The utility of the human papillomavirus DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia

소경아,홍진화,송승훈,이재관,이낙우,이규완 대한부인종양학회 2009 Journal of Gynecologic Oncology Vol.20 No.4

Objective: We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). Methods: A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology and HPV DNA test, and colposcopic biopsies were taken at 3- to 6-month intervals. Thirty-seven patients were followed for more than 6 months; their HPV DNA test results were compared to the cytology results for the prediction of disease prognosis. Results: The degree of VAIN was more severe in patients with a high initial HPV DNA load (p=0.009). Patients with VAIN 2 and VAIN 3 were older than those with VAIN 1 (p=0.005 and 0.008, respectively). In 26 out of 37 patients (70.3%), the VAIN resolved. The other patients had persistent lesions with no progression to invasive vaginal carcinoma. The last follow-up HPV DNA load was significantly higher in the group with persistent VAIN compared to the group with resolved VAIN (p<0.0001). Negative cytology was observed in 25 out of 26 patients in the VAIN resolved group and in nine out of 11 patients in the VAIN persistent group (p=0.205). Conclusion: These results suggest that the HPV DNA test, especially for viral load, was more effective for the diagnosis and prediction of persistent VAIN than cytology. Objective: We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). Methods: A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology and HPV DNA test, and colposcopic biopsies were taken at 3- to 6-month intervals. Thirty-seven patients were followed for more than 6 months; their HPV DNA test results were compared to the cytology results for the prediction of disease prognosis. Results: The degree of VAIN was more severe in patients with a high initial HPV DNA load (p=0.009). Patients with VAIN 2 and VAIN 3 were older than those with VAIN 1 (p=0.005 and 0.008, respectively). In 26 out of 37 patients (70.3%), the VAIN resolved. The other patients had persistent lesions with no progression to invasive vaginal carcinoma. The last follow-up HPV DNA load was significantly higher in the group with persistent VAIN compared to the group with resolved VAIN (p<0.0001). Negative cytology was observed in 25 out of 26 patients in the VAIN resolved group and in nine out of 11 patients in the VAIN persistent group (p=0.205). Conclusion: These results suggest that the HPV DNA test, especially for viral load, was more effective for the diagnosis and prediction of persistent VAIN than cytology.

The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study

소경아,김미정,이기헌,이인호,김미경,이유경,황창선,정미선,기미경,강춘,조치흠,김석모,홍성란,김기태,이원철,박종섭,김태진 대한암학회 2016 Cancer Research and Treatment Vol.48 No.4

Purpose The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). Materials and Methods The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months. Results A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001). Conclusion HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.

산후 출혈의 치료를 위한 자궁 동맥 색전술의 실패와 관련된 인자의 분석(초)

소경아,정현철,윤영선,백유진,조금준,홍순철,송승훈,신정호,이재관,오민정,김해중,허준용 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-

Human Papillomavirus Prevalence and Type Distribution Among 968 Women in South Korea

소경아,홍진화,이재관 대한암예방학회 2016 Journal of cancer prevention Vol.21 No.2

Background: Geographic variation in the prevalence of carcinogenic types and human papillomavirus (HPV) genotype distribution is closely associated with the impact of HPV prophylactic vaccines. We determined the prevalence and distribution of HPV genotypes among healthy women in Korea. Methods: This study included 968 healthy women who were examined at a health promotion center of the Korea University Guro Hospital between January and June 2013. Each participant had a Pap test and a HPV DNA test using the AnyplexTM II HPV 28 Detection system, which detects 19 high-risk HPVs (HR HPVs) and 9 low-risk HPVs (LR HPVs). Women with abnormal cytology and/or positivity for HR HPVs were referred to colposcopic biopsy. Results: Overall HR HPV prevalence based on the assay was 33.7%. Among them, 225 women had single infection and 101 women had multiple infection. The most frequently occurring HR HPV types were 53 (6.5%), 52 (6.1%), 58 (4.8%), 16 (4.5%), and 68 (4.2%). The most frequently occurring LR HPV types were 54 (5.4%), 70 (3.8%), 42 (3.6%), 61 (3.4%), and 44 (3.1%). The prevalence of HPV 16 was highest (17.6%) among women with cervical intraepithelial neoplasia (CIN) and HPV 16 was strongly associated with a diagnosis of CIN2/3 (odds ratio = 20.5; 95% confidence interval: 3.9-107.1; P < 0.0001). Conclusions: HPV 53, 52, 58, 16, and 68 were common HR HPV types among healthy Korean women. HPV16 was the most common type in high-grade CIN lesions, as shown in most studies worldwide. The results might be useful information for cervical cancer prevention in South Korea. (J Cancer Prev 2016;21:104-109)

유방암/대장암 환자의 부인과적 관리

소경아 대한산부인과학회 2022 연수강좌 Vol.66 No.-

Human papillomavirus genotype-specific risk in cervical carcinogenesis

소경아,이인호,이기헌,홍성란,김영준,서현희,김태진 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.4

Objective: To evaluate the risk of genotype-specific human papillomavirus (HPV) infections for the spectrum of cervical carcinogenesis and the distribution of HPV types according to age and different cervical lesionsMethods: This study included HPV-positive women who underwent cervical biopsy at the Cheil General Hospital & Women's Healthcare Center between July 1, 2011 and December 31, 2017. HPV genotyping was conducted using a Cheil HPV DNA chip kit. Results: The study sample consisted of 400 normal, 399 cervical intraepithelial neoplasia (CIN) 1, 400 CIN 2, 400 CIN 3, and 389 cervical cancer cases. HPV 16 was the most common type found with a prevalence of 9.5% in normal, 6.8% in CIN 1, 15.0% in CIN 2, 44.5% in CIN 3, and 64.3% in cervical cancer. The most common HPV types were 16, 52, 58, 53, 51, 56, 68, and 18 in all study samples. HPV 16, 31, 33, and 58 were more common in CIN 2/3 and cancer, and HPV 39, 51, 53, 56, 66, and 68 were more common in CIN 1 and normal cases (p<0.001). In CIN 3 and cervical cancer, HPV 16 was the most common type in all age groups. HPV 52 was the most common type in CIN 2 (all age groups) and in CIN 1/normal (age ≤30 years) cases. Among the high-risk HPV types, 16, 31, 33, 52, and 58 showed significant risk for high-grade disease. Conclusions: HPV 16, 31, 33, 52, and 58 showed the significant risk of high-grade disease for cervical carcinogenesis.

보폐탕이 이산화황에 폭로된 흰쥐의 호흡기 손상에 미치는 영향( I )

소경순,Soh Kyung-Sun 대한예방한의학회 1998 대한예방한의학회지 Vol.2 No.1

Surfur dioxide, one of the air pollutants, has been related increasing morbidity rates due to respiratory damages. To investigate the effect of Bopaetang(補肺湯) on rats induced by exposur of $SO_2$, an experimental study was done the changes on white blood cell(W5C), the content of glycoprotein in treachea and the edema, congestion, inflammatory infiltrates of trachea. The experimental groups are the normal group, control group and sample group( administered Bopaetang to rats induced by exposur of $SO_2$). The results were as follows; 1. The change on WBC on rats induced by exposur of $SO_2$ were made significant differences in sample group compared with control group. 2. The content of Glycoprotein In trachea were made significant differences in sample group compared with control group. 3. The edema, congestion, inflammatory infiltrates of treachea were made significant differences in sample group compared with control group.

최신임상강좌 : 산후출혈의 치료를 위한 동맥색전술의 실패와 관련된 인자의 분석

소경아 ( Kyeong A So ),오윤경 ( Yoon Kyung Oh ),황효순 ( Hyo Soon Hwang ),홍혜리 ( Hye Ri Hong ),조금준 ( Geum Joon Cho ),오민정 ( Min Jeong Oh ),허준용 ( Jun Yong Hur ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.9

목적: 산후출혈로 동맥색전술을 시행한 환자들을 분석하여 동맥색전술의 실패의 원인과 관련된 인자들에 대하여 알아보고자 하였다. 연구 방법: 2004년부터 2008년까지 고려대학교 의료원에서 산후출혈로 동맥색전술을 시행한 60명의 환자의 진료 기록과 동맥 조영술 결과를 후향적으로 분석하여 성공군과 실패군을 비교하였다. 결과: 동맥색전술의 전체 성공률은 88.3% (53/60명)였고 실패한 경우는 11.7% (7/60명)였다. 색전술의 실패는 비정상태반인 경우 통계적으로 유의하게 높았으며 (P=0.034), 특히 태반 유착이 동반된 전치태반의 경우에서 더욱 그러하였다 (P=0.009). 각 대상군의 나이, 분만력, 분만 방법, 출혈시기, 전원 여부, 시술 전 수술 여부, 시술 시 활력징후, 시술 전 혈색소 수치, 분만 후 색전술까지 시간, 중환자실 치료 여부 등은 차이가 없었다. 결론: 산후출혈 환자에서 동맥색전술은 성공률이 높고 합병증이 적은 안전한 시술 방법이나 출혈의 원인이 비정상태반인 경우 동맥색전술이 실패할 가능성이 높다. Objective: To investigate what factors are associated with a failed arterial embolization for postpartum hemorrhage (PPH) and to attempt to estimate efficacy of arterial embolization. Methods: Between 2004 and 2008, 60 patients at Korea University Medical Cencter underwent arterial embolization to control obstetrical hemorrhage. In all cases, arterial embolization was performed because of intractable hemorrhage unresponsive to conservative management. Medical records and angiographic results were reviewed. Arterial embolization failure was defined as the requirement for subsequent surgical procedure to control PPH with the procedure, and its results. Results: Arterial embolization was attempted in 60 of deliveries. Failures occurred in 7 of 60 cases (11.7%) and in 4 of 7 cases (57.1%) of abnormal placentation (placenta previa totalis with or without placenta accrete or increta). Comparison of the failed and successful arterial embolization groups showed no differences in maternal characteristics, clinical status, and angiographic finding. Amount of total transfusion in failed arterial embolization group were larger than successful group although hemoglobin before embolization was not different. Conclusion: The only factor significantly associated with failed arterial embolization was an abnormal placentation. Arterial embolization is a safe and highly effective method to control PPH.

박층 포장용 아크릴 폴리머 콘크리트의 현장 적용성 향상을 위한 연구

소경락,김태우,이현종,김형배,곽병석 한국도로학회 2010 한국도로학회 학술발표회 논문집 Vol.2010 No.3

≪漢語大字典≫第二版商補六則

蕭敬偉 한국한자한문교육학회 2015 漢字 漢文敎育 Vol.36 No.-

The 2nd edition of Hanyu Da Zidian, also known as The Grand Chinese Dictionary, has made some significant revisions on such aspects as definitions, pronunciations, documentary evidences and retrieval of characters. Yet, errors are still found in the dictionary. This paper points out and analyzes several erroneous definitions in the dictionary, and provides suggestions for emendations. 2010年出版的≪漢語大字典≫在糾誤、收字、統一字形等問題上,對初版進行了修訂, 並吸收了近年語言文字學, 辭書學的研究成果, 在注音, 釋義, 列舉書證以至檢索等諸方面, 作出了不少改進. 然而, ≪漢語大字典≫收字兼及古今, 卷帙浩繁,而且成於眾手, 第二版雖經修訂,仍然存在不同方面的疏誤。本文指出≪漢語大字典≫第二版對“厲”, “匡”, “共”, “仵”, “假”, “匕”等字在釋義上的若干問題,並略陳管見,希望能對他日的修訂略有補益。