정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

국내 최초 보툴리누스 중독증 발생 1예

정경태,강도현,유천권,최종현,성원근 대한임상미샐물학회 2003 Annals of clinical microbiology Vol.6 No.2

인천경제자유구역 물류용지 규모산정 및 역할에 관한 연구 : 영종지구 공항물류단지를 중심으로 Incheon Free Economic Zone

정태원,박영태 한국물류학회 2006 물류학회지 Vol.16 No.1

운동생리학 연구의 역사와 과제

정성태,전태원 한국체육사학회 2000 체육사학회지 Vol.6 No.-

The reviews of the developmental history and issues of exercise Physiology have reached to following four suggestions. 1. For the development of exercise physiology, it is necessary to secure specialilst and research facilities and appratus. 2. It is necessary to establish research structures for an educational-industrial complex. 3. The creative academic atmosphere is need to be raised to develop our own unique exercise physiology and exercise science through development of new theories and basic science. 4. It is necessary to joint study with adjacent science for communication of exorcise physiology or exercise science in terms of domestic aspects. It is necessary to change our communication channels from America to Japan or other Europerian nations.

標識鳥에 依한 韓國産 철새集團의 季節的 分布와 그의 生産(Ⅱ)

元炳旿,禹漢貞,具太會,尹茂夫 慶熙大學校 1969 論文集 Vol.6 No.-

Seasonal distribution and ecology of migrant bird populations were studies by mist-netting and banding primarily in the area of Kyunggi-do, Korea during 1967―1968. 1. From 1 January 1967 to 31 December 1968, a total of 57,087 birds of 105 species were banded in Korea. 527 (237 returns) recoveries have been reported in Korea(outside of baning sites) and 26 recoveries of 7 species from abroad. 2. Through a nationwide preliminary survey on the colonial breeding sites of Ardei dae, 14 breeding colonies were found, and, as a result counted 6340 birds of 5 species and 1580 nestling banded. (See Table 3,4 and Fig. 1). 3. Band returns of the House Swallow banded the previous year obtained within Kyunggi-do, showed that the percentage of returns was 5.66% of 1694 adults and 0.66% of 8600 nestlings. Although the returns are invitably lower than the actual number banded, some tendency as to age is indicated, (Table 12). 4. Based on 208 recoveries at nesting and at roosting sites, the distance beween the two was within a radius of 25㎞. (see Fig. 2 and Table 14). 5. An analysis of age composition and ratio sex of some migrants, and their body wieghts.

^(155,156)Gd 동의원소의 keV 영역 중성자 포획단면적 측정

정원정,황정훈,김현,노태익 東亞大學校 2004 東亞論叢 Vol.41 No.-

The Neutron Capture Cross-Section of ^(155,156)Gd were measured in a neutron energy region from 15 to 85 keV using the 3MV Pelletron accelerator of Tokyo Institute of Technology. Pulsed neutrons were produced from the ^(7Li)(p,n)^(7)Be reaction. The incident neutron spectrum on a capture sample was measured by means of a TOF method with a ^(6)Li-glass detector. The capture γ-ray were detected with a large anti-Compton NaI(TI) spectrometer. A pulse-height weighting technique was applied to measured capture γ-ray pulse-height spectra to derive capture yields. The capture cross sections were obtained by using the standard capture cross-section of ^(197)Au. The present results are corrected for isotope impurities of sample because the samples contain various isotope Godolinium. The present results are compared with the previous measurements and the evaluated data of ENDF/B-VI.

氣象環境이 잎담배 生産에 미치는 影響에 關한 硏究

鄭元采,鄭泰益,申周植 충북대학교 엽연초연구소 1980 煙草硏究 Vol.7 No.-

This study was conducted to study the effects of meteorological elements on the yield and quality of flue-cured tobacco. Data for this study was collected in Cheongju, Chungju and Taejeon districts during the period from 1967 to 1979. 1.There was positive correlation between yield and air temperature from maximum growth stage to harvesting time. And there was positive correlation also between quality and air temperature at maximum growth stage, but not significant relationship at the other growing stage. 2.The re were negative correlation between yield and precipitation at harvesting time and between quality and topping time, respectively. 3.There were positive correlations between yield and quality and percentage of possible sunshine at and after topping time. 4.Early and long range weather forecast will be efficiently employed for tobacco cultivation. It is considered that the study on the early and long range weather forecast and on the hastening and/or delaying the planting and maturing of tobacco plants ought to be studied together.

순환식 회전원판법에 의한 하수의 생분해 성능 평가

정원문,임봉수,김태응 大田大學校 環境問題硏究所 1999 환경문제연구소 논문집 Vol.4 No.-

This study was accomplished to estimate the biodegradability of sewage using RBC(Rotating Biological contactors) and to get a basic data for design parameters. RBC systems were applied to laboratory scale reactors with varying HRT feeding sewage as of about BOD 70mg/l, 80mg/l and 120mg/respectively. According to the continuous operation, it showed that RBC w/recycling was similar to RBC w/o recycling in poganic removal efficiency or TP removal effiency, but neither system effectively removed TN. To get the above 90% of BOD removal efficiency, both were recommended to design as BOD organic loading rate was less than about 4.5 to 6.0 g/㎡/d, hydraulic loading was less than about 80ℓ/㎡/d. It showed that RBC w/ recycling was inferior to RBC w/o recycling in TN removal effiency. At the 5.0g/㎡/d, TN removal efficiency RBC of w/ recycling and RBC w/o recycling was about 50%, 70%, respectively. SNR(Specific Nitrification Rate) was tending to increase as shorter HRT. SNR of RBC w/ recycling and RBC w/o recycling was 0.4mgNH₄-N/gMv/hr. 0.7 to 1.0mgNH₄-N/gMv/hr. respectively.

소의 사후 혈액 및 안구수상액에 대한 생화학적 분석

정낙은,이한영,이원태 大韓法醫學會 1999 대한법의학회지 Vol.23 No.2

Background : The determination of postmortem chemical changes and rdlations among body fluids is very important in medicolegal community. Alaboratory result is not useful if appropriate data for comparison are lacking. We think that it is easy to collect specimens from cows and to evaluate the effect of factors which can be artificially controlled. The establishment of reference ranges of chemical constituents on body fluid in cows is the purpose of this study. Method : Studies were performed on 33 deceased cows at the slaugherhouse. Immediately after death, specimens were obtained from the cervial vein and both eyes. All speimens were centrifuged and the supernatants were removed and frozen at-70c until analyzed. The seven chemical contituents(total protein, glucose, creatinine, calcium, sodium and chloride and potassium) were measured, and the reference range were determined. Result : The mean, standard error, standard deviation and reference range of all measured constituents were shown in table 2,3. In comparison mean value of viterous humor with that of blood, the level of total protein was profoundly low(5%). Those of calcium(68%), glucose(40%), and creatinine(36%) were also low. The mean value of sodium showed the similar level(101%), but those of potassium(120%) and chloride(119%) were higher than in blood. Conclusion : The comparison of a locally produced, small set of values often is not appropriate because the underlying statistical assumption are not fulfulled and because of the unbalanced sample size. A more extensive study will be required, using a larger number of subjects, to establish the full range of viariablitily and the effects of factors such as temperature of the postmortem environment.

전류 제어형 PWM 인버어터에 의해 구동되는 유도전동기 서어보 운전시스템의 고성능 제어에 관한 연구

元忠淵,金泰勳 成均館大學校 科學技術硏究所 1989 論文集 Vol.40 No.1

In this paper, the vector control or the field oriented control system of current controlled PWM inverter fed induction motor servo drive system is proposed to obtain good dynamic response. The good dynamic response, however, depends on the controllability of the stator current. In this paper, an optimum current control strategy is proposed, which provides better dynamic response for current control. In order to realize this aim, the authors are adopted the current controlled PWM inverter with hysteresis controller. The controller produces a PWM Voltage waveform based on a comparison of the actual phase currents with a reference current. The time optimal controller is used as a outer loop of the vector control loop to regulate position and/or speed of induction motor. A simple set of switching trajectory is easily obtained by solving a second order state equation. The validity of the optimal control strategy is verified by digital simulation.