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The alpha glucosidase inhibitor, Acarbose (Glucobay^R, Bayer) inhibits carbohydrate digestion and suppresses or delays absorption of the final breakdown products, glucose and fructose when it is taken orally with meal. Therefore, clinical usefulness of acarbose is anticipated in NIDDM patients treated simultaneously by a sulfonylurea compound and acarbose. In the current study its ability to lower plasma glucose levels was studied in 12 placebo-treated NIDDM patients and in 12 patients with NIDDM, poorly controlled on diet plus sulfonylurea drugs. Patients were studied before and 16 weeks after the addition of acarbose to their treatment program, and there was a notable fall in fasting and postprandial plasma glucose concentrations. In addition to the improvement in glycemia, acarbose treatment also led to a notable reduction in Hb A_1c levels. The adverse effects during administration of acarbose was negligible. Only one patient complained of mild abdominal bloating. These data suggest that acarbose may be a useful additional method in the treatment of patients with NIDDM.
Malnutrition-related diabetes mellitus is a form of diabetes peculiar to developing countries within the tropical belt, which comprises two subgroups, fibrocalculous pancreatic diabetes (FCPD) and protein-deficient pancreatic diabetes (PDPD). FCPD is a form of diabetes secondary to chronic calcific pancreatitis, which is not due to alcohol consumption and tend to affect younger people and characterized by insulin-requiring but ketosis-resistant and coexisting malnutrition or pancreatic duct stone. FCPD is diagnosed by demonstrating calculi and signs of chronic pancreatitis by radiographic or ultra-sound imaging, together with evidence of pancreatic exocrine insufficiency. We recently experienced the two cases of fibrocalculous pancreatic diabetes. MRDM deserves further study not only because it is now recognized as a major form of the disease but also because it may improve our understanding of other forms of diabetes.
Incontinentia pigmenti acb.romians(Ito) is characterized by progressive bizarre or whorl-like hypopigmentation on trunk and extrementies during childhood. It is similar to a negative picture of incontinentia pigmenti(Blocb-Sulzberger) and not infrequently associated with mental, bony and ocular defects. The incidence of this disease is predominent in femaIe without hereditary background. Case 1. Two years old female was visited to our clinic because of mottled depigmented patches on right thigh for about 8 months. Case 2. 14 months oId female was visited to our clinic because of linear and. mottled depigmented natches on their limbs for about 7 months. Histopathological findings of both cases shows the focal depigmentation on basal layer. They are treated with steroid ointment with moderate to good effects.
평소에 철저한 혈당관리, 고혈압 치료, 운동을 위시한 체중감량, 술, 담배절제, 과식, 짠 음식, 기름진 음식을 주의 및 관리해야 한다. 요즘은 치료 및 예방에 대한 정보는 각종 매체를 통하여 많이 알려져 있고 또 환자들 스스로 알고 있으나 그것을 실천하지 않는 것이 문제이다. 본인들 스스로 해야 할 운동, 식사요법, 금연을 철저히 실행에 옮겨야 한다. 물론 고혈압, 고지혈증, 당뇨병 조절을 위한 약재를 필요시 담당의사의 지시에 따라 잘 복용해야 하며 심장 합병증을 위시한 각종 합병증에 대한 정기적인 검사가 필요하다.
When we think of the reality of math education in the Korean high schools, there are many low aptitude students who have problems in teaming math due to the difficulties of the subject. Unfortunately, they are neglected due to their low academic abilities. A reluctance to learn, past experiences in math and a lack of interest due to an inappropriate loaming atmosphere are some of the reasons for this problem. Therefore it is most important to stimulate their interest in learning math to teach good learning habits and develop a good attitude towards math.