지표 개발을 통한 우리나라 교통 SOC 스톡의 국제비교

신의철,이재민(Lee, Jae-Min),심양주 대한교통학회 2004 대한교통학회 학술대회지 Vol.46 No.-

사회간접자본(SOC)은 교통, 통신, 전력 등 국가전체의 경제활동에 필요한 기반을 제공하는 공공시설로 정의되는데, 국가 예산상으로는 도로, 철도, 지하철, 공항, 항만 등 교통시설 외에 다목적댐, 치수, 용수사업을 SOC사업으로 분류하고 있다. 우리 경제의 경쟁력 강화를 위해서는 주요 사회간접자본 특히, 도로, 철도, 항만, 공항 등의 교통 인프라를 적기․적소에 공급하여 물류비용을 절감시켜 효율적인 생산 및 소비활동을 뒷받침해야 한다. 사회간접자본 부족을 타개하기 위한 정부 노력의 결과, 교통부문 SOC투자의 경우 2003년에 13.9조원으로 지난 5년간 32.7% 증가하였다. 그러나 이러한 교통부문 SOC 투자규모 대해서, 국가경제 규모에 비해 과잉 투자가 이루어지고 있으므로 줄여야 한다는 견해와 향후 일정기간 지속적으로 현재의 교통 SOC 투자가 유지되어야 한다는 견해가 대립되고 있는 실정이다.

Electrical Characterization of Ultrathin Film Electrolytes for Micro-SOFCs

신의철,안평안,조정모,노호성,황재연,이종호,손지원,이종숙 한국세라믹학회 2012 한국세라믹학회지 Vol.49 No.5

The reliability of solid oxide fuel cells (SOFCs) particularly depends on the high quality of solid oxide electrolytes. The application of thinner electrolytes and multi electrolyte layers requires a more reliable characterization method. Most of the investigations on thin film solid electrolytes have been made for the parallel transport along the interface, which is not however directly related to the fuel cell performance of those electrolytes. In this work an array of ion-blocking metallic Ti/Au microelectrodes with about a 160 μm diameter was applied on top of an ultrathin (1 μm) yttria-stabilized-zirconia/gadolinium-doped-ceria (YSZ/GDC)heterolayer solid electrolyte in a micro-SOFC prepared by PLD as well as an 8-μm thick YSZ layer by screen printing, to study the transport characteristics in the perpendicular direction relevant for fuel cell operation. While the capacitance variation in the electrode area supported the working principle of the measurement technique, other local variations could be related to the quality of the electrolyte layers and deposited electrode points. While the small electrode size and low temperature measurements increaseed the electrolyte resistances enough for the reliable estimation, the impedance spectra appeared to consist of only a large electrode polarization. Modulus representation distinguished two high frequency responses with resistance magnitude differing by orders of magnitude, which can be ascribed to the gadolinium-doped ceria buffer electrolyte layer with a 200 nm thickness and yttria-stabilized zirconia layer of about 1 μm. The major impedance response was attributed to the resistance due to electron hole conduction in GDC due to the ion-blocking top electrodes with activation energy of 0.7 eV. The respective conductivity values were obtained by model analysis using empirical Havriliak-Negami elements and by temperature adjustments with respect to the conductivity of the YSZ layers.

자유연제발표 : 세션2 ; 구성원의 참여방식이 행태에 미치는 영향 -전염병감시체계로 부터의 교훈-

신의철,임지혜,김희선,이기효 한국보건행정학회 2008 한국보건행정학회 학술대회 논문집 Vol.2008 No.2

C형간염 바이러스: 면역과 HCV 백신

신의철 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.4(S)

Hepatitis C virus (HCV) infection is an issue of public health care. Chronic persistent HCV infection often progresses to liver cirrhosis and hepatocellular carcinoma. However, the current standard therapy shows a limited efficacy, and prophylactic vaccine has not been developed yet. Therefore, developments of a novel immunotherapy and effective HCV vaccine are urgent. In this lecture, characteristic features of antibody and T-cell responses will be discussed in chronic HCV infection. In addition, immune status after recovery from HCV infection will also be discussed. Understanding of immune responses against HCV will facilitate the development of effective therapeutic and prophylactic strategies.

국민건강보험공단의 효율적 관리운영모형 개발

신의철,김호종,이은환,강승현,윤영수 대한의사협회 의료정책연구소 2010 대한의사협회 의료정책연구소 연구보고서 Vol.- No.-

Coalition Forces of Immunologists and Oncologists for Defeating Cancer

신의철,Deputy Editor, Immune Network 대한면역학회 2020 Immune Network Vol.20 No.1

There has been a long journey in the effort to harness the immune system for the treatment of cancer since Coley's toxin was first used to treat cancer 120 years ago. However, almost all efforts failed to improve patient outcomes. Meanwhile, the concept of cancer immunosurveillance and immunoediting has been established, and T cells have been considered major players in the immune responses to cancer. Moreover, immunologists have found that tumor antigen-specific T cells are largely ‘exhausted’ in both murine and human tumors. During immune responses, Ag-specific T cells are regulated by various mechanisms, including inhibitory receptors, to avoid excessive and persistent immune responses. These immune checkpoints suppress T-cell responses, particularly in cancer patients, leading to T-cell exhaustion. CTLA-4 and PD-1 are the most well-known immune checkpoint inhibitory receptors and have been targeted for drug development. As a result, anti-CTLA-4 and anti-PD-1/PD-L1 blocking antibodies are now successfully used for cancer treatment and known as immune checkpoint inhibitors (ICIs). The current ICIs have some limitations. First, ICIs fail to control tumors in a significant proportion of cancer patients. Moreover, tumor growth becomes accelerated after ICI treatment in some patients. This is known as hyperprogressive disease (HPD). In addition, certain patients suffer from immune-related adverse events (irAEs) following ICI treatment. However, we do not yet know the mechanisms underlying a non-response, HPD, and irAEs following ICI treatment, hampering mechanism-driven development of new immuno-oncological agents and rationale-based patient management. The recent explosive growth of ‘immuno-oncology’ has been enabled by successful translational research from bench-side basic immunology to bedside clinics. Now, it is time to raise questions from the bedside and answer them with basic immunology. These findings will then be translated to the clinic, creating a virtuous cycle to boost the growth of immuno-oncology. Coalition forces of immunologists and oncologists are necessary to defeat cancer. In the current issue of Immune Network, we publish 10 review articles in the field of tumor immunology and immuno-oncology. First, T-cell exhaustion and inhibitory receptors and co-stimulatory receptors are discussed. The roles of regulatory T cells, γδ T cells IL-17-producing cells, and NANOG signaling in tumor immunity are also described. From the translational and clinical aspect, peripheral blood biomarkers and irAE-related issues are comprehensively reviewed. The recent progress in immunotherapy for non-small cell lung cancer and hepatocellular carcinoma are discussed.

개발조사와 프로젝트형 사업의 비교 및 개선과제

신의철 한국국제협력단 2005 국제개발협력 Vol.2005 No.3

신재생에 계통연계 확대방안

신의철,Sin, Ui-Cheol 대한전기협회 2015 전기저널 Vol.464 No.-

플라즈마 전처리를 통한 Inconel 600 합금 위 CNT 합성 수율 증대

신의철,정구환 한국진공학회 2011 한국진공학회 학술발표회초록집 Vol.40 No.0

New Korean Record of Setarches longimanus (PISCES: Scorpaenidae)

신의철,김진구,주동수 한국수산과학회 2016 Fisheries and Aquatic Sciences Vol.19 No.2

Setarches longimanus (Alcock 1894), in the family Scorpaenidae, was collected from Busan and the coastal waters of Jeju Island,Korea,inJanuaryandNovember2014,respectively.TwospecimensarecharacterizedbyXI,10dorsalfinrays; 19–21pectoralfinrays; III, 5 anal fin rays; a second preopercular spine much shorter than the first and third; and an interorbital width 11.3 %–11.6 % of the standard length. We also analyzed 587 base pairs of the mitochondrial DNA cytochrome c oxidase subunit I sequences in order to confirm the taxonomic status of the specimen. As a result, the sequences of our specimen almost corresponded to those of Chinese S. longimanus (genetic distance, d = 0.005), but considerably differed from those of S. guentheri (d = 0.120–0.124). We propose the new Korean names “Ma-su-gampeng- sok” for the genus Setarches, and “Bul-geun-ma-su-gam-peng” for the species S. longimanus.