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Methylmercury Exposure and Health Effects
홍영습,김유미,이경은 대한예방의학회 2012 예방의학회지 Vol.45 No.6
Methylmercury is a hazardous substance that is of interest with regard to environmental health, as inorganic mercury circulating in the general environment is dissolved into freshwater and seawater, condensed through the food chain, ingested by humans, and consequently affects human health. Recently, there has been much interest and discussion regarding the toxicity of methylmercury, the correlation with fish and shellfish intake, and methods of long-term management of the human health effects of methylmercury. What effects chronic exposure to a low concentration of methylmercury has on human health remains controversial. Although the possibility of methylmercury poisoning the heart and blood vessel system, the reproductive system, and the immune system is continuously raised and discussed, and the carcinogenicity of methylmercury is also under discussion, a clear conclusion regarding the human health effects according to exposure level has not yet been drawn. The Joint FAO/WHO Expert Committee on Food Additives proposed to prepare additional fish and shellfish intake recommendations for consumers based on the quantified evaluation of the hazardousness of methylmercury contained in fish and shellfish, methylmercury management in the Korea has not yet caught up with this international trend. Currently, the methylmercury exposure level of Koreans is known to be very high. The starting point of methylmercury exposure management is inorganic mercury in the general environment, but food intake through methylation is the main exposure source. Along with efforts to reduce mercury in the general environment, food intake management should be undertaken to reduce the human exposure to methylmercury in Korea.
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홍영습,강호진,곽종영,박병래,유창훈,김유미,김헌 대한예방의학회 2011 Journal of Preventive Medicine and Public Health Vol.44 No.3
Objectives: The microRNA (miRNA) miR-196a2 may play an important role in lung cancer development and survival by altering binding activity of target mRNA. In this study, we evaluated their associations with the susceptibility of non-small cell lung cancers (NSCLC) by case-control study in a Korean population. Methods: We performed genotyping analyses for miR-196a2 rs11614913 T/C at miRNA regions in a case-control study using blood samples of 406 NSCLC patient and 428 cancer-free control groups. Results: The total C allele frequencies for miR-196a2 were 48.8% for the patients and 45.6% for the controls; and the genotype frequencies of TT, TC, and CC were 23.7%, 55.2%, and 21.1% for the patients and 31.1%, 46.35%, and 22.4%for the controls (p<0.05). Participants who possesses TC/CC genotypes showed high risk for NSCLC compared to those possessed TT genotypes (OR, 1.42; 95% CI, 1.03 to 1.96). The association was persisted in 60 and older age group, male,smokers, those without family history for cancer. However, no significant association of CC genotypes in recessive genetic model was observed. Conclusions: In conclusion, this case-control study provides evidence that miR-196a2 rs11614913 C/T polymorphisms are associated with a significantly increased risk of NSCLC in a dominant model, indicating that common genetic polymorphisms in miR-196a2 rs11614913 are associated with NSCLC. The association of miR196a2 rs11614913polymorphisms and NSCLC risk require confirmation through additional larger studies.
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Blood Cadmium Concentration of Residents Living near Abandoned Metal Mines in Korea
홍영습,이병국,박정덕,사공준,최재욱,문재동,김대선,김병권 대한의학회 2014 Journal of Korean medical science Vol.29 No.5
The purpose of this study was to investigate demographic and lifestyle variables and bloodcadmium concentrations in residents living near abandoned metal mines in Korea. Bloodcadmium concentrations were measured in 15,161 subjects living around abandoned metalmines (exposed group, n = 14,464) and compared with those living in designated controlareas (control group, n = 697). A questionnaire was provided to all subjects to determineage, gender, mine working history, times of residence, smoking habits and dietary watertype. The geometric mean (95% confidence intervals) of blood cadmium concentration(1.25 [1.24-1.27] μg/L) in the exposed group was significantly higher than in the controlgroup (1.17 [1.13-1.22] μg/L). Mean residence time and mine working history in theexposed group were significantly higher than in the control group. Blood cadmiumconcentrations increased with increasing age, and residence time in both groups, andblood cadmium concentrations were higher in current-smokers than in non-smokers inboth groups. This study shows the geometric mean of blood cadmium concentration inabandoned mining areas are higher than in non-mining areas in the general adult Koreanpopulation.
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