국가예방접종전산등록체계 개발을 위한 민간의료 기관 하부구조 및 환경 조사연구

이무식,김은영,이건세,이석구,홍지영,김건엽,김대경,신의철,이연경,기몽서,나백주,김영택 한국모자보건학회 2003 한국모자보건학회지 Vol.7 No.2

복식 전자궁적출술후 절단부에 발생한 난관탈출증 1예

송은석,이해혁,김태희,김정식,남계현,이권해,고은석 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Prolapse of the fallopian tube into the vaginal vault after hysterectomy is a rare complication. Since most of cases may resolve before detection or remain undiagnosed, the exact incidence is still unknown. Though most common sign of tubal prolapse is tender friable tissue in vaginal cuff, with the simptoms of lower abdominal pain, dysparenunia, vaginal discharge, or postcoital spotting. The definitive diagnosis should be confirmed histologically Recently, we experienced a case of fallopian tube prolapse after abdominal hysterectomy in a 41-year-old woman and report with a brief review of the literature.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

횡문근융해증과 경한 신손상을 동반한 급성 A형 간염 1예

조규민,김창욱,성현진,허준,전부석,이종환,심은희,이석종,이창돈 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.1

A 48-year-old male visited the emergency room of the authors’ hospital due to nausea, vomiting, and myalgia for four days. Acute hepatitis A was identified from the serologic marker of the hepatitis A virus. Mild elevation of the serum creatinine and creatinine phosphokinase(CPK) suggested rhabomyolysis, which was confirmed with the serum aldolase, myoglobin, and urine myoglobin. With supportive care, both the liver and renal func- tions were recovered gradually and fully. This case shows that rhabdomyolysis can be one of the mechanisms of renal complication in cases of acute symptomatic hepatitis A.

식품 기준·규격의 합리적 관리 ·운영에 관한 연구(Ⅰ) : 두부,식용유지, 전분의 분말상 원료에 관하여 Powdered marerials of Tofu, Edible oil, Starch

김희연,홍진환,박혜경,한상배,박종석,이은주,이정성,송경희,최은희,최영준,소경아,성영제,이주엽 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 분말상 원료(전분, 대두분)의 저장유통시 품질변화를 건전성과 안전성 측면에서 검토하여 식품의 기준 ·규격 설정f.」 합지적으로 반영하고자 하였다. 전분과 패두분의 이물을 검사하고, 2종 대두분(중국산, 미국산)을 ?0일간 IS'c와 30t에 저장하면서 성상, 수분, 산가, 과산화물가, 지방산 조성,아플라톡신 BB의 생성여부를 분석하였다. 중국산 대두분 30'』 저장군에서 50일 이후 곰팡이가 발생한 것 이외에 모든 시료에서 양호한 성상을 나타내었고, 전분과 대두닥 모든 시료에서 이물은 검출되지 않았다. 산가는 중국산과 미국산 시료간에 편차를 보여 증국산 30"C, 50일 저장시료에서 약 10배끙도 증가하였고, 과산화물가는 저장 90일후 15'E 저장군은 약 2.3배, 30'c 저장군은 3배정도 증가하였다. 대두분의 주요 지방산은 linoleic acidf18. 2), oleic acid(18 : 1), palmitic acid(16 : 0)이었으며, 3개월 저장에 따른 지방산 함량의 변화는 미미하였다. 아플라톡신 B₁은 모든 시료에서 검출되지 않았다. The objective of this study was to investigate auality changes of type raw materials(starch, soy flour) during various storage conditions. Starchflour(source of China, U.S.A) were slfred under two temperature(15'C, 30'c) forSensory evaluation, (o.reign material test, moisture content, acid value, peroxide ualue,composition, aflatorin Bi were analyzed. China soy flour(stor·ed 30'f) was contaminated by fungj on 50 days. Except for soy flour contardnated by fungi, sensory characteristics were not changed and foreign mater;als were notdetected. Acid value of China soy flour(stored at 30'C, 90 days) was about 10 times higherlevel before storage and acid value was more influenced by source(China, USA). Peroxide valuewas in proportion with the storage period slightly. The major fatty acid of soy flour waslinoleic acid(18 . 2), an(3 the change of fatty acid composition was not observed. Aflatoxlrl Blwas not detected.

지역사회에 봉사하기 위한 복합 다기능교회당 계획안 : 세속석 이용(secular use)의 증진을 위한 열린 교회 디자인 방법 연구

이은석,한요섭 경희대학교 디자인연구원 2004 예술· 디자인학연구 Vol.7 No.1

This paper aims to propose the model of the multi-functional church as a community center. It is based on the background of modern theology and the responsibilities of church itself. Current issues on the contemporary church are 'serving community', 'raising efficiency', 'focusing on other than worship space', and 'raising flexibility'. This study is focused on the efficiency and flexibility to house the complex programs in the same space without losing the original quality of each program.

내분비계 교란물질의 검출계를 이용한 γ-HCH의 미생물에 의한 중간대사산물에 대한 내분비계교란 활성의 평가

이행석,박주석,조은민,문명숙,太田明德,류재천 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

To develop an efficient degradation system for Endocrine disruptors (EDs), it is necessary to have a good system to evaluate rapidly and accurately endocrine-disrupting activities of suspected chemicals and their degradation products. We previously constructed a co-expression system of GAL4 DNA binding domain (DBD)-human estrogen receptorβ ligand binding domain (hERβ LBD) and Gal4p transcriptional activation domain (TAD)-co-activator SRC1 in Saccharomyces cerevisiae with a chromosome-integrated lacZ reporter gene under the control of CYC1 promoter and GAL4 binding site (Upstream Activating Sequence, UAS). Expression of this reporter gene was dependent on the presence of estrogen or endocrine disruptors in the culture medium. Furthermore, the extent of transcriptional activation by those chemicals correlated with their estrogenic activities measured by other assay systems, indicating that this assay system is efficient and reliable for measuring estrogenic activity. We applied this assay system to measure estrogenic activity of microbial degradation products of γ-hexachlorocyclohexane (γ-HCH) by Sphingomonas paucimobilis. Among the γ-HCH metabolites, 2,5-dichlorohydroquinone (2,5-DCHQ) and chlorohydroquinone (CHQ) had similar estrogenic activities to the original chemical, but hydroquinone (HQ), a metabolite at later stage, had no activity at the concentration of 10^-4M, showing the necessity of evaluation of intermediate metabolites in microbial degradation systems.

수중식물과 침전물에 의한 용존산소 변화량 결정 : 하천모델 이용법;a Stream Model Approach

이용석,최은주,박민대,박석순 江原大學校 附設 環境硏究所 1993 環境硏究 Vol.10 No.-

하천모델을 이용하여 한강 지류인 탄천에서 수초와 침전물에 의한 용존산소 변화량을 측정하였다. 수질자료에 따르면 탄천은 상류의 부영양화 지역 (Eutrophic Zone)과 하류의 강부수성 지역 (Polysaprobic Zone)으로 구분되며 상류는 수초의 광합성과 호흡이, 하류는 침전물 산소요구량이 수중 용존산소 농도 결정에 주 역할을 하고 있다. 하천조사는 1990년5월과 10월 2회에 걸쳐 2일간 연속적으로 실시되었다. 조사 결과 상류의 경우 수초 광합성과 호흡에 의한 매우 큰 용존산소 일주변화가 관찰되었다. 그러나 하류의 경우 침전물 산소요구량이 크고 수초 성장이 없기 때문에 일주변화가 거의 나타나지 않는 매우 낮은 농도가 측정되었다. 1차 조사시 상류에서 수중식물의 광합성량과 호흡양은 각각 55~100g 0₂/m²/day, 30~70g 0₂/m²/day으로 측정되었으며, 2차 조사시 각각 40~80g 0₂/m²/day, 25~55g 0₂/m²/day으로 측정되었다. 하류에서는 침전물 산소요구량이 1차 및 2차 조사시 동일하게 4~100g 0₂/m²/day로 측정되었다. The dissolved oxygen changes caused by aquatic plants and sediments were comput-ed in the Tancheon, a tributary of the HanRiver, by utilizing a stream model. According to the collected water quality conditions, the Tancheon was classified into two distinc-tive zones which were eutrophic zone in upstream area and polysaprobic zone in downstream area. The dissolved oxygen levels of the stream were determined mainly by the photosynthesis and respiration of the macrophytes in upstream area and by the sediment oxygen demand in downstream. Field data were obtained from two synoptic stream surveys performed during May and October, 1990 for two consecutive days The high diurnal dissolved oxygen variation was observed in upstream area due to an excessive growth of aquatic plants. In downstream area, however, little diurnal varia-tion with low dissolved oxygen level was observed, which would be attributed to high sediment oxygen demand and no discernible aquatic plant growth. In upstream area, the dissolved oxygen changes caused by the photosynthesis and respiration were ranged from 55g 100g 0₂/m²/day from 30 to 70 g 0₂/m²/day, respectively, during the first survey. The changes were ranged from 40 to 80g 0₂/m²/day for the photosynthesis and from 25 to 55g 0₂/m²/day for the respiration during the second survey, In downstream area, the sediment oxygen demands were measured from 4 to 100g o₂/m²/day during both surveys.

형식적 방법론을 이용한 통신 소프트웨어 개발 지원 환경의 설계와 구현

이은석 성균관대학교 1998 학술회의지원논문목록집 Vol.1998 No.-

금후의 고도의 정보화 사회에서 발생할 다양한 형태의 시스템 요구와 기대에 능동적이고도, 효과적으로 대처해 나가기 위해서는 보다 체계적인 컴퓨터 통신 소프트웨어 개발 방법론의 정비와 확립이 절실히 요구되고 있다. 본 논문에서는 (1)종래의 형식적 기술 기법보다 사용자 친화성(user-friendliness)이 높은 표현 기법으로 통합형 에디터의 제공.(2)(1)에서의 새로운 표현 기법으로부터 국제 표준의 형식적 기술 기법인 LOTOS로의 자동변환법의 제공. (3) 형식사양 수준에서의 소프트웨어 재사용의 방법론을 제공한다. 그 결과, 사용자는 특정FDT(Formal Description Technique)에 대한 깊은 지식이나 충분한 사용 경험이 없어도 시스템에 대한 구조적 요구와 동작요구, 데이터요구만 가지고 최종적으로 원하는 형식사양을 생성해 낼 수 있다. 이는 특정 FDT를 직접적으로 이용하는 것 보다 상대적으로 초기 학 습의 부담이 적고 기술과 이해가 용이하다. Systematic paradigms and methodologies for computer communication software development are essentially required to cupe with diverse system requirements and expectations, to be appeared in the future advanced informarion society actively and effectively This paper describes(I) an integrated editor which has relatively high user fiendliness than other conventional structured editors for formal desciption such as G-LOTOS editors, (2) an automatic translation function to LOTOS from the expression made by the proposed editor. and (3) a software reuse methodology in formal specification level. As a result. a user can generate a formal specification based on LOTOS even if he/she does not have sufficient knowledges and experiences on a specific FDT. This can also reduce the effort required for the initial learning than using a specific FDT directly.

예산지역 낙농가의 경영실태에 관한 조사

이인호,김석은 公州大學校 資源科學硏究所 1998 資源科學硏究論文集 Vol.6 No.-

This survey was carried out to investigated the current status of dairy farming households in Yesan district from Oct., 1997 to 1998. Data obtained from 35 households were collected and analysed on milk yield, milk fat %, recording, management patterns, feeding scale and size, ratio of roughages and concentrates, etc. The results obtained were summarized as follows; 1. The average of daily milk yield in 26 households were below 20kg(74.3%). 2. The milk fat is under 4.0 percentage in whole farming households. 3. 19 households had been keeping book(54.3%), but 16 households (45.7%) had not been keeping book(45.7%). 4. In the patterns of farming management, 20 households were special and professional farming(57.1%), 10 households were additional farming(28.6%). 5. Herd size of dairy farming was larger scale in WTO and IMF, but the cows' capability is lower. 6. The feeding system raising animals in thisarea, the ratio of roughages and concentrates was out of balance in 20households(57.1%).