노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성

유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6

Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

CD34+ 조혈 모세포 이식 2례

김정아,정현식,김원석,윤성수,이홍기,박찬형,박성규,김동욱,이종욱,한치화,민우성,김춘추,김동집 대한조혈모세포이식학회 1996 대한조혈모세포이식학회지 Vol.1 No.1

Background: In most solid tumors, the CD34 antigen has not been detected, so positive selection of CD34+ cells may reduce tumor cell contamination and the CD34+ cells are capable of reconstituting hematopoiesis. We tried CD34+ cell transplantation in two patients. Method: CD34+ cells from chemotherapy + G-CSF mobilized PBPCs or bone marrow were positively selected with an avidin-biotin immunoadsorption column (CEPRATE SC system). Case 1. One course of chemotherapy using cyclophosphamide(200㎎/㎡) and etoposide (4.2g/㎡), combined with G-CSF(5㎍/㎏) S.C. was used in a relapsed lymphoma patient. This patient responded to the induction chemotherapy. CD34+ cells from harvested bone marrow were selected by the CellPro immunoadsorption column. The total number of mononuclear cells loaded onto the CellPro was 2.4×10^(8)/㎏, with 1.1% CD34+ cells. After column separation, the total number of positively selected cells was 5.16×10^(6)/㎏. The number of CFU-GM was 76.8×10⁴/㎏. This patient was treated with melphalan (140㎎/㎡) and TBI (1200cGy) and the positively selected CD34+ cells were infused. The time to neutrophil recovery greater than 0.5×10^(9)/L was 19 days and the time to platelet recovery greater than 50×10^(9)/L was 21 days. Case 2. Two courses of mobilizing chemotherapy were given 4 weeks apart using taxol(210㎎/m2) and adriamycin(60㎎/m2), combined with G-CSF(5㎍/㎏) S.C. in a breast cancer patients with 7 axillary node metastasis. CD34+ cells from each single leukapheresis product were selected by the CellPro immunoadsorption column. In the first collection, the total number of nucleated cells was 4.4×10^(8)/kg, with 0.42% CD34+ cells. In the second collection, the total number of nucleated cell was 2.8× 10^(8)/㎏ with 0.43% CD34+ cells. After colum separation, the total numbers of collected cells were 4.0×106/kg and 4.8×10^(6)/kg, the total number of CD34+ cells were 1.2×10^(6)/㎏ and 0.82×10^(6)/㎏. Colonogenic assays of positively selected CD34+ cells gave rise to myeloid erythroid, and multilineage colonies, with a median of 190 CFU-GM, 190 BFU-E, and 164 CFU-GEMM per 1×10³ adsorbed cells, respectively. High-dose chemotherapy with cumulative doses of 40mg/㎡ mitoxantrone, 750mg/㎡ thioptepa, and 1000mg/㎡ carboplatin was administered. Positively selected CD34+ cells were rapidly infused 24 hours after the end of high-dose chemotherapy. The time to neutrophil recovery greater than 0.5×10^(9)/L was 16 days and the time to platelet recovery greater than 50×10^(9)/L was 20 days.

판폭두께비에 따른 콘크리트 충진 HSS 가새부재의 구조성능

한상환,김욱태 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.2

The purpose of this study is to evaluate the effect of width-thickness ratio (w/t ratio) on structure performance of concrete-filled Hollow Structural Section(HSS) bracing members. It has been found that bracing that experience more rapid strength deterioration and earlier fractures with increasing their w/t ratio. In order to reduce such poor behavior of bracing members having a large w/t ratio, concrete filled tubular bracing members can be used. This study investigated the effect of infilled concrete on bracing members having different w/t ratios. Experimental tests were carried out using quasi-static reversed cyclic loading with a symmetric compression and tension. Five full-scale test specimens were made. The test results showed that concrete filling delayed the occurrence of initial local buckling. Infilled concrete also changed the local buckling mode and reduced the severity of local buckling, thereby the occurrence of cracking and fracture in the concrete filled specimens were delayed. Furthermore, this study showed that infilled concrete is more influential to the specimens having a larger w/t ratio.

CuBr 반도체 양자구슬의 PSHB 현상

한성준,박성욱,김일곤 昌原大學校 基礎科學硏究所 1999 基礎科學硏究所論文集 Vol.11 No.-

We fabricated the CuBr semiconductor quantum dots(Q.D) embedded in the alumino-borosilicate glass. The average radius of Q.D was about 20Å. By measuring the absorption spectrum of glasses with CuBr, we could determine the precipitation of QD. PSHB spectrum was measured by the pump-probe method. According to the increasing of the fluence of pump light. the depth and width of the spectral hole was monotonically increased and saturated. The depth of spectral hole was decreased with the time as the function of the square of exponent.

"IKUTON" 醱酵 고구마 澱粉粕의 養豚飼料 代替에 關한 硏究

韓成郁,鄭昌朝 충남대학교 농업과학연구소 1976 農業技術硏究報告 Vol.3 No.2

Study was conducted to estimate the nutritional effect of substitution levels of "IKUTON" (R) inocculate fermented sweet potato pulp for the growing-finnishing pig rations. Twenty five Large white X Landrace cross-breed (15 kg), mixed sex were used in group feeding at the substitution levels of 0, 10, 20, 30, and 40%. The results obtained were summarized as follow: Voluntary feed intake of experimental diets was lowest in 40%. No significant difference in voluntary feed intake was found in 10, 20, and 30% levels except 40%P<0.05). The feed efficiency was highest in 20%; (3.43), 30%;(3.80), 10%; (3.97), control; (4.53), and 40%; (4.20) respectively. There was tendency toward increasing feed efficiency in 10, 20, 30% levels than control. However, the lowest feed efficiency was found in 40% level. The weeks required to gain 80 kg of live weight were 12 weeks for 10%, 13 weeks for control, 14 weeks for 20%, and 30%, but in 40% level of substitution, no 80kg live weight was found up to the end of experiment (15 weeks). Pigs in 40% level were gained live weight only 64% of control animals. The digestibility of experimental diets was 75.2-78.5%, and water intake per kg dry matter intake was 1.95-2.01ℓ. No significant effects of feed offer interval to the digestibility and water consumption.

경북 지역의 지하수 수질에 관한 연구 3 : 용도별 지하수 수질의 특성 The Characterisrics of Groundwater by Used Types

한성욱,양득석,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

We investigated the contamination of groundwater in Gyeongbuk region about 180 points by used types and by rock types. From the view point of used types, the obtained results were as follows; The concentration of nitrate nitrogen was highest for agriculture used as 5.3mg/l and was medium for life used as 4.2mg/l while faculty used was lowest as 1.8mg/l. In case of chloride ion, the concentration was highest for agriculture use as 39.9mg/l and was medium for faculty used as 34.8mg/l, while life used was lowest as 23.5mg/l. In case of 359mg/l. In case of the concentration of pH and COD, it showed that the relationship with used types was not so good.

제주 돼지의 사육개선을 위한 기초조사 연구

한성욱,김형균,강태숙 제주대학교 1971 논문집 Vol.3 No.-

. The raising and feeding of swine in outhouses(Toilet) arose long ago and become a habit or custom for excrement control. The primary reason for practice is that most Cheju people simply do not like to tauch human feces. As a result of swine living in outhouses (Toilet) there is a great danger to humans of infection with cysticercus cellulosae from eating improperly cooked pork. Farmers do not recognize the offet of cysticercus cellulosae on human beings and must receive adequate education. We can slowly eliminate this problom by teaching and re emphasizing the unsanitary conditions and economic loss arising from this practice of W, C swine raising. The local governments and educated citizens as well as know ledgeable farmers must give continuous instruction and guidance in sanitary practices if we are to alter and eliminate swine feeding in the toilet 1. In Cheju-do the family does not include married children, thus the families are necessarily smaller than the mainland and the number of pigs at any house depends upon number of peoples in the family thus it is usually impossible to feed more than one pig since human feces are utilized as pig feed. 2. Since farmers have only a small amount of feed and feces and aware that the growth rate during a pig's first year is greater than its growth rate during the second year thus indicating a highly efficient utilization of feed during the first year, the farmers usually sell the pig within the first year. 3. Since there is a shortage of sanitary pig feed in Cheju-do greater use should be made of the waste products left over from sweet potato starch production. 4. The primary reason for raising the pig in the toilet is that about 90% of the people do not like to touch human feces out of habit. 5. The first objective in improving the feeding of Cheju swine is the instruction of farmers in the sanitation and health problems and econmic loss involved in raising pigs in the toilet because about 50% of the farmers are ignorant of even the existence of cysticercus cellulosae and its due effect on human beings.

플라즈마 반응기에서 전극의 배열에 따른 탈질반응의 변화

한영욱,이상권 漢陽大學校 環境科學硏究所 2003 環境科學論文集 Vol.24 No.-

플라즈마를 이용한 배연탈황/탈질 동시처리에 관한 많은 연구들이 전기에너지나 첨가제가 SO_2/NOX의 제거효율에 미치는 영향을 살펴보기 위하여 수행되어 왔다. 이러한 연구결과들에 의하면, 플라즈마가 SO_2의 제거에는 커다란 영향을 주지 못하지만, NOX의 제거에는 인가되는 전기에너지에 따라 탈질율이 변화하는 것으로 보고되고 있다. 따라서 본 연구에서는 반응기에 최적의 에너지를 인가하는 방법을 조사하기 위하여 전극 배열에 따른 탈질율의 변화를 확인하기 위한 실험을 수행하였고, 상세한 실험결과는 본문 중에 제시되었다. 본 실험결과, 플라스마를 이용한 배연탈황/탈질의 효율적인 동시처리를 위해서는 방전극의 구조 및 그 영향에 대한 연구, 특히 에너지 소모량을 최소화하는 방전극의 최적화에 대한 연구의 필요성을 암시하고 있다. Many experimental studies on the combined removal of SO_2 and NOX using plasma for the flue gas desulfurization and denitrification have been performed in order to investigate the effect of electric power or additives on the SO_2/NOX removal. The results showed the plasma was not effective on the removal of SO_2, but the change of NOX removal rate by the electric power has been observed. Therefore, this study has been performed to examine the optimized electric power. The effect of arrangement of electrode on th electricity density has been examined to observe the transfer of electric energy, and then the effect of electricity density on the NOX removal has been experimentally observed. The experimental results were discussed in this paper. The results obtained from the experiments suggested the necessity of further study on the structure of discharging electrode and its effect, and the development of the optimized electrode to minimize the energy consumption.

Immobilized metal ion affinity chromatography(IMAC)를 이용한 His-tagged B^30-homoserine 인슐린 전구체의 rapid one-step 분리 정제

한성욱,김동일,조정우 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(B)

To purify His tagged B^30-homoserine insulin precursor from recombinant E. coli using a rapid single-step purification method, immobilized Ni^2+ -affinity chromatography which has been widely used to purify genetically fused to the interest protein was used. His tagged B^30-homoserine insulin precursor, molecular weight 9KDa, expression was accomplished by IPTG induction on pellet centrifuged of flask and batch broth and confirmed by SDS-PAGE either. It showed that recombinant protein is expressed as inclusion body. His-tagged B^30-homoserine insulin precursor which chelated with Ni^2+ metal ion was eluted lX Elution buffer, pH7.9 including 6M Urea with 1000mM imidazole. His tagged B^30-homoserine insulin precursor band was ascertained by SDS-PAGE with freeze dried powder obtained from lX Elution buffer extract.