서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

GRAM 작업 관리용 확장형 실행환경 정보 서비스 시스템 설계

김완규,김현주,정미숙,장경일,박규석 진주산업대학교 산업과학기술연구소 2005 산업과학기술연구소보 Vol.- No.12

Grid computing is an emerging technology that promise to unify resources and computing power in many organizations together. It couples a wide variety of geographically distributed computational resources, and presents them as a unified integrated high-end computer. The Globus Resource Allocation and Management(GRAM) service provides for the management and remote execution of jobs defined using a standard Resource Specification Language(RSL) requested by client in grid environment. However, Currently the GRAM has very limited functionality to support for applications that required special execution environment. Here, we provide a proposal for Execution Environment Information interacted with broker to support the GRAM's special execution environment.

웹 컨텐츠 마이닝을 이용한 개인화 시스템의 설계 및 구현

김일,박규석 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.1

웹 로그 마이닝 시스템은 데이터 클린징(Dats Cleansing), 사용자 구분(User Identification), 세션 구분(Session Identification). 패스 완성(Path Completion), 트랜잭션 구분(Transaction Identification) 등의 전처리 단계를 거쳐 탐색 패턴, 연관성 분석 등의 웹 마이닝을 이용한다. 본 논문에서는 웹사이트를 이용하는 사용자에 대한 취향 분석을 위하여 웹 컨텐츠 마이닝(Web Contents Mining)을 이용한 개인화 시스템을 설계 및 구현하였다. Web log mining system uses navigation pattern. association rule and etc. through preprocess phase. such as data cleansing, user identification, session identification, path completion and transaction identification. In this paper, we design and implement a personalization system using web contents mining for web user's preference analysis.

분산체제에서의 데이타 송신을 위한 난수 이용 암호화 알고리즘의 설계 및 구현

김영근,박규석 慶南大學校 附設 工業技術硏究所 1993 硏究論文集 Vol.11 No.-

분산체제에서의 정보 전송을 위한 알고리즘 SARN(Security Algorithm Using Random Number)을 제안하였다. 난수 생성기에 의해 생성된 Key는 원시 데이타와 연산되어 암호화된 후 Key 재생을 위한 파라미터 값과 함께 전송되며, 수신자는 그 파라미터 값에 의해 Key를 생성하여 암호화된 정보를 복호화한다. In this paper, we propose an encryption algorithm SARN(Security Algorithm using Random Number) to secure the transmitted information in distributed systems. The key generated by the Random Number Generator is operated with the source data and then sended the edcrypted data and the value of parameters for generating the key to the receiver. The receiver generates the key using th parameters and then decrypts the data.

Web 기반 온라인 학습 평가시스템의 설계

박규석,김창근 慶南大學校 附設 工業技術硏究所 1998 硏究論文集 Vol.15 No.3

최근 가상학교에서는 효과적인 실시간 평가시스템을 이용한 피드백식 반복 학습 방식이 주요한 과제가 되고 있다. 본 연구에서는 가상학교에서 적절한 온라인 평가시스템을 구현하였다. 이 시스템은 학생들이 학습과정에서 즉각적인 피드백으로 자기 자신의 평가와 성취도를 파악할 수 있게 하고, 교수는 시험 및 평가에 관련된 과중한 업무를 줄일 수 있도록 한다. Recently a repeated study with an instant feedback through the efficient real-time evaluating system has been a critical issue in the distance learning and self-paced instruction In this paper, we design and implement the online evaluating system, which is applicable appropriately to such as the instruction system, allows the students to understand their accomplishment through the self-evaluating and the instructors to diminish an heavy workload on testing and evaluating the achievements of students by supporting the instant feedback on self-learning.

단세포군 항체를 이용한 Chlamydia trachomatis의 면역형 결정

윤규석,김덕언,최태열 대한감염학회 1993 감염 Vol.25 No.1

An immunotyping of 27 strains of Chlamydia trachomatis isolated from patients with non-gonococcal urethritis or pelvic inflammatory diseases in Korea was achieved in dot-enzyme linked immunosorbent assay (dot-ELISA) with monoclonal antibodies. Monoclonal antibodies were produced with standard techniques by immunization of Balb/c mice and fusion with SP 2/0 myeloma cell. Seven type-specific (D,E,F,H,I,J,L₂), 2 subspecies-specific (B-complex, C-complex) and species-specific (HMC 1-1) monoclonal antibodies were used for immunotyping. Immunotyping of 12 control strains and 27 clinical strains isolated in Korea was studied by using dot-ELISA. Species-specific (HMC 1-1) monoclonal antibody reacted with all control strains and 27 isolated. Subspecies-specific (B-complex) monoclonal antibody reacted with B/HAR-36, Ba/Aphach-2, D/UW-3Cx, E/Bour, LGV type Ⅰ/440, LGV type Ⅱ/CDC control strains and 19 isolates. Type-specific monoclonal antibody of D was reacted with D/UW-3/Cx control strain and 10 isolates. E type-specific monoclonal antibody racted with E/Bour control strain and 6 isolates. F type-specific monoclonal antibody reacted with 5 isolates. Three isolates which racted with subspecies-specific monoclonal antibody didn't react with any type-specific monoclonal antibodies. Subspecies-specific (C-complex) monoclonal antibody reated with A/HAR-13, C/CDC, H/UW-43/Cx, J/UW-36/Cx control strains and 2 clinical isolates, but the isolates did not react with any type-specific monoclonal antibodies. One of 27 clinical isolates reacted with any type-specific monoclonal antibodies. One of 27 isolates reacted with species-specific (HMC 1-1) monoclonal antibody didn't react with any other subspecies-and type-specific monoclonal antibodies. In conclusion, the major immunotypes of C.trachomatis from urogenital system in Korea were D, E and F, and dot-ELISA with monoclonal antibody may contribute for immunotyping as a simple and specific technique.

WC-Co 초경 소지에 R.F sputtering법으로 제조한 TiB₂박막의 열처리 특성

이해석,임재복,김규호 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.1

TiB₂ thin films were deposited by R. F sputtering process on the WC-Co cutting tool. The growth rate of as-deposited films increased with R. F power. As-deposited films were amorphous by XRD measurement. The thermal annealing was performed to crystallize as-deposited films at temperature, which was varied from 900℃ to 1100℃. TiB₂ thin films annealed at 900℃ showed TiB₂, TiB peaks. As annealing temperature increased to 1100t, the intensity of the (101) and (110) peaks of TiB2 became sharp. The morphology of as-deposited films exhibited the granular structure by SEM observations. As the R. F power increased, the spherical particles of the films were coalesced and showed the large granular structure. The films annealed at 900℃ showed a fine crystallized grain and columnar structure. Whereas, the melt phase was formed on the surface of the films above 1000℃. The results of EDS analysis of melt phase show that the melt phase was composed of W, Co elements. The hardness of the films annealed increased with increasing thermal annealing temperature. Whereas, in the case of as-deposited films above R. F power 150W, the hardness of the films annealed above 1000℃ decreased because of melt phase.

桃仁承氣湯 및 그 構成藥物이 瘀血病態模型에 미치는 影響

安圭錫,崔昇勳,金楨氾 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.1

瘀血은 한의학의 독특한 病理槪念으로서 생리적 功能을 상실한 血液이 體內 일정 部位에 凝聚되어 形成한 일종의 病理的 産物이다. 최근에는 瘀血證의 진단표준에 대한 定量化硏究가 많이 진행되어 임상지단 및 활용성이 더욱 높아지고 있으며, 瘀血의 治法으로는 活血化瘀法을 기본으로 兼證에 따라 기타 治法이 配伍되고 있다. 본 실험에 사용한 桃仁承氣湯은 通下活血法에 해당하는 方劑로서, 《傷寒論》에 처음 수록된 이래 下焦의 瘀熱蓄結의 證候를 치료하는데 사용되어 왔다. 이에 저자는 桃仁承氣湯 및 그 構成 藥物이 瘀血에 충분히 효과가 있을 것으로 판단되어 白鼠의 尾靜脈에 dextran을 注入하여 瘀血病態를 유발시키고 약물의 水煎濃縮液을 經口投與하여, 血小板數, fibrinogen 量, prothrombin time(PT), hematocrit(Ht)値, fibrinogen degradation product(FDP) 濃度, 체표온도를 측정하였으며, 또한 hydrocortisone acetate(HA)로 어혈병태를 유발시켜 血小板數, fibrinogen 量, PT, Ht 値, 全血粘度 및 血漿粘度를 측정하여 두 어혈병태모형에서의 실험결과를 살펴보고 또 이를 서로 비교한 결과 有意한 결과를 얻었다. 특히 적외선체열진단기로 대조군과 실험구의 체표온도 변화를 측정하여 유의성있는 결과를 얻은 것은 하나의 성과라 할 수 있다. In order to investigate the effects of Taorenchengqitang and its components on both dextran-induced blood stasis model(Dx Model) and hydrocortisone acetate(HA)-induced blood stasis model(HA Model), rats of Dx Model treated with 10% dextranaqueous solution (i.v. injection, 1.1㎖/200g/day through caudal vein, once) were orally administrated liquid extract of Taorenchengqitang and its components, and then observed platelet, fibrinogen, prothrombin time, hematocrit, FDP level and dermal temperature. Another rats of HA Model (i.m. injection 5㎎/200g/day into the muscular rump, for 7 days) were orally administrated Taorenchengqitang and its components, thereafter measured platelet, fibrinogen, prothrombin time, hematocrit, whole blood viscosity and plasma viscosity. The results were summarized as follows: 1. Platelet was increased significantly in order of Taorenchengqitang, Rhei Undulati Rhizoma, Sodii Sulfas, Cinnamomi Ramulus on Dx Model and in order of Rhei Undulati Rhizoma, Persicae Semen, Taorenchengqitang, Sodii Sulfas as compared with data of control group on HA Model. 2. Fibrinogen Level was increased significantly in order of Rhei Undulati Rhizoma, Sodii Sulfas, Taorenchengqitang, Persicae semen compared with data of control group both on Dx Model and on HA Model. 3. Prothrombin time was shortened significantly in order of Rhei Undulati Rhizoma, Persicae semen, Taorenchengqitang Sodii Sulfas on Dx Model and in order of Rhel Undulati Rhizoma, Sodii Sulfas, Taorenchengqitang, Cinnamomi Ramulus, Persicae Semen compared with data of control group on HA Model. 4. Hematocit was sightly increased in sample groups compared with data of control group on Dx Model, but was stitistically insignificant. 5. FDP was deceased significantly in order of Rhei Undulati Rhizoma, Persicae Semen, Taorenchengqitang, Glycyrrhizae Radix compared with data of control group on Dx Model. 6. Dermal temperature was increased significantly in order of Persicae Semen , Taorenchengqitang after 1hr next to dextran injection; and in order of Persicae Semen, Taorenchengqitang after 2hrs next to dextran injection compared with data of control group on Dx Model. 7. Whole blood viscosity and plasma viscosity were decreased significantly in the most of groups, especially in the low degree of shear rate, compared with data of control group on HA Model. The Cytotoxic effects of Dictamni Cortex Radicis(白蘚皮) and Manitis Squama(穿山甲) on Human cancer cell-lines.

四象醫學에서의 心의 槪念 設定에 관한 硏究

安圭錫,河智容,金義泰 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 四象醫學은 旣存 韓醫學의 五行을 中心으로한 이론체계와는 달리 事·心·身·物의 四元構造로 人體를 인식하므로 旣存醫學의 五行的 思考를 바탕으로 四象醫學에서의 心을 이해하려는 오류를 범하기 쉽다. 이에 본 硏究에서는 四象醫學의 心개념을 보다 정확히하여 四象醫學의 올바른 이해에 도움을 주고자 하였다. 방법 : 四象醫學의 思想的 脈通을 조사하여 東武의 思想的 淵源을 밝혀서 四象醫學에서의 本體觀과 心 相對을 정의하였으며, 東武의 思想的 背景인 儒學과 旣存醫學에서의 心 槪念을 比較 分析하였다. 결과 : 四象醫學에서의 心은 本體觀을 形成하는 太極으로서의 心 槪念과 兩儀之心 및 四象之心 등으로 相對性을 지닌 對峙槪念의 心으로 이해하여야 하며, 旣存醫學의 血肉지心의 生理功能은 四象的 四臟의 生理功能에서 有關的으로 나타나는 것으로 이해하여야 한다. 결론 : 사상의학을 이해함에 있어서는 心의 개념 및 특징을 먼저 파악하는 것이 중요하다고 판단된다.