[만나고 싶었습니다] 충북여성재단 박혜경 대표이사

박혜경 한국여성정책연구원(구 한국여성개발원) 2021 젠더리뷰 Vol.61 No.-

한국 소아의 Mumps 바이러스 항체보유에 관한 혈청학적 진단방법의 비교

박혜경 대한미생물학회 1986 大韓微生物學會誌 Vol.21 No.4

Mumps is an extremly common infectious disease affecting predominantly young children hut it is not a severe disease in terms of mortality. One hundred and two sera from infants of 3 different groups which are vaccinated, unvaccinated and unknown were detected to mumps antibody. The tests used were Complement Fixation(CF) test, Single Radial Hemolysis(SRH) test, Hemagglutination 1nhibition(Hl) test, Enzyme Linked 1mmunosorbent Immunoglobulin G(ELISA IgG) test, Enzyme Linked Immunosorbent Immunoglobulin M(ELISA IgM) test. 1. The rate of positivity for mumps antibody in 102 sera wera 89.16% (74/83) by HI test, 68.83% (53/77) by ELISA IgG test, 64.58% $lt;62/96) by SRH test,63.24%(43/68) by ELISA IgM test and 50.00%(49/98) by CF test. 2. The rate of positivity by 5 tests for 55 sera turned out to be very similar with above results respectively. 3. The correlation coefficients(r) between ELISA IgG test ant HI test, ELISA IgG test and ELISA IgM test were 0.34(P$lt;0.01) and 0,31(P$lt;0.02), respectively. 4. The percentage of apparently natural infection of mumps seemed to be 65.15% (43/66) in infants. 5. Seroconversion rate of mumps by vaccination were 90.91% (10/ll), 6. Among the 53 infants who were tested with ELISA IgG 15 were below 15 months age of(28.30%) and this percentage may be taken as a suggestion that mumps vaccination should be given earlier than present practice. 7. ELISA IgG test was found very sensitive and recommendable method for large scale screening for the presence of antibody to mumps.

클로자핀 사용과 관련된 심한 고중성지방혈증 및 급성 췌장염 1예

박혜경,원혜진,안효승,이반석,김승구,이우제,고경수,이병두 대한내분비학회 2007 Endocrinology and metabolism Vol.22 No.5

Clozapine, an atypical antipsychotic agent, has been linked to several cases of acute pancreatitis and hypertriglyceridemia. However, neither acute pancreatitis nor hypertriglyceridemia associated with clozapine has yet been reported in the Republic of Korea. Based on recent experience, we report on a case of severe hypertriglyceridemia and acute pancreatitis associated with clozapine. A 37-year-old schizophrenic woman in good physical condition presented with abdominal pain of acute onset. She had been taking clozapine for 20 months to control her schizophrenia. On admission, her serum triglyceride level was 6,670 mg/dL. Elevated serum amylase and lipase levels, as well as abdominal computed tomography findings, were compatible with acute pancreatitis. After discontinuing the use of clozapine, the serum triglyceride level was normalized and acute pancreatitis resolved. (J Kor Endocrine Soc 22:381~385, 2007) 비정형 항정신병 약물인 클로자핀은 고중성지방혈증과 급성 췌장염을 유발할 수 있다. 저자들은 약 20개월간 클로자핀을 복용하던 사람에서 심한 고중성지방혈증 및 급성 췌장염이 발생한 증례를 경험하여 문헌고찰과 함께 보고하는 바이다. 클로자핀을 복용하는 사람의 경우 장기적으로 고중성지방혈증 및 급성 췌장염 발생 가능성을 염두에 두고 이에 대해 주의를 기울여야 할 것으로 생각된다.

Polymerase chain reaction으로 설사 영유아 대변 검체에서 adenovirus type 40, 41의 분리 동정

박혜경,서주영,정영해,김경희 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-

Adenovirus is the second leading cause of acute gastroenteritis. As the children with diarrhea by acute adenoviral gastroentertis usually require hospitalization, rapid diagnosis is necessary for proper management. Adenovirus infection can be diagnosed conventionally by the direct electron microscopic observation of the virus particle, isolation of the virus by cell culture, or enzyme immuno assay. Recently, polymerase chain reaction is applied for the detection of adenovirus. In this study, we investigated stools collected from 100 children hospitalized for diarrhea in Ewha womans University Hospital from the September of 1995 to the July of 1996 for adenovirus by polymerase chain reaction. Two oligonucleotide primers, desiginated as hexAA1885 and hexAA1913, were used for the detection of enteric adenovirus type 40 an 41 in PCR. After amplification pf 35 cycles, 300 bp fragments were detected on 1.8% Sea Kem GT agar gel in 14 samples. The stool samples were further analyzed by electron microscopy and immunoblotting. In electron microscopy, icosahedral particles of about 75nm were observed in a^7 of the 14 samples. The 14 samples were collected from children whose mean age was 1.4 years and the sex ratio was 10/4(M/F). The seasonal variation showed acute gastroenteritis by adenovirus infection was frequent in March to May and in September to October in Korea.

오피스 환경의 質的향상과 디자인 方向

朴惠卿 誠信女子大學校 産業美術硏究所 1991 産業美術硏究 Vol.7 No.-

謝靈運 山水詩에 표현된 時空의 특징

박혜경 중국어문논역학회 2007 中國語文論譯叢刊 Vol.S No.20

남성작가의 작품에 나타난 여성의 이미지들

박혜경 동국대학교 한국문학연구소 1997 한국문학연구 Vol.0 No.19

Cytomegalovirus 일차감염의 혈청학적 진단을 위한 면역글로브린 M과 E 측정방법들의 비교연구

박혜경 이화여자대학교 생명과학연구소 1990 생명과학연구논문집 Vol.1 No.-

Sera from 110 children hospitalized with various disease were tested for detection of IgM and IgE antibodies against cytomegalovirus with 5 different EIA methods. Such as the indirect IgM EIA, the antibody capture IgM EIA, the double sandwich IGM EIA, the IgG remove IgM EIA and the indirect IgE EIA. And the methods were compared with each other on terms of positivity rate, mean OD, sensitivity and time consumed according to the obtained data. The results are as follows. 1. The antibody capture IgM EIA method is the most sensitive test for detection of CMV primary infection with sera. The positive reation was evident even to naked eye by its orange color. 2. The antibody capture IgM EIA method seemed necessary of longest time to finish because it involves 2 steps of reaction. 3. The IgG remove IgM EIA method was relatively sensitive and necessary of less time finish compare to others. 4. The antiboby capture IgM EIA method was found to be most sensitive over others for detection of CMV primary infection showing positivity by 37/110(33.6%). 5. Almost same positivites in the double sandwich IgM EIA method (21/110,19.1%) and the IgG remove IgM EIA method (25/110,22.7%) for detection to CMV primary infection were observed. 6. The indirect IgM EIA method showed the lowest positivity by (15/110,13.6%) but seemed necessary of least time to finish. 7. The indirect IgE EIA method showed the lowest positivity (14/110,12.7%) for the detection of CMV primary infection. According to above results, it indicated that the antibody capture IgM EIA and the IgG remove IgM EIA-combined serologic method is the most accurate test for detection of CMV primary infetion among the five methods.

一般 人口群의 紅疫抗體에 對한 血淸學的 硏究

朴蕙瓊 梨花女子大學校 韓國生活科學硏究院 1982 韓國生活科學硏究院 論叢 Vol.30 No.-

홍역은 유행성이 크고 감염성이 강한 어린이 질환중의 하나인데, 1965년부터 구미에서는 집단접종을 시행하여 이환율 합병증 사망율이 현저히 감소되었다. 그러나 홍역예방접종이 잘된 선진국에서도 어린 나이 및 학동기 사춘기 및 젊은 성인층에서 홍역감염이 보고되고 있기에 일반인구군의 홍역항체의 분포가 홍역발생 가능성을 이해하는데 도움을 줄 수 있다고 생각되었다. 이에 저자는 영국 Oxford지역의 여러 연령층으로 나누어 홍역항체를 측정하였다. 사용한 방법은 보체결합반응과 간접 면역형광항체법 두가지 방법으로 동시에 측정하였다. 두 방법에 의한 홍역항체보유율의 경향은 비스하여 생후 6개월∼1세미만의 연령군의 홍역항체보유율이 가장 낮고, 그 다음은 1세∼5세 연령군이 낮았다. 또 홍역보체결합항체의 geometric mean titer는 연령과 더불어 증가하고, 홍역의 유행이 보고된 연령군 즉 학동기 및 젊은 연령층에서 다른 연령층과 비교시 낮은 역가를 나타내었다. 홍역항체 보유 여부에 관한 집단조사에서 간접면역형광법은 편리하게 이용될 수 있는 예민한 방법이라 생각되었다. One hundred sera from general population which were obtained at Virus Laboratory, John Rdacliffe Hospital, Oxford, U.K. during the period from January to June, 1979 were studied with Complement Fixation (CF) test and indirect Immunofluorescence (IF) test for measles virus in order to understand its epidemiologic behavior in immunized community. The results showed that the group of infants between 6 month to under 1 year was the lowest by 31.6∼61.1% at measles antibodies positivity by both methods. The group of children between 1 year to 5 years was the next lowest by 60∼80% as expected by immunization, but not quite complete to prevent sporadic outbreaks of minor size. The other age groups were observed to have very high positivity around 87.5∼100% in general. Besides, it was found from the above results that indirect IF test is a good method for mass survey for measles virus antibodies as sensitive and easy as CF test, but not as time-comsuming.

해산물의 Vitamin B_12 함량 측정

박혜경,성낙응 梨花女子大學校 醫科大學 醫科學硏究所 1978 EMJ (Ewha medical journal) Vol.1 No.2

The content of Vitamin B_12 in various sea products common in Korea were evaluated by microbiological assay method using Lactobacilli leichmannii. The results and discussion are presented.