태안해안국립공원 지역특화자원을 활용한 탐방프로그램 개발 연구

배준호(Joon-ho Bae),남승민(Seung-min Nam),허학영(Hak-young Heo),송창룡(Chang-ryong Song),박현숙(Hyun-suk Park) 국립공원연구원 2021 국립공원연구지 Vol.12 No.1

본 연구를 위해 먼저 국내·외 해상·해안국립공원의 운영프로그램 현황에 대한 조사를 시행하였으며, 조사된 일부 사례의 경우 기후 및 지형적 요인, 그에 따른 생태환경의 차이, 그리고 관련 법령 차이 등의 이유로 즉시 국립공원에 도입하기 보다는 중·장기적 운영계획과 인프라의 확충, 전문성 확보 등 체계적인 준비가 필요한 것으로 나타났다. 보다 적합한 탐방프로그램의 개발을 위해 사업대상지 현장방문을 실시하였으며, 기존 운영프로그램 현황, 각종 시설, 인력현황 파악, 주변 환경 분석, 담당자 인터뷰 등을 통해 맞춤형 탐방프로그램을 구성하였다. 태안해안국립공원의 경우, 연구원 협업 철새 가락지 부착체험, 태안 해변길 - 솔모랫길 탐방, 태안해변 드론 탐방, 마음의 의자, 연날리기, 새와 예술 그리고 … 등의 체험형 프로그램과 한서대학교와 함께하는 해양 안전 교육 프로그램, 유류 오염 교육 프로그램 등의 교육형 프로그램 등 모두 8가지 해양국립공원 운영프로그램이 도출되었다. 제안된 탐방프로그램을 운영하기 위해서는 별도의 장소 및 운영시설의 확충, 예산편성, 운영을 위한 타당성 검토 등이 우선되어야 할 것이다. 특히 탐방프로그램을 효율적으로 운영하기 위해서는 프로그램 지도자의 역량개발이 필요하며, 현재 운영되고 있는 프로그램을 보완하고 새로운 프로그램을 시행하기 위한 추가적 논의가 필요할 것으로 사료된다. For this study, we first examined the currently operating programs of domestic and overseas maritime and costal national parks. It was found that some of the programs require systematic preparations such as mid- and long-term operation plans, infrastructure expansion, and maintenance of professionalism rather than immediately introducing them into national parks due to the differences in climatic and geographic factors, ecological environment, and relevant regulations. To develop more suitable programs, on-site visits were made and the customized programs were suggested by closely examining the status quo and interviewing people in charge of running the currently offered programs. For Taean Coastal National Park, eight programs were recommended as feasible ones, including the experiential programs such as Bird Ringing, Taean Beach Trail - Sol Sand Trail Walking, Travel Taean Beach with Drone, Thinking Chair, Kite Flying, and Culture & Arts Program (Birds, Arts, and …), and the educational programs such as Marine Safety Training and Oil Pollution Awareness Program. For the suggested programs to be realized, the expansion of separate places and operating facilities for each program, budgeting, and feasibility study should be preceded. To operate the programs effectively and efficiently, in particular, it is necessary to develop the competency of program leaders, and additional discussion for supplement the currently operated programs and implement new programs.

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

당뇨병성 다발성 신경병증에 대한 Thioctic acid의 유효성 및 안정성에 관한 연구

박철영,김영설,오승준,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2001 임상당뇨병 Vol.2 No.1

연구배경: 당뇨병성 신경병증은 당뇨병 환자에서 흔히 나타나는 합병증으로서 임상 증상은 가볍거나 없을 수도 있지만 많은 경우에 통증, 작열감, 이감각증이나 무감각증 등의 증상을 동반하지만, 이에 대한 명확한 기전이나 뚜렷한 치료방법이 없었다. 최근에 신경세포내 산화성 스트레스의 증가로 신경세포의 손상이 발생된다는 기전이 주목을 받으면서, 당뇨병성 신경병증 환자에게 항산화제인 thiotic acid를 사용하여 좋은 효과를 관찰한 논문들이 발표되었다. 이에 저자들은 한국의 당뇨병성 다발성 신경병증 환자에서 thiotic acid를 경구 투여 후에 신경병증에 의한 효과 및 안정성을 평가하였다. 방법: 모든 대상 환자에게 Thioctic acid 600㎎ 을 1일 1회 아침 식전 30분에 8주간 투여하여 당뇨병성 다발성 신경병증에 대한 TSS의 개선여부에 대한 임상적 유효성 및 이상반응, 내약성, 실험실적 지표의 변화를 통한 안정성을 관찰하였다. 결과: 치료시작 전에 관찰한 환자가 호소하는 증상은 통증이 가장 많았으며 무감각, 작열감, 이상감각 순의 빈도를 보였다. 통증, 작열감, 이감각증, 무감각증의 평균 TSS는 1차 방문시 5.8± 1.8, 2차방문시는 4.4±1.7, 3차 방문시는 3.1±1.1로 사용기판에 따라 통계학적으로 유의한 증상의 호전이 있었다. 또한 TSS의 개선 뿐만 아니라 통증, 작열감, 이감각증 및 무감각증 각각의 증상도 치료전과 치료 4주 후 및 치료 8주 후를 비교했을 때 통계학적으로 유의한 증상의 호전이 있었다. TSS가 1차 방문 시와 비교했을 때 3차 방문시에 30% 이상 개선되었을 때(1차 방문시에 TSS 4인 환자는 2점 이상 개선되었을때) 임상적으로 의미가 있는 반응으로 간주하고 계산한 반응률은 71.3%였다. 결론: 당뇨병성 다발성 신경병중 환자에 대해 항 산화제인 thioctic acid 600㎎ 경구 투여요법은 당뇨병성 신경병증의 증상완화에 유용하며, 안전한 것으로 사료된다. Background: The study was peformed to evaluate the efficacy and safety of oral treatment with the antioxidant α-lipoic acid (Thioctcid??) in diabetic patients with peripheral polyneuropathy. Methods: Thioctacid?? 600㎎ was orally administered once a day for 8 weeks in 61 diabetic patients with peripheral polyneuropathy. Neuropathic symptom(pain, burning, paresthesia, and numbness) were scored before, and of 4 and 8 weeks after treatment. In addition, neuropathy by the physician and patients at the end of treatment. The primary endpoint was the response role after 8 weeks treatment, defined as an improvement in the total symptom score of at least more than 30%. Results: Efficacy was evaluated among forty-four patients who had completely the study according to the protocol and safety was evaluated among all of 61 patients who had taken the study medication. The response rate after 8 weeks was 77.3%. The total symptom score was significantly decreased of 4-week, and further decreased of 8-week. All the individual scores for neuropathic symptom were also significantly reduced of 4-week and further decreased at 8-week. Conclusion: These finding indicate that oral treatment with thioctacid?? at a dose of 600㎎/day for 8 weeks will improve peripheral polyneuropathy in diabetic patients, without causing any serious adverse events.

檀君神話 硏究(Ⅱ) : 聖顯을 中心으로 Focused on Hierophany

朴勝俊 배화여자대학 1985 培花論叢 Vol.4 No.-

According to Eliade, existence can be interprete as the sacred and the profane. The ordinary is referred to as the profane while the inordinary is the sacred. Mythology is the heirophany and symbol of the sacred world. Dangun mythology is the record of hierophany related to the time and space of cosmogony. The sacred tree at the summit of Mt. Taebaek where the son of Hwan-in, (Sky-God), Hwan-ung descended at the beginning of the world is the consecrated zone. The sacred city was established here. This zone of the sacred is the center of the world, axis mundi and naval of cosmos, where the creation of everything was effected. Here cosmogony was completed, the transformation of Ung-nyeo took place and Dangun was born. Time is irreversible. Time in mythology and ritual, however, is experienced as reversibility. The time when hierophany is realized is the time of the sacred. Thus the sacred time is reversible as it can be repeated. The sacred time which has the symbol of the ritual time in Dangun mythology means the process of the Ung-nyeo's transformation. The transformation through the lapse of time and certain taboos before the ritual is the initiation of death and rebirth and the road leading to the center. Dangun mythology overcame the lapse of time by the recreation and birth. Consequently, Dangun mythology is a mythology expressing soteriological transformation, which recorded the endless pursuit from the profane to the sacred. Dangun mythology is not a simple mythology concerning the foundation of a country but a revelation of man's common desire and wille to be liberated from the fear of time.

檀君神話 硏究

朴勝俊 배화여자대학 1984 培花論叢 Vol.3 No.-

The Dangun myth consists of three motives: Hwanung's descent from the heaven, the transformation of the bear, the hierosgamos of Ungnyeo and Hwanung. There can be found the structure of death and rebirth in each motive. The second motive, again, can be analyses into four mythemes. First, the coexistence of a tiger and a bear in the same cave is the symbol of uroboros, a primodial chaos before the creation of the world. Second, the desire of a bear to become a man means a self-consciousness as a bestial entity, and desire of renewal and rebirth. Third, dietary taboo and the prohibition of light is the painful process for self-realization and is corresponding to the dragon fight found in hero myth. Fourth, the transformation of the bear into a woman, abandoning her bestiality, represents the motive of death and rebirth. The transformation is the process of initiation toward the center, Sindansu as the World Tree. This study can be summarized into the following four items. (1) Dangun-myth contains the archetype of human collective unconsciousness for self-realization. (2) It expresses the ancient Korean viewpoint of man to become a full-fledged man from the state of ignorance through pains. (3) It is a symbolic myth of creation which illustrates the cosmogony from chaos. (4) It demonstrates the creation not by God's wil but by a positive self-will.

총단관결찰로 인한 血淸蛋白分劃像의 變化

朴東烈,曺準承 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.1

총단관결찰후에 血淸蛋白分劃像이 어떻게 變動하는가를 보기 위하여 一定한 其間 같은 條件下에서 동육한 쥐를 使用해서 手術前 正常 血淸과 단관결찰 24, 48 및 72時間째의 血淸을 分離하여 cellulose acetate膜을 利用한 電氣泳勳을 實施해 서 그蛋白分劃像을 調査해 보았다. 正常 쥐血淸의 總蛋白濃度는 7.12 g/dl, albumin 3.11 g/dl (43.6%), α_1-globulin 0.15g/dl(2.1%), α_2-globulin 0.79 g/dl(11.1%), β-globulin 1.71g/dl(24.1%), γ-globulin 1.36 g/dl(19.1%)이었으며 이의 A/G 比는 0.77이었다. 쥐 血淸의 蛋白分劃은 사람血淸의 그것과 比較해서 A/G 比와 albumin및 α_1-globulin의 濃度가 낮고 β-globulin의 濃度는 높았다. 총단관을 結紮한 後의 血淸蛋白의 電氣泳動像은 變動을 나타내었다. 卽 단관결찰 72時間뒤에는 γ-globulin이 約半으로 減少되고 β-globulin은 增加 되었으며 其他의 蛋白分劃에는 別다른 變動이 없었다. Change in eletrophoretic patterns of serum protein after ligation of the common bile duct was investigated in albino rats weighing approximately 200g. Sham operated rats were used as control. Rats were sacrificed 24, 48 and 72 hours after the operation. Serum samples of each group were analyzed for determinations of total protein and its eletrophoretic patterns using a cellulose acetate membrane. In comparison with human, normal rat serum showed lower levels of albumin and alpha 1-globulin, lower A/G ratio and higher level of beta-globulin. The ligation of the common bile duct produced an alteration of electrophoretic patterns of serum protein. In 72 hours after the ligation, beta-globulin level increased apparently, but gamma-globulin level decreased to approximately half of the control.

고정식 교정환자에서 치주건강 유지에 대한 전동치솔의 효과

박성준,황현식,이기헌,경승현 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.2

Patients with fixed orthodontic appliances frequently show ineffective plaque control caused by these orthodontic appliances. Although many methods may be helpful in reducing dental plaque formation, optimal mechanical plaque removal and oral hygiene instruction are the most important factors during orthodontic treatment. The purpose of this study was to evaluate the efficacy of an electric toothbrush, with a specially designed orthodontic brush head, compared to a manual toothbrush on periodontal health in patients with fixed orthodontic appliances. Forty patients were randomly divided into two groups, the electric and the manual toothbrush groups, 1 month after attachment of fixed orthodontic appliances. Periodontal status was measured using a plaque index, a gingival index, a bleeding index, a pocket depth and a relative attachment loss, at baseline and after 3 months, 6 months, 9 months, and 12 months. Oral hygiene instruction was given according to the type of toothbrush used. The Braun Oral-B Plak Control with Ortho OD 15-1 brush was used as the electric toothbrush while the Butler G. U. M 124 was given as the manual toothbrush. By comparing between the electric and the manual toothbrush groups, the following results were obtained: 1. In the manual toothbrush group, the gingival and bleeding indices showed no statistically significant differences. but the plaque index was significantly decreased (p<0.001) and pocket depth as well as relative attachment loss were significantly increased (p<0.01). 2. In the electric toothbrush group, the bleeding index, pocket depth and relative attachment loss showed no statistically significant differences, but the plaque and gingival indices were significantly decreased (p<0.001). 3. In the case of the plaque, gingival and bleeding indices, there were no statistically significant differences between the electric and the manual toothbrush groups. On the contrary, in the case of pocket depth and relative attachment loss, there were statistically significant differences between the electric and the manual toothbrush groups: an increase in the manual toothbrush groups unlike the electric toothbrush groups keeping the same state (p<0.05). These findings suggest that an electric toothbrush is useful to orthodontic patients with fixed appliances.

인유두종 바이러스 양성 및 음성 침윤성 자궁경부암종에서 p53, p21, mdm2 단백의 발현

박인서,한혜승,김태숙,한지영,김준미,주영채,황태숙 대한병리학회 2001 Journal of Pathology and Translational Medicine Vol.35 No.3

특성 길이를 이용한 평직 복합재 볼트 체결부의 강도 예측

박승범,변준형,안국찬 한국안전학회 2003 한국안전학회지 Vol.18 No.4

A study on predicting the joint strength of mechanically fastened woven glass/epoxy composite has been performed. An experimental and numerical study were carried out to determine the characteristic length and joint strength of composite joint. The characteristic lengths for tension and compression were determined from the tensile and compressive test with a hole respectively. The characteristic lengths were evaluated by applying the point stress failure criterion to a specimen containing a hole at the center subjected to tensile loading and a specimen containing a half circular notch at the center subjected to compressive load. The joint strength was evaluated by the Tsai-Wu and Yamada-Sun failure criterion on the characteristic curve. The predicted results of the joint strength were compared with experimental results.