경구용 액체약의 함유된 감미제의 종류와 함량

황민성,김정욱,이상훈 大韓小兒齒科學會 2001 大韓小兒齒科學會誌 Vol.28 No.4

치아우식증을 예방하기 위해 당분을 포함한 음식의 사용을 조절해야 한다는 것에는 동의하지만 어쩔 수 없이 인지되지 못한 체 액체약에 포함된 형태로 공급되는 상당량의 당분이 존재한다. 당분을 포함한 액체약을 장기간 복용할 때는 우식 발생의 위험성이 증가될 수 있다. 본 연구는 경구용 액체약을 처방받는 경우를 고려하여 약제를 통한 당분의 섭취량에 대한 정보를 얻어 치아우식증의 예방에 도움을 주고자 조사를 하였다. 본 연구는 서울대병원 어린이병원에서 처방된 경구용 액체약을 조사하여 소아 환아에서 흔히 사용되는 액체약의 목록을 구하였고, 현재 국내에서 시판되고 있는 액체약을 기준으로 각 제조사에 자료를 요청하여 생상중인 액체약에서 그 속에 함유된 감미제의 종류와 함량에 대해 조사하였다. 아동에서 흔히 사용되는 액체약은 진해거담제, 암모니아혈증 치료제, 항생제, 빈혈약, 진정제, 항히스타민제, 항전간제, 비마약성진통제의 순이었다. 액체약에 함유된 감미제의 평균함량은 52.3±22.4g/100ml이었다. 그리고, 액체약에 함유된 감미제 중 가장 많이 사용되는 것은 백당이었다. Though a consensus seems to exist about the regulation of the use of sugar-containing food, however, an unrecognized and significant supply of cariogenic carbohydrate remains in the form of sugar-containing liquid oral medicine to prevent dental caries, children who are taking long-term sugar-containing liquid medicine have an increased risk of developing dental caries. The aim of this study is to get the information about the sugars in liquid medicines prescribed for the children. To get the information, the number and date of all prescriptions of liquid medicines for one month at pediatric hospital of Seoul National University Hospital were investiagted. From tha tdata, the most frequently used pediatric oral liquid medicine is presented. Then, for the information of the type and contents of sweeteners in that preferred medicines, the manufactures of each medicines were asked for the data of sugar types and contents, and the informations about the medicine contents were collected via facsimile. The most frequently used pediatric oral liquid medicine were followed as expectorant, purge, antibiotic, drug for iron deficiency anemia, sedative, antihistamine, anticonvulsant, NSAIDs in order. The mean value of sweetener content in liquid medicines was 52.3±22.4g/100ml and most frequently used sweetener is sucrose.

부산시 일부지역 강우중 초기 및 후속강우의 이온성분에 관한 연구

황성욱,조정구,최금찬 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

Ion compositions of 1st and 2nd fractions in rainfall water were investigated in Pusan area. pH value, conductivity, and anion·cation components were measured and analyzed from Fall. 1993 to Spring. 1996. High pH value was found to 6.12 on April 1995 in 1st rainfall(1mm below) because of yellow sand phenomena. To contrast, low pH value was indicated to 4.09 on winter 1993. Removal efficiency of ionic compounds was resulted to Mg^(2+) > Ca^(2+) > NO₃^(-) > K^(+) > SO₄^(2-) > Na^(+) > Cl^(-) > NH₄^(+).

미맹출 영구 견치 및 소구치 근원심 폭경 추정에 관한 연구

황민성,김정욱,장기택,이상훈 大韓小兒齒科學會 2002 大韓小兒齒科學會誌 Vol.29 No.1

본 연구는 서울시 치과의사횡에서 주관한 건치아동 선발대회 후보의 경석고모형 162쌍을 분석하여 성별에 따라 하악 영구 4전치 근원심 치관 폭경합의 계측치에서 상악 및 하악의 편측 영구 견치 및 제 1, 2 소구치 근원심 폭경합을 추정하는 회귀방정식과 확률표를 구하였다. 그리고 성별간 차이를 비교하여 다음과 같은 결과를 얻었다. 1. 남자와 여자 모두 동일한 악궁 내에서 좌우측 영구 견치 및 소구치의 폭경합은 유의한 차이가 없었다.(p>0.05). 남녀간의 상하악 좌우측 영구 견치 및 소구치의 폭경합의 계측치(x)에서 상악 및 하악의 편측 영구 견치 및 제 1, 2 소구치의 근원심 폭경합(y)을 추정하기 위한 회귀 방정식은 다음과 같았다. 남자 상악 영구 견치 및 소구치 폭경합 : y=10.45+0.53x 남자 하악 영구 견치 및 소구치 폭경합 : y=10.07+0.51x 여자 상악 영구 견치 및 소구치 폭경합 : y=12.65+0.42x 여자 하악 영구 견치 및 소구치 폭경합 : y=11.70+0.42x 남자+여자 상악 영구 견치 및 소구치 폭경합 : y=11.01+0.50x 남자+여자 하악 영구 견치 및 소구치 폭경합 : y=9.87+0.51x The purpose of this study was to establish regression equations and probability charts for predicting the summ of mesiodistal crown diameters of unerupted unilateral canine and premolars from the sum of mesiodistal crown diameters of four mandibular incisors in Korean male and female. The plaster casts of 162 children(75 boys and 87 girls) among the contestees in 1994-2001 Healthy Dentition Contest in Seoul were measured. Sex differences are compare and the following results were obtained: 1. Bilateral comparison of sum of widths of permanent canine and premolars showed no significant differences for either sex(p>0.05). Sum of widths of permanent canine and premolars of male were significantly larger than that of female(p<0.01). 2. Regression equations for the prediction of sum of widths of permanent canine and premolars in each sex were as follows: Male ∑ Maxillary 345 : y=10.45+0.53x Male ∑ Mandibular 345 : y=10.07+0.51x Female ∑ Maxillary 345 : y=12.65+0.42x Female ∑ Mandibular 345 : y=11.70+0.42x Male+female ∑ Maxillary 345 : y=11.01+0.50x Male+female ∑ Mandibular 345 : y=9.87+0.51x

항공기 Butt Lap Joint 볼트연결 구조부의 손상허용성 시험 및 평가에 대한 연구

황강욱,권정호 울산대학교 2001 공학연구논문집 Vol.32 No.1

본 연구는 항공기 주익이나 동체 표피구조의 Butt Lap Joint 연결부 볼트구멍 주변에 내재된 짧은 모서리 균열을 가진 시험편 구조에 대하여 설계 예상수명 동안의 비행하중스펙트럼하에서 피로균열성장 시험을 수행하고 모서리 균열에 대한 기존의 3차원 응력강도계수 계산식을 이용하여 균열성장해석을 수행한 결과와 실험결과를 비교함으로써 Butt Lap Joint 구조의 손상허용성 평가를 수행하였다. The prediction of fatigue crack growth on the basis of the linear fracture mechanics is in accordance with the cases of through-thickness-cracks or long cracks, however the crack growth pattern of corner crack which is located at joint holes is different. The behaviours of such a short corner crack play an important role on the damage tolerance life of aircraft structures. In this paper fatigue crack growth tests are carried out on the butt lap joint specimens with small corner crack on the bolt hole under expected flight-by-flight load spectrum. And the damage tolerance evaluation is also performed for the design condition of 2 life times.

효율관리대상품목의 에너지소비효율기준 관리의 선진화 방안에 대한 연구

金正勳,黃盛郁 弘益大學校 科學技術硏究所 2005 科學技術硏究論文集 Vol.16 No.-

Nowadays the concern about development and strategies of high-efficient equipments is getting higher globally as Kyoto Protocol has taken effect this year and oil has been rising in price tremendously. Developed countries have already commenced the study and research for this problem and are looking for various solutions. In this paper, situation of managements of energy efficiency standards in foreign countries and Korea is investigated and analyzed. Each country has various laws, strategies, and standards associated with energy efficiency. So the environment and own situation of each country are reflected in the contents and criteria. This paper show how the direction of energy efficiency standards and the management would be developed desirably in the future and why national standards should be gradually internationalized and be prepared for global competency.

신장조직 손상의 진행에 있어서 Renin-Angiotensin System 의 역할에 관한 연구

이강욱,송정헌,강민규,황평주,김종학,나기량,서광선,박정규,신영태 대한신장학회 2001 대한신장학회잡지 Vol.20 No.3

解體主義 建築 디자인의 表現特性에 관한 硏究

尹道根,李正旭,李一珩,黃泰周 弘益大學校 1993 弘大論叢 Vol.25 No.2

The characteristic of Formal Expressions in Deconstructive Architecture were summerized in four features through the results of the analysis. They are as follows. 1) `The relation of architectural element and intertextuality' is expressed in discontinuation of context and refusal of functional building. 2) The concept of trace expresses as connection of place, decomposing of excavation of trace, trace of axis, trace of fragments. 3) Anti-gravity expression is there to express of open cubic, to outgrow of rectangular system, to outgrow of volume, to separate of ground connection. 4) The complex compositon of abstracted geometric form is there to abstracted geometry about indefinite shape, to layer through the overlap and collage, to de-meaning and amusement of form through the pursuit of uncertainty, to indeterminate of formal meaning through operation and composion of similar form cause to the diverse of meaning.

TERUDERMIS를 이용한 골 혹은 건이 노출된 창상의 치료

최민호,이상복,황정욱,양완석,이강길 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Deep skin and soft tissue defects with exposed bone and tendon is difficult to treat, because skin graft rarely survives and flap surgery is sacrifice of donor site. Since "Stage I" membrane was developed by Yannas and Bruke in 1980, numerous kinds of artificial skin have been developed. The adaptability of "Terudermis", developed by the Terumo Co., as an artificial skin composed of sponge made of a fibrillar atelocollagen and a heat-denatured atelocollagen, was clinically evaluated on application to 13 cases presenting deep skin and soft tissue defect with exposed bones and tendons from October 1997 to march 1998. Terudermis has the advantage of allowing early incorporation of fibroblasts and capillaries into its collagen sponge due to very weak dehydrothermal cross-linking. Before Terudermis graft, several days of wet dressing and debridement were required to prepare healthy well- vascularized bed because Terudermis was weak on unsanitary wounds. After bed preparation, Terudermis was grafted like usual skin graft. Tie-over bolster dressing or compressive dressing was used case by case. The dressing was opened 2~3 days after Terudermis grafting. Wet dressing was done daily until the skin graft was done. Autologous skin graft was done 2∼3 weeks after Terudermis graft. Our clinical results indicated that Terudermis was beneficial in treating 77% of our patients. Through the use of this new method, treatment of severe skin and soft tissue defects that are usually treated by musculocutaneous or other conventional skin flaps can be replaced by Terudermis as an new artificial dermis.

국내 조혈모세포이식 환자에서 Human Cytomegalovirus gB 유전형의 분포와 질환과의 연관성 : 예비 보고

최수미,김진희,이동건,박선희,최정현,유진홍,박철민,이종욱,민우성,황응수,신완식,김춘추 대한감염학회 2007 감염과 화학요법 Vol.39 No.2

목적 : 사람 거대세포바이러스(Human cytomegalovirus, 이하 HCMV) glycoprotein B (gB)는 UL55 유전자에 의해 부호화되는 당단백으로, UL55 유전자의 염기서열변화에 따라 4가지 유전형으로 나뉜다. 본 연구에서는 국내 조혈모세포이식 환자들에서 HCMV gB 유전형의 분포와 그 특성을 알아보고, gB 유전형에 따라 특정 HCMV 질환 발생과 연관이 있는지 그 임상적 의미를 분석해 보고자 하였다. 재료 및 방법 : 동종 조혈모세포이식 환자 52명의 혈액검체 94개에 대해, Chou 등이 제시한 방법에 따라, 먼저 UL55 유전자 부위를 nested PCR로 증폭한 후, RsaI과HinfI으로 Restriction fragment length polymorphism(RFLP) 분석을 시행하였다. 결과 : gB type 1은 73.1% (38/52), gB type 2는 13.5%(7/52), gB type 3는 1.9% (1/52), gB type 1과 type 2에 의한 혼합감염은 9.6% (5/52)로 나타났다. gB type 4는 관찰되지 않았다. 1명(1.9%)에서 gB 유전형을 결정할 수 없었는데, RFLP 패턴으로 보아 Trincado 등이 제시한 gB type 7에 해당하는 것으로 생각되었고, 이 새로운 아형에 대해서는 현재 염기서열 분석 중이다. 52명 중 5명(9.6%)에서 HCMV 질환이 발생하였고, 3명에서 HCMV 폐렴, 1명에서 망막염과 위장관염, 나머지 1명에서 망막염이 발생하였다. 5명 중 HCMV 질환과 관련하여 사망한 예는 없었고, 감염된 HCMV는 모두 gB type 1이었다. HCMV gB유전형과 HCMV 질환 발생 사이에 유의한 연관성은 없었고, 단일 주에 의한 감염과 혼합감염에 따른 HCMV 질환발생 사이에도 유의한 연관성은 관찰되지 않았다. 자료 분석 중 gB type 2에 감염되어 있던 환자에서 gB type 1에 재감염 되면서 발열, 간효소 수치 상승 및 pp65 HCMV 항원혈증이 나타난 예가 있었다. 결론 : 연구결과 gB type 1이 아주 우세하고, gB type 4는 검출되지 않았으며, 혼합감염의 빈도가 비교적 낮은 분포를 보였다. 이는 외국의 보고와는 다른 국내 조혈모세포이식 환자에서의 독톡한 감염 양상으로 추정된다. 본 연구에서 HCMV gB 유전형과 질환 발생과의 연관성을 밝힐 수는 없었으나, HCMV 유전형에 대한 연구는 바이러스 감염의 발병기전이나 전파 경로 및 양식과 같은 역학적 연구에 중요한 자료가 될 것이다. 현재 더 많은 수의 조혈모세포이식 환자를 대상으로 연구가 진행 중에 있으며, 앞으로 다른 질환군의 환자나 건강한 잠복 감염자에서의 추가 연구가 필요할 것으로 생각된다. Background : Human cytomegalovirus (HCMV) glycoprotein B (gB) is the major envelope glycoprotein, encoded by the UL55 gene. Based on sequence variation in the UL55 gene, HCMV can be classified into four gB genotypes. Previous studies have suggested an association between HCMV gB genotypes and clinical outcome in the immunocompromised hosts. The goal of this study was to determine the distribution of HCMV gB genotypes and the effect of gB genotype in the developement of HCMV diseases in hematopoietic stem cell transplant (HSCT) recipients in Korea. Materials and Methods : DNA was extracted from 94 blood specimen of 52 allogeneic HSCT recipients with HCMV infection. HCMV gB genotype was determined using polymerase chain reaction to amplify a region of UL55, followed by restriction fragment length polymorphism (RFLP) analysis based on RsaI and HinfI digestion. Results : The distribution of gB types were as follows: gB1, 73.1% (38/52) of patients; gB2, 13.5% (7/52); gB3, 1.9% (1/52) and mixed infection (gB1 and gB2), 9.6% (5/52). While gB4 was not detected, a new genotype (described as gB7 by Trincado et al, 2000) was identified on the basis of their RFLP pattern. During average 708 days’ follow up period, HCMV diseases developed in 5 patients. All of them had gB1 genotype. There was no statistically significant association between the incidence of HCMV diseases and the gB genotypes. Re-infection with gB1 strain was detected in one patient who had been previously infected with gB2. This episode was associated with fever, elevated liver enzyme and positive antigenemia. Conclusion : HCMV gB1 was the dominant genotype and no gB4 was detected in allogeneic HSCT recipients in Korea, which is an unique pattern compared with the previous reports. Although we can not find significant association between the HCMV diseases and the gB genotypes, genotyping of HCMV will serve in the study of pathogenesis and transmission of this virus in transplant patients. Further study is underway with large study population.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.