Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

Clinical Outcome of Modified Cervical Lateral Mass Screw Fixation Technique

Kim, Seong-Hwan,Seo, Won-Deog,Kim, Ki-Hong,Yeo, Hyung-Tae,Choi, Gi-Hwan,Kim, Dae-Hyun The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.52 No.2

Objective : The purpose of this study was 1) to analyze clinically-executed cervical lateral mass screw fixation by the Kim's technique as suggested in the previous morphometric and cadaveric study and 2) to examine various complications and bicortical purchase that are important for b-one fusion. Methods : A retrospective study was done on the charts, operative records, radiographs, and clinical follow up of thirty-nine patients. One hundred and seventy-eight lateral mass screws were analyzed. The spinal nerve injury, violation of the facet joint, vertebral artery injury, and the bicortical purchases were examined at each lateral mass. Results : All thirty-nine patients received instrumentations with poly axial screws and rod systems, in which one hundred and seventy-eight screws in total. No vertebral artery injury or nerve root injury were observed. Sixteen facet joint violations were observed (9.0%). Bicortical purchases were achieved on one hundred and fifty-six (87.6%). Bone fusion was achieved in all patients. Conclusion : The advantages of the Kim's technique are that it is performed by using given anatomical structures and that the complication rate is as low as those of other known techniques. The Kim's technique can be performed easily and safely without fluoroscopic assistance for the treatment of many cervical diseases.

Cisplatin과 Tobramycin이 白鼠 Corti器에 미치는 영향에 關한 電子 顯微鏡的 硏究 : Ultrastructural Study

김동환,신태균,김무강,김홍선,김원식 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

In order to study the morphological changes of Corti’s organ in the rat treated with cisplatin and tobramycin, thirty-three rats, weighing between 200∼250g, were used, and divided into 4 groups, i.e., 3 rats were used for control, and 30 rats were used for 3 experimental groups. Each experimental group was divided into cisplatin-treated, tobramycin-treated, and both cisplatin and tobramycin treated group with 10 rats. Rats were injected with a single dose of 7.7㎎/㎏ of cisplatin intraperitoneally and 50㎎/㎏/day of tobramycin for 2 days intramuscularly, respectively or both. Treated rats were sacrificed on the 3rd and 5th day after the first injection. Results were as follows; 1. Cisplatin-treated group: Outer hair cells of Corti’s organ were degenerated with the formation of vacuoles and appearance of lysosomes, however, inner hair cells showed mild vacuolization. 2. Tobramycin-treated group: NO pathological changes were found in Corti’s organ. 3. Combined cisplatin and tobramycin treated group: Outer and inner hair cells showed vacuolization, appearance of lysosomes, myelin figures and multivesicular body. There were also multivesicular body in the inner phalangeal cell and myelin figure in the Reissner’s membrance. 4. Degeneration of Corti’s organ in the combined treated group was more sever than those of the single cisplatin-treated or tobramycin-treated group. 5. NO pathological differences of Corti’s organ in duration of postinjection were manifested in any groups. It can be concluded that cisplatin induces toxicity to inner ear and cisplatin enhance toxicity more in continued treated with tobramycin.

호주의 유전자변형생물체(Genetically Modified Organisms) 안정성 심사절차 및 유전자변형식품의 표시제도

김태산,김영미,손성한,김용환,박용환 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.1

1. 호주는 GMO의 실험 및 상업화를 규제하는 신법 "유전자기술에 관한 법(Gene Technology Act 2000)을 제정 운영중임 2. GMO를 관리 감독하기 위하여 보건후생성산하에 유전자기술 감독국(Office of the Gene Technology Regulator)이 신설됨 3. GMO를 취급(dealings)형태에 따라서 면제(exemption), 위험이 매우적은 취급(notifiable low risk dealing), 면허(licensing), 등록(register)의 4가지로 분류하여 감독함 4. GM식품의 안전성 심사는 호ㆍ뉴식품청(Australia New Zealand Food Authority, ANZFA)에서 관장하며 호주식품 강령 기준 18(Standard A18 of the Australian Food Standards Code)이 근거 법임 5. ANZFA에서는 제초제 저항성 콩, 옥수수, 면화, 감자, 카놀라 등 6작물 12종의 GM작물에 대하여 식품안정성 확인을 완료함 6. 호주에서는 2001년 12월 7일부터 유전자변형식품의 의무 표시제를 시행하고 있으며 비의도적 혼입 허용치는 1%로 설정함 As Australia's new national gene technology regulatory system began on 21 June 2001, the Office of the Gene Technology Regulator (OGTR) was newly established to regulate GMO related research and GM products throughout the nation. "Gene Technology Act 2000" is the statutory basis the new regulatory system. The OGTR is within the Commonwealth Department of Health and Aged Care, responsible for overseeing the gene technology research and development including the GMO field trials across Australia. For the regulation of genetically modified food, the Australia New Zealand Food Authority(ANZFA) is responsible for developing and reviewing national food standards. All foods available for sale in Australia and New Zealand must comply with the relevant national food standards. ANZFA also responsible for carrying out safety assessments of GM foods on behalf of the Commonwealth, State and Territory Governments of Australia and the Government of New Zealand. The ANZFA's safety assessment process for GM foods is based on concepts and principles that have been developed through international organizations such as the World Health Organization(WHO) and the Food and Agriculture Organization(FAO) and the Organization for Economic Co-operation and Development(OECD). Mandatory labelling of GM foods containing either introduced DNA or protein in the final food came into effect on 7 December, 2001.

Benzoate, m-Toluate, Phenol의 Pseudomonas putida에 의한 생분해

김장규,김석형,김태환,이대광,김남기 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.1

It this study, basic data were obtained for the treatment of industrial waste water which includes aromatic compounds. Substrate concentrations used were 100ppm, 500ppm, and 1,000pprn and initial pH's were pH6, pH7, and pH8 in order to obtain the optimum conditions for treating benzoate, m-toluate, and phenol by Pseudomonas putida(KCTC 1644). Durations were 20hrs for 100ppm, 40hrs for 500ppm, and 60hrs for 1,000ppm before the static growth of Pseudomonas putida. 100% of 100ppm benzoate(0.31g cell/1) was biodegraded at pH6, pH7, and pH8 before 20hrs, 52.8% of 500ppm at pH8 in 40hrs, and 27.9% of 1,000ppm at pH8 in 60hrs. The best initial pH was pH8 for the biodegradation and the growth of Pseudomonas putida in benzoate medium. For m-toluate, the best initial pH was also pH8. At this pH, 40.6% of 10Dppm(0.31 cell/1), 21.9% of 500ppm, and 14.1% of 1,000ppm m-toluate were biodegraded respectively in limited time. But for phenol, the best initial pH was pH7. At this point, 9.8% of 100ppm(0.218 cell/1), 7.1% of 500ppm, and 4.7% of 1,000ppm phenol were biodegraded respectively. Therefore, the best carbon source in this experiment was benzoate. Pseudomonas putida was also able to biodegrade m-cresol, p-hydroxybenzoic acid, and benzaldehyde.

장기간 항갑상선제 투여 후 임의 중단 뒤 재복용시 발생한 무과립구증 1 예

김승만;김태영;박수영;배영환;서영경 정은주;김태균;권민정;박정현;이순희 인제대학교 2011 仁濟醫學 Vol.32 No.-

Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.

Gelation에 의한 방사성 금속염화물의 안정화/고정화 : Part2: 알칼리 금속염화물과 이성분계(Si-P)와의 겔화반응 Part2: Gelation with alkali metal chloride in binary system(SiO2/P2O5)

김인태,박환서,김환영,유재형,김준형 한국공업화학회 2002 응용화학 Vol.6 No.2

By gelation with sodium silicate and phosphorous oxide in binary system, we investigated the possibility to fix the volatile alkali metal chlorides in a highly stable matrix at high temperature if the product gel is further solidified to form glass or ceramic waste form. The binary system with different metal chloride(MCl) loadings underwent gelation reaction at 70℃ for 1 day and dried at 110℃ for 1 day. XRD analysis showed that all the dried gel contained NaCl and some unknown crystalline phase. From the experimental results, the reaction mechanism can be proposed as follows. Also, the possibility of Cs vaporization could be lowered by the application of the new gel-route stabilization/solidification to treat waste salt. (G,Na)+MCl→(G,M)+NaCl, (G.H)+MCI→(G,M)+HCl.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

슬롯후드 입구 균일류 형성 조건

김환태,김태형,하현철,김은아 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1

Slot hoods are most commonly used to provide uniform exhaust air flow and an adequate capture velocity over finite length of contaminant generation, e.g. an open surface tank or over the face of a large hood such as a side-draft design. The function of the slot is solely to provide uniform air distribution. Industrial Ventilation Manual edited by ACGIH (American Conference of Governmental Industrial Hygienists) recommended the conditions to obtain uniform air distribution . slot velocity higher than 10m/s and take-off angle larger than 45 degree. But, in reality, it might not be an easy task to satisfy the conditions for uniform air distribution. By using CFD (Computational Fluid Dynamics), the 81 cases (3 aspect ratios x 3 mean slot velocities x 3 take-off angles x 3 duct velocities) were thus simulated and the coefficients of variance were computed to compare the uniformity of slot face velocities. Generally speaking, either aspect ratio or duct velocity do not affect the uniformity a lot while both slot velocity and take-off angle play a crucial role in forming uniform air distribution.