the future, additional experiments for various machining conditions such as depth of cut and feed rate are strongly necessary so as to design an effective monitoring system for the ceramic machining processes through detecting the AE signal.

티타늄 임플란트의 표면 처리가 골아세포의 증식과 교원질 합성에 미치는 영향

한승규,유상철,김우겸 大韓成形外科學會 2004 Archives of Plastic Surgery Vol.31 No.3

외상성 뇌지주막하출혈을 동반한 두부외상 환자의 예후인자

길승배,김헌주,허철,한용표,홍순기,변진수 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9

The presence of traumatic subarachnoid hemorrhage on the initial computerized tomographic scans has been known to be associated with worse results. By means of a simple and reliable computerized tomographic grade system proposed by Greene and his colleagues, prognostic factors of the traumatic subarachnoid hemorrhage was significantly related to clinical outcome at the time of discharge from acute hospitalization. Between February 1992 and August 1995, 3975 patients were admitted to our department of neurosurgery due to head injury. Clinical data were retrospectively reviewed to ascertain the relationship of the thickness of traumatic subarachnoid hemorrhage, its location, evidence of mass lesion(s), midline shift, obliteration of the basal cistern, and cortical sulcal effacement to outcome. Additionally initial Glasgow coma scale score, arterial gas study systemic blood pressure and prothrombin time were also analyzed for the same purpose. Among 3975 head-injured patients. 213 patients were identified to have traumatic subarachnoid hemorrhage on the initial computerized tomographic scan. Among 213 traumatic subarachnoid hemorrhage patients, the patients treated with calcium channal blocker(32 patients) and 3 patients lost to follow-up were excluded from this study for a total of 178. The computerized tomographic scan findings were divided into a 3 grade system : Grade 1 indicating only traumatic subarachnoid hemorrhage. Grade 2 indicating traumatic subarachnoid hemorrhage with mass lesion(s). Grade 3 indicating traumatic subarachnoid hemorrhage with mass lesion(s) and midline shift. All these data were compared to Glasgow outcome scale on discharge, and arbitarily these were divided into the good(good recovery and moderate disability) and the bad(severe disability, vegetative state and death). The authors conclude that the contributing factors to outcome at discharge were as follows : 1 midline shift(p=0.002), PT≤70%(p<0.001), obliteration of the basal cistern(p=0.001) and cortical sulcal effacement(p=0.001) were shown to the statistically significant. 2. initial computerized tomographic grade contributed to outcome at discharge.

Ti-6Al-4V 합금의 피로특성-열처리, 온도, 주파수의 영향을 중심으로

김승한,김현철,임병수 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

The effect of temperature, frequency and microstructure on fatigue crack propagation property of Ti-6Al-4V alloy has been investigated. The temperatures employed were room temperature, 200℃ and 400℃. The frequencies were 20Hz and 8Hz. The microstructures tested were equiaxed and bimodal microstructures. The bimodal microstructure was obtained by heat treatment of aging the quenched specimen for 1 hour at 500℃ which was solutionized in β-field at 971℃. Mechanical properties, fatigue crack growth rates were measured in different test conditions. From the experimental results, following conclusions were obtained. (1) Bimodal microstructure showed superior strength and fatigue crack growth resistance to equiaxed microstructure. (2) In all test conditions, fatigue crack growth rate increased with test temperature. (3) With the frequency decreasing from 20Hz to 8Hz, fatigue crack growth rate increased.

호산구성 육아종에 병발된 동맥류성 두개골 골낭종 : 증례보고 Case Report

길승배,허철,변진수,한용표,김헌주,홍순기,김명순,홍순원,김윤미 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9

A case of aneurysmal bone cyst(ABC1 secondary to eosinophilic granuloma of the skull is reported. In the skull the presence of ABC secondary to eosinophilic granuloma is rare. We reviewed the clinicopathological and radiological features of this type of eocinophilic granuloma at the cranium.

정신병적 증상이 동반된 기면병 1예

홍승철,송정민,정종현,권용실,한진희,이성필 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.5

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucinations and disrupted nocturnal sleep. We report a patient with a diagnosis of schizophrenia who was subsequently diagnosed as narcolepsy. A case of a 22-year-old woman with concomitant narcolepsy and psychotic symptoms was discussed from a perspective of the diagnosis and therapeutic challenges, particularly on pharmcological treatment dealing with issues raised by their coexistence.

디지털카메라를 이용한 3차원 측량 기법 개발에 관한 연구

崔哲淳,崔勝弼,韓元浩,金東熙 관동대학교 1997 關大論文集 Vol.25 No.2

Photographic survey is possible that it can survey the simultaneous three-dimensional survey about so many points, therefore it is so fast and precisely. We takes a snap the objects with digital carema, and input the data to the computer from this data. We can take the three-dimensional coordinate through relative orientation, absolute orientation and have to check the merit of three-dimensional suveying. Otherwise we can get the error in one centimeter after analysis three-dimension coordinate and we can get the higher precise accuracy cause to set the camera angle of 20∼45 degrees.