부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.

1~2기 본태성 고혈압 환자들에서 Imidapril 대 Enalapril의 항고혈압 효과를 평가하기 위한 무작위, 이중맹검 임상시험

최영진,손대원,김용진,이홍자,채인호,김효수,김철호,오병희,이명묵,박영배,채윤식,이영우 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11

포도당과 이소프로테레놀에 의한 시상하부의 소마토스타틴 분비가 갑상선자극호르몬방출호르몬에 의한 갑상선자극호르몬에 미치는 효과

박철영,양인명,오승준,김덕윤,우정택,김성운,김진우,김영설,최영길 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

POSCO Smart Factory의 핵심역량 분석: VRIO 모형을 중심으로

최영철(Choi, Young-Cheol),박현준(Park, Hyunjun) 한국경영교육학회 2020 경영교육연구 Vol.35 No.6

[연구목적] 본 연구에서는 제조환경의 패러다임 변화 속에 새로운 성장동력으로 스마트 팩토리를 도입한 기업의 경영자원을 분석하여 핵심역량을 파악하고 기업 전반에 미치는 영향을 진단, 시사점을 제공하고자 하였다. [연구방법] 2015년 이후 스마트팩토리를 도입한 포스코를 연구대상으로 선정하고, 자원기반관점에 의거 기업 내부역량 분석에 유용한 VRIO Framework를 통해 스마트팩토리에 영향을 받은 경영자원 분석과 핵심역량을 도출하였다. 또한, 이 핵심역량이 경영성과에 어떠한 영향을 미치는지에 대한 부분도 검토하였다. [연구결과] 포스코 스마트팩토리의 영향을 받은 경영자원을 VRIO 분석한 결과 7개 핵심역량을 도출하였고, 이 핵심역량의 효과로 생산성 향상, 설비고장 비가동율 최소화, 불량률 및 품질 실패비용 감소, 납기준수율, 생산계획 증대로 인한 에너지 비용 절약 등을 통해 재고비용 합리화, 매출액 증대, 비용 절감을 통한 이익 증대, 부가가치 창출, 기업의 가치 극대화 등의 재무적 성과도 거두고 있음을 확인하였다. [연구의 시사점] 스마트팩토리의 도입은 기업이 지속 가능한 경쟁우위를 갖게 하여 핵심역량으로 발전시키며 기업의 성과에 큰 역할을 하지만, 각 기업만의 고유 특성을 고려하여 기업의 대내외자원과 기업의 주변 환경을 결합한 실증연구도 필요하다. [Purpose] In this study, we tried to analyze the management resources of companies that introduced smart factories as new growth engines amid a paradigm shift in the manufacturing environment to identify core competencies, diagnose their impact on the enterprise as a whole, and provide implications. [Methodology] Through VRIO Framework, management resource analysis and core competencies affected by POSCO Smart Factory were derived. It also considered how these core competencies affect management performance. [Findings] The analysis of the management resources affected by POSCO Smart Factory resulted in seven core competencies. It confirmed that the effects of these core competencies have also resulted in financial performance, such as rationalizing inventory costs, increasing sales, creating value-added, and maximizing corporate value. [Implications] The introduction of smart factories plays a significant role in companies’ performance by making them have a sustainable competitive advantage and developing them into core competencies. Still, it is also necessary to conduct empirical studies that combine the companies’ internal and external resources with the environment surrounding.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

목화생육형질의 잡종강세효과

崔周鎬,李喆浩,高永玉 진주산업대학교 농업기술연구소 1999 農業技術硏究所報 Vol.12 No.-

1997년 4월부터 12월까지 진주산업대학교 학생실습포장에서 목화 0개 품종을 이면교배하여 얻은 F_1, F_2 45개 조합을 재료로 생육형질의 교배집단에 따른 잡종강세정도를 산출한 결과는 다음과 같다. 1. 개화일수에서 F_1은 5.12%, F2세대에서는 0.67%, 개면일수에서는 F_1은 0.29%로 강세를 보였으나, F_2에서는 -0.43%로 낮았으며, 개화수는 F_1은 -1.64% F_2는 -0.98%로 부의 강세를 나타냈다. 2. 초장의 F_1은 1.58%, F_2세대에는 5.12%, 절간장에서는 F_1은 10.14%, F_2세대에서는 3.05%의 강세를 보였으나, 결과지수에서는 F_1은 -0.69%, F_2세대에서는 2.22%로 상반된 강세를 나타내었으며, 경직경은 F_1은 3.39%, F_2세대에서는 2.28%로 높은 강세를 보였다. 3. 삭장에서는 F_1은 1.15%, F_2세대에서는 1.96%로 유의한 강세를 보였으며, 삭폭의 F_1은 1.3%, F_2에서는 -2.00%로 상반된 강세를 보였다. 4. 주당전경중에서는 F_1은 -0.50%, F_에서는 -1.13%, 주당근중의 F_1은 -2.53%, F_에서는 -6.76%로 부의 유사한 강세를 나타내었다. For this study, 45 combinations of F1 and F2 generations were bred from 10 varieties of cotton through diallel cross during the period from April to December, 1997. The heterosis effects were analyzed with the following results: 1. Days to flowering showed 5.12% heterosis in F1 generation, and 0.67% in F2; days to maturity, 0.29% in F1, but -043% in F2; number of flowerings per plant, -1.64% in F1 and -0.98% in F2. 2. Plant height showed 1.58% heterosis in F1 and 5.12% in F2; internode length, 10.14% in F1 and 3.05% in F2; number of fruiting branches, -0.69% in F1, but 2.22% in F2; stalk diameter, 3.39% in F1 and 2.28% in F2. 3. Boll length showed 1.15% heterosis in F1 and 1.96% in F2; boll width, 1.3% in F1, but -2.00% in F2. 4. Total weight per plant showed -0.50% heterosis in F1 and -1.13% in F2; root weight per plant, -2.53% in F1 and -6.76% in F2.

제주도 주변 용승역의 생물생태학적 기초 연구 : 부유성 동물플랑크톤의 현존량과 분포특성 Standing Stock and Distribution of pelagic Zooplankton

최영찬,고유봉,오봉철 濟州大學校 基礎科學硏究所 1996 基礎科學硏究 Vol.9 No.2

제주도 서부 고산 연안 용승역에 출현하는 표충 부유성 동물플랑크톤의 특성을 밝히기 위하여 용승역과 그 인접 외해역에서 1993년 4월부터 1994년 3월까지 격월로 부유성 요각류, 화살벌레류, 익족류 및 젤라틴성 동물플랑크톤(Siphonophora 와 Thaliacea)을 조사하였다. 요각류는 6월과 11월에 각각 235ind./㎥, 301ind./㎥로 2차례에 걸쳐 피크를 보여 제주도 주변 연안해역과 일치하고, 출현 개체수에 있어서도 용승역이라고 해서 특별히 높지는 않았다. 젤라틴성 동물플랑크톤은 용승역과 외해역에서는 거의 출현하지 않는 반면, 인접하는 중간역에서만 6월과 11월에 75~458ind./㎥로 다량 출현하는 특성을 보였다. 동물 플랑크톤의 평균 생물량은 35.8ind./㎥으로 11월에 가장 높고 1월에 가장 낮았다. 화살벌레류는 Sagitta의 사체가 6월과 11월의 용승역에서 43~74%로 매우 높게 나타나는 특징을 보였다. 11월의 용승역에 출현한 Sagitta는 48~71%가 요각류인 Oncaea venusta O. mediterranea 및 Candacia bipinata에 의해 부착된 상태에 있었다. 또 각을 갖고 있어서 그 분포가 제한을 받는 유각 익족류는 외해역에서 는 전혀 출현하지 않은 반면, 용승역에서 용승현상이 강한 시기인 11월에 27~64ind./㎥의 높은 밀도로 출현하므로써 요승에 의한 상승류를 이용, 적응하는 부유성 동물플랑크톤의 특성을 보이고 있었다. Daytime surface zooplankton were collected bimonthly from April 1993 to March 1994 at six stations around upwelling and adjacent areas of Gosan, western part of Cheju Island. This paper deals with the occurrence, biomass and some other characteristics of zooplankton in these areas. Copepods had two peaks in the abundance in June(235 ind./㎥)and November(301 ind./㎥), but were not especially abundant in upwelling area. While gelatinous organisms seldom occurred in the upwelling and the outer area with high density of 75ind./㎥(in June) and 458 ind./㎥( in November) at the intermediate area, seasonal values of biomass with mean of 35.8ind./㎥ were the highest in November and the lowest in January. Abundance of chaetognaths(mainly Sagitta spp.) ranged 15~37 ind./㎥, and carcasses of Sagitta occurred very highly in the upwelling area in June(54% of total Sagitta organisms) and November(70.5%). Especially 48~77% of sagitta individuals in upwelling area in November was attached by Oncaea mediterranea, O. venusta and Candacia bipinata. Pteropods with shells were sampled only in the upwelling area during strong upwelling season (November, 27~64 ind./㎥), indicating the characteristics of ascending behavioral adaptation form the bottom water by upwelling.

중추에서 Prostaglandin계가 Renin-angiotensin System에 미치는 영향

최영태,김종승,문성호,오형균,김재훈,전제열,염철호,윤평진 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1

Role of prostaglandins on the renin-angiotensin system in the central nervous system was examined in normotensive and 2-kidney, 1 clip (2K1C) hypertensive rats. The experiment was done under thiopental (50 ㎎/㎏, IP) anesthesia. Captopril and indomethacin were injected into the right lateral cerebral ventricle. Arterial blood pressure and heart rate were recorded from the femoral artery. Intracerebroventricular (ICV) captopril (1 ㎎) caused a decrease in mean arterial pressure in both normotensive and 2K1C hypertensive rats. The depressor response to captopril was more sensitive in hyper-tensive rats than in normotensive rats. Indomethacin treatment (ICV, 200 ㎎) altered the depressor response to captopril neither in normotensive nor in hypertensive rats. These results suggest that the cardiovascular effect of renin-angiotensin system in the central nervous system may not be mediated via prostaglandin systems in normotensive and 2KlC hypertensive rats.

기제와 피부투과촉진제가 아포모르핀의 피부투과에 미치는 영향

최영근,최옥,김건남,박은석,지상철 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of apomorphine, the skin permeation rates of apomorphine from vehicles of different composition were determined using Franz diffusion cells fitted with excised rat skins. Solubility of apomorphine in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of apomorphine. The solvents used were propylene glycol (PG), Transcutol^??, Labrasol^??, Labrafac hydro WL^??, Labrafil WL 2609 BS^?? and isopropyl alcohol. Even though permeation rates of apomorphine from each vehicle were low (0.08-0.36㎍/㎠/hr), the combination of PG and Labrafac^?? increased it significantly. The permeation rates of apomophine from PG/Labrafac^?? mixtures increased as the volume fraction of PG in the mixture increased. The maximum permeation rate of 18㎍/㎠/hr was achieved at 30% of PG, which decreased with further increase of PG fraction. A series of fatty acids, alcohols and monoterpenes were employed as penetration enhancers. Incorporation of each enhancer in the PG/Labrafac^?? (30:70) mixture at the level of 10% improved the skin permeation significantly. The highest permeation rate, 117㎍/㎠/hr, was attained with myristic acid.

國際旅行과 旅券의 國際的 機能

崔哲榮 仁川大學校 法科大學 法學硏究所 1999 仁川法學論叢 Vol.2 No.-